Professor in Residence, Neurological Surgery, UCSF
Member, UCSF Biomedical Sciences Program (BMS) and Herbert Boyer Program in Biological Sciences (PIBS)
| CONTACT | |
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jfike@itsa.ucsf.edu Box 0520, UCSF; San Francisco, CA 94143-0520 |
| EDUCATION | |
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Calif. State Univ. Long Beach, CA, B.A., 1970, Biology
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| PROFESSIONAL EXPERIENCE | |
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1970 - 1971 |
Research Associate, Dept. of Radiological Sciences, University of California, Irvine, CA |
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1972 - 1973 |
Research Assistant, Dept. of Radiation Biology, University of Wisconsin, Madison, WI |
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1974 - 1975 |
Research Associate, Department of Immunochemistry, Evanston Hospital, Evanston, IL |
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1975 - 1976 |
NIH Predoctoral Trainee, Dept. of Radiology and Radiation Biology, Colorado State University, Fort Collins, CO |
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1978 - 1979 |
NIH Postdoctoral Fellow, Dept. of Radiation Biology, George Washington University Medical Center, Washington, DC |
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1979 - 1980 |
NIH Postdoctoral Fellow, Dept. of Radiation Oncology, University of California, San Francisco, CA |
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1980 - 1981 |
Assistant Research Biologist, Dept. of Radiation Oncology, University of California, San Francisco, CA |
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1981 - 1983 |
Adjunct Assistant Professor, Departments of Radiation Oncology and Radiology, University of California, San Francisco, CA |
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1983 - 1991 |
Assistant Professor In-Residence, Departments of Radiation Oncology, Radiology, and Neurological Surgery, University of California, San Francisco, CA |
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1991 - 1998 |
Associate Professor In-Residence, Departments of Neurological Surgery, Radiation Oncology, and Radiology, University of California, San Francisco, CA |
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1998-present |
Professor In-Residence, Departments of Neurological Surgery, Radiation Oncology, and Radiology, University of California, San Francisco, CA |
| HONORS & AWARDS | |
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2003 |
Henry Ford Neurosurgery Distinguished Researcher Lecture. Henry Ford Hospital, Detroit Michigan |
| SELECTED PUBLICATIONS | |
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Gobbel GT, Cann CE, Fike JR : Measurement of regional cerebral blood flow using ultrafast computed tomography: theoretical aspects. Stroke 22:768-771, 1991. |
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Gobbel GT, Cann CE, Iwamoto HS, Fike JR : Measurement of regional cerebral blood flow in the dog using ultrafast computed tomography: experimental validation. Stroke 22:772-779, 1991. |
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Gobbel GT, Marton LJ, Lamborn K, Seilhan TM, Fike JR : Modification of radiation-induced brain injury by alpha-difluoromethylornithine. Radiat Res 128:306-315, 1991. |
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Gobbel GT, Seilhan TM, Fike JR : Cerebrovascular response after interstitial irradiation. Radiat Res 130:236-240, 1992. |
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Gobbel GT, Cann CE, Fike JR : Comparison of Xenon-enhanced CT with ultrafast CT for measurement of regional cerebral blood flow. AJNR Am J Neuroradiol 14:543-550, 1993 |
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Deen DF, Chiarodo A, Grimm EA, Fike JR, Israel MA, Kun LE, Levin VA, Marton LJ, Packer RJ, Pegg AE, Rosenblum ML, Suit HD, Walker MD, Wikstrand CJ, Wilson CB, Wong AJ, Yung WKA : Brain Tumor Working Group report on the 9th International Conference on Brain Tumor Research and Therapy. Organ system program, National Cancer Institute. J Neurooncol 16:243-272, 1993. |
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Fike JR, Gobbel GT, Marton LJ, Seilhan TM : Radiation brain injury is reduced by the polyamine inhibitor alpha-difluoromethylornithine. Radiat Res 138:99-106, 1994. |
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Gobbel GT, Fike JR : A deconvolution method for evaluating indicator-dilution curves. Phys Med Biol 39:1833-1854, 1994. |
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Warnick RE, Fike JR, Chan PH, Anderson DK, Ross GY, Gutin PH : Measurement of vascular permeability in spinal cord using Evans blue spectrophotometry and correction for turbidity. J Neurosci Methods 58:167-171, 1995. |
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Fike JR, Gobbel GT, Chou D, Wijnhoven BPL, Bellinzona M, Nakagawa M, Seilhan TM : Cellular proliferation and infiltration following interstitial irradiation of normal dog brain is altered by an inhibitor of polyamine synthesis. Int J Radiat Oncol Biol Phys 32:1035-1045, 1995. |
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Gavin PR, Fike JR, Hoopes PJ : Central nervous system tumors. Semin Vet Med Surg 10:180-189, 1995. |
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Nakagawa M, Bellinzona M, Seilhan TM, Gobbel GT, Fike JR : Microglial responses after focal radiation-induced injury are affected by a-difluoromethylornithine. Int J Radiat Oncol Biol Phys 36:113-123, 1996. |
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Bellinzona M, Gobbel GT, Shinohara C, Fike JR : Apoptosis is induced in the subependyma of young adult rats by ionizing irradiation. Neurosci Lett 208:163-166, 1996. |
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Shinohara C, Gobbel GT, Lamborn KR, Tada E, Fike JR : Apoptosis in the subependyma of young adult rats after single and fractionated doses of x-rays. Cancer Res 57:2694-2702, 1997. |
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Gobbel GT, Bellinzona M, Vogt AR, Gupta N, Fike JR, Chan PH : Response of post-mitotic neurons to x-irradiation: implications for the role of DNA damage in neuronal apoptosis. J Neurosci 18:147-155, 1998. |
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Fike JR, Gobbel GT, Mesiwala AH, Shin HL, Nakagqwa M, Lamborn KR, Seilhan TM, Elliott PJ : Cerebrovascular effects of the Bradykinin Analog RMP-7 in normal and irradiated dog brain. J Neuro Oncol 37:199-215, 1998. |
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Tibbitts J, Fike JR, Lamborn KR, Bollen AW, Kahl SB : Toxicology of a boronated porphyrin in dogs. Photochem Photobiol 69:587-594, 1999. |
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Parent JM, Tada E, Fike JR, Lowenstein DH : Inhibition of dentate granule cell neurogenesis does not prevent seizure-induced mossy fiber synaptic reorganization in the rats. J Neurosci 19:4508-4519, 1999. |
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Tada E, Yang C, Gobbel GT, Lamborn KR, Fike JR : Long term impairment of subependymal repopulation following damage by ionizing irradiation Expt Neurol 160:66-77, 1999. |
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Tofilon PJ, Fike JR : The radioresponse of the CNS: a dynamic process. Radiat Res 153:357-370, 2000. |
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Tibbitts J, Sambol N, Fike JR, Kahl SB. Plasma pharmacokinetics and tissue distribution of boron following administration of a boronated porphyrin in dogs. J Pharmaceut Sci 89:469-477, 2000. |
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Tada E, Parent JM, Lowenstein DH, Yang C, Fike JR : X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats. Neuroscience 99:33-41, 2000. |
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Monje M, Mizumatsu S, Fike JR, Palmer TD. Irradiation induces neural stem cell dysfunction. Nat. Med. 8: 9555-962, 2002. |
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Mizumatsu S, Monje M, Morhardt D, Rola R, Palmer TD, Fike JR. Extreme sensitivity of adult neurogenesis to low doses of x-irradiation. Cancer Research, 63: 4021-4027, 2003. |
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Coleman CN, Blakely WF, Fike JR, McVittie T, Metting N, Mitchell JB , Moulder J, Preston J, Ricks RC, Schimmerling W, Seed T, Stone H, Tofilon PJ, Wong R. Molecular and Cellular Biology of Moderate Dose (1- 10 Gy) Radiation and Potential Mechanisms of Radiation Protection: Report of a Workshop at Bethesda, MD, December 17-18, 2001. Radiat .Res., 159: 812-834, 2003. |
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Alvarez-Dolado M, Garcia-Verdugo JM, Fike JR, Lois C, Alvarez-Buylla. Fusion of bone marrow derived cells with hepatocytes, cardiomyocytes and Purkinje cells in vivo. Nature. 425: 968-973, 2003. |
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Limoli CL, Giedzinski E, Palmer TD, Fike JR. Radiation Response of rodent neural progenitor cells: linking cellular sensitivity to cell cycle checkpoints, apoptosis and oxidative stress. Radiat. Res. 161: 17-27, 2004. |
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Raber J, Fan Y, Matsumori Y, Liu Z, Weinstein PR, Fike JR, Liu J. Irradiation attenuates neurogenesis and exacerbates cerebral ischemia-induced functional deficits. Ann. Neurol. 55: 381-389, 2004. |
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Raber J, Rola R, LeFevour A, Morhardt DR, Curley J, Mizumatsu S, Fike JR. Radiation-induced cognitive impairments are associated with changes in hippocampal neurogenesis. Radiat. Res. In Press. |
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Rola R, Raber J, Rizk A, Otsuka S, VandenBerg SR, Morhardt DR, Fike JR. Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice. Exptl. Neurol. In Press. |
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1/2/02 |
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