rghadial@itsa.ucsf.edu
(415) 750-2091 (voice)
(415) 751-3927 (fax)

Box 190, 4150 Clement Street, 1A-31, San Francisco, CA 94143-190

Sheffield University, Sheffield, England, MBChB (MD), 1982, Medicine
Royal Hallamshire Hospital, Sheffield, England, Intern, 1983, Medicine
University Hospital, Saskatoon, Saskatchewan, Canada, Resident, 1984, Medicine
Mt. Sinai Hospital, Toronto, Canada Rotating Int., 1985, Medicine
University of Toronto, Toronto, Canada Residency, 1988, Dermatology
University of California, San Francisco, California Postdoctoral Fellow, 1988-90, Dermatology

Ghadially, J.A., Ghadially, R. and Ghadially, F.N.: Long term results of deep defects in articular cartilage. Virchows Arch. B. Cell Path. 24:125-136, 1977.

Ghadially, F.N., Lock, C.J.F., Lalonde, J.A. and Ghadially, R.: Platino-somes produced in synovial membrane by platinum coordination complexes. Virchows Arch. B. Cell Path. 35:123-131, 1981.

Ghadially, F.N., Ghadially, R., Lalonde, J.A.: A comparative ultra-struc-tural study of cutaneous blue naevi of humans and hamsters. J. Submicrosc. Cytol. 18(2):417-432, 1986.

Ghadially, R., and Ramsay, C.A.: Gentamicin: Systemic exposure to a contact allergen. J. Am. Acad. Dermatol. 19:428-430, 1988.

Hogan D., Ghadially, R., McSheffrey, J.B., and Lane, P.: Human immuno-deficiency virus infection and porphyria cutanea tarda. J. Am. Acad. Dermatol. 20:17-20, 1989.

Ghadially, R., et al.: Granuloma annulare in patients with human immunode-ficiency virus infections. J. Am. Acad. Dermatol. 20:232-235, 1989.

Ghadially, R., and Ghadially, F.N.: Anchoring fibrils in a spindle cell squamous carcinoma. J. Submicrosc. Cytol. Pathol. 21(2):249-257, 1989.

Ghadially, R.: Benign familial pemphigus. Article 16960 in Birth Defects Encyclopedia, Alan R. Liss, Inc., 1990.

Ghadially, R.: Acrokeratosis verruciformis. Article 10190 in Birth Defects Encyclopedia, Alan R. Liss, Inc., 1990.

Ghadially, R., Shear, N.: Topical Therapy and percutaneous absorption in Yaffe SJ Edit., Pediatric Pharmacology. Grune and Stratton. 1991.

Hou, S.Y.E., Mitra, A.K., White, S.H., Menon, G.K., Ghadially, R., Elias, P.M. Membrane structures in normal and essential fatty acid deficient stratum corneum: Characterization by ruthenium tetroxide staining and x-ray diffraction. J. Invest. Dermatol. 96:215-223, 1991.

Ghadially, R., Elias, P.M. The effect of petrolatum (VaselineŒ-petroleum jelly) on stratum corneum structure and function. J. Am. Acad. Dermatol. 26:387-396, 1992.

Darny, P.D., Klaisio, C.M., Walker, D.M., Ghadially, R. The importance of proper insertion of norplant contraceptive implants. J. Fam. Pract. Vol. 34, No. 5, 1992.

Menon, G.K., Williams, M.L., Ghadially, R., Elias, P.M. Lamellar bodies as delivery systems for lipolytic enzymes: Implications for normal and abnor-mal desquamation. Br. J. Dermatol. 126:337-345, 1992.

Williams, M.L., Vogel, J.S., Ghadially, R., Brown, B.E., Elias, P.M. Exogenous origin of n-alkanes in pathological scale. Arch. Dermatol. 128:1065-1071, 1992.

Ghadially, R., Williams, M.L., Hou, S.Y.E., Elias, P.M. Membrane structural abnormalities in the stratum corneum of the autosomal recessive ichthyoses. J. Invest. Dermatol. 99:755-763, 1992.

Ghadially, R., Chong, L.P. Ichthyoses and hyperkeratotic disorders. Dermatol. Clin., 597-608. 1992.

Ghadially, R., Ghadially, F.N. Keratoacanthoma. In: Fitzpatrick, T.B., et al. (ed.), Dermatology In General Medicine, McGraw-Hill Book Co., 1993.

Ghadially, R. Granuloma annulare, Actinic Granuloma. In: Arndt, K., et al (ed.), Cutaneous Medicine and Surgery, WB Saunders Co., 1993.

Elias, P.M., Holleran, W.M., Feingold, K.R., Menon, G.K., Ghadially, R., Williams, M.L. Normal mechanisms and pathophysiology of epidermal permeability barrier homestasis. Curr. Opion. in Dermatol., 231-237 1993.

Feingold, K.R., Menon, G.K., Ghadially, R., Elias, P.M. Acetone to break the barrier. Letter to the Editor. J. Invest. Dermatol. 1994.

Ghadially, R, Brown, BE, Sequeira-Martin, SM, Feingold, KR, Elias, PM. The aged epidemal permeability barrier: Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model. J. Clin. Invest. 95:2281-2290, 1995.

Reed, J.T., Ghadially, R., Elias, P.M. Skin type, but neither race nor gender, influence epidermal permeability barrier function. Arch. Dermatol. 131:1134-1138, 1995.

Ghadially, R., Brown, B.E., Reed, J.T., Feingold, K.R., Elias, P.M. Decreased epidermal lipid synthesis accounts for altered barrier function in aged mice. J. Invest. Dermatol 106:1064-1069, 1996.

Ghadially, R. Skin. In: Geriatrics (ed. E.T. Lonergan). Stamford, Connecticut: Appleton & Lange, p. 354-367, 1996.

Ghadially, F.N., Ghadially, R. Tumours of the skin. In: Pathology of Tumours in Laboratory Animals. Volume III - Tumours of the Hamster (ed. V.S. Turusov and U. Mohr). Lyon, France. International Agency for Research on Cancer, p. 1-44, 1996.

Ghadially, R., Reed, J.T., Elias, P.M. Stratum corneum structure and function correlates with phenotype in psoriasis. J. Invest. Dermatol. 107:558-564, 1996.

Menon, G.K., Ghadially, R. Morphology of lipid alterations in the epidermis: A review, electromicroscopy research and techniques. 37:2, April 1997.

Reed, J.T., Ghadially, R., Elias, P.M. Integrity and permeability barrier function of photoaged human epidermis. Arch. Dermatol. 133:395-396, 1997.

Zettersten, E.M., Ghadially, R., Feingold, K.R., Crumrine, D., Elias, P.M. Optimal ratios of topical stratum corneum lipids improve barrier recovery in chronologicaly aged skin. J. Am. Acad. Dermatol. 37:403-408, 1997.

Ghadially, R. Aging and the epidermal permeability barrier: Implications for irritant contact dermatitis. Contact Dermatitis. Am. J. Contact Derm. 9:162-169, 1998.

Zettersten, E., Mao-Qiang, M., Sato, J., Denda, M., Farrell, A., Ghadially, R., Williams, M.L., Feingold, K.R., Elias, P.M. Recessive X-linked ichthyosis: Role of cholesterol-sulfate accumulation in the barrier abnormality. J. Invest. Dermatol. 111:784-790, 1998.

Ghadially, R., Garg, A. Granuloma Annulare. In: James WD, Elston D. (Chief Eds.); eMedicine Dermatology. St. Petersburg: eMedicine Corporation, 2000.

Kao, J.S., Garg, A., Kao, J.S., Man, M.-Q., Chren, M.-M., Crumrine, D., Ghadially, R., Feingold, K.R., Elias, P.M. Testosterone perturbs epidermal permeability barrier homeostasis. J. Invest. Dermatol. 116:443-451, 2001.

Barland, C., Garg, A., Ye, J., Zettersten, E., Feingold, K.R., Elias, P.M., Ghadially, R. Interleukin-1 alpha signaling is a determinant of permeability barrier homeostasis in aged murine skin. J. Invest. Dermatol. 117:416, 2001.

Elias, P.M., Ghadially, R. The aged epidermal permeability barrier: Basis for functional abnormalities. In: Geriatric Dermatology (ed. J. Kowalak) Philadelphia: W.B. Saunders Co. 2001 .

Ghadially, R. Psoriasis and ichthyosis. In: Rawlings A.V. and Leyden J. (eds.) Skin Moisturizers, Marcel Dekker, Inc., In Press 2002.

Ye, J., Calhoun, C., Feingold, K.R., Elias, P.M., Ghadially, R. Alterations in cytokine signaling in aged epidermis: Implications for permeability barrier homeostasis and inflammation. I. IL-1 gene family. Exp. Dermatol. In Press, 2002.

Measuring stem cell frequency in epidermis: a quantitative in- vivo functional assay for long-term repopulating cells. Schneider, T.E., Barland, C., Alex, A.M., Mancianti, M.L., Lu, Y., Cleaver, J.E., Lawrence, H.J., Ghadially, R. P. Natl. Acad. Sci., U.S.A. In Press.

9/12/03