Professor, Medicine, UCSF; and Senior Career Scientist, VA Medical Center, San Francisco
| CONTACT | |
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chris.lau@ucsf.edu VAMC 111C5, San Francisco, CA 94121 |
additional websites: |
| EDUCATION | |
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Harpur College, SUNY-Binghamtom, B.A., 1973, Chemistry
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| PROFESSIONAL EXPERIENCE | |
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1979-82 |
Giannini Research Fellow, Department of Medicine, University of California, San Francisco |
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1982-84 |
Assistant Research Biochemist, Department of Medicine, University of California, San Francisco |
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1984-90 |
Associate Investigator, Howard Hughes Medical Institute, University of California, San Francisco |
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1984-90 |
Assistant Professor, Department of Physiology, University of California, San Francisco |
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1990-present |
Head, Division of Cell and Developmental Genetics, and Member, Cardiology Section, VA Medical Center, San Francisco, California |
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1988-1992 |
Assistant Professor, Dept. of Medicine, University of California, San Francisco |
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1992-2000 |
Associate Professor, Dept. of Medicine, University of California, San Francisco |
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2001-preesnt |
Professor, Dept. of Medicine, University of California, San Francisco |
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1992-present |
Scientist and Senior Scientist Northern California Institute of Research and Education, SF |
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1994-present |
Research Career Scientist, VA Medical Center, San Francisco |
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1998-present |
Member, Cancer Genetics, Cell Cycling/Signaling and Prostate Cancer Programs Cancer Center, UCSF |
| HONORS & AWARDS | |
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1973-76 |
Robert A. Welch Predoctoral Fellowship, University of Texas Health Science Center, Houston |
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1976-79 |
Rosalie B. Hite Predoctoral Fellowship, University of Texas Health Science Center, Houston |
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1975-77 |
Merit Awards, Excellent Student Research, University of Texas Health Science Center, Houston |
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1979-82 |
A.P. Giannini Postdoctoral Fellowship, University of California, San Francisco |
| SELECTED PUBLICATIONS | |
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Su H and Lau Y-FC (1993). Identification of the transcriptional unit, structural organization and promoter sequence of the human sex determining region Y (SRY) gene using a reverse genetic approach. Am J Hum Genet,52:24-38. | |
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Boissonneault G and Lau Y-FC (1993). A testis-specific gene encoding a nuclear HMG box protein located in elongating spermatids. Mol Cell Biol, 13:4323-4330. | |
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Coward P, Nagai K, Chen D, Harrison TD, Nagamine CM and Lau Y-FC (1994). Polymorphism in a polyglutamine tract in Sry correlates with B6.YDom sex reversal. Nature Genetics, 6:245-250. | |
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Dubin RA, Coward P, Lau Y-FC and Ostrer H (1995). Functional comparison of the Mus molossinus and Mus musculus domesticus Sry genes. Mol Endocrin, 9:1645-1654. | |
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Diatchenko L, Lau Y-FC, Campbell AP, Chenchik A, Moqadam F, Huang B, Lukyanov S, Lukyanov K, Gurskaya N, Sverdlov ED and Siebert PD (1996). Suppression subtractive hybridization: A method for generating differential regulated or tissue-specific cDNA probes and libraries. Proc Natl Acad Sci USA, 93:6025-6030. | |
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Zhang JQ, Coward P, Xian MW and Lau Y-FC (1999). In vitro binding and expression studies demonstrate a role for the mouse Sry Q-rich domain in sex determination. Int J Dev Bio, 43:219-227. | |
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Lau Y-FC (1999). Gonadoblastoma, testicular and prostate cancers, and the TSPY gene. Am J Hum Genet, 64:921-927. | |
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Lau Y-FC and Zhang JQ (2000). Expression analysis of thirty-one Y chromosome genes in prostate cancer. Mol Carcin, 27:308-321. | |
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Lau Y-FC, Chou PM, Iezzoni J, Alonzo J and Kömüves LG (2001). Expression of a candidate for gonadoblastoma locus in gonadoblastoma and testicular seminoma. Cytogenet Cell Genet, 91:160-164. | |
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Lau Y-FC Lau H and Kömüves LG (2003). Expression pattern of a gonadoblastoma candidate gene suggests a role of the Y chromosome in prostate cancer. Cytogenet Genome Res, 101:250-260. | |
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Honecker F, Stoop H, de Krijger R, Lau Y-FC, Castrillon D, Oosterhuis JW, Bokemeyer C and Looijenga LHJ (2004). Pathological implications of the expression of markers of testicular carcinoma in situ by fetal germ cells. J Pathol, 203:849-857. | |
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Oh HJ, Li YM and Lau Y-FC (2005). Sry associates with a gene-silencing complex by interacting with a KRAB domain protein. Biol Reprod, 72:407-415 | |
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Taketo T, Lee C-H, Zhang JQ, Li YM, Lee G and Lau Y-FC (2005). Expression of Sry proteins in both normal and sex-reversed XY fetal mouse gonads. Devel Dyn, 233:612-622. | |
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Williams K, Fernandex S, Stien X, Ishii K, Love HD, Lau Y-FC, Roberts RL and Hayward SW (2005). Unopposed c-MYC expression in benign prostatic epithelium causes a cancer phenotype. Prostate, 63:369-384. | |
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Kido T and Lau Y-FC (2005). A Cre gene directed by a human TSPY promoter is specific for germ cells and neurons. Genesis, 42:263-275. | |
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Kersemaekers AM, Honecker F, Stoop H, Cools M, Molier M, Wolffenbuttel K, Bokemeyer C, Li Y, Lau Y-FC, Oosterhuis JW, Looijenga LH (2005). Identification of germ cells at risk for neoplastic transformation in gonadoblastoma: an immunohistochemical study for OCT3/4 and TSPY. Hum Pathol. 36:512-21. | |
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Cools M, Honecker F, Stoop H, Veltman JD, de Krijger RR, Steyerberg E, Wolffenbuttel KP, Bokemeyer C, Lau Y-FC, Drop SL, Looijenga LH (2006). | |
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Maturation delay of germ cells in fetuses with trisomy 21 results in increased risk for the development of testicular germ cell tumors. Hum Pathol. 37:101-11. | |
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Honecker F, Stoop H, Mayer F, Bokemeyer C, Castrillon DH, Lau Y-FC, Looijenga LH, Oosterhuis JW (2006). Germ cell lineage differentiation in non-seminomatous germ cell tumours. J Pathol. 208:395-400. | |
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Oh HJ, Lau YF (2006). KRAB: A partner for SRY action on chromatin. Mol Cell Endocrinol. 2006, 247:47-52. | |
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Hoei-Hansen C, Sehested A, Juhler M, Lau Y-FC, Skakkebaek NE, Laursen H and Rajpert-De Meyts E (2006). New evidence for orgin of intracranial germ cell tumors from primordial germ cells: Analysis of c-Kit, Oct-3/4, AP-2γ, TSPY and others. J Path, 209:25-33. | |
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Oram SW, Liu XX, Lee T-L, Chan WY and Lau Y-FC (2006). TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cells. BMC Cancer, 6: 154. | |
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Li YM, Oh HJ and Lau Y-FC (2006). Poly(ADP-ribose) polymerase I interacts with Sry and modulates its biological activities. Molecular and Cellular Endocrinology, 257-258:35-46. | |
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Kido T and Lau Y-FC (2006). The rat Tspy is preferentially expressed in elongated spermatids and interacts with the core histones. Biochemical Biophysical Research Communications, 350:56-67. | |
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Li YM, Vilain E, Conte F, Rajpert-De Meyts E and Lau Y-FC (2007). TSPY is expressed in early and late stages of gonadoblastoma and testicular carcinoma-in-situ. Urologic Oncology, 25:141-146. | |
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Oh HJ, Kido T and Lau Y-FC (2007). PIAS1 interacts with and represses SOX9 transactivation activity. Mol Reprod Develop, 74:1446-55. | |
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Li YM, Tabatabi ZL, Lee T-L, Hatakeyama S, Ohyama C, Chan W-Y, Looijenga LH and Lau Y-FC (2007). The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors, Human Pathology, 38:1470-81. | |
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de Jong J, Stoop H, Gillis AJ, van Gurp RJ, van Drunen E, Beverloo HB, Lau YF, Schneider DT, Sherlock JK, Baeten J, Hatakeyama S, Ohyama C, Oosterhuis JW, Looijenga LH. (2007). JKT-1 is not a human seminoma cell line. Int J Androl, 30:350-65. | |
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Lau Y-FC, Kido T and Li YM (2007). Chapter 4: The TSPY Gene Family. In Y Chromosome and Male Germ Cell Biology (Y-FC Lau and WY Chan, eds), pp 73-90.World Scientific Press, Singapore. | |
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Cools M, Boter M, van Gurp R, Stoop H, Poddighe P, Lau YF, Drop SL, Wolffenbuttel KP, Looijenga LH. (2007). Impact of the Y-containing cell line on histological differentiation patterns in dysgenetic gonads. Clin Endocrinol 67:184-92. | |
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Kido T and Lau Y-FC (2008). The human Y-encoded testis-specific protein interacts functionally with the translation elongation factor 1A, International Journal of Cancer, in press. | |
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5/30/08 |
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