Professor, Microbiology/Immunology and Medicine, UCSF
Member, Biomedical Sciences Program (BMS) and
Herbert Boyer Program in Biological Sciences (PIBS)
| CONTACT | |
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ganem@cgl.ucsf.edu Box 1753, UCSF; San Francisco, CA 94143-1753 |
additional websites: |
| EDUCATION | |
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Harvard College, Cambridge, MA, A.B., 1972, Biochemistry
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| PROFESSIONAL EXPERIENCE | |
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1980-1982 |
Postdoctoral Fellow, Department of Microbiology, University of California, San Francisco, Laboratory of Dr. Harold Varmus. Area: Molecular Virology. |
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1988-90 |
Associate Professor of Microbiology and Medicine, University of California, San Francisco |
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1990-present |
Professor of Microbiology and Medicine University of California, San Francisco |
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1991-1994 |
Associate Investigator, Howard Hughes Medical Institute |
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1995-present |
Investigator, Howard Hughes Medical Institute |
| HONORS & AWARDS | |
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1972 |
Harkness Scholar, Harvard Medical School |
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1975 |
Soma Weiss Award for Medical Student Research, Harvard Medical School |
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1977 |
Leon Resnick Prize for Research, Harvard Medical School |
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1977 |
Alpha Omega Alpha |
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1984 |
John A. Hartford Fellow |
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1986 |
Kaiser Award for Excellence in Basic Science Teaching |
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1986 |
University of California Academic Senate Teaching Award |
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1986 |
2nd Year Students' Teaching Award for small group teaching |
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1987 |
2nd Year Students' Teaching Award for excellence in lecturing |
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1989 |
2nd Year Students' Teaching Award for excellence in lecturing |
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1991 |
2nd Year Students' Teaching Award for excellence in lecturing |
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1993 |
Elected to American Academy of Microbiology |
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1995 |
4th Year Medical Students' Teaching Award for outstanding preclinical instruction |
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1995 |
Charter Member, Molecular Medicine Society |
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1996 |
2nd Year Medical Students Teaching Award for excellence in lecturing |
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1997 |
Bristol-Myers Squibb Unrestricted Grant for Infectious Disease Research |
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1997 |
Chairman, Gordon Conference on Viruses and Cells |
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1997 |
Elected to Association of American Physicians |
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1997 |
Elected Vice-President, American Society for Clinical Investigation |
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2000 |
UCSF Faculty Research Award Lectureship |
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2001 |
Named to Board of Reviewing Editors, Science |
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2003 |
Elected to the Institute of Medicine of the National Academy of Sciences |
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2004 |
Elected to American Academy of Arts and Sciences |
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2005 |
Elected President, American Society of Virology |
| SELECTED PUBLICATIONS | |
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(selected from a total of 172) |
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Baron, J.L., Gardiner, L., Nishimura, S., Locksley, R. and Ganem, D. (2002). A novel NKT cell subset mediates liver injury in a transgenic mouse model of hepatitis B virus infection. Immunity 16: 583-594. |
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Polson, A., Wang, D., DeRisi, J. and Ganem, D. (2002). Modulation of host gene expression by the constitutively active G-protein coupled receptor of Kaposifs sarcoma-associated herpesvirus, KSHV. Cancer Res. 62:4525-4530. |
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Liang, Y., Chang, J., Lynch, S.J., Lukac, D. and Ganem, D. (2002) The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jk, the target of the Notch signaling pathway. Genes Dev. 16:1977-1989. |
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Grundhoff, A. and Ganem, D. (2003). The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (KSHV) permits replication of terminal repeat-containing plasmids. J Virol. 77:2779-83. |
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Wang, D., Coscoy, L., Zylberberg, M., Avila, P., Boushey, H., Ganem, D. and DeRisi, J. (2002). Microarray-based detection and genotyping of viral pathogens. Proc Nat Acad Sci (USA), 99:15687-92. |
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Bechtel, J., Liang, Y., Hvidding, J. and Ganem, D. (2003). Host range of Kaposifs sarcoma-associated herpesvirus in cultured cells. J Virol, 77: 6474-6481. |
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Liang, Y. and Ganem, D. (2003). Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signaling. Proc Natl Acad Sci U S A. 100:8490-5 |
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Wang, D., Urisman, A., Liu, Y-T., Springer. M., Ksiazek, T.G., Erdman, D.D., Mardis, E.R., Hickenbotham, M., Magrini, V., Eldred, J., Latreille, J.P., Wilson, R.K., Ganem, D. and DeRisi, J.L. (2003). Viral Discovery and Sequence Recovery Using DNA Microarrays. PloS Biol. 1: E2 |
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Grundhoff, A. and Ganem, D. (2004) Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis. J Clin Invest. 113:124-136. |
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Sanchez, D., Gumperz, J. and Ganem, D. (2005). Regulation of CD1d expression and function by a herpesvirus infection. J Clin Invest. 115: 1369-1378. |
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McCormick ,C. and Ganem, D. (2005). The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs. Science 307:739-41 |
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Bechtel, J, Winant, D and Ganem, D (2005) Host and viral proteins in the virion of Kaposifs sarcoma- associated herpesvirus. J Virol. 79: 4952-64. |
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Sullivan, C. and Ganem, D. (2005). A virus-encoded inhibitor that blocks RNA interference in mammalian cells. J Virol.79: 7371-7379. |
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Glaunsinger, B, Chavez, L and Ganem, D (2005) The exonuclease and host shutoff functions of the SOX protein of Kaposi's sarcoma-associated herpesvirus are genetically separable. J Virol. 79: 7396-7401. |
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Sullivan, C, Grundhoff, A, Pipas, J, Tevethia, S and Ganem, D (2005) SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells.. Nature 435: 682-6. |
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Bechtel, J, Grundhoff, A and Ganem D (2005) RNAs in the Virion of Kaposifs Sarcoma-Associated Herpesvirus. J Virol. 79:10138-10146. |
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Sullivan, C. and Ganem, D. (2005) MicroRNAs and Viral Infection. Molecular Cell 20:3-7. |
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Ziegelbauer, J., Grundhoff, A. and Ganem, D. (2006) Exploring the DNA Binding Interactions of the Kaposifs Sarcoma-Associated Herpesvirus Lytic Switch Protein by Selective Amplification of Bound Sequences In Vitro. J Virol. 80: 2958-2967. |
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Grundhoff, A., Sullivan, C. and Ganem, D. (2006) A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses. RNA 12:1-18. |
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Urisman, A., Molinaro, R., Fischer, N., Plummer, S., Casey, G, Klein, E., Malathi, K., Magi-Galluzzi, C., Tubbs, R., Ganem, D., Silverman, R. and DeRisi, J. (2006) Identification of a Novel Gammaretrovirus in Prostate Tumors of Patients Homozygous for R462Q RNASEL Variant. PloS Pathogens 2:0211-0225 |
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McCormick, C. and Ganem, D. (2006) Phosphorylation and Function of the Kaposin B Direct Repeats of Kaposifs Sarcoma-Associated Herpesvirus. J Virol. 80: 6165-6170. |
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Grossmann, C., Podgrabinska, S., Skobe, M. and Ganem, D. (2006) Activation of NF-ƒÈB by the Latent vFLIP Gene of Kaposifs Sarcoma-Associated Herpesvirus Is Required for the Spindle Shape of Virus-Infected Endothelial Cells and Contributes to Their Proinflammatory Phenotype. J Virol. 80: 7179-7185. |
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1/25/07 |
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