Millie Hughes-Fulford, PhD

Tarleton State University, Stephenville, TX, B.S., 1968, Chemistry and Biology
Texas Women’s University, Denton, TX, Ph.D., 1972, Radiation Chemistry
Woods Hole, Post-Graduate Training, 1987, Summer Physiology courses; 1999, Microscopy course

• 1973-1985
  Research Chemist, VAMC San Francisco, CA
• 1977-1984
  Adjunct Assistant Professor; Biochemistry, Department of Medicine; University of California, San Francisco; and San Francisco Extension Faculty, Biochemistry, UC Berkeley
• 1984-1991
  Astronaut Scientist, Spacelab Life Sciences-l, JSC, Houston
• 1984-1994
  Adjunct Associate Professor of Biochemistry, Dept. of Medicine, UCSF, San Francisco
• 1995- 2001
  Deputy Associate Chief of Staff for Education VAMCSF
• 1991-present
  Scientific Advisor to the Undersecretary of the Department of Veteran's Affairs
• 1993-present
  Director, Laboratory of Cell Growth, VAMC/UCSF
• 1993-present
  Scientific Advisor to the UnderSecretary, Dept of Veteran's Affairs, Washington, DC
• 1994-present
  Adjunct Professor in Medicine, Dept. of Medicine, UCSF, San Francisco
• 1996-present
  Research Scientist, NCIRE
• 2001-present
  Principal Medical Investigator, VAMC

• 1965
  National Science Foundation Summer Research Fellow (Undergraduate)
• 1968-1971
  National Science Foundation Fellowship (Graduate)
• 1971-1972
  American Association of University Women's Fellowship
• 1984
  Presidential Award for Federal Employee for Western Region
• 1995
  Woman of the Year Marin county
• 1995
  Named International Zontian, 1995

• (selected from 76)
• R. Tjandrawinata, R. Dahiya, and M. Hughes-Fulford. Induction of cyclooxygenase-2 mRNA by prostaglandin E2 in prostate cancer, British Journal of Cancer, 75:8: 1111-1118, 1997
• R. Tjandrawinata, and M. Hughes-Fulford. Upregulation of Cyclooxygenase 2 by Product, Prostaglandin E2 in prostate cancer Adv. Exp. Med. Biol. 407: 163-170,1997
• M. Hughes-Fulford. Growth Regulation of Gardners Syndrome Colorectal Cancer Cells by NSAIDs Adv. Exp. Med. Biol. 407: 433-441,1997
• R. Tjandrawinata, V. L.Vincent, and M. Hughes-Fulford. Vibrational Force Alters mRNA Expression in Osteoblasts. FASEB 11:493-497. 1997
• M. Hughes-Fulford. Prostaglandin regulation of gene expression and growth in normal and malignant tissues Adv. Exp. Med. Biol. 400A: 269-278,1997
• M. Hughes-Fulford, R. Tjandrawinata, J. Fitzgerald, K. Gasuad and V. Gilbertson. Effects of microgravity on osteoblast growth. ASGSB Bulletin vol. 11(2), 51-60,1998
• M. Hughes-Fulford, R. Tjandrawinata, J. Fitzgerald, K. Gasuad and V. Gilbertson. Effect of microgravity on osteoblast growth activation: Analysis of transcription, translation and morphology, In: Perry M, ed. Biorack on Spacehab: biological experiments on three Shuttle-to-Mir missions. Noordwijk, The Netherlands: ESA Publ. Div. p. 25-32. (European Space Agency SP ; 1222,1999
• M. Hughes-Fulford and V. Gilbertson. Osteoblast fibronectin mRNA, protein synthesis and matrix is not changed after long term exposure to microgravity.(FASEB J 13, S121-1281999
• J. Fitzgerald and M. Hughes-Fulford. Mechanically induced c-fos expression is mediated by cAMP in MC3T3-E1 osteoblasts FASEB J, 13: 553-557,1999
• D. Lum, K. McQuaid, and M. Hughes-Fulford. Co-ordinate up regulation of low-density lipoprotein receptor and cyclooxygenase-2 gene expression in human colorectal adenocarcinomas Int. J of Cancer. 8:83(2): 162-166,1999
• M. Hughes-Fulford. Using cell biology in planning the Mars Mission, The Biochemist 19-23,1999
• M. Lewis and M. Hughes-Fulford. Regulation of heat shock protein message in Jurkat cells cultured under serum starved and gravity altered conditions Journal of Cellular Biochemistry 77(1):127-134, 2000
• J. Fitzgerald, T. Dietz, and M. Hughes-Fulford. PGE2 induced upregulation of c-fos mRNA is primarily mediated by cAMP in MC-3T3 cells. Endocrinology, 141 (1), 1-8,2000
• Y. Chen, M. Hughes-Fulford. Prostaglandin E2 and the protein kinase A pathway mediate arachidonic acid induction of c-fos in human prostate cancer cells British Journal of Cancer, V 82, 12, pp. 2000-2006, 2000
• Y. Chen, M. Hughes-Fulford. Human prostate cancer cells lack feedback regulation of low-density lipoprotein receptor and its regulator, SREBP2. J Cancer. 1;91(1):41-5.2001
• M. Hughes-Fulford, Y. Chen, R. Tjandrawinata. Fatty acid regulates gene expression and growth of human prostate cancer PC-3 cells. Carcinogenesis 22(5):701-7. 2001
• Hughes-Fulford M., The role of signaling pathways in osteoblast gravity perception. J Gravit Physiol. Jul;9(1):P257-60. 2002
• Hughes-Fulford, M., The role os signaling pathways in osteoblast gravity perception. J Gravit Physiology. (1) 257-60,2002
• Millie Hughes-Fulford The role of signaling pathways in osteoblast gravity perception. J Gravit Physiol. Jul;9(1):P257-60,2002
• Hughes-Fulford, M. Changes in gene expression and signal transduction in microgravity. J Gravit Physiol. Jul;8(1):P1-4, 2001
• M Hughes-Fulford, Changes in gene expression in signal transduction in microgravity, Journal of Gravitational Physiology, P1-4, 2002
• Millie Hughes-Fulford Function of the cytoskeleton in gravisensing during spaceflight. Adv Space Res. 2003;32(8):1585-93.
• Millie Hughes-Fulford, Physiological effects of microgravity on osteoblast morphology and cell biology, Advances in Space Biology and Medicine, Volume 8: 129-157 2003.
• Hatton JP, Pooran, M. C-F Li, C Luzzio, Fulford, MH, A short pulse of mechanical force induces gene expression and growth in MC3T3-E1 osteoblasts via an ERK 1/2 pathway, JBMR 1 (1) 1-9, 2003
• Hughes-Fulford, M, Signal transduction and mechanical stress, Scienceonline Sci STKE. 2004 Aug 31;2004(249):RE12.
• Millie Hughes-Fulford, Eiko Sugano, Thomas Schopper, Chai-Fei Li ,J. B. Boonyaratanakornkit and Augusto Cogoli, Early immune response and regulation of IL-2 receptor subunits, Cell Signal. 2005 Sep;17(9):1111-1124. Epub 2005 Feb 25.