(415) 353-2421 (appts)

Box 1270, UCSF; San Francisco, CA 94143-1270

additional websites:

UCSF Physician Referral Directory

Swarthmore College, Swarthmore, PA, B.A., 1977, Biology
Harvard Medical School, M.D., 1981, Medicine
Univ of California, San Francisco, CA, Resident, 1981-84, Internal Medicine
Univ of California, San Francisco, CA, Fellow, 1984-87, Hematology/Oncology

Myers, R.M., Cowie, A., Stuve, L., Hartzog, G., and Gaensler, K.M.L. "Genetic and biochemical analysis of the mouse  major globin promoter," Sixth Conference on Hemoglobin Switching. Stamatoyannopoulos, G. and Nienhuis, A. (eds.). New York, A.R. Liss (1989).

Debs, R.J., Freedman, L.p., Edmunds, S., Gaensler, K.M.L., Duzgunes, H., Yamamato, K.R. "Regulation of gene expression in vivo by liposome-medicated delivery of a purified transcription factor," J Biol Chem 265: 10189-10192, (1990).

Gaensler, K.M.L., Burmeister, M., Brownstein, B.H., Taillon-Miller, P., Myers, R.M. "Physical mapping of yeast artificial chromosomes containing sequences from the human -globin region," Genomics. 10976-10987, (1991).

Debs, R., Pian, M., Gaensler, K.M.L., Clements, J., Friend, D.S., and Dobbs, L. "Prolonged transgene expression in rodent cells," Am J Resp Cell Mol Biol 7:406-413, (1992).

Stribing, R., Brunette, E., Liggit, D., Gaensler, K.M.L., and Debs, R. "Aerosolized gene delivery in vivo," Proc Natl Acad Sci USA 89:11277-11281, (1992).

Gaensler, K.M.L., Kitamura, M., and Kan, Y.W. "Germline transmission and developmental regulation of a 159kb YAC containing the human -globin gene locus in transgenic mice," Proc Natl Acad Sci USA 90:11381-11385, (1993).

Liu, Y., Zhong, w., Tu, G., Gaensler, K.M.L., and Debs, R., "Cationic liposome-mediated intravenous gene delivery," J Biol Chem, 270: 24864-24870, (1995).

Bruch, S.W., Tu, G., Liggitt, D., Metkus, A., Mychaliska, G., Harrison, M.R., Debs., R. J., and Gaensler, K.M.L., "In Utero Gene Therapy," Surgical Forum X2VI: 650-653, (1995).

Perkins. A., Gaensler, K.M.L.,and Orkin, S.H., "Imparied silencing of human fetal hemoglobin expression in the absence of the adult beta-globin gene activator protein E.K.L.F.," Proc Natl Acad Sci USA 93:12267-12272, (1996).

Porcu, S., Kitamura, M., Witkowska, E., Zhang, Z., Mutero, A., Lin, C., Chang, J., and Gaensler., K.M.L., "The human -globin locus introduced by YAC transfer exhibits a specific and reproducible pattern of developmental regulation in the transgenic mice," Blood, 90: 4602-4609, (1997).

Chang, J., Lu, R., Lin, C., Xu, S.M., Kan, Y.W., Porcu, S., Carlson, E., Kitamura, M., Yang, S., Flebbe-Rehwaldt, and Gaensler, K.M.L., "Transgenic knock-out mice exclusively expressing hemoglobin S after transfer of a 240-kb b-globin yeast artificial chromosome," Proc Natl Acad Sci USA 95: 14886-14890, (1998).

Lipshutz, G., Flebbe-Rehwaldt, L., and Gaensler, K.M.L., "Adenoviral-Mediated Gene Expression in the Midgestation Fetal Mouse," J Surg Res 84:150-156, (1999).

Lipshutz, G., Flebbe-Rehwaldt, L., and Gaensler, K.M.L., "Adenoviral-Mediated Gene Transfer to the Peritoneum and Hepatic Parenchyma of Fetal Mice In Utero," Surgery 126:171-177, (1999).

Lipshutz, G., Flebbe-Rehwaldt, L., Harrison, M., and Gaensler, K.M.L., "In Utero Delivery of a Gene Therapy Vector into the Developing Brain," Surgical Forum 3:523-525, (1999).

Lipshutz, G., Sarkar, R., Flebbe-Rehwaldt, L., Kazazian, H., and Gaensler, K.M.L., "Short-term correction of factor VIII deficiency in a murine model of Hemophilia A after delivery of Ad-mFVIII," Proc Natl Acad Sci USA 96:13324-13329, (1999).

Gaensler, K.M.L., Bruch, S., Tu, G., Liggitt, Dl., Metkus, A., Harrison, M., Heath, T.D., and Debs, R.J., "In Utero injection of cationic liposome: DNA complexes into fetal rats produces significant levels of gene expression," Nature Biotech, 17:1188-1192, (1999).

May, C., Rivella, S., Callegari, J., Heller, G., Gaensler, K.M.L., Luzzato, L., and Sadelain, M., "Therapeutic haemoglobin synthesis in -thalassemic mice expressing lenti-virus-encoded human -globin," Nature, 406:82-85, (2000).

Lipshutz, G.L., Wang, L. and Gaensler, K.M.L., "Neonatal correction of hemophilia B after in utero gene therapy," Surgical Forum, 51:423-425, (2000).

Lipshutz, G.L., Flebbe-Rehwaldt, L., and Gaensler, K.M.L., "Re-expression follwing re-administration of an adenoviral vector in adult mice after initial in utero adenoviral administration," Molecular Therapy, 2:374-380, (2000).

Lipshutz, G.L., Gruber, C.A., Contag, C.H., and Gaensler, K.M.L., "In utero delivery of adeno-associated viral vectors: Intraperitoneal gene transfer produces long-term expression," Molecular Therapy, 3:284-292, (2001).

Gaensler, K. M. L., Zhang, Z., Lin, C., Yang, S., Hardt, K., and L. Flebbe-Rehwaldt. "Developmental stage-restricted expression of the human  globin gene cluster is preserved in YAC transgenic mice with deletions in the A to  globin intergenic region"Proc. Nat. Acad. Sci., 100:3374-3379 ( 2003)

Lipshutz, G.L., Titre, D., Brindle, M., Bisconte, A., Contag, C.H., and K.M.L. Gaensler. "Comparison of gene expression after delivery of AAV2 or AAV5 in utero" (Molecular Therapy, 8: 90-98, July 2003)

Basu P., Morris P.E., Haar J.L., Wani M.A., Lingrel J.B., Gaensler K.M.L., and J.A. Lloyd. "KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic beta-like globin genes in vivo" Blood 106(7): 2566-71 (2005).

Rupon JW, Wang SZ, Gaensler K, Lloyd J, Ginder GD. "Methyl binding domain protein 2 mediates {gamma}-globin gene silencing in adult human betaYAC transgenic mice." Proc Natl Acad Sci.,103(17):6617-22 (2006).

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