Emeritus Professor of Cellular & Molecular Pharmacology, UCSF
| CONTACT | |
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ernestkun@comcast.net Box 0450, UCSF; San Francisco, CA 94143-0450 |
| EDUCATION | |
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Berzsenyi College, Sopron, Hungary, Matura, 1937
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| PROFESSIONAL EXPERIENCE | |
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1939-1943 |
Assistant in Physiology, Dept. Physiology, Semmelweiss Univ., Budapest, Hungary |
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1943-1946 |
First Assistant (Adjunctus), Dept. Pharmacology, Semmeiweis Univ., Budapest, Hungary |
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1946-1947 |
Research Assistant |
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1947-1949 |
Research Associate (Instructor), Dept. of Pharmacology, University of Chicago, IL |
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1949-1953 |
Assistant Professor, Department of Medicine, Division of Infectious Diseases, Tulane Univ., School of Medicine, New Orleans, LA (with one year's interruption as USPHS Research Fellow at Univ. Chicago). |
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1953-1955 |
Special Research Fellow of USPHS in Enzyme Chemistry, University of Wisconsin, Institute for Enzyme Research, |
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1956-1960 |
Lecturer in Pharmacology, University of California, San Francisco, CA |
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1960-1965 |
Associate Professor of Biochemistry and Experimental Pharmacology, Senior Member, Cardiovascular Research Institute, University of California, San Francisco, CA |
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1965-1989 |
Professor of Cellular and Molecular Pharmacology and Anatomy; Professor of Biochemistry and Experimental Pharmacology, Senior Member of Cardiovascular Research Institute, University of California, San Francisco, CA |
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1989-present |
Emeritus Professor of Cellular & Molecular Pharmacology, University of California, San Francisco |
| HONORS & AWARDS | |
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1941 |
Research Award of Hungarian Physiological Society |
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1956-1961 |
"Established Investigator" Award of American Heart Association |
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1962-1989 |
Research Career Award of the U.S. Public Health Service |
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1970- |
Fellow, American Association for the Advancement of Science |
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1973- |
Senior Science Award, Humboldt Foundation, Bonn, Germany |
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1993-2000 |
Fellow, Royal Society of Medicine, London, UK |
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Member, Hungarian Academy of Sciences, DSci Award |
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| SELECTED PUBLICATIONS | |
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(1997-present) | |
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Mendeleyev, 1, Young, L.T., Kirsten, E., Vidair, C.A, Hakam, A, Zhen, J., Bauer, P., Buki, K. G. and Kun, E. "Structural specificity and tumoricidal action of methyl-3,5diiodo-4-(4'-methoxyphenoxy) benzoate (DIME)" International J. of Oncology 10, 689-695 (1997). | |
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Zhen, J.Y., Feuerstein, B., Vidair, C.A, Hyun, W.C., Young, L.T., Kirsten, E. and Kun, E. "Cellular analysis of the mode of action of methyl-3,5-diido-4-(4'-methoxyphenoxy) benzoate (DIME) on tumor cells" International J of Oncology 10, 905-910 (1997). | |
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Buki, K.G., Mendeleyev, 3., Kun, A, Comstock, J.A. and Kun, E. "Inhibition of the GTP-dependent polymerization of tubulin by methyl-3,5diido-4-(4'-methoxyphenoxy) benzoate (DIME)" International J. of Oncology 10, 911-913 (1997). | |
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Buki, K.G., Bauer, P.1., and Kun, E. "Isolation and identification of a proteinase from calf thymus that cleaves poly(ADP-ribose) polymerase and histone H1" Biochim. Biophys. Acta 1338, 100-106 (1997). | |
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Szabo, C., Wang, H.R., Bauer, P.1., Kirsten, E., O'Connor, M., Zingarelli, B., Mendeleyev, J., Hasko, G., Vizi, E.S., Saltzman, A.L. and Kun, E. "Regulation of components of the inflammatory response by 5-iodo-6-amino-1,2-benzopyrone, an inhibitor of poly(ADP-ribose) synthetase and pleiotropic modifier of cellular signal pathways" Intenational J. of Oncology 10, 1093-1101, (1997). | |
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Kun, E., Mendeleyev, J. and Rice, W.C. "Adenosine diphosphoribose polymerase binding nitroso aromatic compound useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents" US Patent Number 5,652,260 (1997). | |
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Kun, E., Mendeleyev, J. and Kirsten, E. "Halo-nitro-isoquinolinone compounds and pharmaceutical compositions thereof๎ US Patent Number 5,652,3 67 (1997). | |
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Buki, K.G., Kirsten, E., Bauer, P.1., Vidair, C.A, Kun, A, Mendeleyev, J. and Kun, E. "Inhibition of migration of MDA-MB-23 1 human mammary cancer) cells by methyl-3,5-diiodo-(4'-methoxyphenoxy) benzoate (DIME)" International J of Oncology 11, 1247-1250, (1997). | |
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Kun, E., Mendeleyev, J., Kirsten, E. "Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents" US Patent Number 5,670,518 (1997). | |
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Szabo, Cs., Virag, L., Cuzzocrea, S., Scott, G.S., Hake, P., O'Connor, M.P., Zingarelli, B., San, A and Kun, E. "Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly (ADP-ribose) synthetase" Proc. Natl. Acad. Sci. USA 95: 3867-3872, (1998). | |
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Kun, E. and Mendeleyev, J. "Methods of treating tumors with thyroxine analogues having no significant hormonal activity" US Patent Number 5,736,576 (1998). | |
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Kirsten, E., Buki, K.G., Mendeleyev, J., Vidair, C.k, Kun, A and Kun, E. "Unusual potentiation by vinca akaloids of the cytostatic and cytocidal action of methyl-3,5-diiodo-4-(4'methoxyphenoxy) benzoate (DIME) and its nonhydrolyzable ethanone analog (DIPE) on MDA- MB-23 1 human mammary cancer cells" International J. of Oncology 13: 49-55, (1998). | |
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Kun, E. "Poly(ADP-ribose) polymerase, a potential target for drugs: cellular regulatory role of the polymer and the polymerase protein mediated by catalytic and macromolecular colligative actions" Intl. J. Molt Med. 2: 131-142, (1998). | |
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Endres, Mt, Scott, G.S., Salzman, AL., Kun, Et, Moskowitz, M.A and Szabo, Cs. "Protective effects of 5-iodo-6-amino1,2-benzopyrone, an inhibitor of poly (ADP) ribose synthetase against peroxynitrite-induced glial damage and stroke development" Euro. J Phannacol 351: 377-382 (1998). | |
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Kun, Et "Poly(ADP-ribose) polymerase, a potential target for drugs. II. Regulation of differentiation by the poly(ADP-ribose) system" Intl. J Mol. Med. 2: 291-292 (1998). | |
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Kun, E. and Mendeleyev, J. "Molecular pharmacology of methyl-3,5-diiodo-4- (4'methoxyphenoxy) benzoate (DIME) and its nonhydrolyzable ethanone analog (DIPE)" Int. J. Mol. Med. 2: 585-590 (1998). | |
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Mihalik, R., Bauer, P., Petak, I., Krajcsi, P., Marton, A., Kun, E. and Kopper, L. ''Interaction of cytocidal drugs and the inhibition by 3-nitrosobenzamide." Internat. J. Cancer 82: 875-879 (1999). | |
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Kirsten, E. and Kun, E. "Cancer cell selectivity of 5-iodo-6-aminobenzopyrone (INH2BP) and methyl 3-5-diiodo-4(4 , -methoxyphenoxy) benzoate (DIME)." Internat. J. Mol. Med. 5, 279-281 (2000). | |
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P. I., Buki, K.G., Comstock, J.A. and Kun, E. "Activation of topoisomerase I by poly (ADP-ribose) polymerase. Internat. J. Mol. Med. 5, 533-540 (2000). | |
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Mabley, J.G., Suarez-Pinson, W.L., Hasko, G., Salzman, A.L., Rabinovitch, A., Kun, E. and Szabo, C. Inhibition of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple low dose streptozotocin-induced diabetes. British J. Pharmacol. 133, 908-920, 2001. | |
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Bauer, P.I., Buki, K.G. and Kun, E. Selective augmentation of histone H1 phosphorylation sites by interaction of poly (ADP-ribose) polymerase (PARP) and cdc2-kinase: Comparison with protein kinase C. Internat. J. Mol. Medicine 8, 691-693, 2001. | |
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Bauer, P.I., Chen, H-J., Kenesi, E., Kenessey, I., Buki, K.G., Kirsten, E., Hakam, A., Hwang, J.I. and Kun, E. Molecular interactions between poly (ADP-ribose) polymerase (PARP I) and topoisomerase (Topo I): Identification of topology of binding. FEBS Lett. 25315, 1-2, 2001. | |
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Kun, E. and Bauer, P.I. Cell biological functions of PARP I: an overview. Ital. J. Biochem. 50, 15-18, 2001. | |
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Bauer, P.I., Mendeleyev, J., Kirsten, E., Comstock, J.A., Hakam, A., Buki, K.G. and Kun, E. Anti-cancer action of 4-iodo-3-nitro-benzamide in combination with butionine sulfoximine: inactivation of poly (ADP-ribose) polymerase and tumor glycolysis and the appearance of a poly (ADP-ribose) polymerase protease. Biochemical Pharmacology 63 (No. 2), 455-461, 2002. | |
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Kun, E., Kirsten, E. and Ordahl, C.P. Coenzymatic activity of randomly broken or intact double stranded DNAs in auto- and histone H1 trans-poly-ADP-ribosylation, catalyzed by poly (ADP-ribose) polymerase (PARP I). J. Biol. Chem. 277, 39066-39069, 2002. | |
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Kun, E., Kirsten, E., Mendeleyev, J. Synergistic anticancer action of reversibly and irreversiby acting ligands of poly (ADP-ribose) polymerase. Internat. J. Mol. Med. 11, 191-193, 2003. | |
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Kun, E., Kirsten, E. Mendeleyev, J. and Ordahl, C.P. Regulation of the enzymatic catalysis of poly (ADP-ribose) polymerase by dsDNA, polyamines, Mg2+, Ca2+, histones H1 and H3, and ATP. Biochemistry 43, 210-216, 2004. | |
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Huang, K., Tidyman, W.E., Le, K-U. T., Kirsten, E., Kun, E. and Ordahl, C.P. Analysis of nucleotide sequence-dependent DNA binding of poly(ADP-ribose) polymerase in a purified system. Biochemistry 43, 217-223, 2004. | |
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Kirsten, E., Kun, E., Mendeleyev, J. and Ordahl, C.P. Methods in Molecular Biology 287,. 137-149. Epigenetics Protocols, ed. T.O. Tollefsbol. Humana Press, New Jersey. 2004. |
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3/15/05 |
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