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RANDALL H. KRAMER, PHD

Professor, Oral Biology, Dentistry/Stomatology, UCSF
Co-Leader, Head and Neck Oncology Program, UCSF Helen Diller Family Comprehensive Cancer Center

CONTACT

randall.kramer@ucsf.edu
(415) 476-3275, 476-3274 (voice)
(415) 476-4204 (fax)

Box 0422, UCSF; San Francisco, CA 94143-0422

EDUCATION
University of California, Berkeley, B.A., 1971, Biochemistry Yale University School of Medicine, M.S., 1974, Pharmacology Yale University School of Medicine, Ph.D., 1977, Pharmacology University of California, Irvine, Postdoc., 1977-80, Cell Biology
PROFESSIONAL EXPERIENCE
1977-80	UC Irvine, Department of Cell and Molecular Biology, American Cancer Society Postdoctoral Fellow
1980-85	UC San Francisco, Department of Stomatology and Anatomy, Assistant Professor
1985-91	UC San Francisco, Department of Stomatology and Anatomy, Associate Professor
1991-present	UC San Francisco, Cardiovascular Research Institute
1996-present	UC San Francisco, Oral Cancer Research Center, Director
1997-present	UC San Francisco Cancer Center, Program Leader in Head and Neck Oncology
2005-present	UC San Francisco, Departments of Cell and Tissue Biology, and Anatomy, Professor
HONORS & AWARDS
1983, 1988	National Institutes of Health, Ad Hoc Reviewer, Pathology B Study Section
1984	International Institute for Microcirculation, Cambridge, England, Research Award
1985	Veterans1 Administration, Career Development Program, Reviewer
1986	National Cancer Institute, Cancer Therapeutics Review Committee, Consultant
1987-1989	National Cancer Institute of Canada, Ad Hoc Reviewer, Panel B
1987-1996	National Science Foundation, Research Grant Program, Reviewer
1989	National Institutes of Health, Pathobiochemistry Study Section, Ad Hoc Reviewer
1990, 1994	National Cancer Institute, Program Project, Ad Hoc Reviewer
1990-1993	Gordon Conference, Basement Membranes, Cell Contact and Adhesion, Invited Speaker
1991, 1993	American Cancer Institute, Advisory Committee on Cell and Developmental Biology
1995, 1996, 1999	Oral Biology and Medicine Study Section, Ad Hoc Reviewer
1999, 2004	NCI Workshop, Head and Neck Cancer
2000	NIDCR Review Panel, Genetic Basis of Oral Cancer
2001, 2003	NIDCR Special Review Panel on Oral Cancer
2002, 2004	NCI Head and Neck SPORE Panel Review
2005, 2006	NIH Tumor Microenvironment Study Section
2006	NIDCR Special Review Panel
SELECTED PUBLICATIONS
(from a total >100)
Kramer, R. H., and N. Marks. 1989. Identification of integrin collagen receptors on human melanoma cells. J Biol Chem 264:4684-4688.
Kramer, R. H., K. A. McDonald, and M. P. Vu. 1989. Human melanoma cells express a novel integrin receptor for laminin. J Biol Chem 264:15642-15649.
Ramos, D. M., E. D. Berston, and R. H. Kramer. 1990. Analysis of integrin receptors for laminin and type IV collagen on metastatic B16 melanoma cells. Cancer Res 50:728-734.
Kramer, R. H., Y. F. Cheng, and R. Clyman. 1990. Human microvascular endothelial cells use beta 1 and beta 3 integrin receptor complexes to attach to laminin. J Cell Biol 111:1233-1243.
Kramer, R. H., M. P. Vu, Y. F. Cheng, D. M. Ramos, R. Timpl, and N. Waleh. 1991. Laminin-binding integrin alpha 7 beta 1: functional characterization and expression in normal and malignant melanocytes. Cell Regul 2:805-817.
Lin, C. S., K. Zhang, and R. Kramer. 1993. Alpha 6 integrin is up-regulated in step increments accompanying neoplastic transformation and tumorigenic conversion of human fibroblasts. Cancer Res 53:2950-2953.
Larjava, H., T. Salo, K. Haapasalmi, R. H. Kramer, and J. Heino. 1993. Expression of integrins and basement membrane components by wound keratinocytes. J Clin Invest 92:1425-1435.
Ziober, B. L., M. P. Vu, N. Waleh, J. Crawford, C. S. Lin, and R. H. Kramer. 1993. Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during development. J Biol Chem 268:26773-26783.
Clyman, R. I., J. Tannenbaum, Y. Q. Chen, D. Cooper, P. D. Yurchenco, R. H. Kramer, and N. S. Waleh. 1994. Ductus arteriosus smooth muscle cell migration on collagen: dependence on laminin and its receptors. J Cell Sci 107 ( Pt 4):1007-1018.
Kim, J. P., K. Zhang, J. D. Chen, R. H. Kramer, and D. T. Woodley. 1994. Vitronectin-driven human keratinocyte locomotion is mediated by the alpha v beta 5 integrin receptor. J Biol Chem 269:26926-26932.
Kramer, R. H. 1994. Characterization of laminin-binding integrins. Methods Enzymol 245:129-147.
Matsumoto, K., T. Nakamura, and R. H. Kramer. 1994. Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells. J Biol Chem 269:31807-31813.
Zhang, K., and R. H. Kramer. 1996. Laminin 5 deposition promotes keratinocyte motility. Exp Cell Res 227:309-322.
Zhang, K., J. P. Kim, D. T. Woodley, N. S. Waleh, Y. Q. Chen, and R. H. Kramer. 1996. Restricted expression and function of laminin 1-binding integrins in normal and malignant oral mucosal keratinocytes. Cell Adhes Commun 4:159-174.
Yao, C. C., B. L. Ziober, R. M. Squillace, and R. H. Kramer. 1996. Alpha7 integrin mediates cell adhesion and migration on specific laminin isoforms. J Biol Chem 271:25598-25603.
Ziober, B. L., and R. H. Kramer. 1996. Identification and characterization of the cell type-specific and developmentally regulated alpha7 integrin gene promoter. J Biol Chem 271:22915-22922.
Yao, C. C., B. L. Ziober, A. E. Sutherland, D. L. Mendrick, and R. H. Kramer. 1996. Laminins promote the locomotion of skeletal myoblasts via the alpha 7 integrin receptor. J Cell Sci 109 ( Pt 13):3139-3150.
Yao, C. C., J. Breuss, R. Pytela, and R. H. Kramer. 1997. Functional expression of the alpha 7 integrin receptor in differentiated smooth muscle cells. J Cell Sci 110 ( Pt 13):1477-1487.
Lin, C. S., Y. Chen, T. Huynh, and R. H. Kramer. 1997. Identification of the human alpha6 integrin gene promoter. DNA Cell Biol 16:929-937.
Beviglia, L., K. Matsumoto, C. S. Lin, B. L. Ziober, and R. H. Kramer. 1997. Expression of the c-Met/HGF receptor in human breast carcinoma: correlation with tumor progression. Int J Cancer 74:301-309.
Ziober, B. L., Y. Chen, and R. H. Kramer. 1997. The laminin-binding activity of the alpha 7 integrin receptor is defined by developmentally regulated splicing in the extracellular domain. Mol Biol Cell 8:1723-1734.
Hayashi, Y. K., F. L. Chou, E. Engvall, M. Ogawa, C. Matsuda, S. Hirabayashi, K. Yokochi, B. L. Ziober, R. H. Kramer, S. J. Kaufman, E. Ozawa, Y. Goto, I. Nonaka, T. Tsukahara, J. Z. Wang, E. P. Hoffman, and K. Arahata. 1998. Mutations in the integrin alpha7 gene cause congenital myopathy. Nat Genet 19:94-97.
Kantak, S. S., and R. H. Kramer. 1998. E-cadherin regulates anchorage-independent growth and survival in oral squamous cell carcinoma cells. J Biol Chem 273:16953-16961.
Beviglia, L., and R. H. Kramer. 1999. HGF induces FAK activation and integrin-mediated adhesion in MTLn3 breast carcinoma cells. Int J Cancer 83:640-649.
Ziober, B. L., Y. Q. Chen, D. M. Ramos, N. Waleh, and R. H. Kramer. 1999. Expression of the alpha7beta1 laminin receptor suppresses melanoma growth and metastatic potential. Cell Growth Differ 10:479-490.
Ziober, B. L., M. A. Turner, J. M. Palefsky, M. J. Banda, and R. H. Kramer. 2000. Type I collagen degradation by invasive oral squamous cell carcinoma. Oral Oncol 36:365-372.
Ziober, B. L., S. S. Silverman, Jr., and R. H. Kramer. 2001. Adhesive mechanisms regulating invasion and metastasis in oral cancer. Crit Rev Oral Biol Med 12:499-510.
Kawano, K., S. S. Kantak, M. Murai, C. C. Yao, and R. H. Kramer. 2001. Integrin alpha3beta1 engagement disrupts intercellular adhesion. Exp Cell Res 262:180-196.
Klaffky, E., R. Williams, C. C. Yao, B. Ziober, R. H. Kramer, and A. Sutherland. 2001. Trophoblast-specific expression and function of the integrin alpha 7 subunit in the peri-implantation mouse embryo. Dev Biol 239:161-175.
Vizirianakis, I. S., C. C. Yao, Y. Chen, B. L. Ziober, A. S. Tsiftsoglou, and R. H. Kramer. 2001. Transfection of MCF-7 carcinoma cells with human integrin alpha7 cDNA promotes adhesion to laminin. Arch Biochem Biophys 385:108-116.
Blanco-Bose, W. E., C. C. Yao, R. H. Kramer, and H. M. Blau. 2001. Purification of mouse primary myoblasts based on alpha 7 integrin expression. Exp Cell Res 265:212-220.
Kim, T. W., Q. Chen, X. Shen, J. A. Regezi, D. M. Ramos, H. Tanaka, R. C. Jordan, and R. H. Kramer. 2002. Oral mucosal carcinogenesis in SENCAR mice. Anticancer Res 22:2733-2740.
Vizirianakis, I. S., Y. Q. Chen, S. S. Kantak, A. S. Tsiftsoglou, and R. H. Kramer. 2002. Dominant-negative E-cadherin alters adhesion and reverses contact inhibition of growth in breast carcinoma cells. Int J Oncol 21:135-144.
Yeh, M.-G., B. L. Ziober, B. Liu, G. Lipkina, I. S. Vizirianakis, and R. H. Kramer. 2003. The beta 1 cytoplasmic domain regulates the laminin-binding specificity of the alpha 7 X1 integrin. Mol Biol Cell 14:3507-3518.
Xiao, J., P. Jethanandani, B. L. Ziober, and R. H. Kramer. 2003. Regulation of alpha7 integrin expression during muscle differentiation. J Biol Chem 278:49780-49788.
Ferguson, J. W., B. S. Thoma, M. F. Mikesh, R. H. Kramer, K. L. Bennett, A. Purchio, B. J. Bellard, and R. G. LeBaron. 2003. The extracellular matrix protein betaIG-H3 is expressed at myotendinous junctions and supports muscle cell adhesion. Cell Tissue Res 313:93-105.
Chen, Q., G. Lipkina, Q. Song, and R. H. Kramer. 2004. Promoter methylation regulates cadherin switching in squamous cell carcinoma. Biochem Biophys Res Commun 315:850-856.
Murai, M., X. Shen, L. Huang, W. M. Carpenter, C. S. Lin, S. Silverman, J. Regezi, and R. H. Kramer. 2004. Overexpression of c-met in oral SCC promotes hepatocyte growth factor-induced disruption of cadherin junctions and invasion. Int J Oncol 25:831-840.
Shen, X., and R. H. Kramer. 2004. Adhesion-mediated squamous cell carcinoma survival through ligand-independent activation of epidermal growth factor receptor. Am J Pathol 165:1315-1329.
Kramer, R. H., X. Shen, and H. Zhou. 2005. Tumor cell invasion and survival in head and neck cancer. Cancer Metastasis Rev 24:35-45.
Zhou, H., and R. H. Kramer. 2005. Integrin Engagement Differentially Modulates Epithelial Cell Motility by RhoA/ROCK and PAK1. J Biol Chem 280:10624-10635.
Jethanandani P, Kramer RH. α7 integrin expression is negatively regulated by δEF1 during skeletal myogenesis. J Biol Chem. 2005; 280: 36037-36046.
Ozeki N, Lim M, Yao CC, Tolar M, Kramer RH. 2006. ƒ¿7 integrin expressing human fetal myogenic progenitors have stem cell-like properties and are capable of osteogenic differentiation. Exp Cell Res. 312(20):4162-80.
1/30/07

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