Assistant Adjunct Professor, Surgery, UCSF
Member, Jablons Lab, UCSF
| CONTACT | |
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bhe@cc.ucsf.edu Box 0875, UCSF; San Francisco, CA 94143-0875 |
additional websites: |
| EDUCATION | |
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University of Virginia, PhD, July 2001, Molecular Biology and Genetics
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| PROFESSIONAL EXPERIENCE | |
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1994-1995 |
Graduate Research Assistant, Department of Biology, Tsinghua University, Beijing, China |
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1995-1996 |
Graduate Research Assistant, Biological Timing Center, University of Virginia, VA |
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1996-1997 |
Graduate Teaching Assistant, Department of Biology, University of Virginia, VA |
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1997-2001 |
Graduate Research Assistant, Department of Biology, University of Virginia, VA |
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2001-2002 |
Postdoctoral Researcher, Department of Surgery, University of California, San Francisco, CA |
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2002-2004 |
Assistant Research Molecular Biologist, Department of Surgery, University of California, San Francisco |
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2004-present |
Assistant Adjunct Professor, Department of Surgery, University of California, San Francisco, CA |
| HONORS & AWARDS | |
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1991, 1990, 1989 |
Honor of Outstanding Student, Tsinghua University, China |
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1992 |
Guanghua Scholarship, Tsinghua University, China |
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1993 |
Honor of Outstanding Graduate, Tsinghua University, China |
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1995 |
Hua Luogeng Memorial Fellowship, Tsinghua University, China |
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1996 |
Fellowship, University of Virginia, Charlottesville, VA |
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2004 |
Barbara Isackson Endowed Research Fellow, University of California, San Francisco, CA |
| SELECTED PUBLICATIONS | |
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Yellman C, Tao H, He B, and Hirsh J. Conserved and sexually dimorphic behavioral responses to biogenic amines in decapitated Drosophila. Proc. Natl. Acad. Sci. USA, 1997, 94 (8): 4131-4136. | |
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Geng W, He B, Wang M, and Adler PN. The tricornered gene, which is required for the integrity of epidermal cell extensions encodes the Drosophila NDR kinase. Genetics, 2000, 156: 1817-1828. | |
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He B, and Adler PN. Cellular mechanisms in the development of the Drosophila arista. Mechanisms of Development, 2001, 104: 69-78. | |
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Cong J, Geng W, He B, Liu J, Charlton J, and Adler PN. The furry gene of Drosophila is important for maintaining the integrity of cellular extensions during morphogenesis. Development, 2001, 128: 2793-2802. | |
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He B, and Adler PN. The frizzled pathway regulates the development of arista laterals. BMC Developmental Biology, 2002, 2: 7. | |
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He B, and Adler PN. Genetic controls of arista lateral morphogenesis in Drosophila. Development, Genes and Evolution, 2002, 212 (5): 218-229. | |
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Fei X, He B, and Adler PN. The growth of Drosophila bristles and laterals is not restricted to the tip or base. Journal of Cell Science, 2002, 115 (19): 3797-3806. | |
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He B, You L, Uematsu K, Matsangou M, Xu Z, He M, McCormick F and Jablons DM. Cloning and characterization of a functional promoter of the human SOCS-3 gene, Biochem. Biophys. Res. Comm., 2003, 301: 386-391. | |
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Uematsu K, Kanazawa S, You L, He B, Xu Z, Peterlin M, McCormick F and Jablons DM. Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of beta-catenin. Cancer Research, 2003, 63 (15): 4547-4551. | |
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Uematsu K, He B, You L, Xu Z, McCormick F and Jablons DM. Activation of the Wnt pathway in human non-small-cell lung cancer: evidence of Dishevelled (Dvl) overexpression, Oncogene, 2003, 22(46): 7218-7221. | |
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He B, You L, Uematsu K, Zang K, Xu Z, Costello JF, McCormick F and Jablons DM. SOCS-3 suppresses cell growth and is silenced by frequent hyper-methylation in human lung cancer, Proc. Natl. Acad. Sci. USA, 2003, 100 (24): 14133-14138. | |
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You L, He B, Xu Z, McCormick F and Jablons DM. Future directions-oncolytic viruses. Clinical Lung Cancer, 2004, 5 (4): 226-230. | |
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He B, You L, Uematsu K, Zang K, Xu Z, Matsangou M, McCormick F and Jablons DM. A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells, Neoplasia, 2004, 6: 7-14. | |
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Lee AY, He B, You L, Dadfarmay S, Xu Z, Mazieres J, Mikami I, McCormick F, and Jablons DM. Expression of the secreted frizzled-related protein (sFRP) family is down-regulated by methylation in human lung cancer and mesothelioma, Oncogene, 2004, 23 (39): 6672-6676. | |
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You L, He B, Uematsu K, Xu Z, McCormick F, and Jablons DM. Inhibition of Wnt-1 signaling induces apoptosis in beta-Catenin-deficient mesothelioma cells, Cancer Research, 2004, 64: 3474-3478. | |
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He B, You L, Xu Z, Uematsu K, Mazieres J, Lee AY and Jablons DM. Activity of the suppressor of cytokine signaling-3 (SOCS-3) promoter in human non-small-cell lung cancer, Clinical Lung Cancer, 2004, 5(6): 366-370. | |
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Mazieres J, He B, You L, Xu Z, Lee AY, Mikami I, Reguart N, Rosell R, McCormick F and Jablons DM. Wnt Inhibitory Factor-1 (WIF-1) is silenced by promoter hypermethylation in human lung cancer, Cancer Research 2004, 64: 4717-4720. | |
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You L, He B, Xu Z, Uematsu K, Mazieres J, Fujii N, Mikami I, Reguart N, McIntosh JK, Kashani-Sabet M, McCormick F and Jablons DM. An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth, Cancer Research 2004, 64: 5385-5389. | |
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You L, He B, Xu Z, Uematsu K, Mazieres J, Mikami I, Reguart N, Moody TW, Kitajewski J, McCormick F, and Jablons DM. Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells. Oncogene 2004, 23(36): 6170-6174. | |
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Reguart N, He B, You L, Xu Z, Lee AY, Mazieres J, Mikami I, Rosell R, McCormick F and Jablons DM. Cloning and characterization of a functional promoter of the human Wnt Inhibitory Factor-1 (WIF-1) gene, Biochem. Biophy. Res. Comm., 2004, 323: 229-234. | |
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Lee AY, He B, You L, Xu Z, Mazieres J, Uematsu K, Reguart N, McCormick F and Jablons DM. Dkk-1 antagonizes Wnt signaling and induces apoptosis in b-catenin-deficient human mesothelioma, Biochem. Biophy. Res. Comm., 2004, 323: 1246-1250. | |
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He B, Lee AY, Dadfarmay S, You L, Xu Z, Mazieres J, Uematsu K, Reguart N, Mikami I, McCormick F, and Jablons DM. SFRP4 is silenced by hypermethylation and induces apoptosis in fA-Catenin-deficient human mesothelioma cells, Cancer Research, 2005, 65 (3): 743-748. | |
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Mazieres J, He B, You L, Xu Z and Jablons DM. Wnt signaling in lung cancer, Cancer Letters, 2005, 222: 1-10. | |
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He B, Reguart N, You L, Mazieres J, Xu Z, Lee AY, McCormick F, and Jablons DM. Blockade of Wnt-1 Signaling Induces Apoptosis in Human Colorectal Cancer Cells Containing Downstream Mutations. Oncogene, 2005, 24 (18): 3054-3058. | |
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Mazieres J, You L, He B, Xu Z, Twogood S, Lee AY, Reguart N, Batra S, Mikami I and Jablons DM. Wnt-2 as a new therapeutic target in malignant pleural mesothelioma, International Journal of Cancer, 2005, 117 (2): 326-332. | |
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Mikami I, You L, He B, Xu Z, Batra S, Lee AY, Mazieres J, Reguart N, Uematsu Koizumi K and Jablons DM. Efficacy of Wnt-1 monoclonal antibody in sarcoma cells, BMC Cancer, 2005, May 24; 5(1): 53. | |
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Mazieres J, You L, He B, Xu Z, Lee AY, Mikami I, McCormick F, and Jablons DM. Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis, Oncogene 2005, 24 (34): 5396-5400. | |
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He B, Barg RN, You L, Xu Z, Reguart N, Mikami I, Batra S, Rosell R, Jablons DM. Wnt signaling in stem cells and non small cell lung cancer. Clinical Lung Cancer, 2005, 7 (1): 54-60. (Cover of the July Issue) | |
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Reguart N, He B, Taron M, You L, Jablons DM and Rosell R. The role of Wnt signaling in cancer and stem cells, Future Oncology 2005, 1 (6): 787-797. | |
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Lin Y, You L, Xu Z, He B, Mikami I, Thung E, Chou J, Kuchenbecher K, Kim J, Raz D, Yang C, Chen J, and Jablons DM. Activation of Wnt signaling and WIF-1 silencing due to promoter hypermethylation in nasopharyngeal cancer cell lines. Biochem. Biophys. Res. Comm. 2006, 314: 635-640. | |
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Batra S, Shi Y, Kuchenbecher K, He B, Reguart N, Mikami I, You L, Xu Z, Lin Y, Clement G and Jablons DM. Wnt Inhibitory Factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma. Biochem. Biophys. Res. Comm 2006, 342 (4): 1228-1232. | |
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Ren N, He B, Stone D, Kirakodu S and Adler PN. The shavenoid gene of Drosophila encodes a novel actin cytoskeleton interacting protein that promotes wing hair morphogenesis. Genetics 2006, 172 (3): 1643-1653. | |
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You L, Kim J, He B, Xu Z, McCormick F and Jablons DM. Wnt-1 signal as a potential cancer therapeutic target, Drugs News & Perspectives 2006, 19 (1): 27-31. | |
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Raz DJ, He B, Rosell R and Jablons DM. Bronchioloalveolar carcinoma: a review, Clinical Lung Cancer, 2006, 7 (5): 313-322. | |
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Zhou BB, Peyton M, He B, Liu C, Girard L, Caudler E, Lo Y, Baribaud F, Mikami I, Reguart N, Yang G, Li Y, Yao W, Vaddi K, Gazdar AF, Friedman SM, Jablons DM, Newton RC, Fridman JS, Minna JD and Scherle PA. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer, Cancer Cell, 2006, 10 (1): 39-50. (Cover Story of the Issue) | |
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Raz DJ, He B, Rosell R, and Jablons DM. Current concepts in bronchioloalveolar carcinoma biology. Clinical Cancer Research, 2006, 12 (12): 3698-3704. | |
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Beltrán A, He B, Kim J, Raz DJ, and Jablons DM. Novel therapies targeting signalling pathways in lung cancer. Thoracic Surgery Clinics 2006 (In Press). | |
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Kim J, Mazieres J, You L, Xu Z, He B, and Jablons DM. Wnt inhibitory factor 1 inhibits lung cancer cell growth. The Journal of Thoracic and Cardiovascular Surgery 2006 (In Press). | |
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Beltrán A, He B, and Jablons DM. Developmental signaling pathways in lung cancer: from stem cells to cancer. Current Respiratory Medicine Reviews, 2006 (In Press). | |
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He B, Zhou BB, and Jablons DM. Heregulin as a novel target in lung cancer. Expert Opinion on Therapeutic Targets, 2006 (In Press). | |
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Shi Y, He B, You L, and Jablons DM. The roles of secreted frizzled-related proteins in cancer. Acta Pharmacologica Sinica, 2006 (In Press). | |
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9/26/06 |
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