ira.goldfine@ucsf.edu
(415) 885-7430 (voice)
(415) 885-3787 (fax)

Box 1616, UCSF; San Francisco, CA 94143-1616

University of Michigan, 1963
University of Illinois College of Medicine, M.D., 1967, Medicine
Michael Reese Hospital, Chicago, 1967-1968, Intern in Medicine
University of Chicago, Illinois, 1968-1970, Resident in Medicine

(27 out of a total of 304)

A Saito, H Sankaran, ID Goldfine, JA Williams. Cholecystokinin receptors in brain: characterization and distribution. Science 208(4448): 1155-1156, 1980.

A Saito, JA Williams, ID Goldfine. Alterations in brain cholecystokinin receptors after fasting. Nature 289: 599-564, 198l.

RA Roth, DJ Cassell, KY Wong, BA Maddux, ID Goldfine. Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action. Proc. Natl. Acad. Sci. USA 79: 7312-7316, 1982.

F Purrello, R Vigneri, GA Clawson, ID Goldfine. Insulin stimulation of nucleoside triphosphatase activity in isolated nuclear envelopes. Science 216: 1005-1007, 1982.

RA Roth, DJ Cassell, BA Maddux, ID Goldfine. Regulation of the IR by a monoclonal anti-receptor anti-receptor antibody: evidence that receptor down regulation is independent of insulin action. J. Biol. Chem. 258:12094-12097, 1983.

Y Ebina, L Ellis, K Jarnagin, M Edery, L Graf, E Clauser, J-H Ou, F Maslarz, YW Kan, ID Goldfine, RA Roth, WJ Rutter. The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signaling. Cell, 40:747-758, 1985.

J Forsayeth, A Montemurro, BA Maddux, R DePirro, ID Goldfine. Effect of monoclonal antibodies on human insulin receptor autophosphorylation, negative cooperativity, and down regulation. J. Biol. Chem. 262:4134-4140, 1987.

PW Mamula, ID Goldfine. Cloning and characterization of the human insulin-like growth factor-I receptorgene5' flanking region. DNA Cell Biol. 11(1): 43-50, 1992

JF Youngren, ID Goldfine, RE Pratley. Decreased muscle insulin receptor kinase correlates with insulin resistance in normoglycemic Pima Indians. Am. J. Physiol. 273: E276-83, 1997.

ID Goldfine, MS German, HC Tseng, J Wang, et al. The endocrine secretion of human insulin and growth hormone by exocrine glands of the gastrointestinal tract. Nature Biotechnol. 15(13): 1378-82, 1997.

L Frittitta, D Spampinato, A Solini, R Nosadini, ID Goldfine, R Vigneri, V Trischitta. Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in non-diabetic subjects. Diabetes 47: 1095-1100, 1998.

JF Youngren, ID Goldfine, and RE Pratley. Insulin receptor autophosphorylation in cultured myoblasts correlates to glucose disposal in Pima Indians. Am. J. Physiology 276: E990-E994, 1999.

A Brunetti, G Manfioletti, E Chiefari, ID Goldfine, D Foti. Transcriptional regulation of human insulin receptor gene by the high-mobility group protein HMGI (Y). FASEB 15: 492-500, 2001.

BA Maddux, W See, JC Lawrence, Jr., AL Goldfine, ID Goldfine, JL Evans. Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by alpha-lipoic acid. Diabetes 50: 404-410, 2001.

C Pender, HK Ortmeyer, BC Hansen, ID Goldfine, JF Youngren. Elevated plasma cell membrane glycoprotein levels and diminished insulin receptor autophosphorylation in obese, insulin-resistant Rhesus Monkeys. Metabolism 51: 465-470, 2002.

JL Evans, CJ Heymann, ID Goldfine and LA Gavin. Pharmacokinetics, tolerability, and fructosamine-lowering effect of a novel, controlled release formulation of alpha-lipoic acid. Endocrine Practice 8: 29-35, 2002

Pender C. Goldfine ID, Manchem VP, Evans JL, Spevak WR, Shi S, Rao S, Bajjalaeih S, Maddux BA, Youngren JF. Regulation of insulin receptor function by a small molecule insulin receptor activator. J Biol Chem. 277: 43565-71, 2002.

Li M, Youngren JF, Dunaif A, Goldfine ID, Maddux BA, Zhang BB, Evans JL. Decreased insulin receptor autophosphorylation in fibroblasts from patients with PCOS: effects of serine kinase inhibitors and IR activators. J Clin Endocrinol Metab. 87: 4088-93, 2002.

Evans JL, Goldfine ID, Maddux BA, Grodsky GM, Oxidative Stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr. Rev. 23:599-622, 2002.

Evans JL, Goldfine ID, Maddux BA, Grodsky GM, Are oxidative stress-activated signaling pathways mediators of Insulin resistance and beta cell dysfunction? Diabetes. 52: 1-8,2003

Earle Karen E., Rushakoff Robert J., and Goldfine Ira D. Case Report: Inadvertent Sulfonylure Overdoage and Hypoglycemia in an Elderly Woman; Failure of Serum Hypoglycemia Screening. Diabetes Technol Ther. 2003;5(3):453-4.

Evans JL, Maddux BA, and Goldfine ID. Antioxidants in diabetic complications and insulin resistance. In Diabetes: From Research to Diagnosis and Treatment (I. Raz, J. Sklyer, E. Shafrir, Eds.) Chapter 29. pp. 479-496 2003.

Frasca F., Pandini G., Vigneri R., and Goldfine ID. Insulin and Hybrid Insulin/IGF Receptors Are Major Regulators of Breast Cancer Cells. Breast Disease. 17:73-89, 2003.

Pender C., Goldfine I.D., Tanner C.J., Pories W.J., MacDonald K.G., Havel P.J., Houmard J.A., and Youngren J.F. Muscle Insulin Receptor Concentrations In Obese Patients Post Bariatric Surgery: Relationship to Hyperinsulinemia. International J of Obesity Related Metabolic Disorders. 28(3):363-9, 2004.

Tan C., Wei L., Ottensmeyer P.F., Goldfine I.D., Maddux B., Yip C.C., Batey R.A., Kotra L. Struct based de novo design of ligands using a three-dimensional model of the insulin receptor. Bioorg. Med. Chem. Lett. 14:1407-10, 2004.

Evans J., Youngren J., and Goldfine I.D. Effective Treatments for Insulin Resistance: Trim the Fat and Douse the Fire. Trends in Endocrinology and Metabolism. In Press.

Cheng M., Chen S., Schow, S.R., Manchem V.P., Spevak W.R., Cristobal C.P., Shi S., Macsata R.W., Lum R.T., Goldfine I.D., Keck J.G. In Vitro and In Vivo Prevention of HIV Protease Inhibitor-Induced Insuln Resistance by a Novel Small Molecule Insulin Receptor Activator. J Cellular Biochemistry. In Press.

9/15/04