Nalin Gupta, MD, PhD

Faculty of Science, McGill University, Montreal, Canada, 1981-1983, Program in Biology
Faculty of Medicine, University of Toronto, Canada, MD, 1987, Medicine
Mt. Sinai Hospital, Faculty of Medicine, University of Toronto, Canada, Internship, 1987-1988, Surgery
Dept. of Surgery, University of Ottawa and University of Toronto, Canada, Residency, 1988-1996, Neurosurgery
University of California, San Francisco, PhD, 1996, Biochemistry / Biophysics
Hospital for Sick Children, Toronto, Canada, 1997-98, Peds Neurosurgery

• 1998 - 2000
  Clinical Associate, Section of Neurosurgery, Department of Surgery, University of Chicago
• 2000 - 2007
  Assistant Professor, Departments of Neurosurgery and Pediatrics, University of California San Francisco
• 2000 - present
  Principal Investigator, Brain Tumor Research Center, Department of Neurosurgery, UCSF
• 2001 - present
  Bruce Dettmer Endowed Chair in Pediatric Neurosurgery, UCSF
• 2001-present
  Chief, Division of Pediatric Neurosurgery, UCSF
• 2007 - present
  Associate Professor, Departments of Neurosurgery and Pediatrics, UCSF

• 1981
  J.W. McConnell Scholarship, McGill University
• 1988
  Outstanding Intern, Department of Emergency Medicine, Mount Sinai Hospital
• 1989
  Resident Teaching Award, St. Michael's Hospital, Toronto
• 1994
  Student Travel Award, Radiation Research Society
• 1995
  Junior Scientist Travel Award, International Congress of Radiation Research
• 1995
  
  T.P. Morley Resident Research Award, Division of Neurosurgery, University of Toronto
• 1997
  Resident Teaching Award, St. Michael's Hospital, Toronto
• 1997
  Alan Hudson Resident Teaching Award, Division of Neurosurgery, University of Toronto
• 2003
  Hellman Family Research Award for Junior Faculty, UCSF
• 2004
  Career Development Award, SPORE Grant, UCSF

• NNA Levin, P Brzoska, N Gupta, JD Minna, JW Gray, M Christman. Identification of frequent novel genetic alterations in small cell lung carcinoma. Cancer Res 54:5086-5091, 1994
• N Gupta, R Vij, DA Haas-Kogan, MA Israel, DF Deen, WF Morgan. Cytogenetic damage and the radiation induced G1 phase checkpoint. Radiat Res 145:289-298, 1996
• N Gupta, K Lamborn, DF Deen. A statistical approach for analyzing clonogenic survival data. Radiat Res 145:636-640, 1996
• N Gupta, L Hu, DF Deen. The effect of paclitaxel (Taxol) on human glioma cells used as a single agent and in combination with ionizing radiation. Int J of Radiat Oncol Biol Phys 37:885-895, 1997
• G Gobbel, M Bellinzona, AR Vogt, N Gupta, JR Fike, PH Chan. Response of post-mitotic neurons to X irradiation: implications for the role of DNA damage in neuronal apoptosis. J of Neuroscience 18:147-155, 1998
• J Wang, L Hu, N Gupta, T Shamseldin, T Ozawa, J Klem, M Cardell, DF Deen. Induction and characterization of human glioma clones with different radiosensitivities. Neoplasia 1:138-144, 1999
• NN Khodarev, SJ Advani, N Gupta, B Roizman, RR Weichselbaum. Accumulation of specific RNAs encoding transcriptional factors and stress response proteins against a background or severe depletion of cellular RNAs in cells infected with herpes simplex virus 1. Proc Natl Acad Sci USA 96:12062-12067, 1999
• CA Pelizzari, NN Khodarev, N Gupta, DP Calvin, RR Weichselbaum. Quantitative analysis of DNA array autoradiographs. Nucleic Acids Res 28:4577-81, 2000
• N Gupta, E Nodzenski, NN Khodarev, J Yu, L Khorsani, DW Kufe, RR Weichselbaum. Angiostatin effects on endothelial cells mediated by ceramide and RhoA. EMBO Reports 2:536-540, 2001
• NN Khodarev, JO Park, J Yu, N Gupta, E Nodzenski, B Roizman, RR Weichselbaum: Dose-dependent and independent temporal patterns of gene responses to ionizing radiation in normal and tumor cells, and tumor xenografts. Proc Natl Acad Sci USA 98:12665, 2001
• N Gupta, H Wang, TL McLeod, CCG Naus, S Kyurkchiev, S Advani, J Yu, B Perbal, RR Weichselbaum. Inhibition of glioma cell growth and tumorigenic potential by CCN3 (NOV). Molecular Pathology 54:293, 2001
• AR Cohen, N Gupta. Mass in the forehead of a three-year-old girl. Pediatric Neurosurgery 37:38-47, 2002
• A Quinones-Hinojosa, M Gulati, R Lyon, N Gupta, C Yingling. Spinal cord mapping as an adjunct for resection of intramedullary tumors: surgical technique with case illustrations. Neurosurgery 51:1251, 2002
• N Khodarev, J Yu, E Nodzenski, T Darga, C Brown, H Mauceri, R Yassari, N Gupta, RR Weichselbaum. Tumourendothelium interactions in co-culture: coordinated changes of gene expression profiles and phenotypic properties of endothelial cells. J of Cell Science 116:1013-1022, 2003
• DL Farmer, CS von Koch, WJ Peacock, M Danielpour, N Gupta, H Lee, MR Harrison. In utero repair of myelomeningocele: experimental pathophysiology, initial clinical experience and outcomes. Archives of Surgery 138:872-878, 2003
• HJ Fullerton, AR Aminoff, DM Ferriero, N Gupta, CF Dowd. Neurodevelopmental outcome after endovascular treatment of vein of galen malformations. Neurology 61:1386-1390, 2003
• NN Khodarev, E Labay, T Darga, J Yu, H Mauceri, N Gupta, Y Kataoka, RR Weichselbaum. Endothelial cells co-cultured with wild-type and dominant/negative p53-transfected glioblastoma cells exhibit differential sensitivity to radiation-induced apoptosis. Int J of Cancer 109:214-219, 2004
• N Sanai, AD Tramontin, A Quinones-Hinojosa, NM Barbaro, N Gupta, S Kunwar, MT Lawton, MW McDermott, AT Parsa, J Manuel-Garcia Verdugo, MS Berger, A Alvarez-Buylla. Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration. Nature 427:740-44, 2004
• FL Acosta, DK Binder, AJ Barkovich, IJ Frieden, N Gupta. Neurocutaneous melanosis presenting with hydrocephalus: case report and review of the literature. J Neurosurgery: Pediatrics 102:96-100 2005
• JH Chi, HJ Fullerton, N Gupta. Time trends and demographics of deaths from congenital hydrocephalus in US children: 1979-1998. J Neurosurgery: Pediatrics 103:113-118, 2005
• A Quinones-Hinojosa, P Jun, GT Manley, M Knudson, N Gupta. Airbag deployment and improperly restrained children: a lethal combination. J Trauma 59:1-5, 2005
• JS Smith, H Lin, MC Mayo, A Banerjee, N Gupta, VL Perry, S Cha. Diffusion-weighted MR imaging abnormalities in pediatric patients with surgically-treated intracranial mass lesions. J Neuro-Onc 79:203-209, 2006
• Y Liang, AW Bollen, KD Aldape, N Gupta. FABP7 expression is correlated with survival of patients with glioblastoma in a subcellular localization-dependent manner and mediates EGF-induced glioma-cell migration. BMC Cancer 6:97, 2006
• EB Dinca, JN Sarkaria, MA Schroeder, BL Carlson, R Voicu, N Gupta, MS Berger, CD James. Bioluminescence monitoring of intracranial glioblastoma xenograft response to primary and salvage temozolomide therapy. J Neurosurg 107:610-616, 2007
• YW Wu, NL Green, M Wrensch, S Zhao, N Gupta. Ventriculoperitoneal shunt failure rates in California: 1990-2000. Neurosurgery 61: 557-62, 2007
• Y Liang, M Diehn, AW Bollen, PO Brown, MA Israel, N Gupta. Type I collagen is overexpressed in medulloblastoma and is a component of tumor microenvironment. J Neuro-Oncology 86:133-141, 2008
• Y Liang, AW Bollen, N Gupta. CC chemokine receptor-2A is frequently overexpressed in glioblastoma. J of Neuro-Oncology 86:152-163, 2008