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Helen Diller Family Compr Cancer Ctr
JOHN S. GREENSPAN, PHD

Leland and Gladys Barber Endowed Chair in Dentistry, UCSF
Dean for Research, UCSF School of Dentistry; and Professor of Pathology, Dept of Pathology, UCSF School of Medicine
Director, California AIDS Clinical Research Center; Director, AIDS Research Institute; Director, UCSF AIDS Specimen Bank; Director, UCSF Oral AIDS Center

CONTACT

greenspanj@dentistry.ucsf.edu
(415) 476-1690 (Asst); 415) 476-2220 (voice mail)
(415) 514-0395 (fax)

Box 0422, UCSF; San Francisco, CA 94143-0422

EDUCATION

Royal Free Hospital Medical School, London, BSc(1st class Honors), 1959, Anatomy
Royal Dental School, London, BDS (Honors), 1963, Dentistry
Royal Postgraduate Medical School, London, PhD, 1967, Experimental Pathology
Royal College of Pathologists, MRCPath, 1971, Oral Pathology
Royal College of Pathologists, FRCPath, 1983, Oral Pathology

PROFESSIONAL EXPERIENCE

1963

Fellow, Histochemistry, Royal Postgraduate Medical School, London

1963-71

Assistant Lecturer, through Senior Lecturer, Oral Pathology, Royal Dental Hospital School of Dental Surgery

1969-71

Fellow, Pathology, St. George's Hospital Medical School, London

1972-73

Visiting Associate Professor, Schools of Dentistry and Medicine, UCSF

1971-76

Senior Lecturer/Consultant Pathologist, Royal Dental Hospital School of Dental Surgery, University of London, Consultant to St. George's Hospital and Institute of Dermatology, London

1976-present

Professor, Pathology, School of Medicine, UCSF

1976-88

Professor and Chair, Division of Oral Biology, Department of Stomatology, School of Dentistry, UCSF

1982-present

Director, UCSF AIDS Specimen Bank

1987-91

Associate Director, UCSF Dental Clinical Epidemiology Program

1987-present

Director, UCSF Oral AIDS Center

1988-2001

Professor & Chair, Department of Stomatology, School of Dentistry, UCSF

1993-1999

Director, UCSF AIDS Clinical Research Center (ACRC)

1999-present

Director, UCSF Californai AIDS Research Center (CARC)

2001-present

Leland A. and Gladys K. Barber Distinguished Professor of Dentistry, and Dean for Research, School of Dentistry, UCSF

2003-present

Director, AIDS Research Institute (ARI)

HONORS & AWARDS

1979-81

Chair of Faculty, School of Dentistry, UCSF

1980-82

Chair, NIDR Soft Tissue Disease Panel

1982-present

Fellow, American College of Dentists

1983-84

President, Experimental Pathology Group, International Association for Dental Research

1981-85

Vice Chair, Chair, UCSF Division of the Academic Senate of the University of California

1985-present

Fellow, American Association for the Advancement of Science

1986-89

Vice President, President-elect, President, American Association for Dental Research

1989

Kreshover Lecture Award, NIH-NIDR

1990

Sc. D (h.c.) Georgetown University

1991

Award for Excellence in Research, Experimental Pathology Group, IADR

1993

Oral Biology Research Award, IADR

1994-97

Vice President, President-elect, President, International Association for Dental Research

1995-present

Member, Institute of Medicine

1998

Fellow in Dental Surgery by Election, Royal College of Surgeons of England

2003

Fellow, King's College London

SELECTED PUBLICATIONS

Greenspan JS, Greenspan D. Oral complications of HIV infection. In: Medical Management of AIDS, fourth edition. Sande M, Volberding PA, eds. Saunders WB, Philadelphia. 1994.

Greenspan JS. Oral manifestations of disease. In: Harrison's Principles of Internal Medicine, 13th edition. Wilson JD, Braunwald E, Fauci AS, Isselbacher KJ, Martin JB, Petersdorf RG, Root RK, eds. McGraw-Hill Book Co. 1994.

Greenspan JS, Kahn AJ, Marshall SJ, Newbrun E, Plesh O. Current and future prospects for oral health science and technology. Prepared for the Institute of Medicine Committee on the Future of Dental Education. J Dent Ed 1995;59:149-167.

Greenspan JS, Greenspan D, Palefsky JM. Oral hairy leukoplakia after a decade. Epstein-Barr Virus Report 1995;2:123-128.

Greenspan JS and Greenspan D. Oral manifestations of HIV infection. Proceedings of the Second International Workshop. Quintessence Publishing Co., Carol Stream, Il, 1995.

Palefsky JM, Berline J, Penaranda ME, Lennette E, Greenspan D, Greenspan JS. Sequence variation of latent membrane protein 1 of Epstein-Barr virus strains associated with hairy leukoplakia. JID1996;173:710-714.

Greenspan JS, Greenspan D. Oral diseases in HIV infections. In: AIDS: Etiology, diagnosis, treatment, and prevention. 4th edition. DeVita VT, Hellman S, Rosenberg SA, Curran J, Essex M, Fauci AS, eds. Philadelphia: JB Lippincott Co., 1996.

Greenspan D, Greenspan JS. HIV-related oral disease. Lancet 1996;348:729-733.

PeŠaranda ME, Lagenaur L, Pierik L, Greenspan D, Greenspan JS, Palefsky JM. Expression of the Epstein-Barr virus BDLF-3 and BMRF-2 genes in hairy leukoplakia. J Gen Virol 1997;78:3361-3370.

Jacobson JM, Greenspan JS, Spritzler JS, et al. Thalidomide for the treatment of oral aphthous ulcers in patients with human immunodeficiency virus infection. New Engl J Med 1997;336:1487-1493.

Hilton JF, Donegan E, Katz MH, Canchola AJ, Fusaro RE, Greenspan D, Greenspan JS. Development of oral lesions in human immunodeficiency virus-infected transfusion recipients and hemophiliacs. Amer J Epidemiol 1997;145:164-174.

MacPhail LA, Greenspan JS. Oral ulceration in HIV infection: investigation and pathogenesis. Oral Diseases 1997;3; Supple 1: S190-S193.

Greenspan JS, Greenspan D. Oral complications of HIV infection. In: Medical Management of AIDS. Sande M, Volberding PA,eds. WB Saunders, Philadelphia, 1997;169-180.

Greenspan JS. Sentinels and signposts: the epidemiology and significance of the oral manifestations of HIV disease. Oral Diseases 1997;3:Suppl 1:S13-S17.

Mirowski GW, Greenspan D, Hilton JF, Canchola AJ, MacPhail LA, Maurer T, Berger TG, Greenspan JS. Associations of cutaneous and oral diseases in HIV-infected men. Oral Diseases 1998;4:16-21

Greenspan JS, Regezi JA, Hilton, JF, Greenspan D, Daniels TE, DE Souza YG. Comparison of cytopathic changes in oral hairy leukoplakia with in situ hybridization for EBV DNA. Oral Diseases 1998;4:95-99.

Cruchley AT, De Souza YG, Williams DM, Greenspan D, Greenspan JS. Bromodeoxyuridine incorporation and Ki 67 expression in hairy leukoplakia. Oral Diseases 1998;4:9-15.

Zehnder M, Greenspan JS, Greenspan D, Bickel M. Chemokine gene expression in human alveolar mucosa. Eur J Oral Sci 1999;107:231-235.

Shiboski CH, Neuhaus JM, Greenspan D, Greenspan JS. Effect of receptive oral sex and smoking on the incidence of hairy leukoplakia in HIV-positive gay men. J Acquir Immune Defic Syndr 1999;21:236-242.

Naglik J, Newport G, White TC, Fernandes-Naglik LL, Greenspan JS, Greenspan D, Sweet SP, Challacombe SJ, Agabian N. In vivo analysis of secreted aspartyl proteinase expression in human oral candidiasis. Infect Immun 1999;67:2482-2490.

Greenspan JS, Greenspan D. Intraoral infections. In: Clinical Infectious Diseases: a Practical Approach. Root RK, Editor in chief, Waldvogel F, Corey L, Stamm WE., eds. Oxford University Press, New York, New York, 1999.

Greenspan D, Shirlaw PJ, Greenspan JS. Oropharyngeal disease. In: AIDS Therapy, Dolin R, Masur H, Saag MS, eds. Churchill Livingstone, publisher, New York, New York, 1999.

Greenspan D, Komaroff E, Redford M, Phelan J, Navazesh M, Alves M, Kamrath H, Barr C, Mulligan RA, Greenspan JS. Oral mucosal lesions and HIV viral load in the Women's Intragency HIV Study (WIHS). J Acquir Immune Defic Syndr 2000;25:44-50.

Greenspan JS. Oral manifestations of disease. In: Harrison's 15th edition, Principles of Internal Medicine, Braunwald E, Hauser SL, Fauci AS, et al., eds. McGraw Hill, New York, 2001.

Greenspan D, Canchola AJ, MacPhail LA, Cheikh B, Greenspan JS. Effect of highly active antiretroviral therapy on frequency of oral warts. Lancet 2001;357:1411-1412.

Greenspan D, Greenspan JS. Oral cavity manifestations of AIDS. In: Atlas of Infectious Diseases, 3rd edition, 2001, Milvan M, ed. Current Science, Philadelphia.

Shiboski CH, Wilson CR, Greenspan D, Hilton J, Greenspan JS, Moscicki AB. HIV-related oral manifestations among adolescents in a multicenter cohort study. J Adol Health 2001;295:109-114.

Nicholls J, Kremmer E, Meseda CA , Mackett M, Hahn P, Gulley M, Brink A, Swinnen L, Greenspan J, De Souza Y, Grįsser F, Sham J, Ng MH, Arrand JR. Comparative Analysis of the Expression of the Epstein Barr Virus (EBV) Anti-Apoptotic Gene Bhrf1 in Nasopharyngeal Carcinoma and EBV Related Lymphoid Diseases. J Med Virol. 2001 Sep;65(1):105-13.

Jordan RCK, Daniels TE, Greenspan JS, Regezi JA. Advanced diagnostic methods in oral and maxillofacial pathology. (in Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Dec;92(6):650-69.

Palefsky JM, Berline J, Greenspan D, Greenspan JS. Evidence for trafficking of Epstein-Barr virus strains between hairy leukoplakia and peripheral blood lymphocytes. J Gen Virol. 2002 Feb;83(Pt 2):317-21.

Fleischmann J, Kremmer E, Greenspan JS, Grasser FA, Niedobitek G. Expression of viral and human dUTPase in Epstein-Barr virus-associated diseases. J Med Virol. 2002 Dec;68(4):568-73.

Page-Shafer K, Shiboski CH, Osmond DH, Dilley J, McFarland W, Shiboski SC, Klausner JD, Balls J, Greenspan D, Greenspan JS. Risk of HIV infection attributable to oral sex among men who have sex with men and in the population of men who have sex with men. AIDS. 2002 Nov 22;16(17):2350-2.

Mulligan R, Phelan JA, Brunelle J, Redford M, Pogoda JM, Nelson E, Seirawan H, Greenspan JS, Navazesh M, Greenspan D, Alves M. Baseline Characteristics of Participants in the Women's Interagency HIV Study. Community Dent Oral Epidemiol. 2004 Apr;32(2):86-98.

Greenspan D, Gange S, Phelan JA,, Navazesh M, MacPhail LA, Mulligan R, Alves M, Greenspan JS. Reduced Incidence of Oral Lesions in HIV-1 Infected Women: Changes with Highly Active Antiretroviral Therapy. J. Dent Res. 2004 83(2):145-50

Baumgarth N, Szubin R, Dolganov GS, Watnik M, Greenspan D, Jordan R, Roederer R and Greenspan JS.. Technical Advance: Highly Tissue-Substructure Specific Effects of Human Papilloma Virus in Mucosa of HIV Infected Patients Revealed by Laser Dissection Microscopy-Assisted Gene. American J Pathology. In press.

10/1/04

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