Karin M. Gaensler, MD

Swarthmore College, Swarthmore, PA, B.A., 1977, Biology
Harvard Medical School, M.D., 1981, Medicine
Univ of California, San Francisco, CA, Resident, 1981-84, Internal Medicine
Univ of California, San Francisco, CA, Fellow, 1984-87, Hematology/Oncology

• 1989 - 1991
  Instructor in Medicine, UCSF
• 1989 - present
  Attending Physician, Division of Hematology/Oncology, UCSF
• 1991 - 1992
  Associate, Howard Hughes Medical Institute, Laboratory of Dr. Y.W. Kan
• 1992 - 2001
  Assistant Adjunct Professor of Medicine, UCSF
• 2001 - 2003
  Associate Adjunct Professor of Medicine, UCSF
• 2004 - 2005
  Associate Clinical Professor of Medicine, UCSF
• 2005 - present
  Professor of Medicine, UCSF
• 2006 - present
  Member, UCSF Helen Diller Family Comprehensive Cancer Center Hematopoieitic Malignancies and Pediatric Oncology Programs

• 1988-1990
  American Cancer Society Fellowship
• 1991-1992
  Howard Hughes Medical Institute Fellowship
• 1992-1997
  NIH Physician Scientist Award

• Myers, R.M., Cowie, A., Stuve, L., Hartzog, G., and Gaensler, K.M.L. "Genetic and biochemical analysis of the mouse  major globin promoter," Sixth Conference on Hemoglobin Switching. Stamatoyannopoulos, G. and Nienhuis, A. (eds.). New York, A.R. Liss (1989).
• Debs, R.J., Freedman, L.p., Edmunds, S., Gaensler, K.M.L., Duzgunes, H., Yamamato, K.R. "Regulation of gene expression in vivo by liposome-medicated delivery of a purified transcription factor," J Biol Chem 265: 10189-10192, (1990).
• Gaensler, K.M.L., Burmeister, M., Brownstein, B.H., Taillon-Miller, P., Myers, R.M. "Physical mapping of yeast artificial chromosomes containing sequences from the human -globin region," Genomics. 10976-10987, (1991).
• Debs, R., Pian, M., Gaensler, K.M.L., Clements, J., Friend, D.S., and Dobbs, L. "Prolonged transgene expression in rodent cells," Am J Resp Cell Mol Biol 7:406-413, (1992).
• Stribing, R., Brunette, E., Liggit, D., Gaensler, K.M.L., and Debs, R. "Aerosolized gene delivery in vivo," Proc Natl Acad Sci USA 89:11277-11281, (1992).
• Gaensler, K.M.L., Kitamura, M., and Kan, Y.W. "Germline transmission and developmental regulation of a 159kb YAC containing the human -globin gene locus in transgenic mice," Proc Natl Acad Sci USA 90:11381-11385, (1993).
• Liu, Y., Zhong, w., Tu, G., Gaensler, K.M.L., and Debs, R., "Cationic liposome-mediated intravenous gene delivery," J Biol Chem, 270: 24864-24870, (1995).
• Bruch, S.W., Tu, G., Liggitt, D., Metkus, A., Mychaliska, G., Harrison, M.R., Debs., R. J., and Gaensler, K.M.L., "In Utero Gene Therapy," Surgical Forum X2VI: 650-653, (1995).
• Perkins. A., Gaensler, K.M.L.,and Orkin, S.H., "Imparied silencing of human fetal hemoglobin expression in the absence of the adult beta-globin gene activator protein E.K.L.F.," Proc Natl Acad Sci USA 93:12267-12272, (1996).
• Porcu, S., Kitamura, M., Witkowska, E., Zhang, Z., Mutero, A., Lin, C., Chang, J., and Gaensler., K.M.L., "The human -globin locus introduced by YAC transfer exhibits a specific and reproducible pattern of developmental regulation in the transgenic mice," Blood, 90: 4602-4609, (1997).
• Chang, J., Lu, R., Lin, C., Xu, S.M., Kan, Y.W., Porcu, S., Carlson, E., Kitamura, M., Yang, S., Flebbe-Rehwaldt, and Gaensler, K.M.L., "Transgenic knock-out mice exclusively expressing hemoglobin S after transfer of a 240-kb b-globin yeast artificial chromosome," Proc Natl Acad Sci USA 95: 14886-14890, (1998).
• Lipshutz, G., Flebbe-Rehwaldt, L., and Gaensler, K.M.L., "Adenoviral-Mediated Gene Expression in the Midgestation Fetal Mouse," J Surg Res 84:150-156, (1999).
• Lipshutz, G., Flebbe-Rehwaldt, L., and Gaensler, K.M.L., "Adenoviral-Mediated Gene Transfer to the Peritoneum and Hepatic Parenchyma of Fetal Mice In Utero," Surgery 126:171-177, (1999).
• Lipshutz, G., Flebbe-Rehwaldt, L., Harrison, M., and Gaensler, K.M.L., "In Utero Delivery of a Gene Therapy Vector into the Developing Brain," Surgical Forum 3:523-525, (1999).
• Lipshutz, G., Sarkar, R., Flebbe-Rehwaldt, L., Kazazian, H., and Gaensler, K.M.L., "Short-term correction of factor VIII deficiency in a murine model of Hemophilia A after delivery of Ad-mFVIII," Proc Natl Acad Sci USA 96:13324-13329, (1999).
• Gaensler, K.M.L., Bruch, S., Tu, G., Liggitt, Dl., Metkus, A., Harrison, M., Heath, T.D., and Debs, R.J., "In Utero injection of cationic liposome: DNA complexes into fetal rats produces significant levels of gene expression," Nature Biotech, 17:1188-1192, (1999).
• May, C., Rivella, S., Callegari, J., Heller, G., Gaensler, K.M.L., Luzzato, L., and Sadelain, M., "Therapeutic haemoglobin synthesis in -thalassemic mice expressing lenti-virus-encoded human -globin," Nature, 406:82-85, (2000).
• Lipshutz, G.L., Wang, L. and Gaensler, K.M.L., "Neonatal correction of hemophilia B after in utero gene therapy," Surgical Forum, 51:423-425, (2000).
• Lipshutz, G.L., Flebbe-Rehwaldt, L., and Gaensler, K.M.L., "Re-expression follwing re-administration of an adenoviral vector in adult mice after initial in utero adenoviral administration," Molecular Therapy, 2:374-380, (2000).
• Lipshutz, G.L., Gruber, C.A., Contag, C.H., and Gaensler, K.M.L., "In utero delivery of adeno-associated viral vectors: Intraperitoneal gene transfer produces long-term expression," Molecular Therapy, 3:284-292, (2001).
• Gaensler, K. M. L., Zhang, Z., Lin, C., Yang, S., Hardt, K., and L. Flebbe-Rehwaldt. "Developmental stage-restricted expression of the human  globin gene cluster is preserved in YAC transgenic mice with deletions in the A to  globin intergenic region"Proc. Nat. Acad. Sci., 100:3374-3379 ( 2003)
• Lipshutz, G.L., Titre, D., Brindle, M., Bisconte, A., Contag, C.H., and K.M.L. Gaensler. "Comparison of gene expression after delivery of AAV2 or AAV5 in utero" (Molecular Therapy, 8: 90-98, July 2003)
• Basu P., Morris P.E., Haar J.L., Wani M.A., Lingrel J.B., Gaensler K.M.L., and J.A. Lloyd. "KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic beta-like globin genes in vivo" Blood 106(7): 2566-71 (2005).
• Rupon JW, Wang SZ, Gaensler K, Lloyd J, Ginder GD. "Methyl binding domain protein 2 mediates {gamma}-globin gene silencing in adult human betaYAC transgenic mice." Proc Natl Acad Sci.,103(17):6617-22 (2006).