Adjunct Professor of Medicine and Pediatrics, UCSF
| CONTACT | |
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dobbs@itsa.ucsf.edu Box 1245, UCSF; San Francisco, CA 94143-1245 |
| EDUCATION | |
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Harvard College, Cambridge, Mass, B.A., 1965
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| PROFESSIONAL EXPERIENCE | |
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1970-72 |
Staff Associate, Laboratory of Parasitic Diseases, NIAID, Bethesda |
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1973-74 |
Resident in Medicine, Presbyterian Hospital, New York City |
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1974-75 |
Fellow in Pulmonary Diseases, Roosevelt Hospital, New York City |
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1975-76 |
Fellow in Pulmonary Medicine, UCSF |
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1976-79 |
Assistant Research Physiologist, Cardiovascular Research Institute, UCSF |
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1979-81 |
Co-Director of Pulmonary Medicine, Peralta Hospital, Oakland, CA, Full time private practice. |
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1980-93 |
Assistant Clinical Professor of Medicine, UCSF |
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1982-present |
Associate Staff Member, Cardiovascular Research Institute, UCSF |
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1993-97 |
Associate Professor of Medicine, Adj., UCSF |
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1996-97 |
Associate Professor of Medicine and Pediatrics, Adj., UCSF |
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1998-present |
Professor of Medicine and Pediatrics, Adj., UCSF |
| HONORS & AWARDS | |
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7/82 to 6/87 |
NIH Career Development Award |
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1/82 to 6/82 |
American Cancer Society Faculty Research Award |
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1984 |
Louise & Alston Boyer Young Investigator Award for Laboratory Research |
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1978-79 |
American Diabetes Association Research and Development Award |
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1962-1966 |
NY State Regents Scholarship |
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1962-1966 |
NY State Scholar Incentive Award |
| SELECTED PUBLICATIONS | |
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Guo, D. and Donner, D.B. Tumor necrosis factor promotes phosphorylation and binding of RS-1 to phosphatidyinositol 3-kinase in 3T3-L1 adipocytes. J. Biol. Chem. 271:615-618, 1996. |
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Marino, M., Dunbar, J.D., Wu, L.W, Ngaiza, J.R., Han, H. M., Guo, D., Matsushita, M., Nairn,A., Zhang, Y., Kolesnick, R., Jaffe, E. & Donner, D.B. Inhibition of TNF signal transduction in endothelial cells by dimethylaminopurine. J. Biol. Chem. 271:28624-28629, 1996. |
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Warren, R.S., Yuan, H., Matli, M.R., Ferrara, N., and Donner, D.B. Induction of vascular endothelial cell growth factor by insulin-like growth factor 1 in colorectal carcinoma. J. Biol. Chem. 271:29483-29488, 1996. |
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Dunbar, J.D., Song, H.Y., Guo, D., Wu, L.W. and Donner, D.B. Two-hybrid cloning of a gene encoding TRAP2 a protein that interacts with the intracellular domain of the type 1 TNF receptor. Identity with subunit 2 of the 26S protease. J. Immunol. 158:4252-4259, 1997. |
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Guo, D., Dunbar, J.D., Chuan, H.Y., Pfeffer, L.M. and Donner, D.B. Induction of Jak/STAT signaling by activation of the type 1 TNF receptor. J. Immunol. 160:2742-2750, 1998. |
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Vig, E., Green, M., Liu, Y., Donner, D.B., Mukaida, N., Goebl, M. G. and Harrington, M.A. Modulation of tumor necrosis factor and interleukin-1 dependent NF-B activity by mPLK/IRAK. J. Biol.Chem. 274:13077-13084, 1999. |
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Ozes, O., Mayo, L.D., Gustin, J.A., Pfeffer, S., Pfeffer, L.M. and Donner, D.B. NF-ÄéB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401:82-85, 1999. |
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Pazdernik, N.J., Donner, D.B., Goebl, M.G. and Harrington, M.A. Mouse receptor interacting protein 3 (mRIP3) does not contain a caspase recruiting domain or a death domain, but induces apoptosis and activates NF-ÄéB. Mol. Cell. Biol. 19:6500-6508, 1999. |
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Felts, S.A., Own, B. A.L., Nguyen, P.M., Trepel, J., Donner, D.B., and Toft, D.O. The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. J. Biol. Chem. 275:3305-3312, 2000. |
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Wu, L.W., Mayo, L.D., Dunbar, J.D., Kessler, K.M., Baerwald, M.R., Jaffe, E.A., Wang, D., Warren, R.S., and Donner, D.B. Utilization of distinct signaling pathways by receptors for VEGF and other mitogens in the induction of endothelial cell proliferation. J. Biol. Chem. 275:5096-5103, 2000. |
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Wu, L.W., Mayo, L., Ozes, O., Jaffe, E.A., Warren, R.S., & Donner, D.B. VRAP is an adaptor protein that binds the cytoplasmic domain of KDR, a receptor for vascular endothelial cell growth factor. J. Biol. Chem. 275: 6059-6062, 2000. |
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Guo, D., Wu, L-W., Dunbar, J.D., Mayo, L.D., Gustin, J., Jaffe, E.A., Warren, R.S. and Donner, D.B. Tumor necrosis factor inhibits activation of KDR and VEGF-induced endothelial cell proliferation. J. Biol. Chem. 275:11216-11221, 2000. |
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Wang, D., Donner, D.B. and Warren, R.S. Homeostatic modulation of cell surface KDR and Flt1 expression and expression of the VEGF receptor mRNAs by VEGF. J. Biol. Chem. 275:15905-15911, 2000. |
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Ozes, O.N., Akca, H., Mayo, L.D., Gustin, J.A., Maehama, T., Dixon, J.E. and Donner, D.B. A PI 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes TNF inhibition of signaling through IRS-1. Proc. Natl. Acad. Sci. USA. 98:4640-4645, 2001. |
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Yang, C.H., Murti, A., Pfeffer, S.R., Kim, J.G., Donner, D.B. and Pfeffer, L.M. IFNÄÀ/ÄË promotes cell survival by activating NF-ÄéB through phosphatidyinositol 3-kinase and Akt. J. Biol. Chem. 276:13756-13761, 2001. |
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Gustin, J.A., Maehama, T., Dixon, J.E., and Donner, D.B. The PTEN tumor suppressor protein inhibits TNF induced NF-ÄéB activity. J. Biol.Chem. 276:27740-27744, 2001. |
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Mayo, L.D., Kessler, K.M., Pincheira, R., Warren, R.S. and Donner, D.B. Vascular endothelial cell growth factor activates CRE-binding protein by signaling through the KDR receptor tyrosine kinase. J. Biol. Chem. 276:25184-25189, 2001. |
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Mayo, L.D. and Donner, D.B. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc. Natl. Acad. Sci. USA 98:11598-11603, 2001. |
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Wang, D., Lehman, R.E., Donner, D.B., Matli, M.R., Warren, R.S., & Welton, M.L. Expression and endocytosis of VEGF and its receptors in human colonic vascular endothelial cells. Amer. J. Physiol. G1088-G1096, 2002. |
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Mayo, L.D. and Donner, D.B. The PTEN, Mdm2. p53 tumor suppressor-oncoprotein network. Trends in Biochemical Sciences 27: 462-467, 2002. |
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Su, J.D., Mayo, L.D., Donner, D.B., and Durden, D.L. PTEN and PI 3-kinase inhibitors up-regulate p53 and block tumor induced angiogenesis; evidence for an effect on the tumor and endothelial compartment. Cancer Res. 63:3585-3592, 2003. |
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Gustin, J.A., Pincheira, R., Mayo, L.D., Ozes, O.N., Kessler, K.M., Baerwald, M.R. and Donner, D.B. Tumor necrosis factor activates CRE binding protein through a p38 MAPK/MSK1 signaling pathway in endothelial cells. Amer. J. Physiol., Cell. Physiol. 286: C547-C555, 2004. |
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Gustin, J.A., Ozes, O. N., Akca, H., Pincheira, R., Mayo, L., Li, Q., Rivera Guzman, H., Korgaonkar, C.K., and Donner, D.B. Cell type specific expression of the IÄéB kinases determines the significance of PI 3-kinase/Akt signaling to NF-ÄéB activation. J. Biol. Chem. 279:1615-1620, 2004. |
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Toussaint-Smith, E., Donner, D.B. and Roman, A. Expression of human papillomavirus type 16 E6 and E7 oncoproteins in primary foreskin keratinocytesis is sufficient to alter expression of angiogenic factors. Oncogene 23L2988-2995, 2004. |
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Ozes, O.N., Gustin, J.A., Mayo, L.D., Pincheira, R., and Donner, D.B., Tumor necrosis factor/receptor signaling through the Akt kinase. In Proinflammatory signaling mechanisms in the pulmonary circulation. Humana Press, NJ, 2005. |
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Mayo, L.D., Seo, Y.R., Jackson, M.W., Smith, M.L., Rivera Guzman, J., Korgaonkar, C.K., and Donner, D.B. Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified. J Biol Chem. 280:25953-9, 2005. |
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Matei, D., Emerson, R.E., Lai, Y., Baldrige, L.A., Rao, J., Yiannoutsos, C., and Donner, D.B. Autocrine activation of the PDGFRÄÀ promotes the progression of ovarian cancer. Oncogene, 2005 in press. |
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Gustin, J.A., Korgaonkar, C., Pincheira, R., Li, Q., and Donner, D.B. Akt induces basal and induced processing of NF-ÄéB2 (p100) to p52. J. Biol. Chem. 2005 in press. |
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Schmidt, N.W., Mayo, L.D., Donner, D.B., and Kaplan, M.H. p53 regulates Btk-dependent B cell proliferation but no differentiation. J Leuk Biol. 2005 in press |
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12/12/05 |
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