anita.lal@ucsf.edu
(415) 476-0370 (voice)
(415) 476-0388 (fax)

Box 0520, UCSF; San Francisco, CA 94143-0520

additional websites:

Faculty Profile, Neuro Surgery

University of Delhi, Delhi, India, B.S., 1989, Zoology
Jamia Millia Islamia, New Delhi, India, M.S., 1991, Biosciences
University of Georgia, Ph.D., 1997, Biochemistry and Molecular Biology
Duke University Medical Center, Postdoc, 1998 - 2003, Molecular genetics of brain tumors

Lal A., Schutzbach J.S., Forsee W.T., Neame P.J., and Moremen K.W.: Isolation and expression of murine and rabbit cDNAs encoding 1,2-mannosidase involved in the processing of asparagines-linked oligosaccharides. J Biol Chem 269, 9872-9881, 1994.

Liao Y.F., Lal A., and Moremen K.W.: Cloning, expression, purification and characterization of the human broad specificity lysosomal acid mannosidase. J Biol Chem 271, 28348-28358, 1996.

Merkle R.K., Zhang Y., Ruest P.J., Lal A., Liao Y.F., and Moremen K.W.: Cloning, expression, purification and characterization of the murine lysosomal acid Mannosidase. Biochimica et Biophysica Acta 1336, 132-146, 1997.

Chui D., Oh-Eda M., Liao Y.F., Panneerselvam K., Lal A., Marek K.W., Freeze H.H., Moremen K.W., Fukuda M.N., and Marth J.D.: Alpha mannosidase-II deficiency results in dyserythropoiesis and unveils an alternate pathway in oligosaccharide biosynthesis. Cell 90, 157-167, 1997.

Lal A., Peng P., Kalelka S., Romero P.A., Herscovics A., and Moremen K.W.: Biochemical characterization and substrate specificity of recombinant 1,2-mannosidase IA and 1,2-mannosidase IB and comparison with processing mannosidases in the endoplasmic reticulum and Golgi membranes. Glycobiology 8, 981-995, 1998.

Vallee F., Lal A., Moremen K.W., and Howell P.L.: Purification, crystallization and preliminary X-ray crystallographic analysis of recombinant murine Golgi mannosidase IA, a class I -mannosidase involved in Asn-linked oligosaccharide maturation. Acta Cryst D55, 571-573, 1999.

Gonzalez D.S., Karaveg K., Vandersall-Nairn A.S., Lal A., and Moremen K.W.: Identification, expression and characterization of a cDNA encoding human ER mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis. J Biol Chem 274, 21375-21386, 1999.

Igdoura S.A., Herscovics A., Lal A., Moremen K.W., Morales C.R., and Hermo L.: Alpha-mannosidases involved in N-glycan processing show cell specificity and distinct subcompartmentalization within the Golgi apparatus of cells in the testis and epididymis. Eur J Cell Biol 78, 441-452, 1999.

Lal A, Lash AE, Altschul SF, Velculescu V, Zhang L, McLendon RE, Marrra M, Prange C, Morin PJ, Polyak K, Papadopoulos N, Vogelstein B, Kinzler KW, Strausberg RL & Riggins GJ: A Public Database for Gene Expression in Human Cancers. Cancer Research. 59, 5403-5407, 1999.

Velculescu, V. E., Madden, S. L., Zhang, L., Lash, A. E., Yu, J., Rago, C., Lal, A., Wang, C. J., Beaudry, G. A., Ciriello, K. M., Cook, B. P., Dufault, M. R., Ferguson, A. T., Gao, Y., He, T. C., Hermeking, H., Hiraldo, S. K., Hwang, P. M., Lopez, M. A., Luderer, H. F., Mathews, B., Petroziello, J. M., Polyak, K., Zawel, L., Zhang, W., Zhang, X., Zhou, W., Haluska, F. G., Jen, J., Sukumar, S., Landes, G. M., Riggins, G. J., Vogelstein, B. & Kinzler, K. W. Analysis of human transcriptomes. Nature Genetics 23, 387-388, 1999.

Lal A, Sui I-Mei & Riggins GJ: Serial Analysis of Gene Expression: Probing transcriptomes for molecular targets. Current Opinion in Molecular Therapeutics, 1, 720-726, 1999.

St Croix, B., C. Rago, V. Velculescu, G. Traverso, K.E. Romans, E. Montgomery, A. Lal, G.J. Riggins, C. Lengauer, B. Vogelstein, and K.W. Kinzler, Genes expressed in human tumor endothelium. Science, 289(5482): p. 1197-202, 2000.

Loging, W. T., Lal, A., Siu, I-M., Loney, T. L., Wikstrand, C. J., Marra, M. A., Prange, C., Bigner, D. D., Strausberg, R. L., Riggins, G. J.: Identifying Potential Tumor Markers and Antigens by Database Mining and Rapid Expression Screening. Genome Research. 10: p. 1393-1402, 2000.

Sui I-Mei, Lal A & Riggins GJ: A Database for Normal Gene Expression in the Human Brain. Gene Expression Patterns 1:33-38, 2001.

Lal A., Peters H., St. Croix B., Haroon Z.A., Dewhirst M.W., Kaanders J.H.A.M., van der Kogel A.J., and Riggins G.J.: Transcriptional Response to Hypoxia in Human Tumors. JNCI 93:1337-1343, 2001.

Strausberg RL, Camargo AA, Riggins GJ, Schaefer CF, de Souza SJ, Grouse LH, Lal A, Buetow KH, Boon K, Greenhut SF, and Simpson AJG: An International Database and Integrated Analysis Tools for the Study of Cancer Gene Expression. Pharmacogenomics J 2(3) 156-164, 2002.

Lal A, Glazer CA, Martinson HM, Friedman HS, Archer GE, Sampson JH and Riggins GJ Mutant Epidermal Growth Factor Receptor Up-regulates Molecular Effectors of Tumor Invasion. Cancer Research 62: 3335-3339, 2002.

Jongeneel CV, Iseli C, Stevenson BJ, Riggins GJ, Lal A, Mackay A, Harris RA, OÕHare MJ, Neville AM, Simpson AJG and Strausberg RL: Comprehensive sampling of gene expression in human cell lines with massively parallel signature sequencing. PNAS 100: 4702-4705, 2003.

Siu IM, Lal A, Blankenship J and Riggins GJ: c-Myc promoter activation in medulloblastoma. Cancer Research 63: 4773-4776, 2003

Blackwell KL, Dewhirst MW, Liotcheva V, Snyder S, Broadwater G, Bentley R, Lal A, Riggins GJ, Anderson S, Vredenburgh J, Proja A and Harris LN: HER-2 gene amplification correlates with higher levels of angiogenesis and lower levels of hypoxia in primary breast tumors. Clinical Cancer Research 10: 4083-4038, 2004

Lu J, Lal A, Merrimen B, Nelson S and Riggins GJ: A comparison of gene expression profiles produced by SAGE, long SAGE and oligonucleotide chips. Genomics 84: 631-636, 2004

Cuevas IC, Slocum AL, Jun P, Costello JF, Bollen AW, Riggins GJ, McDermott MW and Lal A: Meningioma transcript profiles reveal deregulated notch signaling pathway. Cancer Research 65: 5070-75, 2005

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