Joachim J. Li, MD, PhD

University of Chicago, Chicago, IL, B.S., M.S., 1980, Chemistry
Johns Hopkins University School of Medicine, Baltimore, MD, M.D., Ph.D., 1988, Medicine/Molecular Biology

• 1980-1982, 1987-1988
  Medical Student, Johns Hopkins University School of Medicine, Baltimore, MD
• 1982-1987
  Graduate Student (Thomas J. Kelly), Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD
• 1988
  Postdoctoral Fellow,Yeast Genetics (Phil Hieter), Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD
• 1989-1993
  Postdoctoral Fellow, Yeast Genetics/Molecular Biology (Ira Herskowitz), Department of Biochemistry and Biophysics, University of California-San Francisco, San Francisco, CA
• 1993-2000
  Assistant Professor, Department of Microbiology and Immunology, University of California-San Francisco, San Francisco, CA
• 2000-present
  Associate Professor, Department of Microbiology and Immunology, University of California-San Francisco, San Francisco, CA

• 1977
  United States Presidential Scholar
• 1979
  Phi Beta Kappa
• 1979-1980
  National Science Foundation Graduate Fellow
• 1987
  Michael A. Shanoff Research Award for Ph.D. Thesis, Johns Hopkins University School of Medicine
• 1989-1990
  Squibb Fellow, Life Sciences Research Foundation
• 1990-1997
  Markey Scholar Award
• 1994-1999
  Rita Allen Scholar
• 1995-1998
  Searle Scholar
• 1998
  Distinction in Teaching Award, UCSF

• Li, J.J., and Kelly, T.J. (1984). Simian virus 40 DNA replication in vitro. Proc. Natl. Acad. Sci. USA. 81:6973-6977.
• Li, J.J., and Kelly, T.J. (1985). Simian virus 40 DNA replication in vitro: specificity of initiation and evidence for bidirectional replication. Mol. Cell. Biol. 5:1238-1246.
• Li, J.J., Peden, K.W.C., Dixon, R.A.F., and Kelly, T.J. (1986). Functional organization of the simian virus 40 origin of DNA replication. Mol. Cell. Biol. 6:1117-1128.
• Li, J.J., Wold, M.S., and Kelly, T.J. (1987). Analysis of SV40 replication in vitro. In Mechanisms of DNA Replication and Recombination, T.J. Kelly and R.M. McMacken, eds., Academic Press, New York, pp. 289-301.
• Yang, L., Liu, L.F., Li, J.J., Wold, M.S., and Kelly, T.J. (1987). The roles of DNA topoisomerases in SV40 DNA replication in vitro. In Mechanisms of DNA Replication and Recombination, T.J. Kelly and R.M. McMacken, eds., Academic Press, New York, pp. 315-326.
• Yang, L., Wold, M.S., Li, J.J., Kelly, T.J., and Liu, L.F. (1987). Roles of DNA topoisomerases in simian virus 40 DNA replication in vitro. Proc. Natl. Acad. Sci. USA. 84:950-954.
• Wold, M.S., Li, J.J., and Kelly, T.J. (1987). Initiation of SV40 DNA replication in vitro: T antigen- and origin-dependent unwinding of the template. Proc. Natl. Acad. Sci. USA. 84:3643-3647.
• Kelly, T.J, Rosenfeld, P.K., Wides, R.J., O'Neill, E., Li, J.J., and Wold, M.S. (1987). Replication of adenovirus and SV40 chromosomes in vitro. In Eukaryotic Chromosome Replication, R.A. Laskey, G.R. Banks, and P.M. Nurse, eds., The Royal Society, London, pp. 35-44.
• Kelly, T.J., Wold, M.S., and Li, J.J. (1988). Initiation of viral DNA replication. Adv. Virus Res. 34:1-42.
• Wold, M.S., Li, J.J., Weinberg, D.H., Virshup, D.M., Sherley, J.M., Verheyen, E., and Kelly, T. (1988). Cellular proteins required for SV40 DNA replication. In Cancer Cells, T. Kelly and B. Stillman, eds., Cold Spring Harbor Laboratory, Cold Spring Harbor, vol. 6, pp. 133-142.
• Wold, M.S., Weinberg, D.H., Virshup, D.M., Li, J.J., and Kelly, T.J. (1989). Identification of cellular proteins required for simian virus 40 DNA replication. J. Biol. Chem. 264:2801.
• Li, J.J., and Alberts, B. (1992). Eukaryotic Initiation Rites. Nature. 357:114-115.
• Li, J.J., and Deshaies, R.J. (1993). Exercising self-restraint: discouraging illicit acts of S and M in eukaryotes. Cell. 74:223-236.
• Li, J.J., and Herskowitz, I. (1993). Use of a one-hybrid system to identify and clone ORC6, a gene encoding the 50kd subunit of the yeast origin recognition complex. Science. 262:1870-1874.
• Li, J.J. (1995). Once and Only Once. Curr. Biol. 5: 472-475.
• Wong, T, and Li, J.J. (1995). Eukaryotic DNA Replication. Curr. Opin. Cell Biol. 7:414-420.
• Kroll, E., Hyland, K., Hieter, P., and Li, J.J. (1996) Establishing genetic interactions by a synthetic dosage lethality phenotype. Genetics. 143: 95-102.
• Detweiler, C. and Li, J.J. (1997). Cdc6p Establishes and Maintains a State of Replication Competence during G1 Phase. J. Cell Sci. 110:753-763.
• Owens, J., Detweiler, C., and Li, J.J. (1997). CDC45 is required in conjunction with CDC7/DBF4 to trigger the initiation of DNA replication. Proc. Nat. Acad. Sci. USA. 94:12521-12526.
• Detweiler, C. and Li, J.J. (1998). Ectopic induction of Clb2 in early G1 phase is sufficient to block prereplicative complex formation in Saccharomyces cerevisiae. Proc. Nat. Acad. Sci. USA. 95: 2384-2389.
• Brachmann, C. B., Davies, A., Cost, G. J., Caputo, E., Li, J.J., Hieter, P., and Boeke, J. D. (1998). Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast 14:115-132.
• Oshiro, G., Owens, J.C. , Shellman, Y., Sclafani, R.A., and Li, J.J. (1999). Cell cycle regulation of Cdc7p kinase activity through regulation of Dbf4p stability. Mol. Biol. Cell. 19:4888-96.
• Nguyen, V., Co, C., Irie, K., and Li, J.J. (2000). Regulation of Cell Cycle-Dependent Mcm Localization by Cdc28/Clb Kinase in Saccharomyces cerevisiae. Curr. Biol. 10:195-205.
• Nguyen, V., Co, C., Li, JJ. (2001) Cyclin-dependent kinases prevent re-replication through multiple overlapping mechanisms. Nature. 411: 1068-1073.
• Green, B.M, Li, J.J. (2005) Loss of re-replication control in Saccharomyces cerevisiae results in extensive DNA damage. Mol Biol Cell 16:421-432.
• Liku, M., Nguyen, V., Rosales, A., Irie, K., and Li, J.J. (2005). CDK phosphorylation of Mcm3 inhibits replication initiation by promoting net nuclear export of Mcm2-7. Mol Biol Cell 16:5026-39.