Professor, Surgery, UCSF
| CONTACT | |
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(415) 353-7444 (appts) Box 1674, UCSF; San Francisco, CA 94143-1674 |
additional websites: |
| EDUCATION | |
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Tulane University, BS, 1970, Biology/Pre-Med
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| PROFESSIONAL EXPERIENCE | |
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1974-75 |
Surgical Internship Charity Hospital, Tulane Division, New Orleans, LA |
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1975-76 |
Surgical Onc. and Res. Fellow, Tulane Univ. School of Medicine, Dept. of Surgery, New Orleans, LA |
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1976-78 |
Research Associate/Academic Trainee, Boston University School of Medicine, Boston, MA |
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1976-78 |
Member, Hubert H. Humphrey Cancer Research Center, Boston, MA |
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1978-79 |
Resident, Internal Medicine New England Deaconess Hospital, Boston, MA |
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1978-79 |
Senior Research Associate, New England Deaconess Hospital Cancer Research Institute, Boston, MA |
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1978-79 |
Clinical Fellow in Medicine, Harvard Medical School, Boston, MA |
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1979-82 |
Resident, General Surgery, University of California, Irvine Medical Center, Irvine, CA |
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1979-82 |
Research Associate, City of Hope National Medical Center, Division of Surgery, Duarte, CA |
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1982-83 |
Chief Surgical Resident, University of California, Irvine Medical Center, Irvine, CA |
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1983-85 |
Surgical Oncology Fellow, Clinical Associate, Medical Staff Fellow, Surgery Branch, Division of Cancer Treatment, National Cancer Institute/National Institutes of Health, Bethesda, MD |
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1985-86 |
Cancer Expert, National Cancer Institute, Division of Cancer Treatment, Surgery Branch, National Institutes of Health, Bethesda, MD |
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1986-91 |
Assistant Professor of Surgery, Univ. of Arizona, College of Medicine, Dept. of Surgery, Tucson, AZ |
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1986-91 |
Member, Arizona Cancer Center, Tucson, AZ |
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1986-91 |
Consulting Surgeon, Veterans Administration Hospital, Tucson, AZ |
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1989-91 |
Faculty Member, Cancer Biology Program, Arizona Cancer Center, Tucson, AZ |
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1990-91 |
Non-Core Faculty Member, Graduate Program, Department of Microbiology and Immunology, University of Arizona, College of Medicine, Tucson, AZ |
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1991-97 |
Associate Professor of Surgery, University of California, San Francisco. San Francisco, CA |
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1997-present |
Professor of Surgery, University of California, San Francisco. San Francisco, CA |
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1991-present |
Attending Surgeon, UCSF/Mount Zion Medical Center, San Francisco, CA |
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1994-present |
Member, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA |
| HONORS & AWARDS | |
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1981 |
Damon Runyon-Walter Winchell Cancer Fund Oncology Fellowship Award, Project Title: Expression of human melanoma membrane antigens as a function of cell cycle and clonogenicity |
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1987-1990 |
American Cancer Society Clinical Oncology Career Development Award |
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1993-97 |
Member, NCI Initial Review Group Cancer Manpower and Training Subcommittee |
| SELECTED PUBLICATIONS | |
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Scholarly Books | |
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Leong SPL (Ed). Malignant Melanoma: Advances in Treatment. Austin, TX:RG Landes Publishing Company, 1992. | |
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Leong SPL (Ed). Immunotherapy of Malignant Melanoma. Austin, TX:RG Landes Publishing Company, 1996. | |
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Leong SPL (Ed). Cutaneous Malignant Melanoma, The Surgical Clinics of North America, Philadelphia, PA: WB Saunders Publishing Company, 1996. | |
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Leong SPL and Wong JH (Ed). Sentinel Lymph Nodes in Human Solid Cancer. The Surgical Clinics of North America, Philadelphia, PA: WB Saunders Publishing Company, 2000. | |
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Leong SPL (Ed). Atlas of Selective Sentinel Lymph Node Dissection for Melanoma and Breast Cancer. Kluwer Academic Publishers, Norwell, MA, in press. | |
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Leong SPL (Ed). Malignant Melanoma, Part I. The Surgical Clinics of North America, Philadelphia, PA: WB Saunders Publishing Company, 2003. | |
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Leong SPL (Ed). Malignant Melanoma, Part II. The Surgical Clinics of North America, Philadelphia, PA: WB Saunders Publishing Company, 2003. | |
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Leong SPL, Kitagawa Y and Kitajima M (Eds). Selective Sentinel Lymphadenectomy For Human Solid Cancer. USA: Springer, 2005. | |
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Hearing VJ and Leong SPL (Eds). From Melanocytes to Malignant Melanoma: Progression to Malignancy, Totowa, New Jersey: Humana Press, 2005. | |
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Referenced Journals: (Selected from 112 references) | |
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Leong SPL, Sutherland CM and Krementz ET. Changes in distribution of human malignant melanoma membrane antigens in the presence of human antibody by immunofluorescence. Canc Res 1977, 37:293-298. | |
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Leong SPL, Cooperband SR, Sutherland CM, et al. Detection of human melanoma antigens in cell-free supernatants. J Surg Res 1978, 24:245-252. | |
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Leong SPL, Cooperband SR, Deckers PJ, et al. Antibody-induced movement of common melanoma membrane antigens on the surface of unfixed human melanoma cells. Cancer Res 1979, 39:2125-2132. | |
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Chee DO, Yonemoto RH, Leong SPL, et al. Mouse monoclonal antibody to a melanoma-carcinoma-associated antigen synthesized by a human melanoma cell line propagated in serum-free medium. Canc Res 1982, 42:3142-7. | |
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Leong SPL, Cooperband SR, Deckers PJ, et al. Serological detection of common human melanoma membrane antigens by microcomplement fixation and immunofluorescence. Oncology 1983, 40:95-101. | |
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Leong SPL. Detection of human malignant melanoma antigens by immunofluorescence and autologous postimmune antimelanoma sera. Ann NY Acad Sci 1983, 420:237-250. | |
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Leong SPL, Bolen JL, Chee DO, et al. Cell Cycle-dependent expression of human melanoma membrane antigen analyzed by flow cytometry. Cancer 1985, 55(6):1276-1283. | |
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Leong SPL, Noguchi PD, Cunningham RE, et al. Expression of a murine B16 melanoma-associated antigen analyzed by flow cytometry. J Surg Res 1985, 38:383-390. | |
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Leong SPL, Noguchi PD, Cunningham RE, et al. Heterogeneous expression of a murine B16 melanoma-associated antigen correlates with cell cycle. Cancer Immuno Immunother 1987, 24:106-112. | |
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Leong SPL, Muller J, Yetter RA, et al. Expression and modulation of a retrovirus-associated antigen by murine melanoma cells. Cancer Res 1988, 48(17):4954-4958. | |
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Trent JM, Meyskens FL, Salmon SE, Ryschon K, Leong SPL, et al. Relationship of cytogenetic abnormalities and clinical outcome in metastatic melanoma. N Engl J Med 1990, 322(21):1508-1511. | |
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Hearing VJ, Leong SPL, Vieira WD and Law LW. Suppression of established pulmonary metastases by murine melanoma-specific monoclonal antibodies. Internatl J Cancer 1991, 47:148-153. | |
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Leong SPL, Granberry ME, Zhou YM, et al. Selection of cytotoxic T lymphocytes against autologous human melanoma from lymph nodes with metastatic melanoma using repeated in vitro sensitization. Clinical & Experimental Metastasis 1991, 9(3):301-317. | |
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Bridge J, Leong, SPL, Burgess AC, et al. Examination of clonal variants from human malignant melanoma studied by chromosome banding analysis. Melanoma Research 1991, 1(4):289-296. | |
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Hendrix MJC, Seftor EA, McDaniel KM, Seftor REB, Chu YW, Yohem KH, Leong SPL, et al. Coexpression of vimentin and cytokeratins by human melanoma tumors cells: Correlation with invasive and metastatic potential. JNCI 1992, 84(3):165-174. | |
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Taylor CW, Grogan TM, Lopez MHA, Leong SPL, et al. Growth and dissemination of human malignant melanoma cells in mice with severe combined immune deficiency. Lab Invest 1992, 67(1):130-137. | |
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Leong SPL, Xu MJ, Alberts DS, et al. Chemosensitivity of human melanoma to cisplatin and heat at doses achievable by isolated hyperthermic perfusion. Regional Cancer Treatment 1993, 4:216-219. | |
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YY, Meloni AM, Altungoz O, Peier A, Karakousis C, Leong SPL, and Sandberg AA. Cytogenetic findings in 21 malignant melanomas. Cancer Genet Cytogenet 1994, 77:69-73. | |
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Leong SPL, Zhou YM, Granberry ME, et al. Generation of cytotoxic effector cells against human melanoma. Cancer Immunology and Immunotherapy 1995, 40:397-409. | |
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Thompson FH, Emerson J, Olson S, Weinstein R, Leavitt SA, Leong SPL, et al. Cytogenetics in 158 patients with regional or disseminated melanoma: subset analysis of near diploid and simple karyotypes. Cancer Genetics and Cytogenetics 1995, 83:93-104. | |
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Leong SPL, Liliental J, Krams SM, Zhou YM, et al. T cell receptor usage by cytotoxic T lymphocytes against autologous human melanoma. Anti Cancer Research 1996, 16(6B):3355-3361. | |
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Leong SPL, Steinmetz I, Habib FA, et al. Optimal selective sentinel lymph node dissection in primary malignant melanoma. Archives of Surgery 1997, 132:666-73. | |
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Leong SPL. The Role of Sentinel Lymph Node in Human Solid Cancer. In Devita, Hellman, Rosenberg, eds. PPO Updates, Vol. 12. Philadelphia: Lippincott-Raven, 1998, pp. 1-12. | |
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Leong SPL, Enders-Zohr P, Zhou YM, Allen RE, Jr., Sagebiel RW, Glassberg AB and Hayes AF. Recombinant human granulocyte macrophage-colony stimulating factor and autologous melanoma vaccine mediate tumor regression in patients with metastatic melanoma. Journal of Immunotherapy, 1999, 22(2):166-174. | |
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Chang JW, Vaquerano JE, Zhou YM, Peng M and Leong SPL. Characterization of dendritic cells generated from peripheral blood of patients with malignant melanoma. AntiCancer Research, 1999, 19(3A):1815-20. | |
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Vaquerano JE, Cadbury P, Treseler PA, Sagebiel R, Leong SPL. Regression of in-transit melanoma of the scalp with intralesional recombinant human granulocyte macrophage-colony stimulating factor (RHGM-CSF). Archives of Dermatology 1999, 135(10):1276-7. | |
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Thelmo, MC, Sagebiel, RW, Treseler, PA, Morita, ET, Nguyen, LH, Kashani-Sabet, M, Leong, SPL. Evaluation of sentinel lymph node status in spindle cell melanomas. Journal of the American Academy of Dermatology, 2001, 44(3):451-5. | |
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Thelmo, MC, Morita, ET, Treseler PA, Nguyen, LH, Allen RE, Sagebiel RW, Kashani-Sabet, M, Leong, SPL . Micrometastasis to in-transit lymph nodes from extremity and truncal malignant melanoma. Annals of Surgical Oncology, 2001, 8:444-448. | |
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Rodrigues LKE, Leong SPL, Kashani-Sabet M, Wong JH: Early experience with sentinel lymph node mapping for Merkel cell carcinoma. Journal American Academy of Dermatology, 2001, 45:303-308. | |
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Li X, Regezi J, Ross FP, Blystone S, Ilic D, Leong SPL, Ramos DM: Intergrin αvβ3 mediates K1735 murine melanoma cell motility in vivo and in vitro. Journal of Cell Science, 2001, 114(14):2665-72. | |
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Leong SPL: Selective sentinel lymph node mapping and dissection for breast cancer. Cancer Treat Res. 2002;111:65-79. | |
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Wu CT, Morita ET, Treseler PA, Esserman LJ, Hwang ES, Kuerer HM, Santos CL, Leong SPL: Failure to harvest sentinel lymph nodes identified by preoperative lymphoscitigraphy in breast cancer patients. The Breast Journal 2003, 9(2):86-90. | |
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Leong SPL: Selective sentinel lymphadenectomy for breast cancer in the United States. Asian J of Surgery 2004;27(4):268-74. | |
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Tan YY, Fan YG, Lu Y, Hwang S, Ewing C, Esserman L, Morita E, Treseler, P and Leong SPL: Ratio of positive to total number of sentinel modes predicts non-sentinel node status in breast cancer patients. The Breast Journal 2005, 11(4):248-53. | |
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Park C, Seid P, Morita ET, Iwanaga K, Weinberg V, Quivey J, Hwang ES, Esserman LJ, Leong SPL: Internal mammary sentinel lymph node mapping for invasive breast cancer: Implications for staging and treatment. The Breast Journal 2005, 11(1):29-33. | |
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Lang JE, Esserman LJ, Ewing CA, Rugo HS, Lane KT, Leong SPL, Hwang ES. Accuracy of sentinel lymph node biopsy following neoadjuvant chemotherapy: effect of clinical nodal status at presentation. J Am Coll Surger 2004, 199(6):856-62. | |
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Haqq C, Nosrati M, Sudilovsky D, Crothers J, Khodabakhsh D, Pulliam BL, Federman S, Miller JR 3rd, Allen RE, Singer MI, Leong SPL, Ljung BM, Sagebiel RW, Kashani-Sabet M: The gene expression signatures of melanoma progression. Proc Natl Acad ScU S A. 2005;102(17): 6092-6097.i | |
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Leong SPL, Morita ET, Sudmeyer M, Chang J, Shen D, Achtem, TA, Allen, RE and Kashani-Sabet M: Heterogeneous patterns of lymphatic drainage to sentinel lymph nodes by primary melanoma from different anatomical sites. Clinical Nuclear Medicine 2005;30(3):150-8. | |
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Shi, J, Kahle A, Hershey JWB, Honchak BM, Warneke, JA, Leong SPL and Nelson MA. Decreased expression of eukaryotic initiation factor 3f deregulates translation and apoptosis in tumor cells. Oncogene (2006), 1-14. | |
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Leong SPL, Accortt NA, Essner, R, Ross M, Gershenwald JE, Pockaj, B, Hoekstra, HJ,Garberoglio,C,White RL, Chu, D, Biel M, Charney, K, Wanebo, H, Avisar, E, Vetto, J and Soong, SJ. Impact of sentinel node status and other risk factors on the clinical outcome of head and neck melanoma patients. Arch Otolaryngol Head Neck Surg. 2006;132:370-373. | |
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Leong SPL, Cady B, Jablons DM, Garcia-A guilar J, Reintgen D, Jakub J, Pendas S, Duhaime L, Cassell R, Gardner M, Giuliano R, Archie V, Calvin D, Mensha L, Shivers S, Cox c, Werner JA, Kitagawa Y and Kitajima M. Clinical patterns of metastasis. Cancer and Metastasis Reviews 2006;25:221-232. | |
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Leong SPL. Paradigm shift of staging and treatment for early breast cancer in the sentinel lymph node era. Breast J. 2006 Sep-Oct;12 Suppl 2:S128-33. | |
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Rangel, J., et al., Torabian S, Shaikh L, Nosrati M, Baehner FL, Haqq C, Leong SP, Miller JR 3rd, Sagebiel RW, Kashani-Sabet M. Prognostic significance of nuclear receptor coactivator-3 overexpression in primary cutaneous melanoma. J Clin Oncol, 2006. 24(28): p. 4565-9. |
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12/11/06 |
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