daldrup@radiology.ucsf.edu
(415) 476-4328 (voice)
(415) 476-0616 (fax)

Box 0628, UCSF; San Francisco, CA 94143-0628

additional websites:

Contrast Agent Research Group
Pediatric Radiology Section

Medical School, University of Münster, Germany, Medicine, 1987-1992 Medical School, University of Münster, Germany, MD Thesis, 1989-1993
Internship in Herford, Zürich and Münster, 1992-1993, Medicine, Surgery, Radiology
Residency, University Hospitals of Münster and the Technical University of Munich, Germany, 1994-1995, 1997-2001, Radiology
Research Fellowship, UCSF Medical Center, 1996, Contrast Media Research
PD Thesis, 2001-2004, Molecular Imaging

Daldrup HE, Shames D, Wendland M, Okuhata Y, Link TM, Rosenau W, Lu Y, Brasch RC: Correlations of Dynamic Contrast Enhanced Magnetic Resonance Imaging with Histologic Tumor Grade: Comparison of Macromolecular and Small Molecular Contrast Media. Caffey Award Paper: Am J Roentgenol 171 (4): 941-949, 1998 and Pediatr Radiol 28: 67-78, 1998

Daldrup HE, Link TM, Blasius S, Kšnemann S, JŸrgens H, Rummeny EJ: Monitoring Radiation-Induced Changes in Bone Marrow Histopathology with Ultra-Small Superparamagnetic Iron Oxide (USPIO) Enhanced MRI. - J Magn Reson Imaging 9: 643-652, 1999

Daldrup-Link HE, Link TM, Mšller H, Wiedermann D, Bonnemain B, Corot C, Rummeny EJ: Carboxymethyldextran-A2-Gd-DOTA Ð enhancement patterns in the abdomen and pelvis in an animal model. European Radiology 11: 1276-1284, 2001.

Daldrup-Link HE, Franzius C, Link TM, Laukamp D, Sciuk J, JŸrgens H, Schober O, Rummeny EJ: Whole Body MR Imaging for Detection of Bone Metastases in children and young adults: comparison with skeletal scintigraphy and FDG PET. Am J Roentgenol 177: 229-236, 2001

Daldrup-Link HE, Rummeny EJ, Ih§en B, Kienast K, Link TM: Iron oxide enhanced MR imaging of bone marrow in patients with non-Hodgkin`s lymphoma: differentiation of tumor infiltration and hypercellular bone marrow. Europ Radiol 11: 1276-1284, 2001

Daldrup-Link HE, Rydland J, Helbich T, Turetschek K, Haraldseth O, Link TM, Brasch RC, Shames D, Rummeny EJ: Quantitative MRI-Estimates of breast tumor microvascular permeabilities to the macromolecular contrast agent Feruglose (Clariscan) correlate with histologic tumor grade: Initial Phase II Multicenter Trial. Radiology 229(3): 885-92, 2003

Daldrup-Link HE, Rudelius M, Oostendorp RAJ, Settles M, Piontek G, Metz S, Heinzmann U, Rummeny EJ, Schlegel J, Link TM: Targeting of Hematopoietic Progenitor Cells with MR Contrast Agents. Radiology 228: 760-767, 2003

Rudelius M*, Daldrup-Link HE, Heinzmann U, Piontek G, Settles M, Link TM, Schlegel J: Highly efficient paramagnetic cellular labeling by standard transfection protocols. Eur J Nucl Med Mol Imaging 30: 1038-1044, 2003.

Daldrup-Link HE, Kaiser A, Helbich T, Werner M, Bjornerud A, Link TM, Rummeny EJ: Macromolecular contrast medium (feruglose) versus small molecular contrast medium (gadopentetate) enhanced magnetic resonance imaging: differentiation of benign and malignant breast lesions. Acad Radiol 10(11):1237-46, 2003

Daldrup-Link HE, Rydland J, Helbich T, Turetschek K, Haraldseth O, Link TM, Brasch RC, Shames D, Rummeny EJ: Quantitative MRI-Estimates of breast tumor microvascular permeabilities to the macromolecular contrast agent Feruglose (Clariscan) correlate with histologic tumor grade: Initial Phase II Multicenter Trial. Radiology 229(3): 885-92, 2003

Daldrup-Link HE, Rudelius M, Metz S, Piontek G, Settles M, Pichler B, Heinzmann U, Weinmann HJ, Schlegel J, Link TM, Rummeny EJ, Oostendorp RAJ: Stem cell tracking with Gadophrin-2 Ð a bifunctional contrast agent for MR imaging, optical imaging and fluorescence microscopy. Eur J Nucl Med Mol Imaging 31(9):1312-21, 2004.

Metz S, Bonaterra G, Rudelius M, Settles M, Rummeny EJ, Daldrup-Link HE: Capacity of Human Monocytes to phagocytose approved iron oxide MR contrast agents. Eur Radiol 14(10):1851-8, 2004

Daldrup-Link HE, Okuhata Y, Wolfe A, Srivastav S, Oie S, Ferrara N, Cohen RL, Shames DM, Brasch RC: Decrease in tumor apparent permeability surface area product to a MRI macromolecular contrast medium following angiogenesis inhibition with correlations to cytotoxic drug accumulation. Microcirculation 11(5):387-96, 2004

Daldrup-Link HE, Okuhata Y, Wolfe A, Srivastav S, Oie S, Ferrara N, Cohen RL, Shames DM, Brasch RC: Decrease in tumor apparent permeability surface area product to a MRI macromolecular contrast medium following angiogenesis inhibition with correlations to cytotoxic drug accumulation. Microcirculation 11(5):387-96, 2004

Daldrup-Link HE, Rudelius M, Piontek G, Metz S, BrŠuer R, Debus G, Corot C, Schlegel J, Link TM, Peschel C, Rummeny EJ, Oostendorp RAJ: Migration of iron oxide labeled human hematopoietic progenitor cells in a xenotransplant model: in vivo monitoring using clinical magnetic resonance imaging equipment. Radiology 234(1): 197-205, 2005

Daldrup-Link HE, Meier R, Rudelius M, Piontek G, Piert M, Metz S, Settles S, Uherek C, Schlegel J, Rummeny EJ: In-vivo Tracking of genetically engineered anti-HER2/neu directed Natural Killer to HER2/neu positive Mammary Tumors with Magnetic Resonance Imaging. Eur Radiol 15(1): 4-13, 2005

Daldrup-Link HE, Rudelius M, Oostendorp RA, Jacobs VR, Simon GH, Gooding C, Rummeny EJ: Comparison of iron oxide labeling properties of hematopoietic progenitor cells from umbilical cord blood and from peripheral blood for subsequent in vivo tracking in a xenotransplant mouse model. Acad Radiol. 12(4):502-10, 2005

Preda A, Turetschek K, Daldrup H, Floyd E, Novikov V, Shames DM, Roberts TPL, Carter WO, Brasch RC: The Choice of Region of Interest Measures in Contrast-Enhanced MRI Characterization of Experimental Breast Tumors. Invest Radiol 40(6): 349-354, 2005

Simon GH, von Vopelius-Feldt J, Wendland M, Schlegel J, Mei-Hsiu C, Daldrup-Link HE: Ultrasmall superparamagnetic iron oxide enhanced MR imaging of normal bone marrow in rodents. Academic Radiology 12(9):1190-7, 2005

Simon GH, Daldrup-Link HE, von Vopelius-Feldt J, Fu Y, Berejnoi K, Schlegel J, Mei-Hsiu C, Wendland M: Comparison of Ferumoxtran-10, Ferumoxytol and SHU555C for MR Imaging of Experimental Arthritis. Investigative Radiology 41(1):45-51, 2006

Metz S, Lohr S, Settles S, Beer A, Woertler M, Rummeny EJ, Daldrup-Link HE: Ferumoxtran-10 enhanced MR imaging of the bone marrow before and after conditioning therapy in patients with Non Hodgkins Lymphoma. Eur Radiol. 16(3):598-607, 2006

Simon GH*, von Vopelius-Feldt J, Wendland M, Fu Y, Piontek G, Schlegel J, Chen, MH, Daldrup-Link HE: MRI of arthritis: Comparison of ultrasmall superparamagnetic iron oxide vs. Gd-DTPA. Journal of Magnetic Resonance Imaging 23(5):720-7, 2006

Daldrup-Link HE, Simon G, Brasch RC: Imaging of Tumor Angiogenesis. Current Approaches and Future Prospects. Current Pharmaceutical Design 12(21):2661-72, 2006

Simon GH, Bauer J, Wendland M, Saborowski O, Fu Y, Corot C, Daldrup-Link HE: T1 and T2 relaxivity of intracellular and extracellular USPIO at 1.5T and 3T clinical MR scanning. Eur Radiol 16(3):738-45, 2006

Daldrup-Link HE, Henning T, Link TM: MR Imaging of Therapy induced Changes of the Bone Marrow. Invited article for Eur Radiol 17(3):743-61, 2007

Saborowski O, Simon G, Raatschen H, Wendland M, Fu Y, Knudsen M, Baehner R, Corot C, Chen MH, Daldrup-Link HE: MR imaging of arthritis with the new, folate-receptor targeted contrast agent P866. Contrast Media & Molecular Imaging Mar 27, 2007 [Epub ahead of print]

Henning T, Saborowski O, Golovko D, Boddington S, Bauer J, Fy Y, Meier R, Pietsch H, Sennino B, Daldrup-Link HE: Cell labeling with the positive MR contrast agent Gadofluorine M. Eur Radiol Jan 6, 2007 [Epub ahead of print]

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