Associate Professor in Residence, Diabetes Center, UCSF
| CONTACT | |
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mhebrok@diabetes.ucsf.edu Box 0540, UCSF; San Francisco, CA 94143-0540 |
additional websites: |
| EDUCATION | |
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Biological-Technical Assistant (BTA) School,
Bückeburg, Germany, Diploma, 1983-1985, Biology
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| PROFESSIONAL EXPERIENCE | |
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1991-1992 |
Diploma thesis, Institute for Immunobiology, Dept. of Tumorbiology, Dr. W. Bessler, advisor |
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1992-1995 |
Graduate student, Max-Planck-Institute for Immunobiology, Freiburg, Dept. of Developmental Biology, Dr. Ernst-Martin Füchtbauer, advisor; Dr. Davor Solter, Head of Department |
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1995 |
Post-doctoral Research Fellow, Max-Planck-Institute for Immunobiology in Freiburg, Dept. of Developmental Biology |
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1996-1999 |
Post-doctoral Research Fellow, Howard Hughes Medical Institute and Dept. of Molecular and Cellular Biology, Harvard University, Dr. Douglas A. Melton, advisor |
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1999-2005 |
Assistant Professor in Residence, Diabetes Research Center, Department of Medicine, University of California, San Francisco |
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2005-present |
Assistant Professor, Diabetes Research Center, Department of Medicine, University of California, San Francisco |
| HONORS & AWARDS | |
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1994 |
Graduate Student Research Award of the Hoechst AG, Frankfurt |
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1995 |
Post-doctoral Fellowship from the Max-Planck Society |
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1996 |
Post-doctoral Fellowship from the German Research Society (DFG) |
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1997-1999 |
Howard Hughes Medical Institute Postdoctoral Fellowship |
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1999 |
Sandler Program in Basic Sciences Junior Faculty Start-up Award |
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2000 |
Sandler Award in Basic Sciences |
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2000 |
Career Development Award, Juvenile Diabetes Foundation |
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2004 |
Guest-Professor, University of Ulm, Germany |
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2006 |
Scholar Award, Juvenile Diabetes Research Foundation |
| SELECTED PUBLICATIONS | |
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Hebrok, M., Wertz, K. and E.-M. Füchtbauer (1994): M-twist is an inhibitor of muscle differentiation. Dev. Biol. 165, 537-544. |
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Rohwedel, J., Horak, V., Füchtbauer, E.-M., Hebrok, M. and A. M. Wobus (1995): M-twist expression inhibits mouse embryonic stem cell-derived myogenic differentiation in vitro. Exp. Cell Res. 220, 92-100. |
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Hebrok, M., Füchtbauer, A. and E.-M. Füchtbauer (1997): Repression of muscle-specific gene activation by the murine twist protein. Exp. Cell Res. 232, 295-303. |
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Kim, S. K., Hebrok, M. and D. A. Melton (1997): Notochord to endoderm signaling is required for pancreas development. Development 124, 4243-4252. |
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Kim, S. K., Hebrok, M. and D. A. Melton (1997): Pancreas development in the chick embryo. Cold Spring Harbour Symp. Quant. Biol. 62, 377-383. |
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Hebrok, M., Kim, S. K. and D. A. Melton (1998): Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes & Development, 12, 1705-1713. |
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Hebrok, M., Kim, S. K. and D. A. Melton (1999): Screening for novel pancreatic genes expressed during embryogenesis. Diabetes 48, 1550-1556. |
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Kim, S. K., Hebrok, M., Li, E., Oh, P., Schrewe, H., Harmon, E. B., Lee, J. S. and D. A. Melton. (2000): Activin receptor patterning of foregut organogenesis. Genes & Development 14, 1866-1871. |
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Hebrok, M., Kim, S. K., St-Jacques, B., McMahon A. P. and D. A. Melton. (2000): Regulation of pancreas development by Hedgehog signaling. Development 127, 4905-4913. |
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Kim, S. K. and Hebrok, M. (2001): Intercellular signals regulating pancreas development and function. Genes & Development 15, 111-127. |
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Hebrok, M. (2003): Hedgehog signaling in pancreas development, Mech. Dev. 120, 45-57. |
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Kawahira, H., Tzanakakis, E., Ma, N., McMahon, A. P., Chuang, P.-T., and M. Hebrok (2003): Combined activities of Hedgehog signaling inhibitors regulate pancreas development. Development 130, 4871-4879. |
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Thayer, S. P., Pasca di Magliano, M., Heiser, P.W., Roberts, D. J., Nielsen, C. M., Lauwers, G. Y., Qi, Y.P., Gysin, S., Fernandez-del Castillo, F., Yajnik, V., Antoniu, B., McMahon, M., Warshaw, A. L., and M. Hebrok (2003): Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425, 851 - 856. |
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Pasca di Magliano, M., and M. Hebrok (2003): Hedgehog signalling in cancer formation and maintenance. Nature Reviews Cancer, 3, 903-911. |
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Heiser, P. W. and M. Hebrok (2004): Development and cancer: Lessons learned in the pancreas. Cell Cycle 3, 270 -272. |
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Hebrok, M. and L. F. Reichardt (2004): Brain meets pancreas: netrin, an axon guidance molecule, controls epithelial cell migration. Trends in Cell Biology, 14, 153-155. |
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Cano, D. A., Murcia, N. S., Pazour, G. J. and M. Hebrok (2004): Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development 131, 3457-3467. |
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Kawahira, H., Scheel. D. W., Smith, S. B., German, M. S., and M. Hebrok (2005): Hedgehog signaling regulates expansion of pancreatic epithelial cells. Dev. Bio, 280, 111-121. |
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Perez, S. Cano, D. A., Dao-Pick, T., Rougier, V., Werb, Z., and M. Hebrok (2005) Matrix Metalloproteinase 2 and 9 are dispensable for pancreatic islet formation and function in vivo. Diabetes 54, 694-701. |
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Lau, J., Kawahira, H., and M. Hebrok (2006): Hedgehog signaling in pancreas development and disease, Cellular and Molecular Life Sciences, 63, 642-52. |
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Heiser, P. W., Lau, J. Taketo, M., Herrera P., and M. Hebrok (2006): Stabilization of β-catenin impacts pancreas growth. Development, 133, 2023-2032. |
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Sekine, S., Lan, B., Bedolli, M., Feng, S. and M. Hebrok (2006): Liver-specific loss of β-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice. Hepatology, 43, 817-825. |
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Pasca di Magliano, M. Sekine, S., Ermilov, A. Brown, J. Dlugosz, A.A., and M. Hebrok (2006): Hedgehog/Ras interactions regulate early stages of pancreatic cancer. Genes & Development, 20, 3161-3173. |
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11/28/06 |
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