Associate Researcher, Manager of Preclinical Therapeutics Core, UCSF Helen Diller Family Comprehensive Cancer Center
| CONTACT | |
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bhann@cc.ucsf.edu Box 0128, UCSF; San Francisco, CA 94143-0128 |
| EDUCATION | |
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Reed College, Portland, Oregon, B.A., 1984, Physics
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| PROFESSIONAL EXPERIENCE | |
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1983-1984 |
Undergraduate: Senior Thesis, Physics, Chemistry Department, Reed College, "UV Spectroscopy of Wursters Blue; A Test of Huckel MO Theory". Advisors; Drs. Rich Bettega, Dennis Hoffman |
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1984 |
Research Assistant, Laboratory of Dr. Steve Arch, Reed College Dept. of Biology. Analysis of neuropeptides released by bag cells of Aplysia californica. |
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1984-1985 |
Post Graduate Research Physiologist, Laboratory of Dr. Louis Reichardt, UCSF School of Medicine, Dept of Physiology, Division of Neuroscience. Purification, characterization and cloning of a laminin binding protein. |
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1988-1992 |
Ph.D. candidate, Laboratory of Dr. Peter Walter, UCSF School of Medicine, Dept. of Biochemistry and Biophysics. Identification and analysis of the signal recognition particle in Saccharomyces cerevisiae. |
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1994-1997 |
Post-doctoral fellow, Laboratory of Prof. David Lane, CRC Labs, Department of Biochemistry, University of Dundee, Scotland. Phospho-regulation of p53: Identification of novel sites of p53 phosphorylation, generation of phospho-peptide antibodies, characterization of ATM, ATR phosphorylation of p53 in collaboration with S. Jackson Lab (Cambridge, England). |
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1997-1999 |
Associate Scientist, Onyx Pharmaceuticals, Richmond, CA, Viral therapy and Cell Cycle groups. Analysis of the mechanism of action and selectivity of an onco-lytic, E1B 55-K deficient adenovirus (ONYX-015). |
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1999-2004 |
Specialist, Laboratory of Dr. Allan Balmain, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco CA. The role of p53 in regulating viral and cellular processes in primary and tumor human cells infected with E1B 55-K deficient adenoviruses. p53 dependent abrogation of 55-K deficient virus replication. |
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2004-present |
Associate Researcher, Director of UCSF Preclinical Core. Working closely with UCSF Breast and Prostate SPORE programs, RTK U54 program, and Pancreas Cancer Research Group to develop new animal models for preclinical studies and to oversee preclinical trials testing novel experimental therapeutics, diagnostics and imaging strategies. |
| HONORS & AWARDS | |
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1984 |
Phi Beta Kappa |
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President's Award for Excellence in Scholarship, Reed College, Portland, OR |
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| SELECTED PUBLICATIONS | |
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Marx, C, Berger C,1 Xu, F, Amend, C, Johnson, J, Scott, G, Hann, B, ParkJ J, and Benz, C. (2006) Validated high-throughput screening of drug-like small molecules for inhibitors of ErbB2 transcription., Assay and Drug Development Technologies, (In press). | |
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Hann, B., Balmain, A. (2003). Replication of an E1B 55kD-deficient adenovirus (ONYX-015) is rescued by gain-of-function rather than loss of function p53 mutants . J. Virol., 77(21):11588-95. | |
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Rauen KA, Sudilovsky D, Le JL, Chew KL, Hann B, Weinberg V, Schmitt LD, McCormick F. (2002). Expression of the coxsackie adenovirus receptor in normal prostate and in primary and metastatic prostate carcinoma: potential relevance to gene therapy. Cancer Res. 62(13): 3812-8. | |
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Ganly, I., Kim, Y.T., Hann, B. C., Balmain, A., Brown, R. (2000). Replication and cytolysis of an E1B-attenuated adenovirus in drug resistant ovarian tumour cells is associated with reduced apoptosis. Gene Therapy, Mar; 8(5):369-75 | |
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Reis, S.J., Brandts, C.H., Chung, A., Biederer, C. H., Hann, B. C., Lipner, E.M., McCormick, F., Korn, W.M. (2000). Loss of p14ARF facilitates replication of the adenovirus mutant dl1520 (ONYX-015) in tumor cells. Nat. Med. 6(10):1128-33. | |
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Smith, G.C.M., Cary, R.B., Lakin, N.D., Hann, B. C., Teo, S.-H., Chen, D.J. and Jackson, S.P. (1999). Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM. Proc. Natl. Acad. Sci. 96: 11134-11139. | |
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Lakin, N.D., Hann, B. C. and Jackson, S.P. (1999). The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53. Oncogene 18: 3989-3995. | |
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Gallimore, P. H., Lecane, P. S., Hann, B., & Grand, R.J. A. 1997. Differentiation is inhibited and a senescence pathway is activated when simian virus 40 tsA 58-transformed human retinoblasts are grown at the restrictive temperature. Cell Gr. and Diff. 8: 763-771. | |
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Brown, J. D., Hann, B. C., Medzihradszky, K. F., Niwa, M. Burlingame, A. L., & Walter, P. 1994. Subunits of the Saccharomyces cerevisiae signal recognition particle required for its functional expression. EMBO J. 13: 4390-4400. | |
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Selinger, D., Brennwald, P., Althoff, S., Reich, C., Hann, B., Walter, P., & Wise, J. A. 1992. Genetic and biochemical analysis of the fission yeast ribonucleoprotein particle containing a homolog of SRP54p. Nucl. Acids Res. 22: 2557-2567. | |
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Hann, B. C., Stirling, C. J., & Walter, P. 1992. SEC65 gene product is a subunit of the yeast signal recognition particle required for its integrity. Nature 356: 532-533. | |
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Hann, B. C., & Walter, P. 1991. The signal recognition particle in S. cerevisiae. Cell 67: 131-144. | |
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Hann, B. C., Poritz, M. A., & Walter, P. 1989. Saccharomyces cerevisiae and Schizosaccharomyces pombe contain a homologue to the 54-kD subunit of the signal recognition particle that in S. cerevisiae is essential for growth. J. Cell Bio. 109: 3223-3230. | |
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Clegg, D. O., Helder, J. C., Hann, B. C., Hall, D. E., & Reichardt, L. F. 1988. Amino acid sequence and distribution of mRNA encoding a major skeletal muscle laminin binding protein: An extracellular matrix-associated protein with an unusual COOH-terminal polyaspartate domain. J. Cell Bio. 107: 699-705. | |
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Hall, D. E., Frazer, K. A., Hann, B. C., & Reichardt, L.F. 1988. Isolation and Characterization of a laminin-binding protein from rat and chick muscle. J. Cell Bio. 107: 687-697. | |
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Review Articles | |
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Hann, B., Balmain, A. (2001). Building ÔvalidatedÕ mouse models of human cancer. Curr Opin Cell Biol., 13: 778-784 | |
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Hann, B. C. & Lane, D. P. 1995 The dominating effect of mutant p53. Nature Genet. 9: 221-222. | |
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Walter, P., Ogg, S. C., & Hann, B. C. 1992. The SRP-dependent protein targeting pathway in Saccharomyces cerevisae. In: Protein synthesis and targeting in yeast. (Brown, A., McCarthy, J., Sherman, F. & Tuite, F., eds), Springer Verlag, Berlin-Heidelberg-New York-Tokyo. |
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1/27/06 |
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