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Helen Diller Family Compr Cancer Ctr
ALEXANDER D. JOHNSON, PHD

Professor, Microbiology/Immunology and Biochemistry/Biophysics; Vice Chair, Department of Microbiology & Immunology, UCSF
Member, Herbert Boyer Program in Biological Sciences (PIBS)

CONTACT

ajohnson@cgl.ucsf.edu
(415) 476-8097, 502-0859 (voice)
(415) 502-4315 (fax)

Box 2200, UCSF; San Francisco, CA 94143-2200

additional websites:

Johnson Lab Website

EDUCATION

Vanderbilt University, Nashville TN, B.A., 1974, Biochemistry
Harvard University, Cambridge MA, M.A., Ph.D., 1980, Biochemistry
University of California, San Francisco, Postdoctoral, 1981-85, Biochemistry

PROFESSIONAL EXPERIENCE

1975-1980

Graduate student with Mark Ptashne, Department of Biochemistry & Molecular Biology, Harvard University.

1980-1981

Postdoctoral fellow with Mark Ptashne, Department of Biochemistry & Molecular Biology, Harvard University.

1981-1985

Postdoctoral fellow with Ira Herskowitz, Department of Biochemistry and Biophysics, UCSF.

1985-1990

Assistant Professor, Department of Microbiology & Immunology, Joint Appointment in Biochemistry and Biophysics, UCSF.

1991-1995

Associate Professor, Departments of Microbiology & Immunology, and Biochemistry and Biophysics.

1995-present

Professor, Departments of Microbiology & Immunology, and Biochemistry and Biophysics.

2003-present

Vice Chair, Department of Microbiology & Immunology, University of California, San Francisco

HONORS & AWARDS

1974

B.A. summa cum laude

1974

Phi Beta Kappa

1974-1977

Dreyfus Scholarship

1981-1983

Damon Runyon-Walter Winchell Postdoctoral Fellowship

1983-1985

American Cancer Society Senior Postdoctoral Fellowship

1986-1990

Pew Scholarship

1998

Elected to American Academy of Microbiology

1999-2004

Burroughs Wellcome Merit Award

SELECTED PUBLICATIONS

(out of 78 total)

Pérez-Martín, J. and Johnson, A.D. (1998) The C-terminal domain of Sin1 interacts with the SWI/SNF complex in yeast. Mol Cell Biol 18: 4157-4164.

Wahi, M., Komachi, K., and Johnson, A.D. (1998) Gene regulation by the yeast Ssn6-Tup1 corepressor. Cold Spring Harbor Symp Quant Biol 63: 446-457.

Stark, M., Escher, D., and Johnson, A.D. (1999) A trans-acting peptide activates the yeast a1 repressor by raising its DNA-binding affinity. Embo J 18: 1621-1629.

Pérez-Martín, J., Uría, J.A., and Johnson, A.D. (1999) Phenotypic switching in Candida albicans is controlled by a SIR2 gene. Embo J 18: 2580-2592.

Hull, C. and Johnson, A.D. (1999) Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans. Science 285: 1271-1275.

Braun, B.R., and Johnson, A.D. (2000). TUP1, CPH1 and EFG1 make independent contributions to filamentation in Candida albicans. Genetics 155: 57-67.

Braun, B.R., Head S.W., Wang, M.S., and Johnson, A.D. (2000). Identification and characterization of TUP1 ив regulated genes in Candida albicans. Genetics 156: 31-44.

Tran, H., Steger, D.J. Iyer, V.R., and Johnson, A.D. (2000). The chromo domain protein Chd1p from budding yeast is an ATP-dependent chromatin-modifying factor. Embo J 19: 2340-2350.

Smith, R. and Johnson, A.D. (2000). A sequence resembling a peroxisomal targeting sequence directs the interaction between the tetratricopeptide repeats of Ssn6 and the homeodomain of a2. Proc Natl Acad Sci USA, 97: 3901-3906.

Sprague, E.R., Redd, J.M., Johnson, A.D. and Wolberger, C. (2000) Structure of the C-terminal domain of Tup1, a corepressor of transcription in yeast. EMBO J. 19: 3016-3027.

Hull, C., Raisner, R., and Johnson, A.D. (2000). Evidence for mating of the asexual yeast Candida albicans in a Mammalian Host. Science 289: 307-310.

Smith, R.L., and Johnson, A.D. (2000). Turning genes off by Ssn6-Tup1: a conserved system of transcriptional repression in eukaryotes. TIBS 25: 325-330.

Braun, B.R., Head S.W., Wang, M.S., and Johnson, A.D. (2000). Identification and characterization of TUP1 ив regulated genes in Candida albicans. Genetics 156: 31-44.

Kadosh, D., and Johnson, A.D. (2001) Rfg1, a protein related to the Saccharomyces cerevisiae hypoxic regulator Rox1, controls filamentous growth and virulence in Candida albicans. Mol Cell Biol 21: 2496-2505.

Uhl, M.A., and Johnson, A.D. (2001) Development of Streptococcus thermophilus lacZ as a reporter gene for Candida albicans. Microbiology 147: 1189-1195.

Braun, B.R., Kadosh, D., and Johnson, A.D. (2001). NRG1, a repressor of filamentous growth in C. albicans, is down-regulated during filament induction. EMBO J 20: 4753-4761.

Miller, M.G., and Johnson, A.D. (2002) White-opaque switching in Candida albicans is controlled by mating-type (MTL) locus homeodomain proteins and allows efficient mating. Cell 110: 293-302.

Lockhart, S.R., Pujol, C., Daniels, K.J., Miller, M.G., Johnson, A.D., Pfaller, M.A., and Soll, D.R. (2002) In Candida albicans, white-opaque switchers are homozygous for mating type. Genetics 162:737-745

Inglis, D.O., and Johnson, A.D. (2002) Ash1 protein, an asymmetrically localized transcriptional regulator, controls filamentous growth and virulence of Candida albicans. Mol Cell Biol 22: 8669-8680.

Simic, R., Lindstrom, D.L., Tran, H.G., Roinick, K.L., Costa, P.J., Johnson, A.D., Hartzog, G.A., and Arndt, K.M. (2003) Chromatin remodeling protein Chd1 interacts with transcription elongation factors and localizes to transcribed genes. EMBO J 22: 1-11.

Bennett, R.J., and Johnson, A.D. (2003) Completion of a parasexual cycle in Candida albicans by induced chromosome loss in tetraploid strains. EMBO J 22: 2505-2515.

Uhl, M.A., Biery, M., Craig, N., and Johnson, A.D. (2003) Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C. albicans. EMBO J 22: 2668-2678.

Bennett, R.J., Uhl, M.A., Miller, M.G., and Johnson, A.D. (2003) Identification and characterization of a Candida albicans mating pheromone. Mol. Cell. Biol. 23: 8189-8201.

Johnson, A.D. (2003) The biology of mating in Candida albicans. Nat. Rev. Microbio. 1: 106-116.

Tsong, A.E., Miller, M.G., Raisner, R.M., and Johnson, A.D. (2003) Evolution of a combinatorial transcriptional circuit: a case study in yeasts. Cell 115: 389-399.

Bennett, R.J., Miller, M.G., Chua, P.R., Maxon, M.E., Johnson, A.D. (2004) Nuclear fusion occurs during mating in C. albicans and is dependent on the KAR3 gene. Mol Micro, Submitted.

11/15/04

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