Thomas Kornberg, PhD

Juilliard School of Music
Columbia College, B.A., 1970, Biology
Columbia University, Ph.D., 1973, Biochemistry
Princeton University, postdoctoral, 1973-1975, Biochemistry
Cambridge MRC Laboratory of Molecular Biology, postdoctoral, 1975-1976, Developmental Genetics

• 1976-1977
  Assistant Professor, Molecular Biology Institute and Department of Chemistry, University of California, Los Angeles
• 1986-present
  Assistant Professor, Associate Professor, Professor, Department of Biochemistry and Biophysics, University of California San Francisco

• 1978
  American Cancer Society Career Development Award
• 2001
  Member, American Academy of Arts and Sciences

• Tabata, T. and Kornberg, T.B. (1994) Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs. Cell 76, 89-102.
• Fristrom, D., Gotwals, P., Eaton, S., Kornberg, T.B., Sturtevant, M., Bier, E., and Fristrom, J.W. (1994) blistered: a gene required for vein/intervien formation in wings of Drosophila. Development 120, 2661-2671.
• Goldsborough, A.S. and Kornberg, T.B. (1994) Allele-specific amplification of Drosophila engrailed and invected transcripts. Proc. Natl. Acad. Sci. USA 91, 12696-700.
• Schwartz, C., Nishida, C. and Kornberg, T.B. (1995) Regulating posterior compartment development invovles repression of cubitus interruptus expression by the engrailed protein. Development 121, 1625-1635.
• Serrano, N., Demeret, C., Dura, J.M., Brock, H.W., Kornberg, T.B., and Maschat, F. (1995) polyhomeotic is a target of engrailed regulation in Drosophila. Development 121, 1691-1703.
• Bourbon, H., Martin-Blanco, E., and Kornberg, T. (1995) Phosphorylation of the Drosophila engrailed protein at a site outside its homeodomain enhances DNA binding. J. Biol. Chem. 270, 11130-11139
• Raeber, A.J., Muramoto, T., Kornberg, T.B., and Prusiner, S.B. (1995) Expression and targeting of Syrian hamster prion protein induced by heat shock in Drosophila melanogaster. Mech. of Development 51, 317-328.
• Kuhn, D.T., Turenchalk, G., Mack, J.A., Packert, G. and Kornberg, T.B. (1995) Analysis of the genes involved in organizing the tail segments of the Drosophila melanogaster embryo. Mech. of Development 53, 3-14.
• Saenz-Robles, M.T., Maschat, F., Scott, M.P. and Kornberg, T.B. (1995) Isolation and characterization of the Drosophila 110 gene, a target of engrailed regulation. Mech. of Development 53, 185-195.
• Tabata, T., Schwartz, C., Gustavson, E., Ali, Z., and Kornberg, T.B. (1995) Creating a Drosophila wing de novo, the role of engrailed, and the compartment border hypothesis. Development 121, 3359-3369.
• Gustavson, E., Goldsborough, A.S., Ali, Z., and Kornberg, T.B. (1996) The Drosophila engrailed and invected genes: partners in regulation, expression and function. Genetics 142, 893-906.
• Goldsborough, A.G. and Kornberg, T.B. (1996) Reduction of transcription by homolog asynapsis in Drosophila imaginal discs. Nature 381, 807-810.
• Aza-Blanc, P., Ramírez-Webber, F.-A., Laget, M.-P., Schwartz, C., and Kornberg. T.B. (1997) Proteolysis inhibited by Hedgehog directs Cubitus interruptus protein to the nucleus and changes its activity as a transcription regulator. Cell 89, 1043-1053.
• Tsuneizumi, K. Nakayama, T., Kamoshida, Y., Kornberg, T.B., Christian, J.L. and Tabata, T. (1997) Daughters against dpp modulates dpp organizing activity in Drosophila wing development. Nature 389, 627-631.
• Ramírez-Weber, F.-A. and Kornberg, T.B. (1999) Cytonemes: cellular processes that project to the principal signaling center in Drosophila imaginal discs. Cell 97, 599-607.
• Aza-Blanc, P. and Kornberg, T.B. (1999) Ci, a complex transducer of the Hedgehog signal. Trends in Genetics 15, 458-462.
• Casso, D., Ramírez-Weber, F.-A., and Kornberg, T.B. (1999) GFP-tagged balancer chromosomes for Drosophila melanogaster. Mech. of Development 88, 229-232.
• Kornberg, T.B. and Krasnow, M.A. (2000) The Drosophila genome sequence: implications for biology and medicine. Science 287, 2218-20.
• Ramírez-Weber, F.-A., Casso, D., Aza-Blanc, P., Tabata, T. and Kornberg, T.B. (2000) Hedgehog signal transduction in the posterior compartments of Drosophila wing imaginal discs. Molec. Cell 6, 479-85..
• Aza-Blanc, P., Lin, H.-Y., Ruiz i Altaba, A., and Kornberg, T.B. (2000) Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities. Development 127, 4293-301.
• Read, D., Butte, M.J., Dernburg, A.F., Frasch, M. and Kornberg, T.B. (2000) Functional Studies of the BTB Domain in the Drosophila GAGA and Mod(mdg4) Proteins. Nucleic Acids Res. 28, 3864-70.
• Chuang, P.-T. and Kornberg, T.B. (2000) On the range of Hedgehog signaling. Cur. Opin. Genet. Dev. 10, 515-22.
• Llano, E., Pendas, A., Aza-Blanc, P., Kornberg, T.B. and Lopez-Otin, C. (2000) Dm1-MMP, a matrix metalloproteinase from drosophila with a potential role in extracellular matrix remodeling during neural development. J. Biol. Chem. 275, 35798-35985.
• Ramírez-Weber, F.-A. and Kornberg, T.B. (2000) Signaling Reaches to New Dimensions in Drosophila Imaginal Discs. Cell 103, 189-192.
• Sato M, Kornberg TB. (2002). FGF is an essential mitogen and chemoattractant for the air sacs of the drosophila tracheal system. Dev Cell. ; 3(2):195-207.