Stephen B. Kahl, PhD

Duke University, Durham, NC, B.S., 1968, Chemistry
Indiana University, Bloomington, IN, Ph.D., 1972, Inorganic Chemistry

• 1972-73
  University of California, Berkeley; Postdoctoral Research Associate with Professor K.N. Raymond, Department of Chemistry
• 1973-74
  University of California, Berkeley; Postdoctoral Research Associate with Professor John H. Reynolds, Department of Physics
• 1974-82
  Wellesley College; Assistant Professor of Chemistry
• 1978-79
  University of California San Francisco; Visiting Assistant Professor of Chemistry (Sabbatical with Professor Manfred E. Wolff)
• 1976,1977, 1983-2004
  Stanford University; Visiting Professor of Chemistry (Summers)
• 1982-85
  University of California San Francisco; Visiting Assistant Professor of Chemistry and Pharmaceutical Chemistry
• 1985-1990
  University of California San Francisco; Assistant Professor of Chemistry and Pharmaceutical Chemistry
• 1990-1995
  University of California San Francisco, Associate Professor of Chemistry and Pharmaceutical Chemistry
• 1993-present
  Vice Chair, Department of Pharmaceutical Chemistry, UCSF
• 1995-present
  Professor of Chemistry and Pharmaceutical Chemistry, University of California San Francisco
• 1995-present
  Member, UCSF Molecular Design Institute
• 1995-present
  Member, UCSF Cancer Center Neuro-Oncology Program
• 1995-present
  Member, UCSF Chemistry and Chemical Biology Graduate Program

• Lieber Memorial University Teaching Award, Indiana University, 1972
• Council for International Exchange of Scholars for Fulbright Fellowship in Ghana, 1978
• Long Foundation Prize for Excellence in Teaching, UCSF, 1985
• Academic Senate Distinguished Teaching Award, UCSF, 1988
• Chosen One of UCSF's 125 Most Outstanding People, 1990
• International Society for Neutron Capture Award for Excellence in Research, 1990

• Simple, High Yield Methods for the Synthesis of Aldehydes Directly from Ortho, Meta and Para-Carborane and Their Further Conversions, P. Dozzo, R.A. Kasar, S.B. Kahl, Inorg. Chem. 44, 8053-8057 (2005).
• Toxicity, Biodistribution, and Convection-Enhanced Delivery of the Boronated Porphyrin BOPP in the 9L Intracerebral Rat Glioma Model, T. Ozawa, J. Afzal, B.J. Wyrick, J. Wang, M. Zhang, K.R. Lamborn, A.W. Bollen, W.F. Bauer, M.-S. Koo, S.B. Kahl, D.F. Deen, Intl. J. Radiat. Biol. Oncol. and Physics 63, 247-252 (2005).
• Synthesis, Characterization and Lipoprotein Association of a Nuclear Targeted Boronated Porphyrin, P. Dozzo, M.-S. Koo, S. Berger, T.M Forte and S.B. Kahl, J. Med. Chem. 48, 357-359 (2005).
• Biodistribution of Boron Compounds in a Model of Human Undifferentiated Thyroid Cancer for Boron Neutron Capture Therapy, M.A. Dagrosa, M. Viaggi, R. Rebagliati, D. Batistoni, S.B. Kahl, G.J. Juvenal and M.A. Pisarev, Molecular Pharmaceutics 2, 151-156 (2005).
• Boron Neutron Capture Therapy for Undifferentiated Thyroid Carcinoma: Preliminary Results with the Combined Use of BPA and BOPP, M. Viaggi, M.A. Dagrosa, J. Longhino, H. Blaumann, O. Calzetta, S.B. Kahl, G.C. Juvenal and M.A. Pisarev, Appl. Radiat. Isotopes 64, 905-909 (2004).
• In Vivo Evaluation of the Boronated Porphyrin TABP-1 in U-87 MG Intracerebral Human Glioblastoma Xenografts, T. Ozawa, R.A. Santos, K.R. Lamborn, A.W. Bollen, W.F. Bauer, M.-S. Koo, S.B. Kahl and D.F. Deen, Molecular Pharmaceutics 1, 368-374 (2004).
• Synthesis of Ether- and Carbon-Linked Polycarboranyl Porphyrin Dimers for Cancer Therapies. M.F. Isaac and S.B. Kahl, J. Organometallic Chem. 680, 232-243 (2003).
• Phase I and Pharmacokinetic Study of Photodynamic Therapy for High Grade Gliomas Using a Novel Boronated Porphyrin (BOPP). M.A. Rosenthal, B. Kavar, J.S. Hill, D.J. Morgan, R.L. Nation, S.S. Stylli, R. Basser, S. Uren, H. Geldard, M.D. Green, S.B. Kahl and A.H. Kaye, J. Clin. Oncol.19, 519-524 (2001).
• Plasma Pharmacokinetics and Tissue Biodistribution of Boron Following Administration of a Boronated Porphyrin in Dogs. J. Tibbitts, N.C. Sambol, J.R. Fike, W.F. Bauer and S.B. Kahl, J. Pharm. Sci. 89, 469-477 (2000).
• Toxicology of a Boronated Porphyrin in Dogs. J. Tibbitts, J.R. Fike, K.R. Lamborn, A.W. Bollen and S.B. Kahl, Photochem. Photobiol. 69, 587-594 (1999).
• Rapid Cage Degradation of 1-Formyl and 1-Alkyloxycarbonyl Substituted 1,2-Dicarba-closo-dodecaboranes by Water or Methanol in Polar Solvents. J.J. Schaeck and S.B. Kahl, Inorg. Chem. 38, 204-206 (1999).
• Synthesis of 3-Amino-1-carboxy-o-carborane and an Improved, General Method for Synthesis of All Three C-Amino-C-carboxy-carborane Amino Acids. R.A. Kasar, G.M. Knudsen and S.B. Kahl, Inorg. Chem. 38, 2936-2940 (1999).
• Boronated Protoporphyrin (BOPP): Localization in Lysosomes of the Human Glioma Cell Line SF-767 with Uptake Modulated by Lipoprotein Levels. D.E. Callahan, T.M. Forte, S.M. Javed Afzal, D.F. Deen, S.B. Kahl, K.A. Bjornstad, W.L. Bauer and E.A. Blakely, Int. J. Radiat. Oncol., Biol., and Physics 45, 761-771 (1999).
• Biopharmaceutics of Boronated Sensitizers: Liposomal Formulation of MnBOPP and Comparative Toxicity in Mice. R. Zhou, S.V. Balasubramanian, S.B. Kahl and R.M. Straubinger, J. Pharm. Sci. 88, 912-917 (1999).
• Anti-HIV-1 Activity of Carborane Derivatives of Porphyrins. A.K. Debnath, S. Jiang, N. Strick, K. Lin, S.B. Kahl and A.R. Neurath, Med. Chem Res. 9, 267-275 (1999).
• Improved Methods for the Synthesis of Porphyrin Alcohols and Aldehydes from Protoporphyrin IX Dimethyl Ester and Their Further Modification. S.B. Kahl, J.J. Schaeck and M.-S. Koo, J. Org. Chem. 62, 1875-1880 (1997).
• Enantioselective Synthesis of L- and D-Carboranylalanine. P.A. Radel and S.B. Kahl, J. Org. Chem. 61, 4582-4588 (1996).
• Photophysics and Intracellular Distribution of a Boronated Porphyrin Therapeutic Agent. P.G. Spizzirri, J.S. Hill, S.B. Kahl and K.P. Ghiggino, Photochem. Photobiol. 64, 975-983 (1996).
• Synthesis and Characterization of a Boronated Metallophthalocyanine for Boron Neutron Capture Therapy. S.B. Kahl and J. Li, Inorg. Chem., 35, 3878-3880 (1996).
• The Biological Effects of Auger Electrons Compared to Alpha Particles and Li Ions. B.H. Laster, G. Shani, S.B. Kahl and L. Warkentien, Acta Onkologia 35, 917-923 (1996).
• A Simple High Yield Synthesis of Polyhedral Carborane Amino Acids. S.B. Kahl and R. A. Kasar, J. Am. Chem. Soc., 118, 1223-1224 (1996).
• Mitochondria are the Functional Intracellular Target for a Photosensitizing Boronated Porphyrin. A.D. Munday, A. Sriratana, J.S. Hill, S.B. Kahl and P. Nagley, Biochem. Biophys. Acta , 1311, 1-4 (1996).
• Time-Resolved Confocal Fluorescence Microscopy of Porphyrins for Phototherapy. P.G. Spizzirri, J.S. Hill, S.B. Kahl and K.P. Ghiggino, Lasers Med. Sci. 11, 237-246 (1996).
• Selective Tumor Kill of Cerebral Glioma by Photodynamic Therapy Using a Boronated Porphyrin Photosensitizer. J.S. Hill, S.B. Kahl, S.S. Stylli, Y. Nakamura, M.S. Koo and A. H. Kaye, Proc. Natl. Acad. Sci. USA, 92, 12126-12130 (1995).
• A Comparative Study on the Pharmacokinetics and Biodistribution of Boronated Porphyrin (BOPP) and Sulfhydryl Boron Hydride (BSH) in the RG-2 Rat Glioma Model. C.P. Ceberg, A. Brun, S.B. Kahl, M.S. Koo, B.R.R. Persson and L.G. Salford, J. Neurosurg. 83, 86-92 (1995).
• Accumulation of 99mTc-LDL in Human Malignant Glioma. J. Lepl, S. Savolainen, H. Gylling, J. Hiltunen, J. Callaway, S. Kahl and M. Frkkil, Br. J. Cancer 71, 383-387 (1995).
• Boronated Metalloporphyrins: A Novel Approach to the Diagnosis and Treatment of Cancer Using Contrast-enhanced MR Imaging and Neutron Capture Therapy. L.R. Huang, R.M. Straubinger, S.B. Kahl, M.S. Koo, J.J. Alletto, R. Mazurchuk, R.I. Chau, S.L. Thamer and R. J. Fiel, J. Magnetic Resonance Imaging 3, 351-356 (1993).
• Subcellular Distribution of Various Boron Compounds and Implications for Their Efficacy in Boron Neutron Capture Therapy by Monte Carlo Simulations. T. Nguyen, G.L. Brownell, S.A. Holden, S.B. Kahl, M. Miura and B. A. Teicher, Radiation Research 133, 33-40 (1993).
• Selective Tumor Uptake of a Boronated Porphyrin in an Animal Model of Cerebral Glioma. J.S. Hill, S.B. Kahl, A.H. Kaye, S.S. Stylli, M.-S. Koo, M.B. Gonzales, N.J. Vardaxis, and C.I. Johnson, Proc. Natl. Sci. U.S.A. 89, 1785-1789 (1992).
• Specific Inhibition of HIV-1 Protease by Boronated Porphyrins. D.L. DeCamp, L.M. Babe, R. Salto, J.L. Lucich, M.S. Koo, S.B. Kahl and C.S. Craik, J. Med. Chem. 35, 3426-3428 (1992).
• In vitro Determination of Uptake, Retention, Distribution, Biological Efficacy and Toxicity of Boronated Compounds for Neutron Capture Therapy: A Comparison of Porphyrins and Sulfhydryl Boron Hydrides. R.G. Fairchild, S.B. Kahl, B.H. Laster, J. Kalef-Ezra, and E.A. Popenoe, Cancer Research 50, 4860-4865 (1990).