Bin Liu, PhD

Princeton University, B.A., June 1990, Molecular Biology and Biochemical Sciences
University of California, San Francisco, Ph.D., Dec. 1994, Biochemistry and Biophysics

• 1995-1997
  Visiting fellow, Department of Dermatology, University of California school of medicine, San Francisco, California
• 1998-2001
  Visiting fellow, Department of Anesthesia and Pharmaceutical chemistry, San Francisco General Hospital, San Francisco, California.
• 2002-2006
  Assistant Professor, Department of Anesthesia, University of California, San Francisco.
• 2006-2011
  Associate Professor, Department of Anesthesia, University of California, San Francisco.
• 2011-present
  Professor, Department of Anesthesia, University of California, San Francisco.
• 2003-present
  Program member, UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco.

• 1990
  Summa Cum Laude (Princeton University)
• 1990
  Phi Beta Kappa (Princeton University)
• 1990
  Sigma Xi (Princeton University)
• 1990
  Sigma Xi Book Award (Princeton University)
• 1990
  E.R. Squibb and Sons Thesis Prize (Princeton University)
• 1990
  George Khoury’65 Prize For Academic Excellence (Princeton University)
• 1990,1991
  Regents’ Fellow (University of California at San Francisco)
• 1994
  Chancellor's Fellow (University of California at San Francisco)
• 1996-1999
  SmithKline Beecham Fellow of the Life Sciences Research Foundation
• 1998
  Scleroderma Research Foundation investigator award
• 2002
  American Cancer Society intramural research award
• 2002
  BioSTAR/UC Discovery award
• 2002
  CaPCure research award
• 2002
  DOD New Investigator award
• 2004
  MARF Investigator award
• 2006
  MARF Investigator award
• 2008
  AACR PanCan Pilot award
• 2009
  UC Discovery SEED award
• 2011
  MARF Investigator award

• Liu, B., Wong, M.L., Tinker, R.L., Geiduschek, E.P., Alberts, B.M. The DNA replication fork can pass RNA polymerase without displacing the nascent transcript. Nature, 366(6450):33-9 (1993). PMID: 8232535
• Liu, B., Wong, M.L., Alberts, B.M. A Transcribing RNA polymerase molecule survives DNA replication without aborting its growing RNA chain. Proc. Natl. Acad. Sci. USA, 91(22):10660-4 (1994). PMID: 7524099
• Liu, B. and Alberts, B.M. Head-on collision between a DNA replication apparatus and RNA polymerase transcription complex. Science, 267(5201):1131-7 (1995). PMID: 7855590
• Liu, B. and Connolly, M.K. The pathogenesis of cutaneous fibrosis. Semin Cutan Med Surg, 17(1):3-11 (1998). PMID: 9512100
• Liu, B. and Marks, J.D. Applying phage antibodies to proteomics: selecting single chain Fv antibodies to antigen blotted on nitrocellulose. Anal. Biochem, 286(1):119-28 (2000). PMID: 11038282
• Liu, B., Huang, L., Sihlbom, C., Burlingame, A.L., Marks, J.D. Towards proteome-wide production of monoclonal antibody by phage display. J Mol Biol, 315(5):1063-1073 (2002). PMID: 11827476
• Liu, B., Conrad, F., Cooperberg, M.R., Kirpotin, D.B., Marks, J.D. Mapping tumor epitope space by direct selection of single chain Fv antibody libraries on prostate cancer cells. Cancer Res, 64(2):704-710 (2004). PMID: 14744788
• Bidlingmaier, S. and Liu, B. Construction and application of a yeast surface-displayed human cDNA library to identify post-translational modification-dependent protein-protein interactions. Mol Cell Proteomics, 5(3):533-40 (2006). PMID: 16321969
• Ruan, W., Sassoon, A., An, F., Simko, J.P. and Liu, B. Identification of clinically significant tumor antigens by selecting phage antibody library on tumor cells in situ using laser capture microdissection. Mol Cell Proteomics, 5(12):2364-73 (2006). PMID: 16982673
• Liu, B., Conrad, F., Roth, A., Drummond, D.C., Simko, J., Marks, J.D. Recombinant full-length human IgG1s targeting hormone refractory prostate cancer. J Mol Med, 85(10):1113-23 (2007). PMID: 17554518
• Goenaga, A-L., Zhou, Y., Legay, C., Bougherara, H., Huang, L., Liu, B., Drummond, D.C., Kirpotin, D.B., Auclair, C., Marks, J.D., Poul, M-A. Characterization of tumor markers combining antibody phage display and intrabody strategies. Mol Immunology, 44(15):3777-3788 (2007). PMID: 17498801
• Roth, A., Drummond, D.C., Conrad, F., Hayes, M.E., Kirpotin, D.B., Benz, C.C., Marks, J.D. and Liu, B. Anti-CD166 single chain antibody-mediated intracellular delivery of liposomal drugs to prostate cancer cells. Mol Cancer Ther, 6(10): 2737-46 (2007). PMID: 17938267
• Bidlingmaier, S. and Liu, B. Interrogating yeast surface displayed human proteome for Identification of small molecule binding proteins. Mol Cell Proteomics, 6(11): 2012-20 (2007). PMID: 17660511
• Liu, B. Exploring cell type-specific internalizing antibodies for targeted delivery of siRNA. Brief Funct Genomic Proteomic, 6(2):112-9 (2007). PMID: 17670766
• An, F., Drummond, D.C., Wilson, S., Kirpotin, D.B., Nishimura, S., Broaddus, C.V. and Liu, B. Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single chain antibodies. Mol Cancer Ther, 7(3):569-78 (2008). PMID: 18319332
• Bidlingmaier, S., Zhu, X., and Liu, B. The utility and limitation of CD133 epitopes in defining tumor stem cell population. J Mol Med, 86(9):1025-32 (2008). NIHMSID 78090
• Conrad, F., Zhu, X., Zhang, X., Chalkley, R.J., Burlingame, A.L., Marks, J.D., and Liu, B. Human antibodies targeting cell surface antigens overexpressed by the hormone refractory metastatic prostate cancer cells: ICAM-1 is a tumor antigen that mediates prostate cancer cell invasion. J Mol Med, 87(5): 507-14 (2009). NIHMSID 164984
• Bidlingmaier, S., He, J., Wang, Y., An, F., Feng, J., Gao, J., Barbone, D., Franc, B., Broaddus, C.V. and Liu, B. Identification of the antigen bound by a tumor-targeting phage antibody using yeast surface human proteome display: MCAM is a mesothelioma-associated cell surface antigen. Cancer Res, 69(4): 1570-77 (2009). NIHMSID 82311
• Drummond, D.C., Noble, C.O., Guo, Z., Hayes, M.E., Connoly-Ingrim, C., Gabriele, B., Hann, B., Liu, B., Park, J.W., Hong, K., Benz, C.C., Marks, J.D., Kirpotin, D.B. Development of a highly stable and targetable nanoliposomal formulation of topotecan. J Control Release. 141(1):13-21 (2010) [Epub ahead of print Aug 15, 2009] PMID: 19686789
• He, J., Wang, Y., Feng, J., Zhu, J., Lan, X., Iyer, A.K., Zhang, N., Seo, Y., VanBrocklin, H.F., and Liu, B. Targeting prostate cancer cells in vivo using a rapidly internalizing novel human single chain antibody fragment. J Nucl. Med., 51(3):427-32 (2010). PMCID: PMC2832590
• Zhu, X., Bidlingmaier, S., Hashizume, R., James, C.D., Berger, M.S. and Liu, B. Identification of internalizing human single chain antibodies targeting brain tumor sphere cells. Mol Cancer Ther, 9(7):2131-41 (2010) [Epub ahead of print June 29]. PMID: 20587664
• Chen, Y., Zhu, X., Zhang, X., Liu, B.*, and Huang, L*. Nanoparticles modified with tumor-targeting scFv Deliver siRNA and miRNA for Cancer Therapy. Mol Therapy, 18(9):1650-6 (2010) [Epub ahead of print July 6]. PMID: 20606648
• Bidlingmaier, S., Wang, Y., Liu, Y., Zhang, N., and Liu, B. Comprehensive analysis of yeast surface cDNA display library selection outputs by exon microarray to identify novel protein-ligand interactions. Mol Cell Proteomics. 2011 Mar; 10(3):M110.005116 (2011) [Epub 2010 Dec 2] PMID: 21127146
• McCabe, K.E., Liu B., Marks, J.D., Wu., H., and Wu, A. An engineered cysteine-modified diabody for PET imaging of ALCAM-positive pancreatic and colorectal tumor models. Molecular Imaging Biology. June 1st (2011) [Epub ahead of print]. PMID: 21630083
• Iyer, A.K., Su, Y., Feng, J.J., Lan, X., Zhu, X., Liu, Y., Gao, G., Seo, Y., VanBrocklin, H.F., Broaddus, V.C., Liu, B., and He, J. Internalizing human single chain antibody fragment enhanced liposome targeting to epithelioid and sarcomatoid mesothelioma in vivo. Biomaterials. 32(10):2605-13 (2011) PMID: 21255833
• Iyer, A.K., Lan, X., Zhu, X., Su, Y., Feng, J., Zhang, X., Gao, D., Seo, Y., VanBrocklin,, H.F., Broaddus, V.C., Liu, B.*, and He, J.* Novel rapidly internalizing human single chain antibody fragment targeting epithelioid and sarcomatoid mesothelioma in vivo. Cancer Res. 2011 Mar 29. [Epub ahead of print] PMID: 21447742
• Bidlingmaier, S. and Liu, B. Construction of yeast surface-displayed cDNA libraries. Methods Mol Biol, 729: 199-210 (2011) PMID: 21365492
• Bidlingmaier, S. and Liu, B. Identification of protein/target molecule interactions using yeast surface-displayed cDNA libraries. Methods Mol Biol, 729:211-23 (2011) PMID: 21365493