Professor, Oral Biology; Professor of Pharmaceutical Chemistry; Professor of Anatomy; Faculty Director, Biomolecular Resource Center, UCSF
Member, Biomedical Sciences Program (BMS), UCSF
| CONTACT | |
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sfisher@cgl.ucsf.edu Box 0512, UCSF; San Francisco, CA 94143- 0512 |
| EDUCATION | |
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Hope College, Holland, Michigan, A.B., 1972, Biology, Chemistry
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| PROFESSIONAL EXPERIENCE | |
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1982-1988 |
Assistant Professor, Dept. of Stomatology, University of California, San Francisco (UCSF), CA |
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1988-1994 |
Associate Professor, Dept. of Stomatology, UCSF, CA |
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1994-present |
Professor, Dept. of Cell and Tissue Biology, UCSF, CA |
| HONORS & AWARDS | |
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1971-72 |
NSF Undergraduate Research Program |
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1972-73 |
NIH Training Grant |
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1978-81 |
NIH National Research Service Award HD05687 |
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1987 |
UCSF Academic Senate Distinguished Teaching Award |
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1988 |
Pew Foundation Faculty Development Award |
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ad hoc reviewer for National Institutes of Health (Oral Biology and Medicine, HED) |
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Wellcome Research Foundation and Medical Research Council of Canada and UK |
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1994 |
Achievement Award in Women's Health (Warner-Lambert Co., National Health Council, Journal of Women's Health) |
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2000 |
Co-Chair, Gordon Conference (Reproductive Tract Biology) |
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1997-2002 |
Member of Reproductive Biology Study Section (NIH), Chair (2000-2002) |
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2000 |
Sadler Award from NICHD |
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2000 |
NIH MERIT Award (DE07244) |
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2001 |
Faculty Director, UCSF Biomolecular Resource Center |
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2001 |
Scientific Advisory Board, Society for Women's Health |
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2002 |
UCSF Graduate Association Outstanding Mentor Award |
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2003 |
Anita Payne Lectureship (U of Mich.) |
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2004 |
UCSF School of Dentistry Faculty Research Award |
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2006 |
Dean's Distinguished Lecturer (U of Colorado) |
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2006 |
Jerry Elliott Memorial Lecture (New England Perinatal Research Society) |
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2006 |
Jerry Elliott Memorial Lecture (New England Perinatal Research Society) |
| SELECTED PUBLICATIONS | |
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(selected from 127 peer-reviewed publications; 2000-2006; 144 total) |
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Janatpour MJ, McMaster MT, Genbacev O, Zhou Y, Dong J, Cross JC, Israel MA, Fisher SJ. Id-2 regulates critical aspects of human cytotrophoblast differentiation, invasion and migration. Development. 2000;127:549-58. |
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Fisher S, Genbacev O, Maidji E, Pereira L. Human cytomegalovirus infection of placental cytotrophoblasts in vitro and in utero: implications for transmission and pathogenesis. J Virol. 2000;74:6808-20. |
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Genbacev O, McMaster MT, Fisher SJ. A repertoire of cell cycle regulators whose expression is coordinated with human cytotrophoblast differentiation. Am J Pathol. 2000;157:1337-51. |
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Prakobphol A, Xu F, Hoang VM, Larsson T, Bergstrom J, Johansson I, Frangsmyr L, Holmskov U, Leffler H, Nilsson C, Boren T, Wright JR, Stromberg N, Fisher SJ. Salivary agglutinin, which binds Streptococcus mutans and Helicobacter pylori, is the lung scavenger receptor cysteine-rich protein gp-340. J Biol Chem. 2000;275:39860-6. |
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Hoang VM, Foulk R, Clauser K, Burlingame A, Gibson BW, Fisher SJ. Functional proteomics: examining the effects of hypoxia on the cytotrophoblast protein repertoire. Biochemistry. 2001;40:4077-86. |
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Genbacev O, Krtolica A, Kaelin W, Fisher SJ. Human cytotrophoblast expression of the von Hippel-Lindau protein is downregulated during uterine invasion in situ and upregulated by hypoxia in vitro. Dev Biol. 2001;233:526-36. |
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Drake PM, Gunn MD, Charo IF, Tsou CL, Zhou Y, Huang L, Fisher SJ. Human placental cytotrophoblasts attract monocytes and CD56(bright) natural killer cells via the actions of monocyte inflammatory protein 1alpha. J Exp Med. 2001;193:1199-212. |
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Ilic D, Genbacev O, Jin F, Caceres E, Almeida EA, Bellingard-Dubouchaud V, Schaefer EM, Damsky CH, Fisher SJ. Plasma membrane-associated pY397FAK is a marker of cytotrophoblast invasion in vivo and in vitro. Am J Pathol. 2001;159:93-108. |
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Norwitz ER, Schust DJ, Fisher SJ. Implantation and the survival of early pregnancy. N Engl J Med. 2001;345:1400-8. |
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Red-Horse K, Drake PM, Gunn MD, Fisher SJ. Chemokine ligand and receptor expression in the pregnant uterus: reciprocal patterns in complementary cell subsets suggest functional roles. Am J Pathol. 2001;159:2199-213. |
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Zhou Y, McMaster M, Woo K, Janatpour M, Perry J, Karpanen T, Alitalo K, Damsky C, Fisher SJ. Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. Am J Pathol. 2002;160:1405-23. |
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Foulk RA, Genbacev O, Lu S, Julian P, Fisher S. Human blastocysts express the adhesion molecule, L-selectin, immediately after hatching. Fertil Steril. 2002;77:S9. |
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Genbacev OD, Prakobphol A, Foulk RA, Krtolica AR, Ilic D, Singer MS, Yang ZQ, Kiessling LL, Rosen SD, Fisher SJ. Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface. Science. 2003;299:405-8. |
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Zhou Y, Bellingard V, Feng KT, McMaster M, Fisher SJ. Human cytotrophoblasts promote endothelial survival and vascular remodeling through secretion of Ang2, PlGF, and VEGF-C. Dev Biol. 2003;263:114-25. |
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Pereira L, Maidji E, McDonagh S, Genbacev O, Fisher S. Human cytomegalovirus transmission from the uterus to the placenta correlates with the presence of pathogenic bacteria and maternal immunity. J Virol. 2003;77:13301-14. |
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Drake PM, Red-Horse K, Fisher SJ. Reciprocal chemokine receptor and ligand expression in the human placenta: implications for cytotrophoblast differentiation. Dev Dyn. 2004;229:877-85. |
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Fisher SJ. The placental problem: linking abnormal cytotrophoblast differentiation to the maternal symptoms of preeclampsia. Reprod Biol Endocrinol. 2004;2:53. |
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Red-Horse K, Zhou Y, Genbacev O, Prakobphol A, Foulk R, McMaster M, Fisher SJ. Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface. J Clin Invest. 2004;114:744-54. |
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Wright A, Zhou Y, Weier JF, Caceres E, Kapidzic M, Tabata T, Kahn M, Nash C, Fisher SJ. Trisomy 21 is associated with variable defects in cytotrophoblast differentiation along the invasive pathway. Am J Med Genet A. 2004;130:354-64. |
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McMaster MT, Zhou Y, Fisher SJ. Abnormal placentation and the syndrome of preeclampsia. Semin Nephrol. 2004;24:540-7. |
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Prakobphol A, Boren T, Ma W, Zhixiang P, Fisher SJ. Highly glycosylated human salivary molecules present oligosaccharides that mediate adhesion of leukocytes and Helicobacter pylori. Biochemistry. 2005;44:2216-24. |
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Weier JF, Weier HU, Jung CJ, Gormley M, Zhou Y, Chu LW, Genbacev O, Wright AA, Fisher SJ. Human cytotrophoblasts acquire aneuploidies as they differentiate to an invasive phenotype. Dev Biol. 2005;279:420-32. |
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Hardt M, Thomas LR, Dixon SE, Newport G, Agabian N, Prakobphol A, Hall SC, Witkowska HE, Fisher SJ. Toward defining the human parotid gland salivary proteome and peptidome: identification and characterization using 2D SDS-PAGE, ultrafiltration, HPLC, and mass spectrometry. Biochemistry. 2005;44:2885-99. |
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Genbacev O, Krtolica A, Zdravkovic T, Brunette E, Powell S, Nath A, Caceres E, McMaster M, McDonagh S, Li Y, Mandalam R, Lebkowski J, Fisher SJ. Serum-free derivation of human embryonic stem cell lines on human placental fibroblast feeders. Fertil Steril. 2005;83:1517-29. |
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Hardt M, Witkowska HE, Webb S, Thomas LR, Dixon SE, Hall SC, Fisher SJ. Assessing the Effects of Diurnal Variation on the Composition of Human Parotid Saliva: Quantitative Analysis of Native Peptides Using iTRAQ Reagents. Anal Chem. 2005;77:4947-54. |
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Maltepe E, Krampitz GW, Okazaki KM, Red-Horse K, Mak W, Simon MC, Fisher SJ. Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta. Development. 2005;132:3393-403. |
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Red-Horse K, Kapidzic M, Zhou Y, Feng KT, Singh H, Fisher SJ. EPHB4 regulates chemokine-evoked trophoblast responses: a mechanism for incorporating the human placenta into the maternal circulation. Development. 2005;132:4097-106. |
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Fisher SJ. Vascular transformation of placental cytotrophoblasts. In: Microvascular Research: Biology and Pathology. Eds. Shepro D. Elsevier, Oxford, 2005. |
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Carson DD, Julian J, Lessey B, Prakobphol A, Fisher SJ. MUC1 is a scaffold for selectin ligands in the human uterus. Frontiers Biosci. 2006;11:2903-9. |
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Essayem S, Kovacic-Milivojevic B, Baumbusch C, McDonagh S, Dolganov G, Howerton K, Larocque N, Mauro T, Ramirez A, Ramos DM, Fisher SJ, Jorcano JL, Beggs HE, Reichardt LF, Ilic D. Hair cycle and wound healing in mice with a keratinocyte-restricted deletion of FAK. Oncogene. 2006;25:1081-9. |
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Takamatsu D, Bensing BA, Prakobphol A, Fisher SJ, Sullam PM. Binding of the streptococcal surface glycoproteins GspB and Hsa to human salivary proteins. Infect Immun. 2006;74:1933-40. |
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Weier JF, Ferlatte C, Baumgartner A, Jung CJ, Nguyen HN, Chu LW, Pedersen RA, Fisher SJ, Weier HU. Molecular cytogenetic studies towards the full karyotype analysis of human blastocysts and cytotrophoblasts. Cytogenet Genome Res. 2006;114:302-11. |
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Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. J Clin Invest. 2006;116:2643-52. |
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Prakobphol A, Genbacev O, Gormley M, Kapidzic M, Fisher SJ. A role for the L-selectin adhesion system in mediating cytotrophoblast emigration from the placenta. Dev Biol. 2006;298:107-17. |
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2/11/07 |
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