Lewis L. Lanier, PhD

Virginia Polytechnic Institute & State U., Blacksburg, VA, B.S. (honors), 1975, Microbiology
Univ. North Carolina - Chapel Hill, NC, Ph.D., 1978, Immunology
Univ. North Carolina - Chapel Hill, NC, Postdoc, 1978-79, Immunology
Univ. New Mexico Med Sch, Albuquerque, NM, Postdoc, 1979-81, Immunology

• 1981-1988
  Senior Research Scientist, Becton Dickinson Monoclonal Center, Inc.
• 1988-1990
  Associate Research Director, Becton Dickinson Immunocytometry Systems
• 1991-1992
  Senior Scientific Staff, Department of Immunology, DNAX Research Institute
• 1993-1996
  Associate Director, Department of Human Immunology, DNAX Research Institute
• 1997-1999
  Director, Department of Immunobiology, DNAX Research Institute
• 1999-present
  Professor, Department of Microbiology & Immunology and Cancer Research Institute, University of California, San Francisco
• 2003-2010
  Vice Chair, Department of Microbiology & Immunology, University of California, San Francisco
• 2010
  Chair, Department of Microbiology & Immunology, University of California, San Francisco

• 1971
  Virginia Polytechnic Institute and State University Freshman Science Scholarship
• 1978-1979
  National Research Service Award Fellowship, University of North Carolina School of Medicine at Chapel Hill Cancer Research Center
• 1979-1981
  Damon Runyon - Walter Winchell Cancer Fund Postdoctoral Fellowship
• 2001
  American Association of Immunologists Distinguished Service Award
• 2002
  William B Coley Award for Distinguished Research in Basic and Tumor Immunology, Cancer Research Institute, New York
• 2003
  American Cancer Society Research Professorship
• 2005
  American Society for Histocompatibility and Immunogenetics Rose Payne Award
• 2006
  NIH Merit Grant Award
• 2010
  Member, National Academy of Sciences

• Lanier, L.L., M. Lynes, G. Haughton and P.J. Wettstein. 1978. Novel type of murine B cell lymphoma. Nature 271:554. PMID: 99664. PMCID: N/A
• Allison, J.P. and L.L. Lanier. 1985. Identification of antigen receptor-associated structures on murine T cells. Nature 314:107. PMID: 2579338. PMCID: N/A
• Lanier, L.L. and A. Weiss. 1986. Presence of Ti (WT31) negative T lymphocytes in normal blood and thymus. Nature 324:268. PMID: 3491323. PMCID: N/A
• Lanier, L.L., S. Cwirla, G. Yu, R. Testi and J.H. Phillips. 1989. Membrane anchoring of a human IgG Fc receptor (CD16) determined by a single amino acid. Science 246:1611-1613. PMID: 2531919. PMCID: N/A
• Lanier, L.L., G. Yu and J.H. Phillips. 1989. Co-association of CD3z with receptor (CD16) for IgG on human natural killer cells. Nature 342:803. PMID: 2532305. PMCID: N/A
• Azuma, M., D. Ito, H. Yagita, K. Okumura, J.H. Phillips, L.L. Lanier and C. Somoza. 1993. B70 antigen is a second ligand for CTLA-4 and CD28. Nature 366:76. PMID: 7694153. PMCID: N/A
• Phillips, J.H., J. Gumperz, P. Parham and L.L. Lanier. 1995. Superantigen-dependent, cell-mediated cytotoxicity inhibited by MHC class I receptors on T lymphocytes. Science 268:403-405. PMID: 7716542. PMCID: N/A
• Lanier, L.L., B.C. Corliss, J. Wu, C. Leong and J.H. Phillips. 1998. Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells. Nature 391:703. PMID: 9490415. PMCID: N/A
• Braud, V.M., D.S.J. Allan, C.A. O'Callaghan, K. Soderstrom, A. D'Andrea, G.S. Ogg, S. Lazetic, N.T. Young, J.I. Bell, J.H. Phillips, L.L. Lanier and A.J. McMichael. 1998. HLA-E binds to natural killer cell receptors CD94/NKG2A, B, and C. Nature 391:795-799. PMID: 9486650. PMCID: N/A
• Bauer, S., V. Groh, J. Wu, A. Steinle, J.H. Phillips, L.L. Lanier, and T. Spies. 1999. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285:727-729. PMID: 10426993. PMCID: N/A
• Wu, J., Y. Song, A.B.H. Bakker, S. Bauer, T. Spies, L.L. Lanier, and J.H. Phillips. 1999. An activating immunoreceptor complex formed by NKG2D and DAP10. Science 285:730. PMID: 10426994. PMCID: N/A
• Paloneva, J., M. Kestila, J. Wu, A. Salminen, T. Bohling, V. Ruotsalainen, P. Hakola, A.B.H. Bakker, J.H. Phillips, P. Pekkarinen, L.L. Lanier, T. Timonen, and L. Peltonen. 2000. Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts. Nature Genetics 25:357-361. PMID: 10888890. PMCID: N/A
• Lanier, L.L. 2001. On guard - activating NK cell receptors. Nature Immunology 2:23-27. PMID: 11135574
• Cerwenka, A., A.B.H. Bakker, T. McClanahan, J. Wagner, J. Wu, J.H. Phillips, and L.L. Lanier. 2000. Retinoic acid-early inducible genes define a ligand family for the activating NKG2D receptor in mice. Immunity 12:721. PMID: 10894171. PMCID: N/A
• Bakker, A.B.H., R.M. Hoek, A. Cerwenka, B. Blom, L. Lucian, T. McNeil, R. Murray, J.H. Phillips, J.D. Sedgwick, and L.L. Lanier. 2000. DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming. Immunity 13:345. PMID: 11021532. PMCID: N/A
• Ravetch, J.V. and L.L. Lanier. 2000. Immune inhibitory receptors. Science 290:84-89. PMID: 11021804. PMCID: N/A
• Wu, J., H. Cherwinski, T. Spies, J.H. Phillips, and L.L. Lanier. 2000. DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells. J. Exp. Med. 192:1059-1067. PMID: 11015446. PMCID: PMC2193316
• Cerwenka A, Baron JL, and Lanier LL. 2001. Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits NK cell-mediated rejection of a MHC class I-bearing tumor in vivo. Proc. Natl. Acad. Sci. USA 98:11521. PMID: 11562472. PMCID: PMC58762
• Arase, H., T. Saito, J.H. Phillips, and L.L. Lanier. 2001. Cutting Edge: The mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (a2 integrin, very late antigen-2). J. Immunol. 167:1141-1144. PMID: 11466327. PMCID: N/A
• Arase, H., E.S. Mocarski, A.E. Campbell, A.B. Hill, and L.L. Lanier. 2002. Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science 296:1323. PMID: 11950999. PMCID: N/A
• Lodoen, M., K. Ogasawara, J.A. Hamerman, H. Arase, J.P. Houchins, E.S. Mocarski, and L.L. Lanier. 2003. NKG2D-mediated NK cell protection against cytomegalovirus is impaired by gp40 modulation of RAE-1 molecules. J. Exp. Med. 197:1245. PMID: 12756263. PMCID: PMC2193789
• Ogasawara, K. J.A. Hamerman, H. Hsin, S. Chikuma, H. Jordon, T. Chen, T. Pertel, C. Carnaud, J.A. Bluestone and L.L. Lanier. 2003. Impairment of NK cell function by NKG2D modulation in NOD mice. Immunity 18:41. PMID: 12530974. PMCID: N/A
• Zompi, S., J.A. Hamerman, K. Ogasawara, E. Schweighoffer, V.L.J. Tybulewicz, J.P. DiSanto, L.L. Lanier, and F. Colucci. 2003. NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases. Nature Immunology 4:565-572. PMID: 12740576. PMCID: N/A
• Rosen, D.B. M. Araki, J.A. Hamerman, T. Chen, T. Yamamura, and L.L. Lanier. 2004. A structural basis for the association of DAP12 with mouse, but not human, NKG2D. J. Immunol. 173:2470-2478. PMID: 15294961. PMCID: N/A
• Lodoen, M., G. Abenes, S. Umamoto, J.P. Houchins, F. Liu, and L.L. Lanier. 2004. The cytomegalovirus m155 gene product subverts NK cell antiviral protection by disruption of H60-NKG2D interactions. J. Exp. Med. 200:1075. PMID: 15477345. PMCID: PMC2211837
• Hamerman, J.A., K. Ogasawara, and L.L. Lanier. 2004. Cutting Edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor. J. Immunol. 172:2001-2005. PMID: 14764662. PMCID: N/A
• Lanier, L.L. 2005. NK cell recognition. Annu. Rev. Immunol, 23:225. PMID: 15771571
• Takaki, R., Y. Hayakawa, A. Nelson, P.V. Sivakumar, S. Hughes, M.J. Smyth, and L.L. Lanier. 2005. IL-21 enhances tumor rejection through a NKG2D-dependent mechanism. J. Immunol. 175:2167-2173. PMID: 16081783. PMCID: N/A
• Hamerman, J.A., N. K. Tchao, C.A. Lowell, and L.L. Lanier. 2005. Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nature Immunology 6:579. PMID: 15895090. PMCID: PMC1282462
• Ogasawara, K., J. Benjamin, R. Takaki, J.H. Phillips, and L.L. Lanier. 2005. Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts. Nature Immunology 6:938. PMID: 16086018. PMCID: PMC1351289
• Routes, J.M., S. Ryan, K. Morris, R. Takaki, A. Cerwenka, and L.L. Lanier. 2005. Adenovirus serotype 5 E1A sensitizes tumor cells to NKG2D-dependent NK cell lysis and tumor rejection. J. Exp. Med. 202:1477. PMID: 16314433. PMCID: PMC2213342
• Rosen, D.B., J. Bettadapura, M. Alsharifi, P.A. Mathew, H.S. Warren, and L.L. Lanier. 2005. Cutting Edge: Lectin-like transcript-1 (LLT1) is a ligand for the inhibitory human NKR-P1A receptor. J. Immunol. 175:7796. PMID: 16339513. PMCID: N/A
• Chen, S., H. Kawashima, J.B. Lowe, L.L. Lanier, and M. Fukuda. 2005. Suppression of tumor formation in lymph nodes by L-selectin-mediated natural killer cell recruitment. J. Exp. Med. 202:1679-1689. PMID: 16352740. PMCID: PMC2212958
• Shiow, L.R., D.B. Rosen, N. Brdickova, Y. Xu, J. An, L.L. Lanier, J.G. Cyster, and M. Matloubian. 2006. CD69 acts downstream of interferon-a/b to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature 440:540-544. PMID: 16525420. PMCID: N/A
• Hesslein, D.G.T., R. Takaki, M.L. Hermiston, A. Weiss, and L.L. Lanier. 2006. Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production. Proc. Natl. Acad. Sci. USA 103:7012. PMID: 16627620. PMCID: PMC1459010
• Hamerman, J.A., J.R. Jarjoura, M.B. Humphrey, M.C. Nakamura, W.E. Seaman, and L.L. Lanier. 2006. Cutting Edge: Inhibition of Toll-like receptor and Fc-receptor responses in macrophages by TREM-2 and DAP12. J. Immunol. 174:2051. PMID: 16887962. PMCID: N/A
• Carr, W.H., D.B. Rosen, H. Arase, D.F. Nixon, J. Michaelsson, and L.L. Lanier. 2007. Cutting Edge: KIR3DS1, a gene implicated in resistance to progression to AIDS, encodes a DAP12-associated receptor expressed on NK cells that triggers NK cell activation. J. Immunol. 178:647. PMID: 17202323. PMCID: PMC2561215
• Kim, J., C.K. Chang, T. Hayden, F-C. Liu, J. Benjamin, J.A. Hamerman, L.L. Lanier, and S-M. Kang. 2007. The activating immunoreceptor NKG2D and its ligands are involved in allograft transplantation rejection. J. Immunol. 179:6416. PMID: 17982029. PMCID: 17982029
• Vilarinho, S., K. Ogasawara, S. Nishimura, L.L. Lanier, and J.L. Baron. 2007. Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus. Proc. Natl. Acad. Sci. U.S.A. 104:18187. PMID: 17991774. PMCID: PMC2084318
• Fang, M., L.L. Lanier, and L. Sigal. 2008. A role for NKG2D in NK cell-mediated resistance to poxvirus disease. Plos Pathogen 4,e30. PMID: 18266471. PMCID: PMC2233669
• Satoh, T., J. Arii, T. Suenaga, J. Wang, A. Kogure, J. Uehori, N. Arase, I. Shiratori, S. Tanaka, Y. Kawaguchi, P.G. Spear, L.L. Lanier, and H. Arase. 2008. PILRa is a herpes simplex-virus-1 entry co-receptor that associates with glycoprotein B. Cell 132:935. PMID: 18358807. PMCID: PMC2394663
• Sun, J.C. and L.L. Lanier. 2008. Tolerance of NK cells encountering their viral ligand during development. J. Exp. Med. 205:1819. PMID: 18606858. PMCID: PMC2525590
• Lanier, L.L. 2008. Up on the tightrope: Natural Killer cell activation and inhibition. Nature Immunology 9:495. PMID: 18425106. PMCID: PMC2669298
• Sun, J.C. and L.L. Lanier. 2008. Cutting Edge: Viral Infection Breaks NK Cell Tolerance to "Missing Self". J. Immunol. 181:7453. PMID: 19017932. PMCID: PMC2587071
• Sun, J.C., J.N. Beilke, and L.L. Lanier. 2009. Adaptive immune features of Natural Killer cells. Nature 457:557. PMID: 19136945. PMCID: PMC2674434
• Kielczewska, A., M. Pyzik, T. Sun, A. Krmpotic, M.B. Lodoen, M. Munks, M. Babic, A.B. Hill, U.H. Koszinowski, S. Jonjic, L.L. Lanier, and S.M. Vidal. 2009. Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 is associated with NK cell-mediated resistance to infection. J. Exp. Med. 206:515. PMID: 19255146. PMCID: PMC2699136
• Orr, M.T., J.C. Sun, D.G.T Hesslein, H. Arase, J.H. Phillips, T. Takai, and L.L. Lanier. 2009. Ly49H signaling through both DAP10 and DAP12 is required for optimal NK cell responses to mouse cytomegalovirus infection. J. Exp. Med. 206:807. PMID: 19332875. PMCID: PMC2715124
• Sun, J.C., A. Ma, and L.L. Lanier. 2009. Cutting Edge: IL-15-independent NK cell response to mouse cytomegalovirus infection. J. Immunol. 183:2911. PMID: 19648279. PMCID: PMC2745285
• Cao, W., L. Bover, M. Cho, X. Wen, S. Hanabuchi, M. Bao, D.B. Rosen, Y-H. Wang, J.L. Shaw, Q. Du, C. Li, N. Arai, Z. Yao, L.L. Lanier, and Y-J. Liu. 2009. Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. J. Exp. Med. 206:1603. PMID: 19564354. PMCID: PMC2715090
• Orr, M.T., W.J. Murphy, and L.L. Lanier 2010. "Unlicensed" NK cells dominate the response to cytomegalovirus infection. Nature Immunology, 11:321.