Matthias Hebrok, PhD

Biological-Technical Assistant (BTA) School, Bückeburg, Germany, Diploma, 1983-1985, Biology
Albert-Ludwigs University, Freiburg, Germany, Diploma/ Master Ph.D., 1986-1992, Cell & Molecular Biology
Max-Planck-Institute for Immunobiology, Freiburg, Germany, 1992-1995, Developmental Biology
Harvard University, Department of Molecular & Cell Biology and Howard Hughes Medical Institute, Cambridge, MA Postdoctoral Training, 1996-1999, Developmental Biology

• 1991-1992
  Diploma thesis, Institute for Immunobiology, Dept. of Tumorbiology, Dr. W. Bessler, advisor
• 1992-1995
  Graduate student, Max-Planck-Institute for Immunobiology, Freiburg, Dept. of Developmental Biology, Dr. Ernst-Martin Füchtbauer, advisor; Dr. Davor Solter, Head of Department
• 1995
  Post-doctoral Research Fellow, Max-Planck-Institute for Immunobiology in Freiburg, Dept. of Developmental Biology
• 1996-1999
  Postdoctoral Research Fellow, Howard Hughes Medical Institute and Dept. of Molecular and Cellular Biology, Harvard University, Dr. Douglas A. Melton, advisor
• 1999-2005
  Assistant Professor in Residence, Diabetes Center, University of California, San Francisco
• 2005-2009
  Associate Professor, Diabetes Center, University of California, San Francisco
• 2008
  Interim Director, Diabetes Center, University of California, San Francisco
• 2009-2010
  Associate Director of Research, Diabetes Center, University of California, San Francisco
• 2009-present
  Professor of Medicine, Diabetes Center, University of California, San Francisco
• 2010
  Interim Director, Diabetes Center, University of California, San Francisco
• 2010-present
  Director, Diabetes Center, University of California, San Francisco

• 1994
  Graduate Student Research Award of the Hoechst AG, Frankfurt
• 1995
  Post-doctoral Fellowship from the Max-Planck Society
• 1996
  Post-doctoral Fellowship from the German Research Society (DFG)
• 1997-1999
  Howard Hughes Medical Institute Postdoctoral Fellowship
• 1999
  Sandler Program in Basic Sciences Junior Faculty Start-up Award
• 2000
  Sandler Award in Basic Sciences
• 2000
  Career Development Award, Juvenile Diabetes Foundation
• 2004
  Guest-Professor, University of Ulm, Germany
• 2006
  Scholar Award, Juvenile Diabetes Research Foundation

• Hebrok, M., Kim, S. K., St-Jacques, B., McMahon A. P. and D. A. Melton. (2000): Regulation of pancreas development by Hedgehog signaling. Development 127, 4905-4913. PMID:11044404
• Kim, S. K. and Hebrok, M. (2001): Intercellular signals regulating pancreas development and function. Genes & Development 15, 111-127. PMID:11157769
• Hebrok, M. (2003): Hedgehog signaling in pancreas development, Mech. Dev. 120, 45-57. PMID:12470295
• Kawahira, H., Tzanakakis, E., Ma, N., McMahon, A. P., Chuang, P.-T., and M. Hebrok (2003): Combined activities of Hedgehog signaling inhibitors regulate pancreas development. Development 130, 4871-4879. PMID:12917290
• Thayer, S. P., Pasca di Magliano, M., Heiser, P.W., Roberts, D. J., Nielsen, C. M., Lauwers, G. Y., Qi, Y.P., Gysin, S., Fernandez-del Castillo, F., Yajnik, V., Antoniu, B., McMahon, M., Warshaw, A. L., and M. Hebrok (2003): Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425, 851 - 856. PMID: 14520413
• Pasca di Magliano, M., and M. Hebrok (2003): Hedgehog signalling in cancer formation and maintenance. Nature Reviews Cancer 3, 903-911. PMID: 14737121
• Heiser, P. W. and M. Hebrok (2004): Development and cancer: Lessons learned in the pancreas. Cell Cycle 3, 270 -272. PMID: 15226261
• Hebrok, M. and L. F. Reichardt (2004): Brain meets pancreas: netrin, an axon guidance molecule, controls epithelial cell migration. Trends in Cell Biology 14, 153-155. PMID: 15134068
• Cano, D. A., Murcia, N. S., Pazour, G. J. and M. Hebrok (2004): Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development 131, 3457-3467. PMID: 15226261
• Kawahira, H., Scheel. D. W., Smith, S. B., German, M. S., and M. Hebrok (2005): Hedgehog signaling regulates expansion of pancreatic epithelial cells. Dev. Bio. 280, 111-121. PMID: 15766752
• Perez, S. Cano, D. A., Dao-Pick, T., Rougier, V., Werb, Z., and M. Hebrok (2005) Matrix Metalloproteinase 2 and 9 are dispensable for pancreatic islet formation and function in vivo. Diabetes 54, 694-701. PMID: 15734845
• Lau, J., Kawahira, H., and M. Hebrok (2006): Hedgehog signaling in pancreas development and disease. Cellular and Molecular Life Sciences 63, 642-52. PMID: 16465449
• Heiser, P. W., Lau, J. Taketo, M., Herrera P., and M. Hebrok (2006): Stabilization of β-catenin impacts pancreas growth. Development 133, 2023-2032. PMID: 16611688
• Sekine, S., Lan, B., Bedolli, M., Feng, S. and M. Hebrok (2006): Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice. Hepatology 43, 817-825. PMID: 16557553
• Pasca di Magliano, M. Sekine, S., Ermilov, A. Brown, J. Dlugosz, A.A., and M. Hebrok (2006): Hedgehog/Ras interactions regulate early stages of pancreatic cancer. Genes & Development 20, 3161-3173. PMID: 17114586
• Cano D. A., Sekine S. and M. Hebrok (2006): Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis. Gastroenterology 131 (6):1856-69. Epub 2006 Oct 26. PMID: 17123526
• Sekine, S., Gutierrez, P. J. A., Lan, B. M., Feng, S. and M. Hebrok (2007): Liver-specific loss of beta-catenin results in delayed hepatocyte proliferation after partial hepatectomy. Hepatology 45 (2):361-368. PMID: 17256747
• Cano, D. A., Hebrok, M., and M. Zenker (2007): Pancreatic development and disease. Gastroenterology 132, 745-762. PMID: 17258745
• Morton, J.P., Mongeau, M.E., Morris, J.P., Klimstra, D.S., Lee, Y.C., Kawaguchi, Y., Wright, C.V.E., Hebrok, M., and B. C. Lewis (2007): Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. PNAS 104, 5103-5108. PMID: 17372229
• Rulifson, I. C., Heiser, P., Karnik, S. K., ten Berge, D., Gu, X., Taketo, M., Nusse, R., Hebrok, M., and Seung K. Kim (2007): Wnt signaling regulates pancreatic beta-cell proliferation. PNAS 104, 6247-6352. PMCID: PMC1847455
• Robbins, D. J. and M. Hebrok (2007): Hedgehogs: La Dolce Vita. EMBO Reports 8, 451-455. PMID: 17431408
• Puri, S. and M. Hebrok (2007): Dynamics of embryonic pancreas development using real-time imaging, Dev. Biol. 306(1):82-93, Mar 12. PMID: 17448459
• Nawroth, R., Cervantes, S., McManus, M., Hebrok, M. and S. D. Rosen (2007): Extracellular sulfatases, elements of the wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells. PLoS ONE 2007 Apr 25;2:e392. PMID: 17460759
• Pasca di Magliano, M. Biankin, A. V., Heiser, P. W., Cano, D. A., Gutierrez, P. J. A., Deramaudt, T., Segara, D., Dawson, A. C., Kench, J. G., Henshall, S. M., Sutherland, R. L., Dlugosz, A., Rustgi, A. K., and M. Hebrok (2007): Wnt signaling in pancreatic cancer. PLoSONE 2(11): e1155. PMID: 17982507
• Lee, J., Wu, X., Pasca di Magliano, M., Peters, E. C., Wang, Y., Hong, J., Hebrok, M., Ding, S., Cho, C. Y. and P. G. Schultz. (2007): A Small Molecule Antagonist of the Hedgehog Signaling Pathway. ChemBioChem 8 (16):1916-1919. PMID: 17886323
• Burris, R. and M. Hebrok (2007): Pancreatic innervation in mouse development and beta-cell regeneration. Neuroscience 150 (3):592-602. Epub 2007 Oct 11. PMID: 18006238
• Regard. J., Kataoka, H., Cano, D., Camerer, E., Yin, L., Zheng, Y.-W., Dolganov, G., Kobilka, B., Scanlan, T., Hebrok, M. and S. R. Coughlin (2007): Probing cell type specific functions of Gi signaling in vivo identifies novel regulators of insulin secretion. Journal of Clinical Investigation 117 (12):4034-43. PMID: 17992256
• Cano, D.A., Rulifson, I.C., Heiser, P.W., Swigart, L.B., Pelengaris, German, M.S., Evan, G. I., Bluestone, J.A., and M. Hebrok (2008): Regulated beta-cell regeneration in the adult mouse pancreas, Diabetes 7 (4): 958-966, Dec 14. 2007. PMID: 18083786
• Bluestone, J.A. and M. Hebrok (2008): Safer, longer-lasting regulatory T cells with stable beta-catenin. Nature Medicine 14(2):118-119. PMID: 18256611
• Heiser, P. W., Cano, D. A., Kim, G. E., Kench, J. G., Klimstra, D. S., Taketo, M., Biankin, A. V., and M. Hebrok (2008): Stabilization of beta-catenin induces pancreas tumor formation. Gastroenterology 2008 Jul 9. 135(4):1288-300. PMID: 18725219
• Cano, D. A., and M. Hebrok (2008): Hedgehog spikes pancreas regeneration, Gastroenterology 135, 347-351. PMID: 18619970
• Cano, D.A., Rulifson, I.C., Heiser, P.W., Swigart, L.B., Pelengaris, German, M.S., Evan, G. I., Bluestone, J.A., and M. Hebrok (2008): Regulated beta-cell regeneration in the adult mouse pancreas, Diabetes 7 (4): 958-966, Dec 14. 2007.
• Puri, S., Cano, D. A., and M. Hebrok (2009): A role for Von-Hippel Lindau Protein in Pancreatic beta-cell function. Diabetes, 58(2):433-41, 2008 Nov. 25.
• Cervantes, S., Yamaguchi, T. and M. Hebrok (2009): Wnt5a is essential for intestinal elongation. Developmental Biology, 326(2):285-94, 2008 Dec 7. PMID: 19100728
• Puri, S., Cano, D. A., and M. Hebrok (2009): A role for Von-Hippel Lindau Protein in Pancreatic beta-cell function. Diabetes, 58(2):433-41, 2008 Nov. 25. PMID: 19033400
• Nolan-Stevaux, O., Lau, J., Truitt, M. L., Chu, G. C., Hebrok, M., Fernandez-Zapico, M. and D. Hanahan (2008): GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes & Development 23 (1): 24-36. PMID:19136624
• Kockel, L., Kerr, K., Melnick, M., Hebrok, M. and N. Perrimon (2008): Dynamic switch of negative feedback regulation in Drosophila Akt-Tor signaling. in revision.
• Sekine, S., Ogawa, R., Ito, R., Hiraoka, N., McManus, M.T., Kanai, Y., and M. Hebrok (2009): Hepatocyte-specific disruption of Dicer1 induces dysregulated oncofetal gene expression and promotes hepatocarcinogenesis. Gastroenterology, 136: 2304-2315. PMID: 19272382
• Nolan-Stevaux, O., Lau, J., Truitt, M. L., Chu, G. C., Hebrok, M., Fernandez-Zapico, M. and D. Hanahan (2009): GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes & Development 23 (1): 24-36.
• Morris, J. P., Cano, D. A., Sekine, S., Wang, S. and M. Hebrok (2010): beta-catenin blocks Kras dependent reprogramming of acini into pancreatic cancer precursor lesions in mice. J Clin Invest., 120(2):508-20; 2010 Jan 11. pii: 40045. doi: 10.1172/JCI40045.
• Cervantes, S., Lau, J., Cano, D. A., Borromeo-Austin, C. and M. Hebrok (2010): Primary cilia regulate Gli/Hedgehog activation in pancreas. PNAS, in press.