fried@cc.ucsf.edu
(415) 502-4334 (voice)
(415) 502-3179 (fax)

Box 0128, UCSF; San Francisco, CA 94143-0128

additional websites:

Fried Lab Website

Hunter College, New York City, NY, A.B., 1965, Biology
California Institute of Technology. Pasadena, CA, Ph.D., 1969, Virology

(selected from 151)

GRIFFIN, B.E., FRIED, M. and A. COWIE. Polyoma DNA-A physical map. Proc. Natl. Acad. Sci. USA. 71, 2077-2081 (1974).

GRIFFIN, B.E. and M. FRIED. Amplification of a specific region of the polyoma virus genome. Nature. 256, 175-79 (1975).

MILLER, L. K. and M. FRIED. Construction of infectious polyoma hybrid genomes in vitro. Nature. 259, 598-601 (1976).

MILLER, K. and M. FRIED. Construction of the genetic map of the Polyoma genome. J. Virol. 18, 824-32 (1976).

MILLER, L. K., COOKE, B. E. and M. FRIED. Fate of mismatched base-pair regions in polyoma heteroduplex DNA during infection of mouse cells. Proc. Natl. Acad. Sci. USA. 73, 3073-77 (1976)

HEWICK, R. M., WATERFIELD, M. D., MILLER, L. K. and M. FRIED. Correlation between genetic loci and structural differences in the capsid proteins of polyoma virus plaque morphology mutants. Cell. 11, 331-338 (1977).

ZAIN, S., SAMBROOK, J., ROBERTS, R.J., KELLER, W., FRIED, M. and A. R. DUNN. Nucleotide sequence analysis of the leader segments in a cloned copy of adenovirus 2 fiber mRNA. Cell. 16, 851-861 (1979).

FRIED, M., KLEIN,B., MURRAY, K., GREENAWAY,P.,TOOZE, J., BOLL. W. and C. WEISSMANN. Infectivity in mouse fibroblasts of polyoma DNA integrated into plasmid pBR322 or lambdoid phage DNA. Nature. 279, 811-116 (1979).

LANIA, L., GRIFFITHS, M., COOKE, B. ITO, Y. and M. FRIED. Untransformed rat cells containing free and integrated DNA of a polyoma nontransforming (Hr-t) mutant. Cell. 18, 793-802 (1979).

SMITH, A. E., SMITH, R., GRIFFIN, B. E. and M. FRIED. Protein kinase activity associated with polyoma virus middle T antigen in vitro. Cell. 18, 915-924 (1979).

LANIA, L., BOAST, S. and M. FRIED. Excision of polyoma virus genomes from chromosomal DNA by homologous recombination. Nature. 295, 349-350 (1982).

HAYDAY, A., RULEY, H. E. and M. FRIED. Structural and biological analysis of integrated polyoma virus DNA and its adjacent host sequences cloned from transformed rat cells. J. Virol. 44, 67-77 (1982).

RULEY, H.E. and M. FRIED. Clustered illegitimate events in mammalian cells, which involve very short sequence homologies. Nature. 304, 181-184 (1983).

WILSON, J. B., HAYDAY, A., COURTNEIDGE, S. and M. FRIED. A frameshift at a mutational hotspot in the polyoma virus early region generates two new proteins that define T-antigen functional domains. Cell. 44, 477-487 (1986).

FORD, M. and M. FRIED. Large inverted duplications are associated with gene amplification. Cell 45,425-30 (1986).

WILLIAMS, T. and M. FRIED. An inverted duplication-transposition event in mammalian cells at an illegitimate recombination join. Mol. Cell. Biol. 6, 2179-2184 (1986).

WILLIAMS, T. and M. FRIED. A mouse locus at which transcription from both DNA strands produces mRNAs complementary at their 3' ends. Nature. 322, 275-279 (1986).

WILLIAMS, T. J. and M. FRIED. The MES-1 murine enhancer element is closely associated with the heterologous 5' ends of two divergent transcription units. Mol. Cell. Biol. 6, 4558-4569 (1986).

PASSANANTI, C., DAVIES, B., FORD, M. and M. FRIED. Structure of an inverted duplication formed as a first step in a gene amplification event: Implications for a model of gene amplification. EMBO J. 6, 1697-1703 (1987).

HUXLEY, C., WILLIAMS, T. and M. FRIED. One of the tightly clustered genes of the mouse Surfeit Locus is a highly expressed member of a multigene family whose other members are predominantly processed pseudogenes. Mol. Cell. Biol. 8, 3898-3905 (1988).

GIALLONGO, A., YON, J. and M. FRIED. The ribosomal protein L7a is encoded by a gene (Surf-3) within the tightly clustered mouse Surfeit locus. Mol. Cell. Biol. 9, 224-231 (1989).

DAVIES, B., FEO, S., HEARD, E. and M. FRIED. A strategy to detect and isolate an intron- containing gene in the presence of multiple processed pseudogenes. Proc. Natl. Acad Sci. USA. 86, 6691-95 (1989).

HUXLEY, C. and M. FRIED. The mouse Surfeit Locus contains a cluster of 6 genes associated with 4 CpG-rich islands in 32 kb of genomic DNA. Mol. Cell. Biol. 10, 615-624 (1990).

LENNARD, A.C. and M. FRIED. The bidirectional promoter of the divergently transcribed mouse Surf-1 and Surf-2 genes. Mol. Cell. Biol. 11,1281-1294 (1991). COLOMBO, P., YON, J., GARSON, G. and M. FRIED. Conservation of the organization of five tightly clustered genes of the Surfeit locus over 600 million years of divergent evolution. Proc. Natl. Acad Sci. USA. 89, 6358-6362 (1992).

YON, J., JONES, T., GARSON, K., SHEER, D. and M. FRIED. The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1. Hum. Mol. Genet. 2, 237-240 (1993).

LENNARD, A., GASTON, K. and M. FRIED. The Surf-1 and Surf-2 genes and their bidirectional promoter elements are conserved between mouse and human. DNA and Cell Biology 13, 1117-1126 (1994).

FEO, S., DI LIEGRO, C., JONES, T., READ, M. and M. FRIED. The DNA region around the c- myc gene and it amplification in human tumour cell lines. Oncogene 9, 955-961 (1994).

ARMES, N. and M. FRIED. The genomic organization of the region containing the D. melanogaster rpL7a Surf-3) gene(differs from that of the mammalian and avian Surfeit loci. Mol. Cell. Biol. 15, 2367-73 (1995).

FEO, S., DI LIEGRO, C, MANGANO, R, READ, M. and M. FRIED. The amplicons in HL60 cells contain novel cellular sequences linked to MYC locus DNA. Oncogene 13, 1521-1529 (1996).

ARMES, N. and M. FRIED. Surfeit Locus gene homologues are widely distributed in invertebrate genomes. Mol. Cell. Biol. 16, 5591-5596 (1996).

GILLEY, J., ARMES, N. and M. FRIED. Fugu genome is not a good mammalian model. Nature 385, 305-6 (1997).

MOR, O., READ, M. and M. FRIED. p53 in polyoma virus transformed REF52 cells. Oncogene 16, 3113-20 (1997).

MANGANO, R., PIDDINI, E., CARRAMUSA, L., DUHIG, T., FEO, S. and M. FRIED. Chimeric amplicons containing the c-myc gene in HL60 cells. Oncogene 17, 2771-2777 (1998).

GILLEY, J. and M. FRIED. Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. Hum. Mol. Genet. 8, 1313-1320 (1999).

DUHIG,T., RUHRBERG, C., MOR, O. and M. FRIED. The human Surfeit Locus, Genomics 52, 72-82 (1998).

ALLAN, L. and M. FRIED. p53-dependent apoptosis or growth arrest induced by different forms of radiation in U20S Cells: p21(WAF1/CIP1)repression in UV induced apoptosis. Oncogene 18, 5403-5412 (1999).

TIRANTI, V., LAMANTEA, E., UZIEL,G., ZEVIANI, M., GASPARINI, P., MARZELLA, R., ROCCHI, M. and M. FRIED. Leigh syndrome transmitted by uniparental disomy of chromosome 9. J Med Genet 36 927-928 (1999)

ALLAN, L., DUHIG, T., READ, M. and M. FRIED. The p21(WAF1/CIP1) promoter is methylated in Rat-1 cells: stable restoration of p53-dependent p21 (WAF1/CIP1) expression after transfection of a genomic clone containing the p21(WAF1/CIP1) gene. Mol. Cell. Biol. 20, 1291-1298 (2000).

LOMAX, M. and M. FRIED. Polyoma virus disrupts ARF signalling to p53. Oncogene 20, 4951-4960 (2001).

GILLEY, J. and M. FRIED. One INK4 gene and no ARF at the Fugu equivalent of the human p15INK4A /ARF p16 INK4B tumor suppressor locus. Oncogene 20, 7447-7452 (2001).

HUOT, T.J., ROWE, J., HARLAND, M., DRAYTON, S., BROOKES, S., CHANDRA, G., PURKIS, P., FRIED, M., BATAILLE, V., HARA, E., NEWTON-BISHOP, J. and G. PETERS. Biallelic mutations in p16INK4 confer resistance to Ras and Ets induced senescence in human diploid fibroblasts. Mol. Cell. Biol. 22, 8135-8143 (2002).

DRAYTON, S., ROWE, J., JONES, R., VATCHEVA, R., CUTHBERT-HEAVENS, D., MARSHALL, J., FRIED, M., and G. PETERS. Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes. Cancer Cell 4, 301-310 (2003).

MOULE, M. G., COLLINS, C.H, MCCORMICK, F. and M. FRIED. Role for PP2A in ARF signaling to p53. Proc. Natl. Acad. Sci. USA 101, 14063-66 (2004).

O"SHEA, C. and M. FRIED, Modulation of the ARF-p53 pathway by the Small DNA Tumor Viruses. Cell Cycle 4, 449-452 (2005).

RODRIGUEZ-VICIANNA, P., COLLINS, C.H., MOULE, M.G. and M. FRIED. Chromosomal instability at a mutational hotspot in polyoma middle T-antigen affects its ability to activate the ARF-p53 tumor suppressor pathway. Oncogene 25 1454-1462 (2006). (Epub Oct 31, 2005).

RODRIGUEZ-VICIANNA, P., OSES-PRIENTO, J, BURLINGAME, A. ,FRIED, M. and MCCORMICK, F. A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of pp1 functions as an M-Ras effector to modulate Raf activity. Mol. Cell 22, 217-230 (2006).

HUNT, A., MOULE, M.G. and M. FRIED. The rat ARF protein is translated from two closely spaced ATG start codons and can transcriptionally activate p53 in the absence of p53 stabilization. Cell Cycle 5, 1325-1330 (2006).

RODRIGUEZ-VICIANNA, COLLINS, C.H. and M. FRIED. Polyoma and SV40 proteins differentially regulate PP2A to activate distinct cellular signaling pathways involved in growth control. Proc. Natl. Acad. Sci. USA 103, 19290-19295 (2006).

2/1/07