defranco@cgl.ucsf.edu
(415) 476-5488 (voice)
(415) 476-6185 (fax)

Box 0552, UCSF; San Francisco, CA 94143-0552

Harvard College, Cambridge MA, A.B., 1975, Biochemical & Molecular Biology
University of California, Berkeley, CA, Ph.D., 1979, Biochemistry
National Institutes of Health, Bethesda MD, Postdoctoral, 1979-83, Immunology

Horne, M., P.E. Roth, and A.L. DeFranco (1996). Assembly of the truncated immunoglobulin heavy chain D into antigen receptor-like complexes in pre-B cells but not in B cells. Immunity 4: 145-158.

Richards, J.D., M.R. Gold, S.L. Hourihane, A.L. DeFranco, and L. Matsuuchi (1996). Reconstitution of B cell antigen receptor-induced signalling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase. J. Biol. Chem. 271: 6458-6466.

Hambleton, J., S. Weinstein, L. Lem, and A.L. DeFranco (1996). Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proc. Natl. Acad. Sci. USA 93: 2774-2778.

Harmer, S., and A.L. DeFranco (1997). Shc possesses two Grb2 binding sites needed for the efficient formation of complexes with SOS in B lymphocytes. Molec. Cell. Biol. 17: 4087-4095.

Chan, V.W.F., F. Meng, P. Soriano, A.L. DeFranco, and C.A. Lowell (1997). Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and downregulation. Immunity 7: 69-81.

Crowley, M.T., P.S. Costello, M. Turner, F. Meng, C. Lowell, V.L.J. Tybulewicz, and A.L. DeFranco (1997). A critical role for Syk in signal transduction and phagocytosis mediated by Fc receptors on macrophages. J. Exp. Med. 186: 1027-1039.

Chan, V.W.F., C.A.Lowell, and A.L. DeFranco (1998). Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes. Curr. Biol. 8: 545-553.

MacKichan, M.L., and A.L. DeFranco (1999). Role of ceramide in lipopolysaccharide (LPS)-induced signaling. LPS increases ceramide rather than acting as a structural homolog. J. Biol. Chem. 274: 1767-1775.

Harmer, S. and A.L. DeFranco (1999). The SH2-containing inositol phosphatase SHIP forms a ternary complex with Shc and Grb2 in antigen receptor-stimulated B lymphocytes. J. Biol. Chem. 274: 12183-12191.

Fitzer-Attas, C.J., M.T. Crowley, A.J. Finn, F. Meng, A.L. DeFranco, and C.A. Lowell (2000). Fc receptor-mediated phagocytosis in macrophages lacking the Src-family tyrosine kinases Hck, Fgr, and Lyn. J. Exp. Med. 191: 669-682.

Weinstein, S.L., A.J. Finn, S. Dave, F. Meng, C.A. Lowell, J.S. Sanghera, and A.L. DeFranco (2000). Phosphatidylinositol 3-kinase and mTOR mediate Lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-. J. Leuk. Biol. 67: 405-414.

Yu, C.C.K., T.S.B. Yen, C.A. Lowell, and A.L. DeFranco (2001). Lupus-like kidney disease in mice deficient in Src-family protein tyrosine kinases Lyn and Fyn. Curr. Biol. 11:34-38.

Richards, J.D., S. Dave, C.-H. G. Chou, A.A. Mamchak and A.L. DeFranco (2001). Inhibition of the MEK/ERK signaling pathway blocks a subset of B cell responses to antigen. J. Immunol.166:3855-64.

Tian, M.-X., C.-H. Chou, and A.L. DeFranco (2001). Apoptosis induced by the antigen receptor and Fas in a variant of the immature B cell line WEHI-231 and in splenic immature B cells. Internat. Immunol. 13:581-592.

Gupta, N. and A.L. DeFranco (2003). Visualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B lymphocyte activation. Molec. Biol. Cell 14: 432-444.

Nishiya, T. and A.L. DeFranco (2004). Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors. J. Biol. Chem. 279:19008-17.

Tian, M.X., G. Gonzalez, B. Scheer, and A.L. DeFranco (2005). Bcl10 can promote survival of antigen-stimulated B lymphocytes. Blood 106: 2105-12.

Nishiya, T. Kajita, E., Miwa, S. and A.L. DeFranco (2005). TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements. J. Biol. Chem. 280: 37107-17.

Gupta, N., B. Wollscheid, J.D. Watts, B. Scheer, R. Aebersold, and A.L. DeFranco (2006). Quantitative proteomic analysis of B cell lipid rafts reveals that ezrin regulates antigen receptor-mediated lipid raft dynamics. Nature Immunol. 7: 625-633.

Invited Reviews

DeFranco, A.L. (1997). The complexity of signaling pathways activated by the BCR. Curr. Opin. Immunl. 9: 296-308.

DeFranco, A.L. (2000). B-cell activation 2000. Immunol. Rev. 176: 176: 5-9. (Co-organized issue).

Ohashi, P. S. and A.L. DeFranco (2002). Making and Breaking Tolerance. Curr. Opin. Immunol. 14: 744-759.

Yu, C.Y., A. Mamchak, and A. L. DeFranco (2003). Signaling mutations and autoimmunity. Curr. Dir. Autoimmun. 6: 61-88 (B cell Biology and Autoimmunity, D. Nemazee ed).

DeFranco, A.L. (2005). The B cell antigen receptor. In Topley and Wilson's Microbiology and Microbial Infections 10th Ed. Immunology volume, S.H.E. Kaufmann and M. Steward, eds. Hodder Arnold, London, pp.339-352.

Gupta, N., Weiss, A. and A.L. DeFranco (2006). Signal transduction by T and B lymphocyte antigen receptors. In Primary Immunodeficiency Diseases, a Molecular and Genetic Approach, 2nd edition. H.D. Ochs, C.I.E. Smith, and J. Puck, eds. Oxford University Press: Oxford, in press, pp. 71-92.

12/11/06