flett@msg.ucsf.edu
(415) 476-5080 (voice)
(415) 476-1902 (fax)

Box 2240, UCSF; San Francisco, CA 94143-2240

additional websites:

Fletterick Lab Website

Marietta College, Marietta, Ohio, B.S., 1965, Chemistry
Cornell University, Ithaca, New York, Ph.D., 1970, Physical Chemistry
Yale University, New Haven, Connecticut, Department of Molecular Biophysics and Biochemistry, Laboratory of Prof. Thomas Steitz, Postdoctoral Fellow, 1970-1971, X-ray Crystallography
Yale University, New Haven, Connecticut, Department of Biophysics and Biochemistry, Postdoctoral Fellow, 1971-1973, X-ray Crystallography

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Webb P, Nguyen NH, Chiellini G, Yoshihara HA, Cunha Lima ST, Apriletti JW, Ribeiro RC, Marimuthu A, West BL, Goede P, Mellstrom K, Nilsson S, Kushner PJ, Fletterick RJ, Scanlan TS, Baxter JD. (2002) Design of thyroid hormone receptor antagonists from first principles. J Steroid Biochem Mol Biol. 83(1-5): 59-73.

Sablin, E.P., Krylova, I.N., Fletterick, R.J., and H.A. Ingraham (2003) Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1. Mol Cell. 11(6): 1575-85.

Borngraeber, S., Budny, M.J., Chiellini, G., Cunha Lima, S., Togashi, M.,Webb, P., Baxter, J., Scanlan, T., Fletterick , R.J.(2003) Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor. PNAS 100(26): 15358-63.

Waugh SM and Fletterick RJ. (2004) Crystallization and analysis of serine proteases with ecotin. Protein Crystallography in Drug Discovery 20, 171-186.

Sablin EP, Fletterick RJ. (2004) Coordination between motor domains in processive kinesins. J Biol Chem. 279(16): 15707-10.

Vinogradova, M.V., Reddy, V.S., Reddy, A. S.N., Sablin, E.P., and R.J. Fletterick (2004) Crystal structure of kinesin regulated by Ca2+/calmodulin. J. Biol. Chem, 279(22): 23504-9.

Shipley K, Hekmat-Nejad M, Turner J, Moores C, Anderson R, Milligan R, Sakowicz R, and RJ Fletterick. (2004) Structure of a kinesin microtubule depolymerization machine. EMBO J. 23(7): 1422-32

Ruggles SW, Fletterick RJ, Craik CS. (2004) Characterizing structural determinants of Granzyme B reveals potent mediators of extended substrate specificity. J Biol Chem. 279(29): 30751-9.

Hur E, Pfaff S, Payne E, Gron H, Buehrer B, and RJ Fletterick. (2004) Accommodation at the androgen receptor coactivator binding interface. PLoS Biology 2(9): e274.

Sandler B, Webb P, Apriletti JW, Huber R, Togashi M, Juric S, Nilsson S, Wagner R, Fletterick RJ, Baxter JD (2004) ÒThyroxine-Thyroid Hormone Receptor InteractionsÓ. J Biol Chem 279(53): 55801-8

EstŽbanez-Perpi–‡ E, Moore JM, Mar E, Rodrigues E, Nguyen P, Baxter J, Buehrer B, Webb P, Fletterick RJ and RK Guy (2005) The molecular mechanisms of coactivator utilization in ligand dependent transactivation by the androgen receptor. J Biol Chem 280(9): 8060-8. Epub 2004 Nov 24

Krylova I, Sablin EP, Moore J, Xu RX, Waitt GM, McKay A., Juzumiene D, Bynum JM, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ,Willson TM, and HA Ingraham. (2005) Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell 120: 343-355.

Vinogradova MV, Stone DB, Malanina GG, Karatzaferi C, Cooke R, Mendelson RA, Fletterick RJ. (2005) Ca2+-regulated structural changes in troponin. PNAS U S A. 2005 102(14): 5038-43. Epub 2005 Mar 22.

Blumenschein TM, Stone DB, Fletterick RJ, Mendelson RA, Sykes BD. (2005) alcium-dependent changes in the flexibility of the regulatory domain of TnC in the troponin complex. JBC. 280(23): 21924-32.

Togashi M, Borngraeber S, Sandler B, Fletterick RJ, Webb P and Baxter JD (2005) Conformational adaptations of nuclear receptor ligand binding domains to agonists: Potential for novel approaches to ligand design J. Steroid Biochem. Mol. Biol Proceedings of the 16th International Symposium of The Journal of Steroid Biochemistry and Molecular Biology 93, Issues 2-5 : 127-137.

Togashi M, Nguyen P, Fletterick R, Baxter JD, Webb P. (2005) Rearrangements in thyroid hormone receptor charge clusters that stabilize bound 3,5',5-triiodo-L-thyronine and inhibit homodimer formation. J Biol Chem. 280(27): 25665-73

Arnold LA, Estebanez-Perpina E, Togashi M, Jouravel N, Shelat A, McReynolds AC, Mar E, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. (2005) Discovery of small molecule inhibitors of the interaction of thyroid hormone receptor with transcriptional coregulators. J Biol Chem. 280(52):43048-55.

Fletterick RJ. (2005) Molecular modelling of the androgen receptor axis: rational basis for androgen receptor intervention in androgen-independent prostate cancer. BJU Int. Dec; 96 Suppl 2:2-9.

Blumenschein TM, Stone DB, Fletterick RJ, Mendelson RA, Sykes BD. (2006) Dynamics of the C-Terminal Region of TnI in the Troponin Complex in Solution. Biophys J. 90(7): 2436-44.

Pirani A, Vinogradova MV, Curmi PM, King WA, Fletterick RJ, Craig R, Tobacman LS, Xu C, Hatch V, Lehman W. (2006) An atomic model of the thin filament in the relaxed and ca(2+)-activated States. J Mol Biol. 357(3): 707-17.

Arnold LA, Estebanez-Perpina E, Togashi M, Shelat A, Ocasio CA, McReynolds AC, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. (2006) A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding. Sci STKE. 2006 Jun 27; (341):pl3.

Wang SX, Pandey KC, Somoza JR, Sijwali PS, Kortemme T, Brinen LS, Fletterick RJ, Rosenthal PJ, McKerrow JH. (2006) Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. Proc Natl Acad Sci U S A. Aug 1;103(31):11503-8.

Luginbuhl B, Kanyo Z, Jones RM, Fletterick RJ, Prusiner SB, Cohen FE, Williamson RA, Burton DR, Pluckthun A. (2006) Directed Evolution of an Anti-prion Protein scFv Fragment to an Affinity of 1 pM and its Structural Interpretation. J Mol Biol. Oct 13; 363(1): 75-97. Epub 2006 Jul 21.

12/11/06