leitmand@obgyn.ucsf.edu
(415) 502-5262 (voice)
(415) 502-7866 (fax)

Box 0556, UCSF; San Francisco, CA 94143-0556

University of California, Berkeley, California, B.S., 1980, Natural Resources
California State University, Hayward, California, M.S., 1983, Biology
Stanford University, Stanford, California, Ph. D., 1987, Physiology
University of California, Davis, California, M.D., 1993, Medicine

Leitman, D.C., Benson, S.C. and Johnson, L.K. Glucocorticoids stimulate collagen and noncollagen protein synthesis in cultured vascular smooth muscle cells. J. Cell Biol. 98:541-549, 1984.

Leitman, D.C., Waldman, S.A., Rapoport, R.M., and Murad, F. Specific atrial natriuretic factor receptors mediate increased cyclic GMP accumulation in cultured bovine aortic endothelial and smooth muscle cells. Trans. Amer. Assoc.Physicians 98:243-252, 1985.

Leitman, D.C., Fiscus, R.R. and Murad, F. Forskolin, phosphodiesterase inhibitors and cyclic AMP analogs inhibit proliferation of cultured bovine aortic endothelial cells. J. Cell. Physiology 127:237-243, 1986.

Leitman, D.C., and Murad, F. Comparison of binding and cyclic GMP accumulation by atrial natriuretic peptides in endothelial cells. Biochimica et Biophysica Acta 885:74-79, 1986.

Kuno,T., Andresen, J.W., Kamisaki, Y., Waldman, S.A., Chang, L., Saheki, S., Leitman, D.C., Nakane, M. and Murad, F. Co-purification of an atrial natriuretic factor receptor and particulate guanylate cyclase from rat lung. J. Biol. Chem. 261:5817-5823, 1986.

Leitman, D.C., Andresen, J.W., Kuno,T., Kamisaki,Y., Chang, J-K and Murad, F. Identification of multiple binding sites for atrial natriuretic factor by affinity cross-linking in cultured endothelial cells. J. Biol. Chem. 261:11155-11160, 1986.

Leitman, D.C., Andresen, J.W., Kuno,T., Kamisaki,Y., Chang, J-K and Murad, F. Identification of two binding sites for atrial natriuretic factor in endothelial cells: Evidence for a receptor subtype coupled to guanylate cyclase. Trans. Amer. Assoc. Physicians 99:103-113, 1986.

Leitman, D.C. and Murad, F. Atrial natriuretic factor receptor heterogeneity and stimulation of particulate guanylate cyclase and cyclic GMP. Endocrin. Metab. Clin. N. Amer. 16:79-106, 1987.

Leitman, D.C., Agnost, V.L., Tuan, J., Andresen, J. W. and Murad, F. Atrial natriuretic factor and sodium nitroprusside increase cyclic GMP in cultured rat lung fibroblasts by activating different forms of guanylate cyclase. Biochem. J. 244: 66-71, 1987.

Schroder, H., Leitman, D.C., Bennett, B.M., Hayward, L.D. and Murad, F. Cultured rat lung fibroblasts as a model for organic nitrate-induced cyclic GMP accumulation and activation of guanylate cyclase. J Applied Card.2:310-311, 1987.

Leitman, D.C., Andresen, J.W., Catalano, R.M., Waldman, S.A., Tuan, J.J., and Murad, F. Atrial natriuretic peptide binding, cross-linking and stimulation of cyclic GMP accumulation and particulate guanylate cyclase activity in cultured cells. J. Biol. Chem. 263:3720-3728, 1988.

Leitman, D.C., Agnost, V.A., Catalano, R.M., Schroder, H., Waldman, S.A., Bennett, B.M., Tuan, J.J. and Murad, F. Atrial natriuretic peptide, oxytocin and vasopressin increase cyclic GMP in LLC-PK1 kidney epithelial cells. Endocrinology 122:1478-1485, 1988.

Schroder, H., Leitman, D.C., Bennett, B.M., Waldman, S.A. and Murad, F. Glyceryl trinitrate induced-desensitization of guanylate cyclase in cultured rat lung fibroblasts. J. Pharmacol. Exper. Therap. 245:413-418, 1988.

Leitman, D.C., Molina, C.R., Waldman, S.A. and Murad, F. Atrial natriuretic peptide receptors and the guanylate cyclase-cyclic GMP system. In: Biological and molecular aspects of atrial factors. UCLA symposia and cellular biology 81:36-59, 1988.

Bennett, B.M., Leitman, D.C., Schroeder, H., Kawamoto, J.H., Nakatsu, K., and Murad, F. Relationship between biotransformation of glyceryl trinitrate and cyclic GMP accumulation in various cultured cell lines. J. Pharmacol. Exper. Therap. 250:316-323, 1989.

Waldman, S.A., Rapoport, R.M., Fiscus, R.R., Leitman, D.C., Chang, L.Y. and Murad, F. Regulation of particulate guanylate cyclase by atriopeptins: Relation between peptide structure, receptor binding and enzyme kinetics. Biochimica et Biophysica Acta 992:157-162, 1989.

Waldman, S.A., Leitman, D.C., Chang, L.Y. and Murad, F. Comparison of particulate guanylate cyclase in cells with and without atrial natriuretic peptide receptor binding activity. Molec. Cell. Biochem. 90:19-25, 1989.

Leitman, D.C. and Murad, F. Structure and function of atrial natriuretic peptide receptor subtypes. In: Atrial natriuretic peptides. CRC press, pgs. 77-93, 1990.

Waldman, S.A., Leitman, D.C., and Murad, F. Immunoaffinity purification of soluble guanylate cyclase. Methods in Enzymology 195:391-396, 1991.

Leitman, D. C., Chang, C-H, Kohse, K. P., Hirata, M., Song, D-L, Waldman, S. A., and Murad, F. Signal transduction pathways of atrial natriuretic peptide receptor subtypes. In: Atrial and Brain Natriuretic Peptides, Eds.H. Imura and H. Matsuo. pgs.149-164, 1991.

Leitman, D. C., Ribeiro, R. C. J., Mackow, E. R., Baxter, J. D., and West, B. L. Identification of a tumor necrosis factor responsive element in the tumor necrosis factor-a gene. J. Biol. Chem. 266:9343-9346, 1991.

Leitman, D. C., Mackow, E. R., Williams, T., Baxter, J. D., and West, B. L. The core promoter of the tumor necrosis factor-a gene confers phorbol ester responsiveness to upstream transcriptional activators. Molec. Cell. Biol. 12:1352-1356, 1992.

Leitman, D. C., Waldman, S. A., and Murad, F. Regulation of particulate guanylate cyclase by natriuretic peptides and Escherichia coli heat stable enterotoxin. Adv. Pharmacology 26:67-86, 1994.

Leitman, D. C., Costa, C., Graf., H., Baxter, J. D., and Ribeiro, R. C. J. Thyroid Hormone Activation of Transcription is Potentiated by Activators of Cyclic AMP-dependent Protein Kinase. J. Biol. Chem. 36:21950-21955, 1996.

An, J., Ribeiro, R.C.J., Webb, P. Gustafsson, J. A., Lomri, N., Kushner, P. J., Baxter, J. D., and D. C. Leitman. Estradiol repression of tumor necrosis factor-a transcription requires estrogen receptor activation function-2 and is enhanced by coactivators. Proc. Natl. Acad. Sci. USA 96:15161-15166, 1999.

Mueller, M. D., Vigne, J. L., Minchenko, A., Lebovic, D. I., Leitman, D. C., and R. N. Taylor. Regulation of vascular endothelial growth factor (VEGF) gene transcription by estrogen receptors alpha and beta. Proc. Natl. Acad. Sci. USA 97:10972-10977, 2000.

Baker, V. L., Leitman, D., and R. B. Jaffe. Selective estrogen receptor modulators in reproductive medicine and biology. Obstet. Gynecol. Survey, 55:S21-47, 2000.

An, J., Tzagarakis-Foster, C. Scharschmidt, T. C., Lomri, N., and D. C. Leitman. Estrogen receptor a selective transcriptional activity and coregulator recruitment by phytoestrogens. J. Biol. Chem. 276:17808-17814, 2001.

Tzagarakis-Foster, C., An, J., Geleziunas, R. and D. C. Leitman. Estradiol represses human T-cell leukemia virus type I tax activation of tumor necrosis factor-a gene transcription. In Preparation.

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