Mignon Lee-Cheun Loh, MD

Bryn Mawr College, Bryn Mawr, PA, B.A., 1987, History of Art
Columbia University College of Physicians and Surgeons, M.D., 1991, Medicine
Harvard University School of Public Health, 1999, Clinical Effectiveness
University California San Francisco Medical School, 2001, Advanced Training in Clinical Research

• 1991-1992
  Intern in Pediatrics, University of California-San Francisco, San Francisco, CA.
• 1992-1994
  Resident in Pediatrics, The Children's Hospital, Boston, Harvard Medical School, Boston, MA.
• 1995-1996
  Clinical Fellow, Pediatric Hematology-Oncology, The Children's Hospital, Boston and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
• 1996-1998
  Research Fellow, Division of Hematology-Oncology, The Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
• 1998-1999
  Instructor, Harvard Medical School, Boston, MA
• 1999
  Research Fellow, Brigham and Women's Hospital, Boston, MA
• 1999-2006
  Assistant Professor of Clinical Pediatrics, University of California, San Francisco Medical School, San Francisco, CA.
• 2006-present
  Associate Professor of Clinical Pediatrics, University of California, San Francisco Medical School, San Francsico, CA.

• 1987
  Cum Laude, Bryn Mawr College
• 1988, 1989
  Harriet Judd Sartain Memorial Scholarship
• 1990
  Hannah Longshore Memorial Scholarship
• 1991
  Arnold Gold Foundation Award, Columbia University College of Physicians and Surgeons
• 1995-1999
  Recipient, Research Training Grant (5T32HL07574), PI: Samuel Lux, MD
• 1999-2004
  Recipient, K23 award, Mentors: D. Gary Gilliland, MD, Ph.D 1999 and Kevin M. Shannon MD, 2000-2004
• 1999-2002
  Recipient, Child Health Research Center award, PI: Larry Shapiro, MD, PhD
• 2007-2012
  Leukemia Lymphoma Society, Scholar in Clinical Research

• Loh ML, Mclean TW, Buckley JR, Howells W, Gilliland DG, Smith FO. "Lack of TEL/AML1 fusion in pediatric AML; further evidence for lineage specificity of TEL/AML1." (1998) Leukemia Research, 22(5) 461-464.
• Loh ML, Silverman LB, Young ML, Neuberg D, Golub TR, Sallan SE, Gilliland D.G. "Incidence of TEL/AML1 fusion in children with relapsed acute lymphoblastic leukemia." (1998) Blood 92(12):4792-7.
• Pousti, TJ, Upton J, Loh ML, Grier, HE. "Congenital Fibrosarcoma of the Upper Extremity." Plast Reconstruct Surg 1998; 102(4): 1158-62.
• Golub TR, Slonim D, Tamayo P, Huard C, Gaasenbeck M, Mesirov J, Loh ML, Downing J, Bloomfield C, Lander ES. "Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring." (1999) Science 286:531-537
• Song, WJ, Sullivan MG, Legare RD, Hutchings S, Tan X, Kufrin D, Ratajcak J, Resende IC, Haworth C, Hock R, Loh M, Felix C, Roy DC, Busque L, Kurnit D, Willman C, Gewirtz AM, Speck NA, Bushweller JH, Li FP, Gardiner K, Poncz M, Maris JM, Gilliland DG. "Haploinsufficiency of CBFA2 causes familial thrombocytopenia w/ propensity develop acute myelogenous leukaemia." (1999) Nature Genetics 2:166-175.
• Loh ML, Samson Y, Motte E, Moreau LA, Dalton V, Waters S, Sallan SE, Gilliland DG. "t(2;8)(p12;q24) associated with a cryptic t(12;21)(p13;q22) TEL/AML1 gene rearrangement in a child with Acute lymphoblastic leukemia." (2000) Cancer Genetics and Cytogenetics: 122:79-82.
• Schwaller J, Parganas E, Wang D, Cain D, Aster JC, Williams IR, Lee CK, Gerthner R, Kitamura T, Frantsve J, Anastasiadou E, Loh ML, Levy DE, Ihle JN, Gilliland DG. "Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2." (2000) Molecular Cell 6:693-704.
• Ferrando AA, Neuberg DS, Staunton, J, Loh ML, Huard C, Raimondi SC, Behm FG, Pui CH, Downing JR, Gilliland, DG, Lander ES, Golub TR, Look AT. "Gene Expression Signatures Define novel oncogenic pathways in T-Cell Acute Lymphoblastic Leukemia." (2002) Cancer Cell ; 1:72-77.
• Loh ML, Ahn P, Perez-Atayde AR, Gebhardt MC, Shamberger RE, Gilliland DG, Grier HE. "Treatment of Infantile Fibrosarcoma with Neoadjuvant Chemotherapy: Results from the Dana-Farber Cancer Institute and Children's Hospital, Boston." (2002) J. Pediatr Hematol Oncol.;24:722-726.
• Loh ML, Rubnitz JE. " TEL/AML1 positive leukemia: Prognostic significance and Therapeutic approaches." (2002) Curr. Opin. in Hematol ; 9(4): 345-52.
• Loh ML, Matthay KK "Neonatal malignancies." Chapter, Avery's Diseases of the Newborn, eighth ed. (2005), Elsevier Saunders, Philadelphia, PA.
• McHale, CM, Wiemels JL, Zhang L, Ma X, Buffler PA, Loh ML, Smith MT "Pre-natal origin of TEL/AML1 positive acute lymphoblastic leukemia in children born in California" (2003) Genes, Chromosomes, and Cancer; 37 (1): 36-43.
• Loh ML, Vattikuti S, Reynolds MG, Carlson EJ, Schubbert S, Lieuw KH, Cheng JW, Stokoe D, Bonifas JM, Curtis NP, Gotlib J, Meshinchi S, LeBeau MM, Emanuel P, Shannon KM. "Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis." (2004) Blood. 103(6):2325-31
• Tartaglia M, Niemeyer CM, Shannon KM, Loh ML. "SHP-2 and Myeloid Malignancies" Curr. Opin. in Hematol. (2004) 11: 44-50.
• Loh ML, Reynolds MG, Vattikuti S, Gerbing R, Alonzo T, Carlson E, Cheng J, Lee C, Lange B, Meshinchi S. "PTPN11 mutations in pediatric AML: A report from the Children's Cancer Group" (2004) Leukemia Nov;18(11):1831-4.
• Loh ML, Martinelli S, Cordeddu V, Reynolds MG, Vattikuti S, Lee CM, Wulfert M, Germing U, Haas P, Niemeyer C, Beran ME, Strom S, Lubbert M, Sorcini M, Estey EH, Gattermann N, Tartaglia M. "Acquired PTPN11 mutations occur rarely in adult patients with chronic myelomonocytic leukemia and myelodysplastic syndromes" (2005), Leukemia Research, 29(4):459-62.
• Bentires-Alj M, Paez JG, David, F, Keilhack H, Halmos B, Naoki K, Maris, JM, Richardson A, Bardelli A, Sugarbaker DJ, Richards WG, Du J, Girard L, Minna JD, Loh ML, Fisher DE, Velculescu VE, Vogelstein B, Meyerson M, Sellers WR, and Neel BG "Activating mutations of the Noonan Syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult AML." (2004) Cancer Research,2004 Dec 15;64(24):8816-20.
• Zhang, IH, Zane, LT, Braun B, Maize J, Zoger S, Loh, ML "A case of congenital leukemia with leukemia cutis." (2006) Journal of American Academy of Dermatology. Feb; 54 :S22-7
• Ma X, Buffler PA, Wiemels JL, Selvin S, Metayer C, Loh M, Does MB, Wiencke JK. "Ethnic difference in daycare attendance, early infections, and risk of childhood acute lymphoblastic leukemia." (2005) Cancer Epidemiol Biomarkers Prev. 14(8):1928-34.
• Schubbert S, Lieuw K, Rowe SL, Lee CM, Li X, Loh ML, Clapp DW, Shannon KM "Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells" (2005) Blood 106:311-317.
• Kratz, CP, Niemeyer CM, Castleberry RP, Cetyn M, Bergstrasser E, Emanuel PD, Hasle H, Kardos K, Klein C, Kojima S, Stary J, Trebo M, Zecca M, Gelb BD, Tartaglia M, Loh ML. "The mutational spectrum of PTPN11 in Juvenile Myelomonocytic Leukemia" (2005), Blood 106:2183-5.
• Levine RL, Loriaux M, Huntly BJ, Loh M, Beran M, Stoffregen E, Berger R, Clark JJ, Willis SG, Nguyen K, Flores N, Estey E, Gattermann N, Armstrong S, Look TA, Griffin JD, Bernard OA, Gilliland DG, Druker BJ, Deininger MW. "The JAK2 V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia." (2005) Blood 106(10):3377-9
• Aldrich, MC, Zhang L, Wiemels JL, Ma X, Loh ML, Selvin S, Feusner J, Smith MT, Buffler PA. "Cytogenetics of Hispanics and white with childhood acute lymphoblastic leukemia in California." (2006) Cancer Epidemiol Biomarkers Prev. 15(3):578-81
• Bennett CM, Roger ZR, Kinnamon DD, Bussel JB, Mahoney DH, Abshire TC, Sawaf H, Moore TB, Loh ML, Glader BE, Ware RE, MacCarthy M, Mueller BU, Olson TA, Lorenzana AN, Feig SA, Mentzer WC, Buchanan GR, Sanchez R, Feldman HA, Neufeld EJ. "Prospective phase I/II Study of Rituximab in childhood and adolescent chronic ITP." (2006) Blood 107(7):2639-42
• Loh ML, Goldwasser MA, Silverman LB, Poon WM, Vattikuti S, Cardoso AA, Neuberg DS, Sallan SE, Gilliland DG. "Prospective analysis of TEL/AML1 positive patients treated on Dana-Farber Cancer Institute Consortium Protocol 95-01." (2006) Blood, 107(11):4508-13
• Schultz KR, Pullen DJ, Sather HN, Shuster JJ, Devidas M, Borowitz MJ, Carroll AJ, Heerema NA, Rubnitz JE, Loh ML, Raetz EA, Winick NJ, Hunger SP, Carroll WL, Gaynon PS, Camitta BM. "Risk- and response-based classification of childhood B-precursor acute lymphoblastic leukemia: a combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children's Cancer Group (CCG)." (2007) Blood 109(3):926-35.
• Kratz CP, Niemeyer CM, Thomas C, Bauhuber S, Matejas V, Bergstrasser E, Flotho C, Flores NJ, Haas O. Hasle H, van den Heuvel-Eibrink MM, Kucherlapati RS, Lang P, Roberts AE, Stary J, Strahm B, Swanson KD, Trebo M, Zecca M, Neel B, Locatelli F, Loh ML, Zenker M. "Mutation analysis of Son of Sevenless in juvenile myelomonocytic leukemia." Leukemia 2007 May;21(5):1108-9
• Barry E, DeAngelo DJ, Neuberg D, Stevenson K, Loh ML, Asselin BL, Barr RD, Clavell LA, Hurwitz CA, Moghrabi A, Samson Y, Schorin M, Cohen HJ, Sallan SE, Silverman LB "Favorable outcome for adolescents with acute lymphoblastic leukemia treated on Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium Protocols." J Clin Oncol. 2007 Mar 1;25(7):813-9.
• Archambeault S, Flores N, Yoshimi Y, Kratz CP, Reising M, Fischer A, Noellke P, Locatelli F, Sedlacek P, Flotho C, Zecca M, Emanuel PD, Castleberry RP, Niemeyer CM, Bader P, Loh, ML. Development of an Allele-specific Minimal Residual Disease Assay for Patients with Juvenile Myelomonocytic Leukemia (2008) Blood. 111(3):1124-1127
• Swanson KD, Winter JM, Reis M, Bentires-Ali M, Greulich H, Grewal R, Hruban RH, Yeo CJ, Yassin Y, Iartchouk O, Montgomery K, Whitman SP, Caligiuri MA. Loh ML, Gilliland DG, Look AT, Kucherlapati R, Kern SE, Meyerson M, Neel BG. "SOS1 mutation are rare in human malignancies: implications for Noonan Syndrome patients." (2008) Genes Chromosomes Cancer 47(3): 253-9.
• Kotecha N, Flores NJ, Irish JM, Simonds E, Sakai D, Archambeault S, Diaz-Flores E, Coram M, Shannon KM, Nolan GP, Loh ML. "Single Cell Profiling Identifies Aberrant STAT5 Activation in Myeloid Malignancies with Specific Clinical and Biologic Correlates." (2008) Cancer Cell, 7;14(4):335-43, selected for cover article.