Professor, Laboratory Medicine, UCSF; Associate Laboratory Director for Life Sciences, and Life Sciences Division Director, Lawrence Berkeley National Laboratory (LBNL)
Co-Leader, Breast Oncology Program, UCSF Helen Diller Family Comprehensive Cancer Center; Principal Investigator, UCSF Breast SPORE
| CONTACT | |
|
JWGray@lbl.gov
Lawrence Berkeley Nat'l Laboratory, Life Sciences Division |
additional websites: |
| EDUCATION | |
|
Colorado School of Mines, Golden, CO, Prof. Eng., 1968, Physics
|
|
| PROFESSIONAL EXPERIENCE | |
|
1972-1991 |
Biomedical Scientist, Biomedical Sciences Division, Lawrence Livermore National Laboratory (LLNL), University of California, Livermore, CA. |
|
1982-1991 |
Cytophysics Section Leader, Biomedical Sciences Division, LLNL, Livermore, CA. |
|
1984-1991 |
Adjunct Professor of Laboratory Medicine, UCSF, San Francisco, CA. |
|
1990-1995 |
Member, National Advisory Council for Human Genome Research |
|
1991-Present |
Professor of Laboratory Medicine and Radiation Oncology, UCSF, San Francisco, CA |
|
1991-1997 |
Director; Division of Molecular Cytometry, Dept. of Lab. Med. UCSF, San Francisco. CA |
|
1992-1998 |
Senior Scientist (faculty), Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA |
|
1992-1998 |
Director, Resource for Molecular Cytogenetics, LBNL, Berkeley, CA |
|
1995-1997 |
Interim Director, UCSF Cancer Center, UCSF, San Francisco, CA |
|
1997-2002 |
Science Council; Radiation Effects Research Foundation |
|
1997-Present |
Program Leader; Breast Oncology and Cancer Genetics Research Programs |
|
1999-Present |
Member, Genome Study Section |
|
2003 - Present |
Director, Division of Life Sciences, Lawrence Berkeley National Laboratory, Berkeley, CA |
|
2003 - Present |
Associate Director, Lawrence Berkeley National Laboratory, Berkeley, CA |
|
2004-present |
Member, Board of Scientific Advisors National Institutes of Health |
|
2005-present |
Translational Research Working Group, National Cancer Institute, NIH |
| HONORS & AWARDS | |
|
1985 |
13th Radiation Research Society, Research Award |
|
1986 |
U.S. Department of Energy, E.O. Lawrence Award |
|
1996 |
Fellow: American Association for the Advancement of Science |
|
1997 |
Exceptional Service Award: U.S. Department of Energy |
|
1999 |
Schiffer Award; Cell proliferation Society |
|
2000 |
Boerhave Professor, Leiden University, the Netherlands |
|
2001 |
Curt Stern Award, American Society for Human Genetics |
|
2003 |
SPORE Leadership Award, National SPORE Program Office |
|
2005 |
Alumni Fellow, Kansas State University |
|
2005 |
Distinguished Achievement Award, Colorado School of Mines |
|
2005 |
Doctor of Medicine, Honoris Causa, Tampere University |
| SELECTED PUBLICATIONS | |
|
(Selected from 329 total) |
|
|
Kallioniemi A, Kallioniemi O-P, Sudar D, Rutovitz D, Gray J, Waldman F, Pinkel D. (1992) Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science 258:818-821. |
|
|
Pinkel D, Segraves R, Sudar D, Clark S, Poole I, Kowbel D, Collins C, Kuo WL, Chen C, Zhai Y, Dairkee SH, Ljung BM, Gray JW, Albertson DG. (1998) Quantitative high resolution analysis of DNA copy number variation in breast cancer using comparative genomic hybridization to DNA microarrays. Nat. Genet. 20:207-211. |
|
|
Shayesteh L, Lu Y, Kuo WL, Baldocchi R, Godfrey T, Collins C, Pinkel D, Powell B, Mills GB, Gray JW. (1999) PIK3CA is implicated as an oncogene in ovarian cancer. Nat. Genet. 21:99-102. |
|
|
Albertson DG, Ylstra B, Segraves R, Collins C, Dairkee SH, Kowbel D, Kuo WL, Gray JW, Pinkel D. (2000) Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene. Nat. Genet. 25:144-146. |
|
|
Jain AN, Chin K, Borresen-Dale AL, Erikstein BK, Eynstein Lonning P, Kaaresen R, Gray JW. (2001) Quantitative analysis of chromosomal CGH in human breast tumors associates copy number abnormalities with p53 status and patient survival. Proc Natl Acad Sci USA 98:7952-7957. |
|
|
Hodgson G, Hager JH, Volik S, Hariono S, Wernick M, Moore D, Nowak N, Albertson DG, Pinkel D, Collins C, Hanahan D, Gray JW. (2001) Genome scanning with array CGH delineates regional alterations in murine islet carcinomas. Nat. Genet. 29:459-64. |
|
|
Albertson DG, Collins C, McCormick F, Gray JW. (2003) Chromosome aberrations in solid tumors. Nat. Genet. 34:369-76. |
|
|
Volik S, Zhao S, Chin K, Brebner JH, Herndon DR, Tao Q, Kowbel D, Huang G, Lapuk A, Kuo WL, Magrane G, De Jong P, Gray JW, Collins C. (2003) End sequence profiling: Sequence-based analysis of aberrant genomes. Proc Natl Acad Sci USA 100:7696-701. |
|
|
Chin K, de Solorzano CO, Knowles D, Jones A, Chou W, Rodriguez EG, Kuo WL, Ljung BM, Chew K, Myambo K, Miranda M, Krig S, Garbe J, Stampfer M, Yaswen P, Gray JW, Lockett SJ. (2004) In situ analyses of genome instability in breast cancer. Nat. Genet., 36:984-988. |
|
|
Cheng KW, Lahad JP, Kuo WL, Lapuk A, Yamada K, Auersperg N, Liu J, Smith-McCune K, Lu KH, Fishman D, Gray JW, Mills GB. (2004) The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers. Nat. Med. 10:1251-11256 |
|
|
Macrae M, Neve RM, Rodriguez-Viciana P, Haqq C, Yeh J, Chen C, Gray JW, McCormick F. (2005) A conditional feedback loop regulates Ras activity through EphA2. Cancer Cell. 8:111-8. |
|
|
Hodgson JG, Malek T, Bornstein S, Hariono S, Ginzinger DG, Muller WJ, Gray JW. (2005) Copy number aberrations in mouse breast tumors reveal loci and genes important in tumorigenic receptor tyrosine kinase signaling. Cancer Res. 65:9695-704. |
|
|
Bussey KJ, Chin, K, Lababidi S, Reimers M, Reinhold WC, Kuo W-L, Gwadry F, Ajay Kouros-Mehr H, Fridlyand J, Jain A, Collins C, Nishizuka S, Tonon G, Roschke A, Gehlhaus K, Kirsch I, Scudiero DA, Gray JW, Weinstein JN. (2006) Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel. Mol Cancer Ther. 5:853-67. |
|
|
Cheng, K.W, Lahad, J.P, Kuo, W.-L, Lapuk, A, Yamada, K, Auersperg, N, Liu, J, Smith-McCune, K, Lu, K.H, Fishman, D, Gray, J.W, Mills, G.B. (2004) The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers. Nat. Med. 10:1251-11256 |
|
|
Chin K, DeVries, S Fridlyand J, Spellman, P, Roydasgupta R, Kuo,W.-L, Lapuk A, Neve R, Qian Z, Ryder T, Chen, F, Feiler, H, Tokuyasu, T, Kingsley, C, Dairkee, S, Meng, Z, Chew, K, Pinkel, D, Jain A, Ljung B Esserman L, Albertson D, Waldman F, Gray JW. (2006) Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell 10:529-41. |
|
|
Neve RM, Chin K, Fridlyand J, Yeh J, Baehner F, Fevr T, Clark L, Bayani N, Coppe J, Tong F, Speed T, Spellman PT, Devries S, Lapuk A, Wang NJ, Kuo WL, Stilwell JL, Pinkel D, Albertson DG, Waldman FM, McCormick F, Dickson RB, Johnson MD, Lippman M, Ethier S, Gazdar A, Gray JW. (2006). A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 10:515-27. |
|
|
PATENTS |
|
|
Dolbeare, F. and Gray, J.W. Flow cytometric measurement of total DNA and incorporated halodeoxyuridine US Patent #4,585,736 (1986); #4,780,406 (1988); #4,812,394 (1989). |
|
|
Gray, J.W. and Pinkel, D. Methods for chromosome-specific staining US Patent #5,447,841 (1995). |
|
|
Pinkel, D., Gray, J.W., Kallioniemi, A., Kallioniemi, O.-P., Sakamoto, M., Waldman, F. Comparative genomic hybridization (CGH) US Patent #5,665,549 (1997), #5,721,098 (1998), .#5,965,362 (1999), #5,976,790 (1999), #6,335,167 (2002). |
|
|
Shayesth, L. and Gray, J.W. Genetic alterations associated with cancer. U.S. Patent #6,277,563 (2001), #6,475,732 B1 (2002). |
|
|
Gray, J.W., Pinkel, D., Albertson, D., Collins, C., Baldocchi, R. Comparative fluorescence hybridization to oligonucleotide microarrays. U.S. Patent #6,465,182 B1 (2002). |
|
|
Collins, C., Volik, S., Gray, J.W. End sequence profiling. U.S. Patent #6,785,614 (2004). |
|
|
1/2/07 |
|
|
photo: Majed Abolfazli |
|
