Ira D. Goldfine, MD

University of Michigan, 1963
University of Illinois College of Medicine, M.D., 1967, Medicine
Michael Reese Hospital, Chicago, 1967-1968, Intern in Medicine
University of Chicago, Illinois, 1968-1970, Resident in Medicine

• 1970
  Visiting Scientist, Dept. of Endocrinology, Karolinska Hospital, Stockholm, Sweden
• 1970-71
  Postdoctoral Fellow, National Institutes of Health, National Institute of Arthritis and Metabolic Diseases, Diabetes Section, Bethesda, Maryland
• 1971-73
  Staff Associate, National Institutes of Health, National Institute of Arthritis and Metabolic Diseases, Diabetes Section, Bethesda, Maryland
• 1973-80
  Assistant Professor in Residence, Department of Medicine, UCSF
• 1977-78
  Clinical Investigator, Veterans Administration Hospital, San Francisco, California
• 1979-87
  Director, Cell Biology Research Laboratory, Mount Zion Medical Center
• 1980-85
  Associate Professor in Residence, Departments of Medicine and Physiology, UCSF
• 1985-Present
  Professor in Residence, Departments of Medicine and Physiology, UCSF
• 1987-Present
  Director, Division of Diabetes & Endocrine Research, Mount Zion Med Ctr, UCSF

• 1963
  State of Illinois Scholar
• 1988
  Mary Jane Kugel Award, Juvenile Diabetes Foundation
• 1989
  Rosenthal Award, American College of Physicians
• 1995
  Mount Zion Distinguished Alumni Award

• (27 out of a total of 304)
• A Saito, H Sankaran, ID Goldfine, JA Williams. Cholecystokinin receptors in brain: characterization and distribution. Science 208(4448): 1155-1156, 1980.
• A Saito, JA Williams, ID Goldfine. Alterations in brain cholecystokinin receptors after fasting. Nature 289: 599-564, 198l.
• RA Roth, DJ Cassell, KY Wong, BA Maddux, ID Goldfine. Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action. Proc. Natl. Acad. Sci. USA 79: 7312-7316, 1982.
• F Purrello, R Vigneri, GA Clawson, ID Goldfine. Insulin stimulation of nucleoside triphosphatase activity in isolated nuclear envelopes. Science 216: 1005-1007, 1982.
• RA Roth, DJ Cassell, BA Maddux, ID Goldfine. Regulation of the IR by a monoclonal anti-receptor anti-receptor antibody: evidence that receptor down regulation is independent of insulin action. J. Biol. Chem. 258:12094-12097, 1983.
• Y Ebina, L Ellis, K Jarnagin, M Edery, L Graf, E Clauser, J-H Ou, F Maslarz, YW Kan, ID Goldfine, RA Roth, WJ Rutter. The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signaling. Cell, 40:747-758, 1985.
• J Forsayeth, A Montemurro, BA Maddux, R DePirro, ID Goldfine. Effect of monoclonal antibodies on human insulin receptor autophosphorylation, negative cooperativity, and down regulation. J. Biol. Chem. 262:4134-4140, 1987.
• PW Mamula, ID Goldfine. Cloning and characterization of the human insulin-like growth factor-I receptorgene5' flanking region. DNA Cell Biol. 11(1): 43-50, 1992
• JF Youngren, ID Goldfine, RE Pratley. Decreased muscle insulin receptor kinase correlates with insulin resistance in normoglycemic Pima Indians. Am. J. Physiol. 273: E276-83, 1997.
• ID Goldfine, MS German, HC Tseng, J Wang, et al. The endocrine secretion of human insulin and growth hormone by exocrine glands of the gastrointestinal tract. Nature Biotechnol. 15(13): 1378-82, 1997.
• L Frittitta, D Spampinato, A Solini, R Nosadini, ID Goldfine, R Vigneri, V Trischitta. Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in non-diabetic subjects. Diabetes 47: 1095-1100, 1998.
• JF Youngren, ID Goldfine, and RE Pratley. Insulin receptor autophosphorylation in cultured myoblasts correlates to glucose disposal in Pima Indians. Am. J. Physiology 276: E990-E994, 1999.
• A Brunetti, G Manfioletti, E Chiefari, ID Goldfine, D Foti. Transcriptional regulation of human insulin receptor gene by the high-mobility group protein HMGI (Y). FASEB 15: 492-500, 2001.
• BA Maddux, W See, JC Lawrence, Jr., AL Goldfine, ID Goldfine, JL Evans. Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by alpha-lipoic acid. Diabetes 50: 404-410, 2001.
• C Pender, HK Ortmeyer, BC Hansen, ID Goldfine, JF Youngren. Elevated plasma cell membrane glycoprotein levels and diminished insulin receptor autophosphorylation in obese, insulin-resistant Rhesus Monkeys. Metabolism 51: 465-470, 2002.
• JL Evans, CJ Heymann, ID Goldfine and LA Gavin. Pharmacokinetics, tolerability, and fructosamine-lowering effect of a novel, controlled release formulation of alpha-lipoic acid. Endocrine Practice 8: 29-35, 2002
• Pender C. Goldfine ID, Manchem VP, Evans JL, Spevak WR, Shi S, Rao S, Bajjalaeih S, Maddux BA, Youngren JF. Regulation of insulin receptor function by a small molecule insulin receptor activator. J Biol Chem. 277: 43565-71, 2002.
• Li M, Youngren JF, Dunaif A, Goldfine ID, Maddux BA, Zhang BB, Evans JL. Decreased insulin receptor autophosphorylation in fibroblasts from patients with PCOS: effects of serine kinase inhibitors and IR activators. J Clin Endocrinol Metab. 87: 4088-93, 2002.
• Evans JL, Goldfine ID, Maddux BA, Grodsky GM, Oxidative Stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr. Rev. 23:599-622, 2002.
• Evans JL, Goldfine ID, Maddux BA, Grodsky GM, Are oxidative stress-activated signaling pathways mediators of Insulin resistance and beta cell dysfunction? Diabetes. 52: 1-8,2003
• Earle Karen E., Rushakoff Robert J., and Goldfine Ira D. Case Report: Inadvertent Sulfonylure Overdoage and Hypoglycemia in an Elderly Woman; Failure of Serum Hypoglycemia Screening. Diabetes Technol Ther. 2003;5(3):453-4.
• Evans JL, Maddux BA, and Goldfine ID. Antioxidants in diabetic complications and insulin resistance. In Diabetes: From Research to Diagnosis and Treatment (I. Raz, J. Sklyer, E. Shafrir, Eds.) Chapter 29. pp. 479-496 2003.
• Frasca F., Pandini G., Vigneri R., and Goldfine ID. Insulin and Hybrid Insulin/IGF Receptors Are Major Regulators of Breast Cancer Cells. Breast Disease. 17:73-89, 2003.
• Pender C., Goldfine I.D., Tanner C.J., Pories W.J., MacDonald K.G., Havel P.J., Houmard J.A., and Youngren J.F. Muscle Insulin Receptor Concentrations In Obese Patients Post Bariatric Surgery: Relationship to Hyperinsulinemia. International J of Obesity Related Metabolic Disorders. 28(3):363-9, 2004.
• Tan C., Wei L., Ottensmeyer P.F., Goldfine I.D., Maddux B., Yip C.C., Batey R.A., Kotra L. Struct based de novo design of ligands using a three-dimensional model of the insulin receptor. Bioorg. Med. Chem. Lett. 14:1407-10, 2004.