Anthony L. DeFranco, PhD

Harvard College, Cambridge MA, A.B., 1975, Biochemical & Molecular Biology
University of California, Berkeley, CA, Ph.D., 1979, Biochemistry
National Institutes of Health, Bethesda MD, Postdoctoral, 1979-83, Immunology

• 1972-1975
  Undergraduate research, laboratory of Dr. Jack Strominger. HLA antigens.
• 1976-1979
  Graduate research, laboratory of Dr. Daniel E. Koshland, Jr. Bacterial chemotaxis.
• 1979-1983
  Postdoctoral research, laboratory of Dr. William E. Paul. B cell activation.
• 1983-1988
  Assistant Professor, UCSF, Department of Microbiology & Immunology,
• 1988-1994
  Associate Professor, UCSF, Department of Microbiology & Immunology
• 1989-1990
  Sabbatical with David Baltimore, Whitehead Insititute, MIT, Cambridge, MA
• 1994-present
  Professor, UCSF, Department of Microbiology & Immunology
• 1997-1998
  Sabbatical with Suzanne Cory, Walter and Eliza Hall Institute, Melbourne, Australia
• 1998-2004
  Scientific Advisory Board, Abgenix, Inc. Fremont, CA
• 1999-2009
  Chairman, Department of Microbiology & Immunology, UCSF

• 1974
  Dreyfuss Foundation Fellow
• 1975
  Phi Beta Kappa, Harvard University
• 1975-78
  NSF Predoctoral Fellow
• 1979-82
  Helen Hay Whitney Postdoctoral Fellow; 2nd Rose Lieberman Lecturer, NIH 10/93
• 1994
  NIAID Merit Award
• 1997-98
  NIH Fogarty Senior International Award

• Chan, V.W.F., F. Meng, P. Soriano, A.L. DeFranco, and C.A. Lowell (1997). Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and downregulation. Immunity 7: 69-81.
• Crowley, M.T., P.S. Costello, M. Turner, F. Meng, C. Lowell, V.L.J. Tybulewicz, and A.L. DeFranco (1997). A critical role for Syk in signal transduction and phagocytosis mediated by Fcγ receptors on macrophages. J. Exp. Med. 186: 1027-1039. PMC2199061
• Chan, V.W.F., C.A.Lowell, and A.L. DeFranco (1998). Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes. Curr. Biol. 8: 545-553.
• Fitzer-Attas, C.J., M. Lowry, M.T. Crowley, A.J. Finn, F. Meng, A.L. DeFranco, and C.A. Lowell (2000). Fcγ receptor-mediated phagocytosis in macrophages lacking the Src-family tyrosine kinases Hck, Fgr, and Lyn. J. Exp. Med. 191: 669-682. PMC2195832
• Yu, C.C.K., T.S.B. Yen, C.A. Lowell, and A.L. DeFranco (2001). Lupus-like kidney disease in mice deficient in Src-family protein tyrosine kinases Lyn and Fyn. Curr. Biol. 11:34-38.
• Richards, J.D., S. Dave, C.-H. G. Chou, A.A. Mamchak and A.L. DeFranco (2001). Inhibition of the MEK/ERK signaling pathway blocks a subset of B cell responses to antigen. J. Immunol.166:3855-64.
• Gupta, N. and A.L. DeFranco (2003). Visualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B lymphocyte activation. Molec. Biol. Cell 14: 432-444. PMC149983
• Nishiya, T. and A.L. DeFranco (2004). Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors. J. Biol. Chem. 279:19008-17.
• Tian, M.X., G. Gonzalez, B. Scheer, and A.L. DeFranco (2005). Bcl10 can promote survival of antigen-stimulated B lymphocytes. Blood 106: 2105-12. PMC1895143
• Nishiya, T. Kajita, E., Miwa, S. and A.L. DeFranco (2005). TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements. J. Biol. Chem. 280: 37107-17.
• Gupta, N., B. Wollscheid, J.D. Watts, B. Scheer, R. Aebersold, and A.L. DeFranco (2006). Quantitative proteomic analysis of B cell lipid rafts reveals that ezrin regulates antigen receptor-mediated lipid raft dynamics. Nature Immunol. 7: 625-633.
• Hou, B., B. Reizis, and A.L. DeFranco (2008). Toll-like receptors activate innate and adaptive immunity using dendritic cell-dependent and -independent mechanisms. Immunity 29: 272-82. PMC2847796
• Mamchak, A.A., B.M. Sullivan, B. Hou, L.M. Lee, J.K. Gilden, M.F. Krummel, R.M. Locksley, and A.L. DeFranco (2008). Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells. J. Immunol. 181: 5374-5385. PMC2657555
• Gross, A.J., J.R. Lyandres, A.K. Panigrahi, E..T.L. Prak, and A.L. DeFranco (2009). Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B Cell tolerance. J. Immunol. 182: 5382-92. PMC2840041
• Mamchak, A.A., C.B.F. Thien, S.A. Dagger, J. Lyandres, S. Jiang, W.Y. Langdon, and A.L. DeFranco (2010). Unaltered negative selection and regulatory T cell development of self-reactive thymocytes in TCR transgenic Fyn-deficient mice. Eur. J. Immunol. 40: 539-547. PMC submission in process (NIHMS179030)
• Scapini, P., Y. Hu, C.L. Chu, T.S. Migone, A.L. DeFranco, M.A. Cassatella, and C.A. Lowell (2010). Myeloid cells, BAFF, and IFN-γ establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J. Exp. Med. 207:1757-73.