Bo_Hang@lbl.gov
(510) 495-2537 (voice)
(510) 486-6488 (fax)

Lawrence Berkeley Nat'l Laboratory, Life Sciences Division
One Cyclotron Road, Mailstop:DONNER
Berkeley, CA 94720

additional websites:

Hang Lab Website at LBNL

Nanjing Medical University, Nanjing, China, M.D., 1982, Medicine
Shanghai Medical University, Shanghai, China, M.S., 1988, Experimental Pathology
Univ. of Med. & Den. of New Jersey, NJ, USA, Ph.D., 1994, Biochem & Mol. Biol. (DNA Repair)

Lambert MW, Tsongalis GJ, Lambert WC, Hang B, Parrish DD. (1992) Defective DNA endonuclease activities in Fanconi's anemia cells, complementation groups A and B. Mutat Res., 273, 57-71.

Hang B, Yeung AT, Lambert MW. (1993) A damage-recognition protein which binds to DNA containing interstrand cross-links is absent in Fanconi anemia, complementation group A cells. Nucleic Acids Res., 21, 4187-92.

Kumaresan KR, Hang B, Lambert MW. (1995) Human endonucleolytic incision of DNA 3' and 5' to a site-directed psoralen monoadduct and interstrand cross-link. J. Biol. Chem., 270, 30709-16.

Chenna A, Hang B, Rydberg B, Kim E, Pongracz K, Bodell WJ, Singer B. (1995) The benzene metabolite p-benzoquinone forms adducts with DNA bases that are excised by a repair activity from human cells that differs from an ethenoadenine glycosylase. Proc. Natl. Acad. Sci. USA, 92, 5890-4.

Hang B, Chenna A, Rao S, Singer B. (1996) 1,N6-ethenoadenine and 3,N4-ethenocytosine are excised by separate human DNA glycosylases. Carcinogenesis, 17, 155-7.

Hang B, Chenna A, Fraenkel-Conrat H, Singer B. (1996) An unusual mechanism for the major human AP endonuclease involving 5' cleavage of DNA containing a benzene-derived exocyclic adduct in the absence of an AP site. Proc. Natl. Acad. Sci. USA, 93, 13737-41.

Singer B, Hang B. (1997) Perspective: What structural features determine repair enzyme specificity and mechanism in chemically modified DNA? Chem. Res. Toxicol., 10, 713-32.

Hang B, Singer B, Margison GP, Elder RH. (1997) Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminate repair of 1,N6-ethenoadenine and hypoxanthine but not of 3,N4-ethenocytosine or 8-oxoguanine. Proc. Natl. Acad. Sci. USA, 94, 12869-74.

Hang B, Rothwell DG, Sági J, Hickson ID, Singer B. (1997) Evidence for a common active site for cleavage of an AP site and the benzene-derived exocyclic adduct, 3,N4-benzetheno-dC, in the major human AP endonuclease. Biochemistry, 36, 15411-18.

Singer B, Hang B. (1998) Role of chemical structure in determination of repair enzyme substrate specificity and mechanism. In: DNA and Free Radicals: Techniques, Mechanisms and Applications. Eds: Auoma, O.I. and Halliwell, B. OICA International, Santa Lucia, 27-53.

Hang B, Chenna A, Sági J, Singer B. (1998) Differential repair of the benzene-derived adduct, 1,N6-benzetheno-dA, by the major human AP endonuclease HAP1 and Escherichia coli exonuclease III and endonuclease IV. Carcinogenesis, 19, 1339-43.

Hang B, Chenna A, Sági J, Singer B. (1998) Correlation between sequence-dependent glycosylase repair and the thermal stability of oligonucleotide duplexes containing 1,N6-ethenoadenine. J. Biol. Chem., 273, 33406¥

Hang B, Medina M, Fraenkel-Conrat H, Singer B. (1998) A 55-kDa protein isolated from human cells shows DNA glycosylase activity toward 3,N4-ethenocytosine and the G/T mismatch. Proc. Natl. Acad. Sci. USA, 95, 13561-66.

Sagi J, Chenna A, Hang B, Singer B. (1998) A single cyclic p-benzoquinone adduct can destabilize a DNA oligonucleotide duplex. Chem Res Toxicol., 11, 329-34.

Sági J, Hang B, Singer B, (1999) Sequence dependent repair of synthetic AP sites in 15-mer and 35-mer oligomers: role of thermodynamic stability imposed by neighbor bases. Chem. Res. Toxicol., 12, 917-23.

Singer B, Hang B. (1999) Mammalian enzymatic repair of etheno and p-benzoquinone exocyclic adducts derived from the carcinogens, vinyl chloride and benzene. In: Exocyclic DNA adducts in mutagenesis and carcinogenesis, Eds: Singer, B. and Bartsch, H., IARC Scientific Publications, No 150, p233-47.

Singer B, Hang B. (2000) Commentary: Nucleic acid sequence and repair: role of adduct, neighbor bases and enzyme specificity. Carcinogenesis, 21, 1071-8.

Rothwell DG, Hang B, Gorman MA, Freemont PS, Singer B, Hickson ID. (2000) Substitution of Asp 210 in HAP1 (APE/Ref-1) eliminates endonuclease activity but stabilizes substrate binding. Nucleic Acids Res., 28, 2207-13.

Sagi J, Perry A, Hang B, Singer B. (2000) Differential destabilization of the DNA oligonucleotide double helix by a T.G mismatch, 3,N4-ethenocytosine, 3,N4-ethanocytosine, or an 8-(hydroxymethyl)-3,N4-ethenocytosine adduct incorporated into the same sequence contexts. Chem Res Toxicol., 13, 839-45.

Hang B, Downing G, Guliaev AB, Singer B. (2002) Novel activity of Escherichia coli mismatch uracil glycosylase (MUG) excising 8-(hydroxymethyl)-3,N4-ethenocytosine, a potential product resulting from glycidaldehyde reaction. Biochemistry, 41, 2158-65.

Singer B, Medina M, Wang Z, Guliaev AB, Hang B. (2002) 8-(hydroxymethyl) 3,N4-etheno-dC, a potential carcinogenic glycidaldehyde product, miscodes in vitro using mammalian polymerases. Biochemistry, 41, 1778-85.

Guliaev AB, Hang B, Singer B. (2002) Structural insights by molecular dynamics simulations into differential repair efficiency for ethano-A vs. etheno-A adducts by the human alkylpurine-DNA-N-glycosylase (APNG). Nucleic Acids Res., 30, 3778-87.

Hang B, Singer B. (2003) Protein-protein interactions involving DNA glycosylases. Chem Res Toxicol., 16, 1181-95.

Hang B, Chenna A, Guliaev AB, Singer B. (2003) Miscoding properties of 1,N6-ethanoadenine, a DNA adduct derived from reaction with the antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea. Mutat Res., 531(1-2), 191-203.

Guliaev, AB, Singer B, Hang B. (2004) Chloroethylnitrosoureas-derived ethano adenine and cytosine adducts are substrates for E. coli glycosylases excising analogous etheno adducts. DNA Repair, 3, 1195-208.

Guliaev AB, Hang B, Singer B. (2004) Structural insights by molecular dynamics simulations into specificity of the major human AP endonuclease toward the benzene-derived DNA adduct, pBQ-C. Nucleic Acids Res., 32, 2844-52.

Hang B. (2004) Repair of exocyclic DNA adducts: rings of complexity. BioEssays., 26, 1195-208.

Xie Z, Zhang Y, Guliaev AB, Shen H, Hang B, Singer B, Wang Z. (2005) The p-benzoquinone DNA adducts derived from benzene are highly mutagenic. DNA Repair, 8, 1399-409.

Wang P, Guliaev AB, Elder RH, Hang B. (2006) Alkylpurine-DNA-N-glycosylase excision of 7-(hydroxymethyl)-1,N6-ethenoadenine, a glycidaldehyde-derived DNA adduct. DNA Repair, 5, 23-31.

Hang B. (2006) Base Excision Repair, in DNA Repair, Genetic Instability, and Cancer (Eds. Wei, Q., Li, L. & Chen, D.), World Scientific Publishing Co. Pte. Ltd., Singapore. In press.

5/25/06