nigel@itsa.ucsf.edu
(415) 502-5495 (voice)
(415) 476-8201 (fax)

Box 0414, UCSF; San Francisco, CA 94143-0414

additional websites:

Killeen Faculty Profile

University of Toronto, Canada, Bsc (hons), 1985, Microbiology
University of Oxford, England, D.Phil., 1988, Immunology

Killeen, N., Barclay, A.N., Willis, A.C. & Williams, A.F. (1987). The sequence of rat leukosialin (W3/13 antigen) reveals a molecule with O-linked glycosylation of one third of its extracellular amino acids. EMBO J. 6:4029-34.

Killeen, N., Moessner, R., Arvieux, J., Willis, A.C. & Williams, A.F. (1988) The MRC OX-45 antigen of rat leukocytes and endothelium is in a subset of the immunoglobulin superfamily with CD2, LFA-3 and carcinoembryonic antigens. EMBO J. 7:3087-3091.

Cyster, J., Somoza, C., Killeen, N. & Williams, A.F. (1990) Protein sequence and gene structure for mouse leukosialin (CD43), a T lymphocyte mucin without introns in the coding sequence. Eur. J. Immunol. 20:875-81.

Killeen, N., Moriarty, A., Teh, H.-S. & Littman, D.R. (1992) Requirement for CD8-MHC class I interaction in positive and negative selection of developing T cells. J. Exp. Med. 176:89-97.

Killeen, N., Stuart, S.G. & Littman, D.R. (1992) Development and function of T cells in mice with a disrupted CD2 gene. EMBO J. 11:4329-4336.

Killeen, N., Sawada, S. & Littman, D.R. (1993) Regulated Expression of Human CD4 Rescues T-Helper Cell Development in Mice Lacking Expression of Endogenous CD4. EMBO J. 12:1547-1553.

Davis, C.B, Killeen, N., Crooks, M.E.C., Raulet, D. & Littman, D.R. (1993) Evidence for a Stochastic mechanism in the differentiation of mature subsets of T lymphocytes. Cell 73:237-247.

Killeen, N. & Littman, D.R. (1993) Helper T cell development in the absence of CD4-p56^lck association. Nature 364:729-732.

Locksley, R.M., Reiner, S.L., Hatam, F. Littman, D.R & Killeen, N. (1993) Helper T cells without CD4: control of Leishmaniasis in CD4-deficient mice. Science 261:1448-1451.

Bendelac, A., Killeen, N., Littman, D.R. & Schwartz, R.H. (1994) A subset of CD4+8- alphabetaTCR+ thymocytes selected by class I MHC molecules on hemopoietic cells. Science 263:1774-1778.

Sawada, S., Scarborough, J., Killeen, N. & Littman, D.R. (1994) Lineage-specific transcriptional silencing of the CD4 gene. Cell 17:917-929.

Van Oers, N.S.C., Killeen, N. & Weiss, A. (1994) ZAP-70 is constitutively associated with tyrosine phosphorylated TCRzeta in murine thymocytes and lymph node T cells. Immunity. 1:675-685.

Tarakhovsky, A., Kanner, S.B., Hombach, I., Ledbetter, J.A., Killeen, N. & Rajewsky, K. (1995) A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science 269:535-537.

Van Oers, N.S.C., Killeen, N. & Weiss, A. (1996) Lck regulates the tyrosine phosphorylation of the TCR subunits and ZAP-70 in murine thymocytes. J. Exp. Med. 183:1053-1062.

Matechak, E.O., Killeen, N., Hedrick, S.M. & Fowlkes, B.J. (1996) MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity 4:337-347.

Teh, S.J., Killeen, N., Tarakhovsky, A., Littman, D.R. & Teh, H.-S. (1997) CD2 regulates the positive selection and function of antigen-specific CD4-CD8+ T cells. Blood, 89:1308-1318.

Fowell, D.J., Magram, J., Turck, C.W., Killeen, N. & Locksley, R.M. (1997) Impaired Th2 subset development in the absence of CD4. Immunity 6:559-569.

Brown, D.R., Moskowitz, N.H., Killeen, N. & Reiner, S.L. (1997) A role for CD4 in peripheral T cell differentiation. J. Exp. Med. 186, 101-107.

Liao, X.C., Fournier, S., Killeen, N., Weiss, A., Allison, J.P. & Littman, D.R. (1997) Itk negatively regulates induction of T Cell proliferation by CD28 costimulation. J. Exp. Med. 186: 221-228.

Fon, E.A., Pothos, E.N. Sun, B.-C., Killeen, N., Sulzer, D. & Edwards, R.H. (1997) Vesicular transport regulates monoamine storage and release but is not essential for amphetamine action. Neuron. 19:1271-1283 .

Killeen, N. (1997) Thy-1 - Hiding in full view. Current Biology. 7:R799-R807.

Reiner, S.L., Fowell,D.J., Moskowitz,N.H., Swier,K., Brown,D.R., Brown,C.R., Turck,C.W., Scott,P.A., Killeen, N. & Locksley, R.M. (1998) Control of L. major by a monoclonal T cell repertoire. J. Immunol. 160:884-889.

Irving, B.A., Alt, F.W. & Killeen, N. (1998) Thymocyte development in the absence of pre-T cell receptor extracellular domains. Science. 280: 905-908.

Kadlecek, T.A., van Oers, N.S.C., Lefrancois, L., Olson, S., Finlay, D., Chu, D.H., Connolly, K., Killeen, N. and Weiss, A. (1998) Differential requirements for ZAP-70 in TCR signaling and T cell development. J. Immunol. 161:4688-4694.

Killeen, N., Irving, B.A., Pippig, S., & Zingler, K.,A. (1998) Signaling checkpoints during the development of T lymphocytes. Current Opinion in Immunology. 10:360-367.

Shelbourne, P.F., Killeen, N., Hevner, R.F., Johnston, H.M., Tecott, L., Lewandoski, M., Ennis, M., Ramirez, L., Li, X., Iannicola, C., Littman, D.R. & Myers, R.M. (1999) A Huntington disease CAG expansion at the murine Hdh locus is unstable and associated with increased aggressive behavior in mice. Human Molecular Genetics. 8:763-874.

Law, D.A., Guzman, F.R., Ministri-Madrid, K., Killeen, N. and Phillips, D.R. (1999) The integrin cytoplasmic tyrosine (ICY) motif is required for outside-in aIIbb3 signalling and normal platelet function. Nature. 401, 808-811.

Peña-Rossi, C., Zuckerman, L.A., Strong, J., Chan, S., Kwan, J., Ferris, W., Tarakhovsky, A., Beyers, A.D. and Killeen, N. (1999) Negative regulation of CD4 lineage development and responses by CD5. J. Immunol. 163:6494-6501.

Pippig, S., Peña-Rossi, C., Long, J., Reiner, S.L., Birkeland, M.L., Fowell, D.J., Godfrey, W.R., Locksley, R.M., Barclay, A.N. and Killeen, N. (1999) Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40). J. Immunol. 163:6520-6529.

Gramaglia, I., Jember, A., Pippig, S.D., Weinberg, A.D., Killeen, N. and Croft, M. (2000) The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion J. Immunol. 165: 3043-3050.

Majeti, R., Xu, Z., Parslow, T.G., Olson, J.L., Daikh, D.I., Killeen, N. and Weiss, A. (2000) An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity. Cell. 103: 1059-1070.

Dennehy, K.M., Ferris, W.F., Veenstra, H., Zuckerman, L.A., Killeen, N., and Beyers, A.D. (2001) Determination of the tyrosine phosphorylation sites in the T cell transmembrane glycoprotein CD5. International Immunology 13: 149-156.

Strong, J. Wang, Q. and Killeen, N. (2001) Impaired survival of T helper cells in the absence of CD4. Proceedings of the National Academy of Sciences USA. 98: 2566-2571.

Locksley, R.M., Killeen, N. and Lenardo, M.J. (2001) The TNF and TNF-receptor superfamilies: integrating mammalian biology. Cell. 104: 487-501.

Sosinowski, T., Killeen, N. and Weiss, A. (2001) Src-like adaptor protein (SLAP) downregulates the TCR on double-positive thymocytes and inhibits positive selection. Immunity In press.

Wang, Q., Malherbe, L., Zhang, D., Zingler, K., Glaichenhaus, N. and Killeen, N. (2001) CD4 promotes breadth in the T cell receptor repertoire. Submitted.

1/8/02