egoetzl@itsa.ucsf.edu
(415) 476-5339 (voice)
(415) 476-6915 (fax)

Box 1711, UCSF; San Francisco, CA 94143-1711

Amherst College, Amherst, MA, B.A., 1962, Biology
Harvard Medical School, Boston, MA, M.D., 1966, Medicine/Microbiology

An, S., Bleu, T., Hallmark, O.G., and Goetzl, E.J. Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. J. Biol. Chem. 273:7906-7910, 1998.

Goetzl, E.J., Kong, Y., and Mei, B. Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in association with suppression of Bax. J. Immunol. 162:2049-2056, 1999. Goetzl, E.J., Lee, H., Azuma, T., Stossel, T.P., Turck, C.W., and Karliner, J.S. 2000. Gelsolin binding and cellular presentation of lysophosphatidic acid. J. Biol. Chem. 275: 14573-14578.

Goetzl, E.J., Kong, Y., and Voice, J.K. 2000. Differential constitutive expression of functional receptors for lysophosphatidic acid by human blood lymphocytes. J. Immunol. 164:4996-4999.

Zheng, Y., Voice, J., Kong, Y., Goetzl, E.J. 2000. Altered expression and functional profile of lysophosphatidic acid receptors in mitogen-activated human blood T lymphocytes. FASEB J., 14:2387-2389 (full-text online).

Zheng, Y., Kong, Y., Goetzl, E.J., 2001 Lysophosphatidic acid receptor-selective effects on Jurkat T cell migration through a matrigal model basement membrane. J. Immunol. 166:2317-2322.

Chun, J., Goetzl, E.J., Hla, T., Igarashi, Y., Lynch, K.R., Moolenaar, W., Pyne, S., and Tigyi, G. International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacological Reviews 54:265-269, 2002.

Lee, H., Liao, J.-J., Graeler, M., Huang, M.-C., and Goetzl, E.J. Lysophospholipid regulation of mononuclear phagocytes. Biochimica et Biophysica Acta 1582:175-177.

Graeler, M., Shankar, G., and Goetzl, E.J. Cutting Edge: Suppression of T cell chemotaxis by sphingosine 1-phosphate. J. Immunol. 169:4084-4087, 2002.

Graeler, M. and Goetzl, E.J. Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells. FASEB J. 16:1874-1878, 2002.

Dolezalova, H., Shankar, G., Huang, M.-C., Bikle, D.D., and Goetzl, E.J. Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate. J. Cell. Biochem., 88:732-743, 2003.

Graeler, M.H., Kong, Y., Karliner, J.S., and Goetzl, E.J., Protein kinase C epsilon-dependence of the recovery from down regulation of S1P1 G protein-coupled receptors of T lymphocytes. J. Biol. Chem., 2003, vol.278, No. 30, pp.27737-27741

Dorsam, G., Graeler, M, Seroogy, C., Kong, Y., Voice, J., and Goetzl, E.J., Transduction of multiple effectsof sphingosine 1-phosphate on T cell functions by S1P1 G protein-coupled receptor. J. of Immunology, 2003, 171: 3500-3507

Gobeil F, Bernier SG, Vazques-Tello A, Brault S, Beauchamp MH, Quiniou C, Marrache AM, Checchin D, Sennlaub F, Hou X, Nader M, Bkaily G, Riberiro-da-Silva A, Goetzl EJ, Chemtob S. Modulation of Pro-inflammatory Gene Expression by Nuclear Lysophosphatidic Acid Receptor Type-1. J. Biol. Chem. 278:38875-38883, 2003.

GrŠler MH, Goetzl EJ. The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G protein-coupled receptors. FASEB J. Express Article - Vol. 18:551-553, March 2004. Full text Ð 10.1096/fj.03-0910fje.

Goetzl EJ, Dembrow D, Van Brocklyn JR, GrŠler MH, Huang M-C. An IgM-kappa rat monoclonal antibody specific for the type 1 sphingosine 1-phosphate G protein-coupled receptor with antagonist and agonist activities. Immunology Letters 93:63-69, 2004.

Goetzl EJ, Tigyi G. Lysophospholipids and their G protein-coupled receptors in biology and diseases. J Cell Biochem. 2004 Aug 1;92(5):867-8.

Grinninger C, Wang W, Oskoui KB, Voice JK, Goetzl EJ. A natural variant type II G protein-coupled receptor for vasoactive intestinal peptide with altered function. J Biol Chem. 2004 Sep 24;279(39):40259-6.

Jin ZQ, Goetzl EJ, Karliner JS. Sphingosine kinase activation mediates ischemic preconditioning in murine heart. Circulation. 2004 Oct 5;110(14):1980-9.

Goetzl EJ, Rosen H. Regulation of immunity by lysosphingolipids and their G protein-coupled receptors. J Clin Invest. 2004 Dec;114(11):1531-7.

Graler MH, Huang MC, Watson S, Goetzl EJ. Immunological effects of transgenic constitutive expression of the type 1 sphingosine 1-phosphate receptor by mouse lymphocytes. J Immunol. 2005 Feb 15;174(4):1997-2003.

Rosen H, Goetzl EJ. Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. Nat Rev Immunol. 2005 Jul;5(7):560-70.

Wang W, Graeler MH, Goetzl EJ. Type 4 sphingosine 1-phosphate G protein-coupled receptor (S1P4) transduces S1P effects on T cell proliferation and cytokine secretion without signaling migration. FASEB J, Issue: 12. 19: 1731-3, Oct/2005.

Fieger CB, Huang MC, Van Brocklyn JR, Goetzl EJ. Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosines. FASEB J, Issue: 13. 19: 1926-8, Nov/2005.

Goetzl EJ. Changing paradigms in the immunologic science of allergy. Curr Allergy Asthma Rep, Issue: 1. 6: 1-3, Jan/2006.

Gobeil F, Zhu T, Brault S, Geha A, Vazquez-Tello A, Fortier A, Barbaz D, Checchin D, Hou X, Nader M, Bkaily G, Gratton JP, Heveker N, Ribeiro-da-Silva A, Peri K, Bard H, Chorvatova A, D'Orléans-Juste P, Goetzl EJ, Chemtob S. Nitric oxide signaling via nuclearized e-NOS modulates expression of the immediate early genes i-NOS and mPGES-1. J Biol Chem, Mar/30/2006.

12/12/06