Eric Delwart, PhD

University of Newcastle, England, B.Sc., 1980, Biochemistry & Genetics
University of Geneva, Switzerland, M.Sc., 1982, Molecular Biology
University of Wisconsin at Madison, Ph.D., 1990, Oncology

• 1982-1984
  Research Assistant, Dept. of Molecular Biology, Genentech Inc., San Francisco, California.
• 1984-1990
  Graduate training, Oncology, University of Wisconsin at Madison.
• 1990-1994
  Post-doctoral Scholar, Dept. of Microbiology & Immunology, Stanford University, California.
• 1994-1996
  Assistant Professor of Pathology, New York University School of Medicine, New York
• 1994-1999
  Staff Investigator, The Aaron Diamond AIDS Research Center, New York
• 1996-1999
  Assistant Professor, Rockefeller University, New York
• 1999-present
  Associate Adjunct Professor, Dept. of Medicine, University of California, San Francisco, CA
• 1999-2008
  Director of Molecular Virology, Assoc. Investigator, Blood Systems Research Institute, SF,CA
• 2008-present
  Director of Molecular Virology, Senior Investigator, Blood Systems Research Institute, SF, CA
• 2008-present
  Professor, Dept. of Laboratory Medicine, University of California, San Francisco, CA

• 1. Delwart EL, Shpaer EG, Louwagie J, McCutchan FE, Grez M, Rubsamen-Waigmann H, Mullins JI. Genetic relationships determined by a DNA heteroduplex mobility assay: analysis of HIV-1 env genes. Science 1993;262:1257-61.
• 2. Delwart EL, Sheppard HW, Walker BD, Goudsmit J, Mullins JI. Human immunodeficiency virus type 1 evolution in vivo tracked by DNA heteroduplex assays. J Virol 1994;68:6672-83. PMC237088.
• 3. Kalish ML, Baldwin A, Raktham S, Wasi C, Luo C-C, Schochetman G, Mastro TD, Young NL, Vanichseni S, Rubsamen-Waigman H, von Briesen H, Mullins JI, Delwart EL, Herring B, Esparza J, Heyward WL, Osmanov S. The evolving molecular epidemiology of HIV-1 envelope in injecting drug users in Bangkok, Thailand: implications for HIV vaccine trials. AIDS 1995;9:851-7.
• 4. Delwart EL, Busch MP, Kalish ML, Mosley JW, Mullins JI. Rapid molecular epidemiology of HIV-1 transmission. AIDS Res Hum Retrovir 1995;11:1081-93.
• 5. Delwart EL, Pan H, Sheppard HW, Wolpert D, Neumann AU, Korber B, Mullins JI. Slower evolution of human immunodeficiency virus type 1 quasispecies during progression to AIDS. J Virol 1997;71:7498-508. PMC192096
• 6. Delwart EL, Mullins JI, Gupta P, Learn GH Jr, Holodniy M, Katzenstein D, Walker BD, Singh MK. Human immunodeficiency virus type 1 populations in blood and semen. J Virol 1997;72:617-23. PMC109415
• 7. Delwart EL, Pan H, Neumann A, Markowitz M. Rapid, transient, changes at the env locus of plasma HIV-1 populations during the emergence of protease inhibitor resistance. J Virol. 1998;72:2416-21. PMC109541
• 8. Delwart EL. A new HIV-1 group: abstract and commentary. JAMA. 280:1960.
• 9. Rodrigo AG, Shpaer EG, Delwart EL, Iversen AKN, Gallo MV, Brojatsch J, Hirsh MS, Walker BD, Mullins JI. Coalescent estimates of HIV-1 generation time in vivo. Proc Natl Acad Sci 1999;96:2187-91. PMC26758
• 10. Gordon CJ, Delwart EL. Genetic diversity of primary HIV-1 isolates and their sensitivity to antibody-mediated neutralization. Virology 2000;272:326-30.
• 11. Foley B, Pan H, Buchbinder S, Delwart EL. Apparent founder effect during the early years of the San Francisco HIV type 1 epidemic (1978-79). AIDS Res. Hum. Retrovir 2000;16:1463-9.
• 12. Doukhan L, Delwart EL. Use of tissue culture-amplified human immunodeficiency virus type 1 to study evolutionary changes in vivo. J Infect Dis. 2001;183:173-5.
• 13. Doukhan L, Delwart EL. Population genetic analysis of the protease locus of HIV-1 quasispecies undergoing drug selection using a denaturing gradient-heteroduplex tracking assay. J Virol 2001;75:6729-36. PMC114399.
• 14. Machado D, Delwart EL, Diaz RS, de Oliveira CF, Alwes K, Rawal BD, Sullivan M, Gwinn M, Clark KA, Busch MP. Use of the sensitive/less-sensitive (detuned) EIA strategy for targeting genetic analysis of HIV-1 to recently infected blood donors. AIDS 2002;16:113-9.
• 15. Foley B, Donegan E, Silitonga N, Wignall FS, Busch MP, Delwart EL. Importation of multiple HIV type 1 strains into West Papua, Indonesia (Irian Jaya). AIDS Res Hum Retroviruses. 2001;17:1655-9.
• 16. Delwart EL, Magierowska M, Royz M, Foley B, Peddada L, Smith R, Heldebrant, Conrad, Busch. Homogeneous quasispecies in 16/17 individuals during very early HIV-1 primary infection. AIDS 2002;16:189-95.
• 17. Alves K, Canzian M, Delwart EL. HIV type 1 envelope quasispecies in the thymus and lymph nodes of AIDS patients. AIDS Res Hum Retroviruses. 2002;18:161-5.
• 18. Bernardin F, Doukhan L, Longone-Miller A, Champagne P, Sekaly R, Delwart EL. Estimate of the total number of CD8+ clonal expansions in healthy adults using a new DNA heteroduplex-tracking assay for CDR3 repertoire analysis. J Immunol Methods. 2003;274:159-75.
• 19. Gonzales MJ, Delwart EL, Rhee S-Y, Tsui R, Zolopa AR, Taylor J, Shafer RW. Lack of detectable human immunodeficiency virus type 1 superinfection during 1072 person-years of observation. J Infect Dis 2003;188:397-405. PMC2547470.
• 20. Delwart EL, Orton S, Parekh B, Dobbs T, Clark K, Busch MP. 2% of HIV positive US blood donors are infected with non-subtype B strains. AIDS Res Hum Retrovir 2003;19:1065-70.
• 21. Bernardin F, Herring BL, Peddada L, Delwart EL. Primary infection of a male plasma donor with divergent HIV variants from the same source followed by rapid fluctuations in their relative frequency and viral recombination. AIDS Res Hum Retroviruses. 2003;19:1009-15.
• 22. Bernardin F, Magierowska M, Dandekar S, Van Rompay KK, Delwart EL. Number of CD4+ and CD8+ T-cell CDR3 clonotypes expanding during acute infection of macaques with simian immunodeficiency virus. Virology. 2004;322:105-17.
• 23. Tsui R, Herring B, Barbour JD, Grant RM, Bacchetti B, Kral A, Edlin B, Delwart EL. HIV1 superinfection was not detected following 215 years of injection drug user exposure. J.Virol 2004;78:94-103. PMC303392.
• 24. Magierowska M, Bernardin F, Garg S, Silvija S, Miller M, Van Rompay K, Delwart EL. Highly uneven distribution of tenofovir-selected SIV in different anatomical sites of rhesus macaques. J.Virol 2004;78:2434-4. PMC369237.
• 25. Delwart EL, Kalmin ND, Jones TS, Ladd DJ, Tobler LH, Tsui R, Busch MP. First report of human immunodeficiency virus transmission via an RNA-screened blood donation. Vox Sang 2004;86:171-7.
• 26. Herring BL, Page-Shafer K, Tobler LH, Delwart EL. Frequent hepatitis C virus superinfection in injection drug users. J Infect Dis 2004;190:1396-403.
• 27. Kapoor A, Jones MS, Shafer B, Rhee S-Y, Kazanjian P, Delwart EL. Sequencing-based detection of low-frequency human immunodeficiency virus type 1 drug-resistant mutants by an RNA/DNA heteroduplex generator-tracking assay. J. Virol 2004;78:7112-23. PMC421662.
• 28. Herring B, Tsui R, Peddada L, Busch, MP, Delwart EL. Wide range of quasispecies diversity during primary Hepatitis C virus infection. J Virol 2005;79:4340-46. PMC1061543.
• 29. Fiebig EW, Heldebrant CM, Smith RI, Conrad AJ, Delwart EL, Busch MP. Intermittent low-level viremia in very early primary HIV-1 infection. JAIDS. 2005;39:133-7.
• 30. Jones MS, Kapoor A, Lukashov VV, Simmonds P, Hecht F, Delwart EL. New DNA viruses identified in patients with acute viral infection syndrome. J Virol 2005;79:8230-6. PMC1143717.
• 31. Bernardin F, Kong D, Peddada L, Baxter-Lowe L.-A, Delwart EL. Human Immunodeficiency Virus Mutations during the First Month of Infection Are Preferentially Found in Known Cytotoxic T-Lymphocyte Epitopes J Virol 2005;79:11523-8. PMC1193571.
• 32. Delwart EL, Kuhns MC, Busch MP. Surveillance of the genetic variation in incident HIV, HCV, and HBV infections in blood and plasma donors: Implications for blood safety, diagnostics, treatment, and molecular epidemiology. J Med Virol. 2006;78:S30-S5.
• 33. Fryer JF, Kapoor A, Minor PD, Delwart EL, Baylis SA. Novel parvovirus and related variant in human plasma. Emerg Infect Dis. 2006;12:151-4.
• 34. Bernardin F, Herring B, Page-Shafer K, Kuiken C, Delwart EL. Absence of HCV viral recombination following superinfection. J Viral Hepat. 2006;13(8):532-7.
• 35. Trautmann L, Janbazian L, Chomont N, Said EA, Gimmig S, Bessette B, Boulassel MR, Delwart EL, Sepulveda H, Balderas RS, Routy JP, Haddad EK, Sekaly RP. Upregulation of PD-1 expression on HIV-specific CD8+T cells leads to reversible immune dysfunction. Nat Med. 2006;12(10):1198-202. Erratum in: NatMed. 2006 12(11):1329.
• 36. Johnson JA, Rompay KK, Delwart EL, Heneine W. A rapid and sensitive real-time PCR assay for the K65R drug resistance mutation in SIV reverse transcriptase. AIDS Res Hum Retroviruses. 2006;22(9):912-6.
• 37. Herring BL, Bernardin F, Caglioti S, Stramer S, Tobler L, Andrews W, Cheng L, Rampersad S, Cameron C, Saldanha J, Busch MP, Delwart EL. Phylogenetic analysis of WNV in North American blood donors during the 2003-2004 epidemic seasons. Virology 2007;363(1):220-8.
• 38. Jones MS 2nd, Harrach B, Ganac RD, Gozum MM, Dela Cruz WP, Riedel B, Pan C, Delwart EL, Schnurr DP. New adenovirus species found in a patient presenting with gastroenteritis. J Virol. 2007;81(11):5978-84.
• 39. Bernardin F, Stramer SL, Rehermann B, Page-Shafer K, Cooper S, Bangsberg DR, Hahn J, Tobler L, Busch M, Delwart EL. High levels of subgenomic HCV plasma RNA in immunosilent infections. Virology 2007;365(2):446-56. PMC2001282.
• 40. Fryer JF, Delwart EL, Hecht FM, Bernardin F, Jones MS, Shah N, Baylis SA. Frequent detection of the parvoviruses, PARV4 and PARV5, in plasma from blood donors and symptomatic individuals. Transfusion 2007;47(6):1054-61.
• 41. Fryer JF, Delwart EL, Bernardin F, Tuke PW, Lukashov VV, Baylis SA. Analysis of two human parvovirus PARV4 genotypes identified in human plasma for fractionation. J Gen Virol. 2007;88:2162-7.
• 42. Bernardin F, Tobler L, Walsh I, Williams JD, Busch M, Delwart EL. Clearance of hepatitis C Virus RNA from the peripheral blood mononuclear cells of blood donors who spontaneously or therapeutically control their plasma viremia. Hepatology 2007;47:1446-1452.
• 43. Kapoor A, Victoria J, Simmonds P, Wang C, Shafer RW, Nims R, Nielsen O, Delwart EL. A highly divergent picornavirus in marine mammal. J Virol. 2008;82(1):311-20. PMC2224395
• 44. Kapoor A, Shapiro B, Shafer RW, Shulman N, Rhee SY, Delwart EL. Multiple independent origins of a protease inhibitor resistance mutation in salvage therapy patients. Retrovirology 2008;5(1):7. PMC2265302
• 45. Vallerini D, Barozzi P, Quadrelli C, Bosco R, Potenza L, Riva G, Gregorini G, Sandrini S, Tironi A, Montagnani G, De Palma M, Torelli G, Delwart EL, Luppi M. Parvoviruses in blood donors and transplant patients, Italy. Emerg Infect Dis. 2008;14(1):185-6.
• 46. Kapoor A, Slikas E, Simmonds P, Chieochansin T, Naeem A, Shaukat S, Alam M, Sharif S, Angez M, Zaidi S, Delwart EL. A newly identified Bocavirus species in human stool. J Infect Dis. 2009. 199(2): p. 196-200Victoria J, Kapoor A, Dupuis K, Schnurr D, Delwart EL. Rapid identification of known and new viruses from animal tissues. PLOS Pathogen 2008;4(9):e1000163. PMC2533695.
• 47. Keele BF, Giorgi EE, Salazar-Gonzalez JF, Decker JM, Pham KT, Salazar MG, Sun C, Grayson T, Wang S, Li H, Wei X, Jiang C, Kirchherr JL, Gao F, Anderson JA, Ping LH, Swanstrom R, Tomaras GD, Blattner WA, Goepfert PA, Kilby JM, Saag MS, Delwart EL, Busch MP, Cohen MS, Montefiori DC, Haynes BF, Gaschen B, Athreya GS, Lee HY, Wood N, Seoighe C, Perelson AS, Bhattacharya T, Korber BT, Hahn BH, Shaw GM. 2008. Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection. Proceedings of the National Academy of Sciences 2008;105(21):7552-7. PMC2387184.
• 48. Kapoor A, Victoria J, Simmonds P, Slikas E, Chieochansin T, Naeem A, Shaukat S, Sharif S, Masroor Alam M, Angez M, Wang C, Shafer RW, Zaidi S, Delwart EL. A highly prevalent and genetically diversified new Picornaviridae genus in South Asian children. Proceedings of the National Academy of Sciences. 2008. 105(51): p. 20482-7. PMC2629322.
• 50. Li, L., J. Victoria, A. Kapoor, A. Naeem, S. Shaukat, S. Sharif, M.M. Alam, M. Angez, S.Z. Zaidi, and E. Delwart Genomic characterization of novel human parechovirus type. Emerg Infect Dis, 2009. 15(2): p. 288-91. PMC2657611