greenspand@dentistry.ucsf.edu
(415) 476-3080 (voice)
(415) 476-4204 (fax)

Box 0422, UCSF; San Francisco, CA 94143-0422

Royal Free Hospital, School of Medicine, 2nd BDS, Basic Sciences
University of London, England University of London, BDS, 1964, Dentistry
Royal College of Surgeons, England, LDS RCS Dentistry
University of California San Francisco, Fellow, 1978, Oral Medicine
University of London, DSc (Med), 1991, Oral Medicine

PUBLICATIONS PERTINENT TO PROPOSED RESEARCH

Greenspan, D., Greenspan, J.S., Conant, M., Petersen, V., Silverman, S., Jr., and DeSouza, Y.: Oral 'hairy' leukoplakia in male homosexuals: evidence of association with both papillomavirus and a herpes-group virus. Lancet 2: 831-834, 1984.

Greenspan, J.S., Greenspan, D., Lennette, E.T., Abrams, D.I., Conant, M.A., Petersen, V., and Freese, U.K.: Replication of Epstein-Barr virus within the epithelial cells of oral "hairy" leukoplakia, an AIDS-associated lesion. N. Engl. J. Med. 313:1564-1571, 1985.

Greenspan, D., Greenspan, J.S., Hearst, N.G., Pan, L.-Z., Conant, M.A., Abrams, D.I., Hollander, H., and Levy, J.A.: Relation of oral hairy leukoplakia to infection with the human immunodeficiency virus and the risk of developing AIDS. J. Infect. Dis. 155;475-481, 1987.

Leggott, P.J., Robertson, P.B., Greenspan, D., Wara, D.W., Greenspan, J.S.:Oral manifestations of primary and acquired immunodeficiency diseases in children. Pediatr. Dent. 9(2):98-104, 1987.

Greenspan, D., de Villiers, E.M., De Souza, Y., and Greenspan, J.S.: Unusual HPV types in oral warts in association with HIV infection. J. Oral Pathol. 17:482-487, 1989.

Schiodt, M., Greenspan, D., Levy, J.A., Nelson, J.A., Chernoff, D., Hollander, H., and Greenspan, J.S. Does HIV cause salivary gland disease? AIDS 3:1989, 819-822.

Greenspan, D., De Souza, Y.G., Conant, M.A., Hollander, H.H., Chapman, S.K., Lenntte, E.T., Petersen, V., and Greenspan, J.S.: Efficacy of desciclovir in the treatment of Epstein-Barr virus infection in oral hairy leukoplakia. J. Acquir. Immune. Defic. Syndr. 1990; 3:571-583.

De Souza, Y.G., Freese, U.K., Greenspan, D. and Greenspan, J.S.: Diagnosis of Epstein-Barr virus infection in hairy leukoplakia by using nucleic acid hybridization and noninvasive techniques. J Clin Microbiol 1990; 28:2775-2778.

Greenspan, D., Greenspan, J.S., Pindborg, J.J., and Schiodt, M. AIDS and the Mouth. Munksgaard, Copenhagen, 1990

Feigal, D.W., Katz, M.H., Greenspan, D., Westenhouse,J., Winkelstein, W., Lang, W., Samuel,M.,Buchbinder,S.P., Hessol,N.A., Lifson,A.R., Rutherford,G.W., Moss,A., Osmond,D., Shiboski,S., Greenspan, J.S., The prevalence of oral lesions in HIV-infected homosexual and bisexual men: Three San Francisco Epidemiologic Cohorts. AIDS 1991; 5:519-525

Greenspan, D., Greenspan, J.S., Overby,G., Hollander, H., Abrams. D.I., Macphail, L.A., Borowsky, C., Feigal, D.W. Risk factors for rapid progression from hairy leukoplakia to AIDS: A nested case control study. J. Acquir Immune Defic Syndr 1991; 4:652-658

Katz M.H, Greenspan D, Westenhouse J., Hessol N.A. Buchbinder S.P., Lifson A.R., Shiboski, S, Moss A, Samuel M, Winklestein W, Feigal D.W, Greenspan J.S. Progression to AIDS in HIV-infected homosexual and bisexual men with oral candidiasis and hairy leukoplakia: results from three San Francisco epidemiological cohorts. AIDS 1992;6:95-100

Miyasaki SH, Hicks JB, Greenspan D, Polacheck I, MacPhail LA, White TC, Agabian N, Greenspan JS. The identification and tracking of Candida albicans isolates from oral lesions in HIV-seropositive individuals. J Acq Immuno Def Syn 1992;1039- 1046.

Greenspan D, Greenspan JS. The mouth in human immunodeficiency virus infection. Seminars in Derm 1994;13:144-150.

Greenspan D. Treatment of oral candidiasis in HIV infection. Oral Surg Oral Med Oral Pathol 1994;78:211-216.

Ramos-Gomez FJ, Greenspan D, Greenspan JS. Orofacial manifestations and management of HIV-infected children. Oral Maxill Surg Clin N Amer 1994;6:37-47.

Shiboski CH, Hilton JF, Greenspan D, Westenhouse JL, Derish P, Vranizan K, Lifson AR, Canchola A, Katz MH, Cohen JB,

Moss AR, Greenspan JS. HIV-related oral manifestations in two cohorts of women in San Francisco. J Acquir Immune Defic Syndr 1994;7:964-971.

Greenspan JS and Greenspan D. Oral manifestations of HIV infection. Quintessence Publishing Co., Carol Stream, Il, 1995.

Greenspan JS, Greenspan D, Palefsky JM. Oral hairy leukoplakia after a decade. Epstein-Barr Virus Report 1995;2:123-128.

Greenspan D, Greenspan JS. HIV-related oral disease. Lancet 1996;348:729-733.

Palefsky JM, Berline J, Penaranda ME, Lennette E, Greenspan D, Greenspan JS. Sequence variation of latent membrane protein 1 of Epstein-Barr virus strains associated with hairy leukoplakia. JID 1996;173:710-714.

MacPhail LA, Hilton JF, Dodd CL, Greenspan D. Prophylaxis with nystatin pastilles for HIV-associated oral candidiasis. J cquir Immune Defic Syn Hum Retrovirol 1996;12:470-476.

Shiboski CH, Hilton JF, Neuhaus JM, Canchola A, Greenspan D, et al. Human immunodeficiency virus-related oral manifestations and gender. Arch Int Med 1996;156:2249-2254.

Greenspan D, Shirlaw PJ. Management of the oral mucosal lesions seen in association with HIV infection. Oral Diseases 1997;3(suppl 1):S229-234. Palacio H, Hilton JF, Canchola AJ, Greenspan D. Effect of cigarette smoking on HIV-related oral lesions. J Acquir Immune Defic Synd and Human Retrovirol 1997;14:338-342.

Greenspan D. Oropharyngeal candidiasis in HIV infection. Chapter in: Cutaneous Infection and Therapy. Aly R and Beutner KR, eds. Marcel Dekker, Inc., publisher, New York,1997;223-231.

Hilton JF, Donegan E, Katz MH, Canchola AJ, Fusaro RE, Greenspan D, Greenspan JS. Development of oral lesions in human immunodeficiency virus-infected transfusion recipients and hemophiliacs. Amer J Epidemiolo 1997;145:164-174.

Mirowski GW, Greenspan D, Hilton JF, Canchola AJ, MacPhail LA, Maurer T, Berger TG, Greenspan JS. Associations of cutaneous and oral diseases in HIV-infected men. Oral Diseases 1998;4:16-21

Greenspan JS, Greenspan D. Intraoral infections. In: Clinical Infectious Diseases: a Practical Approach. Root RK, editor in chief, WaldvogelF, Corey L, Stamm WE., eds. Oxford University Press, New York, New York, 1999.

Greenspan D, Shirlaw PJ, Greenspan JS. Oropharyngeal disease. In: AIDS Therapy, Dolin R, Masur H, Saag MS, eds. Churchill Livingstone, publisher, New York, New York, 1999.

Naglik J, Newport G, White TC, Fernandes-Naglik LL, Greenspan JS, Greenspan D, Sweet SP, Challacombe SJ, Agabian N. In vivo analysis of secreted aspartyl proteinase expression in human oral candidiasis. Infect Immun 1999;67:2482-2490.

Shiboski CH, Neuhaus JM, Greenspan D, Greenspan JS. Effect of receptive oral sex and smoking on the incidence of hairy leukoplakia in HIV-positive gay men. J Acquir Immune Defic Syndr 1999;21:236-242.

Zehnder M, Greenspan JS, Greenspan D, Bickel M. Chemokine gene expression in human alveolar mucosa. Eur J Oral Sci 1999; 107:231-235.

Dodd MJ, Dibble SL, Miaskowski C, Greenspan D, Paul SM, Shiba G, Larson P. Randomized clinical trail of the effectiveness of 3 commonly used mouthwashes to treat chemotherapy-induced mucositis. Oral Surg Oral Med Oral patholg Oral Med 2000;90:39-47.

Greenspan D, Komaroff E, Redford M, Phelan J, Navazesh M, Alves M, Kamrath H, Barr C, Mulligan RA, Greenspan JS. Oral mucosal lesions and HIV viral load in the Womenês Intragency HIV Study (WIHS). J Acquir Immune Defici Syn 2000;25:44-50.

Navazesh M, Mulligan N, Komaroff E, Redford M, Greenspan D, Phelan J. The prevalence of xerostomia and salivary gland hypofunction in a cohort of HIV-positive and at risk-women. J Det Res 2000;79:1502-1507.

Greenspan D, Canchola AJ, MacPhail LA, Cheikh B, Greenspan JS. Oral warts and HAART. Lancet 2001;357:1411-1412.

Greenspan D, Greenspan JS. Oral cavity manifestations of AIDS. In: Atlas of Infectious Diseases, 3rd edition, 2001, Milvan M, ed. Current Science, Philadelphia.

Greenspan D, Canchola AJ, MacPhail LA, Cheikh B and Greenspan JS. Effect of highly active antiretroviral therapy on frequency of oral warts. Lancet; 2001, 357 1411-2

Dodd MJ, Dibble S, Miaskowski C, Paul S, Cho M, MacPhail L, Greenspan D, Shiba G. A comparison of the affective state and quality of life of chemotherapy patients who do and do not develop chemotherapy-induced oral mucositis. J Pain Symptom Manage 2001 Jun;21(6):498-505

Shiboski C, Wilson CM, Greenspan D, Hilton J, Greenspan JS, Moscicki A-B, and the Adolescent Medicine HIV/AIDS Research Network. HIV-Related Oral Manifestations Among Adolescents in the Multicenter Cohort Study. J Adolescent Health; 2001;295;115-122

Hilton JF, Alves M, Anastos K, Canchola AJ, Cohen M, Delapenha R, Greenspan D, Levine A, MacPhail LA, Micci SJ, Mulligan R, Navazesh M, Phelan J, Tsaknis P. Accuracy of diagnoses of HIV-related oral lesions by medical clinicians. Findings from the Women's Interagency HIV Study. Community Dent Oral Epidemiol 2001 Oct;29(5):362-72

Palefsky JM, Berline J, Greenspan D and Greenspan JS. Evidence for trafficking of Epstein- Barr virus strains between hairy leukoplakia and peripheral blood lymphocytes. J Gen Virol; 2002 83;317-21

Page-Shafer K, Shiboski CH, Osmond D, Dilley J, McFarland, Shiboski S, Klausner JD, Balls J, Greenspan D, Greenspan JS. Risk of HIV Infection attributable to oral sex among men who have sex with men and in the population of men who have sex with men. AIDS; 2002 16, 2350

Brodin P, Bennett I, Appleton J, Bonta Y, Feher E, Fiehn NE, Greenspan D, Hjorting- Hansen E, Latta M, O'Connell B, Sidlauskas A, Skaleric U. Ensuring research productivity in the future faculty. Eur J Dent Educ. 2002 Oct; 6 Suppl 3:97-106.

Dodd MJ, Miaskowski C, Greenspan D, MacPhail L, Shih A, Shiba G, Facione N Paul SM. Radiation induced mucositis: A randomized clinical trial of micronized sucralfate versus salt and soda mouthwashes. Cancer Investigation 2003;21:21-33

Navazesh M, Mulligan R, Barron Y, Redford M, Greenspan D, Alves M, Phelan J. A 4-year longitudinal evaluation of xerostomia and salivary gland function in the Women's Interagency HIV Study participants. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2003 95 (6): 693-8

Naglik JR, Rodgers CA, Shirlaw PJ, Dobbie JL, Fernandes-Naglik LL, Greenspan D, Agabian N, Challacombe SJ. Differential expression of Candida albicans secreted aspartyl proteinase and phospholipase B genes in humans correlates with active oral and vaginal infections. J Infect Dis 2003; 188(3): 469-79

McAllister SC, Hansen SG, Ruhl RA, Raggo CM, DeFilippis VR, Greenspan D, Truh K, Moses AV. Kaposi's Sarcoma-Associated Herpesvirus (KSVH) Induces Heme Oxygenase-1 Expression and Activity in KSHV-In fected Endotheleial cells. 2004; Blood 103 (3465-73)

Greenspan D, Gange S, Phelan JA,, Navazesh M, MacPhail LA, Mulligan R, Alves M, Greenspan JS. Reduced Incidence of Oral Lesions in HIV-1 Infected Women: Changes with Highly Active Antiretroviral Therapy. J. Dent Res. 2004 83(2): 145-150

Hilton JF, MacPhail LA, Pascasio L, Sroussi HY, Cheikh B, Labao ME, Malvin K, Greenspan D, Dodd MJ. Self-care intervention to reduce oral candidiasis recurrences in HIV-positive persons; a pilot study. Community Dentistry and Oral Epidemiology 2004; 32 190-200

Mulligan R, Phelan JA, Brunelle J, Redford M, Pagoda JM, Nelson E, Seirawan H, Greenspan JS Navazesh M, Greenspan D, Alves M. Baseline Characteristics of Participants in the Women's Interagency HIV Study. Community Dentistry Oral Epidemiology. 2004 32:86-98

Baumgarth N, Szubin R, Dolganov GM, Watnik M, Greenspan D, Jordan R, Roederer M, Greenspan JS. Technical Advance: Highly Tissue-Substructure Specific Effects of Human Papilloma Virus in Mucosa of HIV Infected Patients Revealed by Laser Dissection Microscopy-Assisted Gene. American J Path 2004 Sep; 165(3):707-18.

Phelan JA, Mulligan R, Nelson E, Brunelle J, Alves M, Navazesh M, Greenspan D, Dental Caries in HIV-Seropositive Women. J Dent Res. 2004 Nov; 83(11):869-73.

Navazesh M, Mulligan R, Pogoda J, Greenspan D, Alves M, Phelan JA, Greenspan JS, Slots J. The effect of HAART on Salivary Microbiota in the Women's Interagency HIV Study (WIHS). Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Dec; 100(6):701-8.

Hodgson T, Greenspan D, Greenspan JS. Oral Lesions of HIV Disease and HAART in Industrialized Countries. Adv Dent Res. 2006 Apr 1; 19(1):57-62

Alves M, Mulligan R, Passaro D, Gawell S, Navazesh M, Phelan J, Greenspan D, Greenspan JS. Longitudinal Evaluation of Loss of Attachment in HIV-Infected Women Compared to HIV-Uninfected Women. J Periodontol. 2006 May; 77 (5):773-779

Tugizov S, Herrerra R, Veluppillai, Grenspan JS, GreenspanD, Palefsky JM EBV Infected Monocytes Facilitate Dissemination of EBV within the Oral Mucosal Epithelium. J Virol. 2007 Mar 21; [Epub ahead of print]

12/19/07