UCSF Helen Diller Family Comprehensive Cancer Center

David M. Jablons, MD

Ada Distinguished Professorship in Thoracic Oncology, UCSF

CONTACT

(415) 885-3882 (appts)
(415) 353-9525 (fax)

Box 1724, UCSF; San Francisco, CA 94143-1724

additional websites:

UCSF Physician Referral Directory
Thoracic Oncology Lab

EDUCATION

Yale College, BA, 1975-79, American Literature
Albany Medical Col. of Union U, MD, 1979-84
Naval Hospital, Intern, 1984-85, Surgery
Tufts University, Resident, 1985-86, Surgery
National Cancer Institute, National Institutes of Health, Fellow, 1986-89, Surgical Oncology
Tufts University, 1989-91, Surgery
Brigham & Women's Hospital, Fellow, 1992-92, Lung Transplantation
Cornell University Medical Center, Fellow, 1991-93, Surgery

PROFESSIONAL EXPERIENCE

1993-95

Naval Medical Center, Attending, Cardiothoracic Surgery

1994-95

University of California, San Francisco School of Medicine, Assistant Clinical Professor, Cardiothoracic Surgery

1995-00

University of California, San Francisco School of Medicine, Assistant Professor, Cardiothoracic Surgery

2000-04

University of California, San Francisco School of Medicine, Associate Professor, Cardiothoracic Surgery

2004-present

University of California, San Francisco School of Medicine, Professor, Cardiothoracic Surgery

2007-present

University of California, San Francisco School of Medicine, Ada Distinguished Professor of Thoracic Oncology Surgery

1986-89

Fleet Hospital, Lieutenant, Medical Corps, USNR Staff Surgeon

1989-91

Fleet Hospital, Lieutenant Commander, Medical Corps,USNR Staff Surgeon

1991-93

Fleet Hospital, Lieutenant Commander, Medical Corps,USNR Staff Surgeon

1997-present

UCSF Medical Center, Chief, Section of General Thoracic Surgery

SELECTED PUBLICATIONS

(from 127)

Kim JY, Harvard C, You L, Xu Z, Kuchenbecker K, Baehner R, Jablons D. Stathmin is overexpressed in malignant mesothelioma., Anticancer Res 27: 39-44

Uematsu K, Seki N, Seto T, Isoe C, Tsukamoto H, Mikami I, You L, He B, Xu Z, Jablons DM, Eguchi K. Targeting the Wnt signaling pathway with dishevelled and cisplatin synergistically suppresses mesothelioma cell growth., Anticancer Res 27: 4239-42

Yagui-Beltrán A, He B, Jablons DM. The role of cancer stem cells in neoplasia of the lung: past, present and future., Clin Transl Oncol 10: 719-25, Nov/2008.

Okamoto J, Mikami I, Tominaga Y, Kuchenbecker KM, Lin YC, Bravo DT, Clement G, Yagui-Beltran A, Ray MR, Koizumi K, He B, Jablons DM. Inhibition of Hsp90 leads to cell cycle arrest and apoptosis in human malignant pleural mesothelioma., J Thorac Oncol 3: 1089-95, Oct/2008.

Raz DJ, Ray MR, Kim JY, He B, Taron M, Skrzypski M, Segal M, Gandara DR, Rosell R, Jablons DM. A multigene assay is prognostic of survival in patients with early-stage lung adenocarcinoma., Clin Cancer Res 14: 5565-70, Sep/1/2008.

Skrzypski M, Jassem E, Taron M, Sanchez JJ, Mendez P, Rzyman W, Gulida G, Raz D, Jablons D, Provencio M, Massuti B, Chaib I, Perez-Roca L, Jassem J, Rosell R. Three-gene expression signature predicts survival in early-stage squamous cell carcinoma of the lung., Clin Cancer Res 14: 4794-9, Aug/1/2008.

You L, Xu Z, Punchihewa C, Jablons DM, Fujii N. Evaluation of a chemical library of small-molecule Dishevelled antagonists that suppress tumor growth by down-regulating T-cell factor-mediated transcription., Mol Cancer Ther 7: 1633-8, Jun/2008.

Wilson SM, Barbone D, Yang TM, Jablons DM, Bueno R, Sugarbaker DJ, Nishimura S, Gordon GJ, Broaddus VC. mTOR Mediates Survival Signals in Malignant Mesothelioma Grown as Tumor Fragment Spheroids., Am J Respir Cell Mol Biol May/29/2008.

Calhoun R, Jablons D, Lau D, Gandara DR. Adjuvant treatment of stage IB NSCLC: the problem of stage subset heterogeneity., Oncology (Williston Park) 22: 511-6; discussion 516, 521-3, Apr/30/2008.

Chou J, Lin YC, Kim J, You L, Xu Z, He B, Jablons DM. Nasopharyngeal carcinoma-Review of the molecular mechanisms of tumorigenesis., Head Neck Apr/29/2008.

Rosell R, de Las Peas R, Balaa C, Santarpia M, Salazar F, de Aguirre I, Reguart N, Villa S, Wei J, Ramirez JL, Molina MA, Ramon y Cajal S, Jablons D, Taron M. Translational research in glioblastoma multiforme: molecular criteria for patient selection., Future Oncol 4: 219-28, Apr/2008.

Kim J, Raz D, Jablons D. Unmet need in lung cancer: can vaccines bridge the gap?, Clin Lung Cancer 9 Suppl 1: S6-12, Feb/2008.

Reich J, Asaph J, Raz DJ, Jablons DM. Natural history of stage I lung cancer., Chest 132: 2062-3, Dec/2007.

Mazieres J, Tovar D, He B, Acosta-Jacobo N, Marty-Detraves C, Clanet C, Pradines A, Jablons DM, Favre G. Epigenetic regulation of RhoB loss of expression in lung cancer., BMC Cancer 7: 220, Nov/30/2007.

Clément G, Guilleret I, He B, Yagui-Beltrán A, Lin YC, You L, Xu Z, Shi Y, Okamoto J, Benhattar J, Jablons D. Epigenetic alteration of the Wnt inhibitory factor-1 promoter occurs early in the carcinogenesis of Barrett's esophagus., Cancer Sci Nov/13/2007.

Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL. Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients., J Clin Invest 117: 3551-3562, Nov/1/2007.

Shi Y, He B, You L, Jablons DM. Roles of secreted frizzled-related proteins in cancer., Acta Pharmacol Sin 28: 1499-504, Sep/2007.

Raz DJ, Kim JY, Jablons DM. Diagnosis and treatment of bronchioloalveolar carcinoma., Curr Opin Pulm Med 13: 290-6, Jul/2007.

Brouchet L, Bauvin E, Marcheix B, Bigay-Game L, Renaud C, Berjaud J, Falcoze PE, Venissac N, Raz D, Jablons D, Mazires J, Dahan M. Impact of induction treatment on postoperative complications in the treatment of non-small cell lung cancer., J Thorac Oncol 2: 626-31, Jul/2007.

Gandara DR, Wakelee H, Calhoun R, Jablons D. Adjuvant chemotherapy of stage I non-small cell lung cancer in North America., J Thorac Oncol 2: S125-7, Jul/2007.

Raz DJ, Zell JA, Ou SH, Gandara DR, Anton-Culver H, Jablons DM. Natural history of stage I non-small cell lung cancer: implications for early detection., Chest 132: 193-9, Jul/2007.

Shi Y, He B, Kuchenbecker KM, You L, Xu Z, Mikami I, Yagui-Beltran A, Clement G, Lin YC, Okamoto J, Bravo DT, Jablons DM. Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells., Int J Cancer May/29/2007.

Raz DJ, Jablons DM. EGFR expression and mutational analysis as a predictive test., J Clin Oncol 25: 2144; author reply 2144-5, May/20/2007.

Raz DJ, Jablons DM. Five-gene signature in non-sall-cell lung cancer., N Engl J Med 356: 1582; author reply 1583, Apr/12/2007.

Lin YC, You L, Xu Z, He B, Yang CT, Chen JK, Mikami I, Clément G, Shi Y, Kuchenbecker K, Okamoto J, Kashani-Sabet M, Jablons DM. Wnt Inhibitory Factor-1 Gene Transfer Inhibits Melanoma Cell Growth., Hum Gene Ther 18: 379-386, Apr/2007.

Lee AY, Raz DJ, He B, Jablons DM. Update on the molecular biology of malignant mesothelioma., Cancer Mar/8/2007.

Chen AM, Jahan TM, Jablons DM, Garcia J, Larson DA. Risk of cerebral metastases and neurological death after pathological complete response to neoadjuvant therapy for locally advanced nonsmall-cell lung cancer: clinical implications for the subsequent management of the brain., Cancer Mar/6/2007.

Clément G, Jablons DM, Benhattar J. Targeting the Wnt signaling pathway to treat Barrett's esophagus., Expert Opin Ther Targets 11: 375-389, Mar/2007.

Brouchet L, Bauvin E, Marcheix B, Bigay-Game L, Renaud C, Berjaud J, Falcoze PE, Venissac N, Raz D, Jablons DM, Mazieres J, Dahan. Impact of Induction Treatment on Postoperative Complications in the Treatment of Non-Small Cell Lung Cancer,, Journal of Thoracic Oncology 03/2007.

Kim J, You L, Xu Z, Kuchenbecker K, Raz D, He B, Jablons D. Wnt inhibitory factor inhibits lung cancer cell growth., J Thorac Cardiovasc Surg 133: 733-7, Mar/2007.

Raz DJ, Glidden DV, Odisho AY, Jablons DM. Clinical characteristics and survival of patients with surgically resected, incidentally detected lung cancer., J Thorac Oncol 2: 125-30, Feb/2007.

Fujii N, You L, Xu Z, Uematsu K, Shan J, He B, Mikami I, Edmondson LR, Neale G, Zheng J, Guy RK, Jablons DM. An Antagonist of Dishevelled Protein-Protein Interaction Suppresses {beta}-Catenin-Dependent Tumor Cell Growth., Cancer Res 67: 573-9, Jan/15/2007.

Leong SP, Cady B, Jablons DM, Garcia-Aguilar J, Reintgen D, Werner JA, Kitagawa Y. Patterns of metastasis in human solid cancers., Cancer Treat Res 135: 209-21, 2007.

Mazieres J, Tovar D, He B, Nieto-Acosta J, Marty-Detraves C, Clanet C, Pradines A, Jablons DM, Favre G. Epigenetic Regulation of RhoB loss of expression in lung cancer, BMC Cancer TBD: TBD, 2007.

Raz DJ, Odisho AY, Franc BL, Jablons DM. Tumor fluoro-2-deoxy-D-glucose avidity on positron emission tomographic scan predicts mortality in patients with early-stage pure and mixed bronchioloalveolar carcinoma., J Thorac Cardiovasc Surg 132: 1189-95, Nov/2006.

Raz D, Zell J, Karnezis A, Odisho A, Ignatius I, Anton Culver H, Jablons DM. Misclassification of Bronchioloalveolar Carcinoma with Cytologic Diagnosis of Lung Cancer., Journal of Thoracic Oncology 1: 943-948, Nov/2006.

Raz DJ, Zell JA, Karnezis AN, Odisho A, Ignatius Ou SH, Anton-Culver H, Jablons DM. Misclassification of bronchioloalveolar carcinoma with cytologic diagnosis of lung cancer., J Thorac Oncol 1: 943-8, Nov/2006.

Zhou BB, Peyton M, He B, Liu C, Girard L, Caudler E, Lo Y, Baribaud F, Mikami I, Reguart N, Yang G, Li Y, Yao W, Vaddi K, Gazdar AF, Friedman SM, Jablons DM, Newton RC, Fridman JS, Minna JD, Scherle PA. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer., Cancer Cell 10: 39-50, Jul/2006.

Raz DJ, He B, Rosell R, Jablons DM. Current concepts in bronchioloalveolar carcinoma biology., Clin Cancer Res 12: 3698-704, Jun/15/2006.

Leong SP, Cady B, Jablons DM, Garcia-Aguilar J, Reintgen D, Jakub J, Pendas S, Duhaime L, Cassell R, Gardner M, Giuliano R, Archie V, Calvin D, Mensha L, Shivers S, Cox C, Werner JA, Kitagawa Y, Kitajima M. Clinical patterns of metastasis., Cancer Metastasis Rev 25: 221-32, Jun/2006.

Raz D, Jablons DM. Bronchioloalveolar Carcinoma Is Not Associated with Younger Age at Diagnosis: an Analysis of the SEER Database. , J Thorac Oncol. 1: 339-343, 5/1/2006 12:00:00 AM.

Raz DJ, Jablons DM. Bronchioloalveolar carcinoma is not associated with younger age at diagnosis: an analysis of the SEER database., J Thorac Oncol 1: 339-43, May/2006.

Batra S, Shi Y, Kuchenbecker KM, He B, Reguart N, Mikami I, You L, Xu Z, Lin YC, Clément G, Jablons DM. Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma., Biochem Biophys Res Commun 342: 1228-32, Apr/21/2006.

Lin YC, You L, Xu Z, He B, Mikami I, Thung E, Chou J, Kuchenbecker K, Kim J, Raz D, Yang CT, Chen JK, Jablons DM. Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines., Biochem Biophys Res Commun 341: 635-40, Mar/10/2006.

Raz DJ, He B, Rosell R, Jablons DM. Bronchioloalveolar carcinoma: a review., Clin Lung Cancer 7: 313-22, Mar/2006.

Rosell R, Cecere F, Cognetti F, Cuello M, Sanchez JM, Taron M, Reguart N, Jablons D. Future directions in the second-line treatment of non-small cell lung cancer., Semin Oncol 33: S45-51, Feb/2006.

Nemunaitis J, Jahan T, Ross H, Sterman D, Richards D, Fox B, Jablons D, Aimi J, Lin A, Hege K. Phase 1/2 trial of autologous tumor mixed with an allogeneic GVAX((R)) vaccine in advanced-stage non-small-cell lung cancer., Cancer Gene Ther Jan/6/2006.

You L, Kim J, He B, Xu Z, McCormick F, Jablons DM. Wnt-1 signal as a potential cancer therapeutic target., Drug News Perspect 19: 27-31, 2006.

He B, Jablons DM. Wnt signaling in stem cells and lung cancer., Ernst Schering Found Symp Proc 5: 27-58, 2006.

Reguart N, He B, Taron M, You L, Jablons DM, Rosell R. The role of Wnt signaling in cancer and stem cells., Fut Oncol 1: 787-797, Dec/2005.

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