Rik Derynck, PhD

University of Louvain, Belgium, Lic.Sc.(M.Sc.), 1974, Zoology
University of Ghent, Belgium, Ph.D., 1981, Molecular Biology

• 1973-1974
  Undergraduate thesis with Dr. Henri Koch, Catholic University, Louvain, Belgium
• 1974-1981
  Predoctoral Fellow/Research Associate with Dr. Walter Fiers, State University, Ghent, Belgium
• 1981-1985
  Scientist, Dept. of Molecular Biology, Genentech Inc., South San Francisco
• 1985-1990
  Senior Scientist, Departments of Molecular and Developmental Biology, Genentech Inc., South San Francisco
• 1991-present
  Professor, Department of Cell and Tissue Biology and Department of Anatomy, University of California San Francisco
• 2002-present
  Director, UCSF Program in Craniofacial and Mesenchymal Biology, University of California San Francisco
• 2002-present
  Co-Director, UCSF Institute for Regeneration Medicine

• (out of 204 total)
• Derynck, R., Content, J., Declercq, E., Volckaert, G., Tavernier, J., Devos, R., and Fiers, W. (1980) Isolation and structure of a human fibroblast interferon gene. Nature 285, 542-547.
• Derynck, R., Remaut, E., Saman, E., Stanssens, P., Declercq, E., Content, J., and Fiers, W. (1980) Expression of human fibroblast interferon gene in Escherichia coli. Nature 287, 193-197.
• Derynck, R, Roberts, AB, Winkler, ME, Chen, EY and Goeddel, DV. (1984) Human transforming growth factor-α: precursor structure and expression in E. coli. Cell 38, 287-297.
• Derynck, R, Jarrett, JA, Chen, EY, Eaton, DH, Bell, J., Assoian, RK, Roberts, AB, Sporn, MB and Goeddel, DV. (1985) Human transforming growth factor-β cDNA sequence and expression in tumor cell lines. Nature 316, 701-705.
• Schreiber, AB, Winkler, ME and Derynck, R. (1986) Transforming growth factor-α is a more potent angiogenic mediator than epidermal growth factor. Science, 232, 1250-1253.
• Rosenthal, A, Lindquist, PB, Bringman, TS, Goeddel, DV and Derynck, R. (1986) Expression in rat fibroblasts of a transforming growth factor-α cDNA results in transformation. Cell 46, 301-309.
• Bringman, TS, Lindquist, PB and Derynck, R. Different transforming growth factor-α species are derived from a glycosylated and palmitoylated transmembrane precursor. (1987) Cell 48, 429-440.
• Coffey, RJ, Derynck, R, Wilcox, JN, Bringman, TS, Goustin, AS, Moses, HL and Pittelkow, MR. (1987) Production and auto-induction of transforming growth factor-α in human keratinocytes. Nature 328, 817-820.
• Derynck, R, Lindquist, PB, Lee, A, Wen, D, Tamm, J, Graycar, JL, Rhee, L, Mason, AJ, Miller, DA, Coffey, RJ, Moses, HL and Chen, EY. (1988) A new type of transforming growth factor-β, TGF-β3. EMBO J. 7, 3737-3743.
• Brachmann, R, Lindquist, PB, Nagashima, M, Kohr,W, Lipari, T, Napier, M and Derynck, R. (1989) Transmembrane TGF- precursors activate EGF/TGF-α receptors. Cell 56, 691-700.
• Streuli, C.H., Schmidhauser, C., Kobrin, M., Bissell, M.J., and Derynck, R. (1993) Extracellular matrix regulates expression of the TGF-β1 gene. J. Cell Biol. 120, 253-260.
• Chen, R.-H., Ebner, R. and Derynck, R. (1993) Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-β activities. Science 260, 1335-1338.
• Ebner, R., Chen, R.-H., Shum, L., Lawler, S., Zioncheck, T., Lee, A., Lopez, A.R., and Derynck, R. (1993) Cloning of a type I TGF-β receptor and its effect on TGF-β binding to the type II receptor. Science 260, 1344-1348.
• Ebner, R., Chen, R.-H, Lawler, S., Zioncheck, T., and Derynck, R. (1993) Determination of type I receptor ligand specificity by the type II receptors for TGF-β or activin. Science 260, 1344-1348.
• Filvaroff, E. H., Ebner, R., and Derynck, R. (1994) Inhibition of myogenic differentiation in myoblasts expressing a truncated type II TGF-β receptor. Development, 121, 185-195.
• Shum, L., Reeves, S.A., Kuo, A.C., Fromer, E.S., and Derynck, R. (1994) Association of the transmembrane TGF-α precursor with a protein kinase complex. J. Cell Biol., 125, 903-916.
• Miettinen, P.J., Ebner, R., Lopez, A.R., and Derynck, R. (1994) TGF-β-induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J. Cell Biol. 127, 2021-2037.
• Erlebacher, A., Filvaroff, E.H., Gitelman, S.E., and Derynck, R. (1995) Toward a molecular understanding of skeletal development. Cell 80, 371-378.
• Miettinen, P.J., Berger, J.E., Meneses, J., Phung, Y., Pedersen, R.A., Werb, Z., and Derynck, R. (1995) Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 376, 337-341.
• Chen, R.-H, Miettinen, P.J., Maruoka, E.M., Choy, L. and Derynck, R. (1995) A WD-domain protein that is associated with and phosphorylated by the type II TGF-β receptor. Nature 377, 548-552.
• Erlebacher, A. and Derynck, R. (1996) Increased expression of TGF-β2 in osteoblasts results in an osteoporosis-like phenotype. J. Cell Biol., 132, 195-210.
• Zhang, Y., Feng, X.-H., Wu, R.-Y., and Derynck, R. (1996) Receptor-associated Mad homologs synergize as effectors of the TGF-β response. Nature 382, 168-172.
• Feng, X.-H., and Derynck, R. (1997) A kinase subdomain of the transforming growth factor-β (TGF-β) receptor determines the TGF-β intracellular signaling specificity. EMBO J. 16, 3912-3923.
• Derynck, R. and Feng, X.-H. (1997) TGF-β receptor signaling. B.B.A. Reviews in Cancer 1333, F105-F150.
• Feng, X.-H., Zhang, Y., Wu, R.-Y., and Derynck, R. (1998) The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 function as coactivators for the transcription factor Smad3 in TGF-β-induced transcriptional activation. Genes Dev. 12, 2153-2163 .
• Zhang, Y., Feng, X.-H., and Derynck, R. (1998) Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription. Nature 394, 909-914.
• Griswold-Prenner, I., Kamibayashi, C., Maruoka, E.M., Mumby, M.C., and Derynck, R. (1998) Physical and functional interactions between type I TGF-β receptors and Bα, a WD40-repeat subunit of phosphatase 2A. Mol. Cell. Biol., 18, 6595-6604.
• Choy, L., and Derynck, R. (1998) The type II TGF-β-receptor-associated protein TRIP-1 acts as a modulator of the TGF-β response. J. Biol. Chem. 273, 31455-31462.
• Derynck, R, Zhang, Y, and Feng, X.H. (1998) Smads: transcriptional activators of TGF-β responses. Cell 95, 737-740.
• Fan, H. and Derynck, R. (1999) Ectodomain shedding of TGF-α and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades. EMBO J. 18, 6962-6972.
• Shi, W., Fan, H., Shum, L., and Derynck, R. (2000) The tetraspanin CD9 associates with transmembrane TGF-α and regulates TGF-α-induced EGFR activation and cell proliferation. J. Cell Biol 148, 591-601.
• Choy, L., Skillington, J., and Derynck, R. (2000) Roles of autocrine TGF-β receptor and Smad signaling in adipocyte differentiation. J. Cell. Biol. 149, 667-681.
• Feng, X.-H., Lin, X., and Derynck, R. (2000) Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B expression in response to TGF-β. EMBO J. 19, 5178-5193.
• Kuo, A., Zhong, C., Lane, W.S. and Derynck, R. (2000) Transmembrane transforming growth factor-α tethers to the PDZ-domain containing, Golgi-membrane-associated protein p59/GRASP55. EMBO J. 19, 6427-6439.
• Zhang, Y., Chang, C., Gehling, D.J., Hemmati-Brivanlou, A., and Derynck, R. (2001) Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. Proc. Natl. Acad. Sci.USA, 98, 974-979.
• Alliston, T., Choy, L., Ducy, P., Karsenty, G., and Derynck, R. (2001) TGF-β-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation. EMBO J. 20, 2254-2272.
• Derynck, R., Akhurst, R.J., and Balmain, A. (2001) TGF-β signaling in tumor suppression and cancer progression. Nature Genetics 29, 117-129 (Erratum Nature Genetics 29, 351).
• Liu, D., Black, B.L., and Derynck, R. (2001) TGF-β inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Genes Dev. 15, 2950-2966.
• Skillington, J., Choy, L., and Derynck, R. (2002) Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of pre-adipocytes. J. Cell Biol. 159: 135-146.
• Choy, L. and Derynck, R. (2003) TGF-β inhibits adipocyte differentiation by Smad3 interacting with C/EBP and repressing C/EBP transactivation function. J. Biol. Chem. 278, 9609-9619.
• Derynck, R. and Zhang,Y. (2003) TGF-β family signaling: Smad-dependent and Smad-independent pathways. Nature, 425, 577-584.
• Qin, B.Y., Liu, C., Lam, S.S., Srimath, H., Delston, R., Correia, J.J., Derynck, R. and Lin, K. (2003) Crystal structure of IRF-3 transactivation domain reveals mechanism of autoinhibition and virus-induced phospho-activation. Nature Struct. Biol. 10, 913-921
• Liu, D., Kang, J.S. and Derynck, R. (2004) TGF-β-activated Smad3 represses MEF2-dependent transcription in myogenic differentiation. EMBO J 23, 1557-1566.
• Pardoux, C. and Derynck, R. (2004) JNK regulates expression and autocrine signaling of TGF-β1. Molecular Cell 15, 170-171.
• Alliston, T., Ko, T.C., Cao, Y., Liang, Y.-Y., Feng, X.-H., Chang, C. and Derynck, R. (2005) Repression of BMP and activin-inducible transcription by Evi-1. J. Biol. Chem., 280, 24227-24237.
• Kang, J. S., Alliston, T., Delston, R., and Derynck, R. (2005) Repression of Runx2 function by TGF-β through recruitment of class II histone deacetylases by Smad3. EMBO J. 24, 2543-2555.
• Feng, X.-H. and Derynck, R. (2005) Specificity and versatility in TGF-β signaling through Smads. Annu. Rev. Cell Dev. Biol. 21, 659-693.
• Balooch, G., Balooch, M., Nalla, R.K., Schilling, S., Filvaroff, E.H., Marschall, G.W., Marshall, S.J., Ritchie, R.O., Derynck, R., and Alliston, T. (2005) TGF-β signaling regulates the mechanical properties and composition of bone matrix. Proc. Natl. Acad. Sci. USA 102, 18813-18818.