Associate Professor and Vice-Chair, Radiation Oncology, UCSF
| CONTACT | |
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(415) 353-9807 (appts) Box 1708, UCSF; San Francisco, CA 94143-1708 |
additional websites: |
| EDUCATION | |
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Harvard University Cambridge, MA, A.B., 1986, Biochemical Sciences
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| PROFESSIONAL EXPERIENCE | |
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1989-1990 |
Research Fellow, Laboratory of Dr. J. Michael Bishop, G. W. Hooper Foundation, University of California, San Francisco, CA |
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1991-1992 |
Medical Intern, California Pacific Medical Center, San Francisco, CA |
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1992-1994 |
Postdoctoral Fellow, Laboratory of Dr. Mark Israel, Brain Tumor Research Institute, University of California, San Francisco, CA |
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1994-1997 |
Resident, Department of Radiation Oncology, University of California, San Francisco, CA. |
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1996-1997 |
Chief Resident, Department of Radiation Oncology, University of California, San Francisco, CA |
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1997-2003 |
Assistant Professor, Dept. of Radiation Oncology, University of California, San Francisco, CA |
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2002-present |
Associate Professor, Dept. of Radiation Oncology, University of California, San Francisco, CA |
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2003-present |
Vice-Chair for Research, Dept. of Radiation Oncology, University of California, San Francisco, CA |
| HONORS & AWARDS | |
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1985 |
Joseph L. Barrett Award for Teaching, Harvard University |
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1986 |
Phi Beta Kappa |
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1986 |
Thomas T. Hoopes Prize and summa cum laude awarded to Senior Honors Thesis |
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1989 |
Howard Hughes Medical Institute Medical Student Research Training Fellowship |
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1991 |
Alpha Omega Alpha |
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1995 |
Junior Scientist Travel Award, 10th International Congress of Radiation Research |
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1995 |
ASTRO Basic Scientist Research Award |
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1996 |
American Cancer Society Clinical Oncology Fellowship |
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1996 |
Radiological Society of North America (RSNA) Roentgen Fellow/Resident Research Award |
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1997 |
RSNA Scholar Award |
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1998 |
UCSF Dean representative to Association of American Medical Colleges Professional Development Seminar for Junior Women Faculty, Santa Fe, New Mexico |
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1999 |
Pfizer Scholars Grant for New Faculty |
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1999 |
First place: CAP competition, General Clinical Research Center National Meeting; Arlington, VA |
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1999 |
American Society of Clinical Oncology Career Development Award |
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1999 |
UCSF-Mount Zion Clinical Investigator Award |
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April 22-May 5, 2001 |
European Cancer Centre Visiting Professor |
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2002 |
Henry J. Kaiser Award for Excellence in Teaching, UCSF School of Medicine |
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2002 |
UCSF Nominee: Association of American Medical Colleges (AAMC) Humanism in Medicine Award |
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2003 |
Teaching Award Nominee, School of Medicine, University of California, San Francisco, CA |
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2004 |
Nominee: Henry J. Kaiser Award for Excellence in Teaching, UCSF School of Medicine |
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2005 |
Selected one of Best San Francisco Doctors for San Francisco Magazine, January 2005 |
| SELECTED PUBLICATIONS | |
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Haas, DA; Ablin, AR; Miller, C; Zoger, S; Matthay, KK. Complete Pathological Maturation and Regression of Stage IVS Neuroblastoma Without Treatment. Cancer 1988, 62:818-825. | |
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Haas-Kogan, DA; Kogan, SC; Levi, D; Dazin, P; T'ang, A; Fung, YKT; Israel, MA. Inhibition of Apoptosis by the Retinoblastoma Gene Product. EMBO 1995, 14:461-472. | |
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Haas-Kogan, DA; Dazin,P; Hu, L; Deen, DF; Israel, MA. p53-Independent Apoptosis: A Mechanism of Radiation-Induced Cell Death of Glioblastoma Cells. The Cancer Journal. 1996, 2:114-121. | |
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Haas-Kogan, DA; Yount, G; Haas, M; Levi, D; Kogan, SC; Hu, L; Vidair,C; Deen, DF; Israel MA. P53-Dependent G1 Arrest and P53-Independent Apoptosis Influence the Radiobiologic Response of Glioblastoma. International Journal of Radiation Oncology Biology and Physics, 1996, 36:95-103. | |
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Haas-Kogan, DA; Shalev, N; Wong, M; Mills, G; Yount, G; Stokoe, D. PKB/Akt Activity is Increased in Glioblastoma Cell Lines due to Mutation of PTEN. Current Biology 1998, 8:1195-1198 | |
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Haas-Kogan, DA; Kogan, SC; Yount, G; Hsu,J; Deen, DF, Israel, MA. P53 Function Influences the Effect of Fractionated Radiotherapy on Glioblastoma Tumors. Int J Rad Onc Bio Phy 1999, 43(2):399-403. | |
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Zundel, W; Schindler, C; Haas-Kogan, DA; Koong, A; Kaper, F; Chen, E; Gottschalk, AR; Ryan, HE; Johnson, RS; Jefferson, AB; Stokoe, D; Giaccia, AJ. Loss of PTEN facilitates Hif-1 mediated gene repression. Genes and Developement, 2000, 14:391-396. | |
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Haas-Kogan DA, Fisch BM, Wara WM, Swift PS, Farmer DL, Harrison MR, Albanese C, Weinberg V, Matthay KK. Intraoperative Radiation Therapy For High Risk Pediatric Neuroblastoma. Int J Rad Onc Bio Phy, 2000, 47(4):985-992. | |
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Bertucio, CS; Wara, WM; Matthay, KK; Johnston, JO; Ablin, AR; Weinberg VK, OfDonnell, RJ; Haas-Kogan, DA. Functional Outcome Of Limb-Sparing Therapy For Pediatric Soft-Tissue Sarcomas of the Extremity. Int J Rad Onc Bio Phy, 2001, 49(3):763-769. | |
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Gottschalk, AR; Basila, D; Wong, M; Dean, NM; Stokoe, D; Haas-Kogan, DA. The PTEN-induced G1 Growth Arrest Requires p27Kip1 and is Independent of p53. Cancer Research, 2001, 61:2105-2111. | |
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Yount GL, Afshar G, Ries S, Korn M, Shalev N, Aldape KD, McCormick, F, and Haas-Kogan DA. Transcriptional Activation of TRADD Mediates p53-independent Radiation-induced Apoptosis of Glioma Cells. Oncogene, 2001, 20:2826-2835. | |
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Haas-Kogan DA, Bristow R, and Maity A. Young Investigators Workshop-Radiation Research Program, Radiation Oncology Sciences Program, National Cancer Institute, NIH, August 1-2, 2000. Int J Rad Onc Bio Phy, 2001, 49(5):1505-1516. | |
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Ermoian RO, Furniss CS, Lamborn DR, Basila D, Berger MS, Gottschalk AR, Nicholas MK, Stokoe DF, Haas-Kogan DA. Dysregulation of PTEN and PKB is Associated with Glioma Histology and Patient Survival. Clinical Cancer Research, 2002, 8(5):1100-1106. | |
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Haas-Kogan DA, Missett BT, Wara WM, Sarah SS, Lamborn KR, Prados MD, Fisher PG, Huhn SL, Fisch BM, Berger MS and Le QT. Radiation Therapy for Intracranial Germ Cell Tumors. Int J Rad Onc Bio Phy, 2003, 56(2):511-518. | |
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Haas-Kogan, DA, Swift, PS, Selch M, Haase, G, Seeger, RC, Gerbing, RB, Stram,DO, Matthay, KK. Radiotherapy for High-Risk Neuroblastoma: A Childrenfs Cancer Group Study. Int J Rad Onc Bio Phy, 2003, 56(1):28-39. | |
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Pore N, Liu S, Haas-Kogan DA, O'Rourke DM, Maity A. PTEN Mutation And Epidermal Growth Factor Receptor Activation Regulate Vascular Endothelial Growth Factor (VEGF) mRNA Expression In Human Glioblastoma Cells By Transactivating The Proximal VEGF Promoter. Cancer Research, 2003, 63(1):236-241. | |
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Hirose Y, Katayama M, Stokoe D, Haas-Kogan DA, Berger MS, Pieper RO. The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agents. Mol Cell Biol. 2003, 23(22):8306-8315. | |
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Yount GL, Qian Y, Moore D, Basila D, West J, Aldape K, Arvold N, Shalev N, Haas-Kogan DA. Berberine Sensitizes Human Glioma Cells, but Not Normal Glial Cells, to Ionizing Radiation In Vitro." J Exp Therapeutics Onc, 2004, J Exp Ther Oncol, 2004, 4(2):137-143. | |
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Pore N, Li B, Shu HK, Li B, Haas-Kogan DA, Stokoe D, Milanini-Mongiat J, Pages G, OfRourke DM, Bernhard E and Maity A. Sp1 is involved in Akt-mediated induction of VEGF expression through a HIF-1 independent mechanism. Mol Biol Cell, 2004,15(11):4841-4853. | |
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Haas-Kogan DA, Prados MD, Tihan T, Eberhard DA, Jelluma N, Arvold ND, Baumber R, Lamborn KR, Kapadia A, Malec M, Berger MS, and Stokoe D. Epidermal Growth Factor Receptor, Protein Kinase B/Akt, and Glioma Response to Erlotinib. Journal of the National Cancer Institute, 2005; 97(12):880-887. | |
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Gottschalk AR, Doan A, Nakamura JL, Haas-Kogan DA and David Stokoe. Inhibition of PI3 kinase causes cell death through a PKB dependent mechanism and growth arrest through a PKB independent mechanism. Int J Rad Onc Bio Phy, 2005, 61(4):1183-1188 | |
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Haas-Kogan, D. A., Prados, M. D., Lamborn, K. R., Tihan, T., Berger, M. S. and Stokoe, D. Biomarkers to predict response to Epidermal Growth Factor Receptor inhibitors. Cell Cycle, 2005, 4(10):95-98. | |
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Nakamura JL, Karlsson A, Arvold ND, Gottschalk AR, Pieper R, Stokoe D, and Haas-Kogan DA. PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas. J Neurooncol. 2005, 71(3):215-22. | |
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Laprie A, Pirzkall A, Haas-Kogan DA, Cha S, Banerjee A, Barkovich J, Prados MD, Le T, Crawford F, Lu Y, Nelson, S, and McKnight. Longitudinal Multivoxel MR Spectroscopy study of Pediatric Diffuse Brainstem Gliomas treated by Radiotherapy. Int J Rad Onc Bio Phy, 2005; 62(1):20-31. | |
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Mellinghoff IK, Wang Y, Haas-Kogan DA, Zhu S, Dia EQ, Lu KV, Koji Yoshimoto K, Huang JHY, Chute DJ, Riggs BL, Horvath S, Liau LM, Cavenee WK, Rao N, Beroukhim R, Lee JC, Sellers WR, Stokoe D, Prados M, Cloughesy TF, Sawyers CL, and Mischel PS. Molecular determinants of EGFR kinase inhibitor response in glioblastoma. New England Journal of Medicine, 2005, 353(19):2012-2024. | |
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Gomez DR, Missett BT, Wara WM, Lamborn KR, Prados MD, Chang S, Berger MS and Haas-Kogan, DA. High failure rate in spinal ependymomas with long-term follow-up. Neuro-Oncology, 2005; 7(3):254-259. | |
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Arvold ND, Guha N, Wang D, Matli M, Deen DF, Warren RS, and Haas-Kogan, DA. Hypoxia-induced Radioresistance Is Independent of Hypoxia-inducible Factor-1¿ in Vitro. Int J Rad Onc Bio Phy, 2005; 62(1):207-212. | |
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Entin-Meer M, Rephaeli A, Yang X, Nudelman A, VendenBerg SR and Haas-Kogan DA. Butyric acid prodrugs are histone deacetylase inhibitors that demonstrate anti-neoplastic activity and radiosensitizing capacity in the treatment of malignant gliomas. Molecular Cancer Therapeutics, 2005, 4(12):1952-1961. | |
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Tran QNH, Kim AC, Gottschalk AR, Wara, WM, Phillips TL, O'Donnell RJ, Weinberg V, and Haas-Kogan DA. Clinical Outcomes of Intraoperative Radiation Therapy for Extremity Sarcomas, Sarcoma, 2006, 1:1-6. | |
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Rephaeli A, Entin-Meer M, Angel D, Tarasenko N, Gruss-Fischer T, Bruachman I, Phillips DR, Cutts SM, Haas-Kogan DA, Nudelman A. The selectivty and anti-metastatic activity of oral bioavailable butyric acid prodrugs. Invest New Drugs. 2006 Feb 24; | |
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Afshar G, Basila D, Furniss S, Yount GL, Arvold ND, Koller E, Haas-Kogan DA. Radiation-induced caspase-8 expression mediates p53-independent apoptosis in glioma cells. Cancer Res. 2006, 66:4223-32. | |
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Jelluma N, Yan X, Stokoe D, Evan GI, Dansen TB, and Haas-Kogan DA. Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes. Mol Cancer Res. 2006, 4(5):319-30. | |
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Mishra KK, Puri DR, Missett BT, Lamborn KR, Prados MD, Berger MS, Banerjee A, Gupta N, Wara MW and Haas-Kogan DA. The role of up-front radiation therapy for incompletely resected pediatric WHO grade II low-grade gliomas. Neuro-oncol. 2006, 8(2):166-74. |
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12/6/06 |
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