(415) 353-3638 (voice)
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Box 0946, UCSF; San Francisco, CA 94143-0946

Sichuan University, China B.S. 1991 Radiochemistry
Chinese Academy of Sciences, China M.S. 1994 Chemistry
Peking University, China Ph.D 1997 Radiochemistry
Catholic University of Louvain, Belgium Fellowship 2000-2001 Chemistry
University of Massachusetts Medical Center, USA Fellowship 2001-2003 Radiochemistry

J. He, Y.H.Wu, X.Y.Wang, and Y.F.Liu: Synthesis, characterization and biodistribution of new 99mTcN nitrido complexes with derivatives of alkyl xanthate. J. Labeled Compds. & Radiopharma. 1997, XXXIX(8), 645-650.

2. J. He, Yong-Hui Wu, Xiang-Yun Wang, Yuan-Fang Liu: Synthesis of new neutral complexes containing [99mTcNPh]3+ core. Acta Scientiarum Naturalium Universitatis. 1998, 34(4), 447-452.

3. J. He, L. Xu, Z. Zhou. Preparation of high purity insulating magnesium oxide from bittern. Proceedings of 6th Annual Meeting of Applied Chemistry, Chinese Chemical Society. 1999, 253-258.

4. J. He, S. Wu, Z.Sun. Wood liquefacation and applications in polymer materials. Chinese Wood Industry. 2002, 2: 9-11, 18.

5. J. He, N. Belghein, R.B.Clarkson, H.M.Swartz, Bernard Gallez: Biopolymer coated paramagnetic carbon particles for in vivo EPR oximetry: stability of the responsiveness to pO2 in vitro and in vivo. Physics in Medicine & Biology. 46(12), 3323-3329, 2001.

6. J. He, N. Belghein, P. Ceroke, R.B.Clarkson, H.M.Swartz, Bernard Gallez: Development of biocompatible film holding paramagnetic carbon particles: evaluation of their performance and stability for in vivo EPR oxymetry. Magnetic Resonance in Medicine. 46, 610-614, 2001.

7. ZF. Su, J. He, M. Rusckowski, D.J. Hnatowich, In vitro cell studies of technetium-99m labeled RGDHYNIC peptide, a comparison of tricine and EDDA as co-ligands. Nucl Med Biol. 2003 Feb;30(2):141-9.

8. C. Liu, G. Liu, N. Liu, Y. Zhang, J. He, M. Rusckowski, D. J. Hnatowich, Radiolabeling morpholinos with 90Y, 111In, 188Re and 99mTc, Nucl Med Biol. 2003;30(2):207-14.

9. G.Liu, S.Zhang, J. He, N.Liu, S. Gupta, M. Rusckowski, DJ Hnatowich.The Influence of Chain Length and Base Sequence on the Pharmacokinetic behavior of 99mTc-Morpholinos in Mice. Quart J Nucl Med. 2002; 46: 233-243.

10. G. Liu, S. Zhang, J. He, M.Rusckowski, DJ. Hnatowich: Improving radiolabeling 99mTc labeling of S-Acety-NHS-MAG3 conjugated biomolecules. Bioconjugate Chemistry, 2002;13:893-897.

11. Liu G., He J., Zhang SR, Liu C., Rusckowski M, Hnatowich DJ, Cytosine residues influence kidney accumulations of 99mTc-labeled morpholino oligomers. Antisense and Nucleic Acid Drug Development, 2002, 12: 393-398.

12. Liu G, Liu C, Zhang S, He J, Liu N, Gupta S, Rusckowski M, Hnatowich DJ. Investigations of 99mTc morpholino pretargeting in mice. Nucl Med Commun. 2003 Jun;24(6):697-705.

13. Liu G, He J, Dou S, Gupta S, Vanderheyden J-L, Yumin Zhang, Mary Rusckowski, Donald J Hnatowich. Pretargeting in tumored mice with radiolabeled cytosine-free morpholino oligomers. Eur. J. Nucl. Med.& Mol Imaging 2004, 31, 417-424.

14. Zhang Y, Liu C, Liu N, Flores G, He J, Rusckowski M and Hnatowich DJ. Electrostatic Binding with Tat and other Cationic Peptides Increases Cell Accumulation of 99mTc- Antisense DNAs without Entrapment. Molecular Imaging & Biology. 2003, 5(4): 240-247.

15. Jiang He, Guozheng Liu, Suresh Gupta, Yumin Zhang, Mary Rusckowski and Donald J. Hnatowich. Amplification targeting-a modified pretargeting approach with potential for signal amplification-Proof of a Concept. J.Nuclear Medicine 2004; 45:1087-1095.

16. Jiang He, Changbin Liu, Jean-Luc Vanderheyden, Guozheng Liu, Shuping Dou, Mary Rusckowski, Donald J. Hnatowich. Radiolabeling morpholinos with 188Re tricarbonyl provides improved in vitro and in vivo stability to re-oxidation. Nuclear Medicine Communication. 2004, 25(7): 731-736.

17. Yumin Zhang, Jiang He, Guozheng Liu, Jean-Luc Venderheyden, Suresh Gupta, Mary Rusckowski and Donald J. Hnatowich. Initial Observations of 99mTc-labeled Locked Nucleic Acids for Antisense Targeting. Nuclear Medicine Communication. 2004 25(11): 1113-8.

18. Jiang He, Guozheng Liu, Surong Zhang, Jean-Luc Vanderheyden, Ning Liu, Changbin Liu, Yuming Zhang, Suresh Gupta, Mary Rusckowski, Donald J. Hnatowich. A comparison of in vitro and in vivo stability in mice of two morpholino duplexes differing in chain length. Bioconjugate Chemistry. 2003, 14: 1018-1023.

19. Jiang He, Guozheng Liu, Surong Zhang, Mary Rusckowski and Donald J. Hnatowich. Pharmacokinetics in mice of four oligomer-conjugated polymers for amplification targeting. Cancer biotherapy & Radiopharmaceuticals 2003, 18, 941-947.

20. K. Nakamura, C Fan, G Liu, S. Gupta, J He, S Dou, A. Kubo, M. Rusckowski and D. J. Hnatowich. Evidence of Antisense Tumor Targeting in Mice. Bioconjugate Chem. 2004, 15, 1475-1480.

21. G. Liu, S. Dou, J. He, J-L Vanderheyden, M Rusckowski, and D. J. Hnatowich. Preparation and Properties of 99mTc(CO)3+-Labeled N,N-Bis(2-pyridylmethyl)-4-aminobutyric Acid. Bioconjugate Chem. 2004, 15, 1441-1446.

22. J He, G. Liu, J. L. Vanderheyden, S. Dou, M. Rusckowski, D. J. Hnatowich. Affinity enhancement bivalent morpholino for pretargeting: Initial evidence by surface plasmon resonance. Bioconjugate Chemistry 2005, 16(2):338-45.

23. YM Zhang, CH Tung, J He, N Liu, CB Liu, J Summerton, G Wright, JL Vanderheyden, GZ Liu, M Rusckowski and DJ Hnatowich. Cell Culture Studies of A Novel Technetium-99m Labeled Antisense Chimera Consisting of A Tat Peptide Conjugated to A Morpholino Oligomer. Nuclear Med. Biol. 2006;33:263-269.

24. Jiang He,* Xinrong Liu, Surong Zhang, Guozheng Liu, and Donald J. Hnatowich. Affinity Enhancement Bivalent Morpholinos for Pretargeting: Surface Plasmon Resonance Studies of Molecular Dimensions. Bioconjugate Chem., 2005, 16 (5), 1098 -1104.

25. G. Liu, J. He, S. Dou, S. Gupta, M Rusckowski, and D. J. Hnatowich. Further investigations of morpholino pretargeting in mice-establishing quantitative relations in tumor. Eur J Nucl Med Mol Imaging. 2005, 32(9):1115-23.

26. JL Vanderheyden, G Liu, J He, B Patel, JF. Tait and DJ. Hnatowich. Evaluation of 99mTc-MAG3-annexin V: influence of the chelate on in vitro and in vivo properties in mice. Nuclear Medicine & Biology. 2006;33:135-144.

27. XR Liu, K Nakamura, Y Wang, Ye Wang, G Liu, J He, H Ding, P Lu, M Rusckowski, A Kubo, and DJ Hnatowich. Initial Mechanistic Studies of Antisense Targeting in Cells. J. Nucl Med.2006;47:360-368.

28. YM Zhang, CH Tung, J He, N Liu, CB Liu, J Summerton, G Wright, JL Vanderheyden, GZ Liu, M Rusckowski and DJ Hnatowich. Cell Culture Studies of A Novel Technetium-99m Labeled Antisense Chimera Consisting of A Tat Peptide Conjugated to A Morpholino Oligomer. Nuclear Med.Biol.2006;33:263-269.

29. M.Dinguizli, S. Jeumont, N. Beghein, J. He, T. Walczak, P.N. Lesniewski, H. Hou, O.Y. Grinberg, Artur Sucheta, H.M. Swartz, PG Rouxhet, and B. Gallez. Development and evaluation of biocompatible films in polytetrafluoroethylene polymers holding lithium phthalocyanine crystals for their use in EPR oximetry. Biosens Bioelectron. 2006; 21(7):1015-22.

30. G Liu, S. Dou, J. He, D Yin, S Gupta, S Zhang, Y Wang, M Rusckowski and D.J. Hnatowich. Radiolabeling of MAG(3)-morpholino oligomers with (188)Re at high labeling efficiency and specific radioactivity for tumor pretargeting. Appl Radiat Isot. Appl Radiat Isot. 2006; 64(9):971-8.

31. X Liu, K Nakamura, Y Wang, S Zhang, J He, G Liu, S Dou, A Kubo, M Rusckowski, DJ Hnatowich. Improved delivery in cell culture of radiolabeled antisense DNAs by duplex formation. Molecular Imaging & Biology 2007; 8 (5); 278-283.

32. G. Liu, S. Dou, G. Mardirossian, J He, S Zhang, X Liu, M Rusckowski and D.J. Hnatowich Successful Radiotherapy of Tumor in Pretargeted Mice by 188Re-Radiolabeled Phosphorodiamidate Morpholino Oligomer, a Synthetic DNA Analogue. Clin Cancer Res. 2006; 12(16):4958-4964.

33. G Liu, S Dou, J He, X Liu, M. Rusckowski, DJ Hnatowich. Predicting the biodistribution of radiolabeled cMORF effector in MORF-pretargeted mice. Eur J Nucl Med Mol Imaging. 2007; 34(2):237-46.

34. J He, M Rusckowski, Y Wang, S Dou, X Liu, S Zhang, G Liu and DJ Hnatowich. Optical pretargeting of tumor with fluorescent MORF oligomers. Molecular Imaging & Biology 2007; 9(1):17-23.

35. J He, G Liu, S Dou, S Gupta, M Rusckowski and DJ Hnatowich. An Improved Method for Covalently conjugating Morpholino oligomers to Antitumor Antibodies. Bioconjugate Chemistry. 2007, 18, 983-988.

36. He J, Jones EF, vanBrocklin HF, Seo Y, Hanahan D, Franc BL. Nanoprobes for medical diagnosis and management: Current status of nanotechnology in molecular imaging. Current Nanoscience. 2008; 4(1): 17-29.

37. Pan MH, Gao DW, Feng JJ, He J, Seo YH, Tedesco J, Wolodzko JG, Hasegawa BH, and Franc BL. Biodistributions of 177Lu- and 111In- labeled 7E11 Antibodies to Prostate-Specific Membrane Antigen in Xenograft Model of Prostate Cancer and Potential Use of 111In-7E11 as a Pretherapeutic Agent for 177Lu-7E11 Radioimmunotherapy. Mol Imaging Biol. 2008 Nov 25. [Epub ahead of print].

38. Watkins GA, Jones EF, Scott Shell M, Vanbrocklin HF, Pan MH, Hanrahan SM, Feng JJ, He J, Sounni NE, Dill KA, Contag CH, Coussens LM, Franc BL. Development of an optimized activatable MMP-14 targeted SPECT imaging probe. Bioorg Med Chem. 2009; 17(2):653-9.

39. Bidlingmaier S, He J, Wang Y, An F, Feng JJ, Gao DW, Nishimura SL, Franc BL, Broaddus C and Liu B. Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma. Cancer Research 2009; 69(4):1570-7.

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