Clifford.Lowell@ucsf.edu
(415) 476-2963 (voice)
(415) 502-6497 (fax)

Box 0100, UCSF; San Francisco, CA 94143-0100

Stanford University, B.S., 1979, Biology
The Johns Hopkins University School of Medicine, M.D., 1986, Medicine
The Johns Hopkins University School of Medicine, Ph.D., 1986, Biochemistry/Molecular Biology

(selected references, total peer reviewed articles =102)

Varmus, H.E., Lowell, C.A. (1994). Cancer Genes and Hematopoiesis. Blood 83, 5 - 9.

Lowell, C.A., Soriano, P., Varmus, H.E. (1994). Functional Overlap in the src-Gene Family: Inactivation of hck and fgr Impairs Natural Immunity. Genes and Development 8, 387-398.

Berton, G., Yan, S.R., Fumagalli, L., Lowell, C.A. (1996) Neutrophil Activation by Adhesion: Mechanisms and Pathophysiological Implications. Int. J. Clin. Lab. Res. 26, 160-177

Lowell, C.A., Soriano, P. (1996). Knockouts of Src-Family Kinases: Stiff Bones, Wimpy T-cells and Bad Memories. Genes and Development, 10, 1845-1858

Lowell, C.A., Niwa, M., Soriano, P., Varmus, H. E. (1996). Deficiency of the Hck and Src Tyrosine Kinases Results in Extreme Levels of Extramedullary Hematopoiesis. Blood 87, 1780-1792.

Lowell, C.A., Fumagalli, L., Berton, G. (1996). Deficiency of Src-family Kinases p59/61hck and p58c-fgr Results in Defective Adhesion-dependent Neutrophil Functions. J. Cell Biol., 133, 895-910.

Meng, F., Lowell, C.A. (1997) LPS-Induced Macrophage Activation and Signal Transduction in the Absence of Src-Family Kinases Hck, Fgr and Lyn. J. Exp. Med., 185, 1661-1670.

Chan, V.W.F., Meng, F., Soriano, P., DeFranco, A.L., Lowell, C.A. (1997) Characterization of the B-Lymphocyte Populations in Lyn-Deficinet Mice and the Role of Lyn in Signal Initiation and Downregulation. Immunity, 7, 69-81.

Lowell, C.A. , Berton, G. (1998) Resistance to Endotoxic Shock and Reduced Neutrophil Migration in Mice Deficient for the Src-family Kinases Hck and Fgr. Proc.Natl.Acad.Sci. , 95, 7580-7584.

Chan, V.W.F., Lowell, C.A., DeFranco, A,L, (1998) Defective Negative Regulation of Antigen Receptor Signaling in Lyn-deficient B Lymphocytes. Current Biology, 8, 545-553.

DeFranco, A.L, Chan, V., Lowell, C.A. (1998) Positive and Negative Roles of the Tyrosine Kinase Lyn in B-cell Function. Semin. Immunol., 10, 299-308.

Meng, F., Lowell, C.A.. (1998) A β1 Integrin Signaling Pathway Involving Src-Family Kinases, Cbl, and PI-3 Kinase is Required for Macrophage Spreading and Migration. EMBO J., 17, 4391-4403.

Mócsai, A., Ligeti, E., Lowell, C.A., Berton, G. (1999) Adhesion-dependent Degranulation of Neutrophils Requires the Src-family kinases Fgr and Hck. J. Immunol., 162, 1120-1126.

Lowell, C.A., Berton, G. (1999) Integrin Signal Transduction in Myeloid Leukocytes. J. Leuk. Biol, 65, 313-320.

Berton, G., Lowell, C.A. (1999) Integrin Signaling in Neutrophils and Macrophages. J. Cell Signaling, 11, 621-635.

Suen, P.W., Ilic, D., Caveggion, E., Berton, G., Damsky, C.H., Lowell, C.A. (1999) Impaired Integrin-Mediated Signal Transduction/Altered Cytoskeletal Structure in Hck/Fgr Deficient Macrophages. J. Cell Sci, 112, 4067-4078.

Brady, K.A., Atwater, S.K. , Lowell, C.A. (1999) Flow Cytometric Detection of CD10 (cALLA) on Peripheral Blood B Lymphocytes of Neonates. British J. Haematology, 107, 712-715.

Fitzer-Attas, C.J., Lowry, M., Crowley, M.T., Meng, F., DeFranco, A.L., Lowell, C.A. (2000) Fcγ Receptor Mediated Phagocytosis In Macrophages Lacking Src-Family Tyrosine Kinases Hck, Fgr, And Lyn. J. Exp. Med., 191, , 669-681.

Hasegawa, M., Fujimoto, M., Poe, J.C., Steeber, D.A., Lowell, C.A., Tedder, T.F. (2001) A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice. J Immunol. 167: 2469-2478.

O'Laughlin, B., Radosevic, N, Taylor, M., DeBerry, C., Metcalf, D., Zhou, M., Lowell, C.A., Linnekin, D. (2001) Lyn is required for normal SCF-induced proliferation and chemotaxis of primary hematopoietic cells. Blood 98: 343-350.

Yu, C., Yen, B., Lowell, C.A., DeFranco, A.L. (2001) Lupus-like Autoimmune Disease in Mice Lacking the Src-family Kinases Fyn and Lyn. Current Biology. 11, 34-38.

Pereira, S., Zhu, M., Mócsai, Lowell, C.A. (2001) Resting Murine neutrophils express Functional α4 integrins which signal through Src-family kinases. J. Immunol., 166: 4115-4123.

Stafford, S., Lowell, C.A., Sur, S., Alam, R. (2002) Lyn tyrosine kinase is important for IL-5-stimulated eosinophil differentiation. J. Immunol. 168: 1978-1983.

Mócsai, A., Zhou, M., Meng, F., Tybulewicz, V.L., Lowell, C.A. (2002) Syk is Required for Integrin Signaling in Neturophils. Immunity 16: 547-558.

Obergfell, A,, Eto, K., Mócsai, A., Buensuceso, C., Moores, S.L., Brugge, J.S., Lowell, C.A., Shattil, S.J. (2002) Coordinate Interactions of Csk, Src, and Syk Kinases with αIIbβ3 Initiate Integrin Signaling to the Cytoskeleton. J. Cell Biol. 157:265-275

Vicentini, L., Mazzi, P., Caveggion, E., Continolo, S., Fumagalli, L., Lapinet-Vera, J.A., Lowell, C.A., Berton, G. (2002) Fgr deficiency results in defective eosinophil recruitment to the lung during allergic airway inflammation. J Immunol. 12: 6446-6454.

Abtahian F., Guerriero, A., Sebzda, E., Zhou, R., Mócsai, A., Myers. E.E., Jackson, D.G., Ferrari, V.A., Tybulewicz,V., Lowell, C.A., Lepore, J.J., Koretzky, G.A., Kahn,M.L. (2003) Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science 299: 247-251.

Caveggion, E., Continolo, S., Pixley, F.J., Stanley, E.R., Bowtell, D.D., Lowell, C.A., Berton, G. (2003) Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement. J Cell Physiol. 195:276-289.

Mócsai, A., Zhang, H., Jakus, Z., Kitaura, J., Kawakami, T., Lowell, C.A. (2003) G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells. Blood 101: 4155-4163.

Pereira, S., Lowell, C.A. (2003) The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling. J. Immunol. 171:1319-1327.

Newbrough, S.A., Mócsai, A., Clemens, R.A., Wu, J.N., Silverman, M.A., Singer, A.L., Lowell, C.A., Koretzky, G.A. (2003) SLP-76 Regulates Fc Receptor and Integrin Signaling in Neutrophils. Immunity 19: 761-769

Mocsai, A., Humphrey, M.B., Van Ziffle, J.A., Hu, Y., Burghardt, A., Spusta, S.C., Majumdar, S., Lanier, L.L., Lowell, C.A., Nakamura, M.C. (2004) The immunomodulatory adapter proteins DAP12 and FcRγ-chain regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc. Natl. Acad. Sci. (USA) 101:6158-6163.

Lowell, C.A. (2004) Src-family kinases: rheostats of immune cell signaling. Mol. Immunol. 41:631-643.

Jakus, Z., Berton, G., Ligeti, E., Lowell, C.A., Mócsai, A. (2004) Responses of neutrophils to anti-integrin antibodies depends on costimulation through low affinity FcγRs: full activation requires both integrin and non-integrin signals. J. Immunol., 173, 2068-2077.

Kitaura, J., Xiao, W., Maeda-Yamamoto, M., Kawakami, Y., Lowell, C.A., Kawakami, T. (2004) Early divergence of Fc receptor I signals for receptor up-regulation and internalization from degranulation, cytokine production, and survival. J Immunol., 173: 4317-4323.

Tassiulas, I., Hu, X., Ho, H., Kashyap, Y., Hu, Y. Lowell, C.A., Ivashkiv, L. (2004) Syk kinase potently enhances type I IFN STAT 1 activation and inflammatory activity. Nature Immunol., 5:1181-1189.

Pereira, S., Zhang, H., Takai, T., Lowell, C.A. (2004) The inhibitory receptor PIR-B negatively regulates neutrophil and macrophage integrin signaling. J. Immunol., 173:5757-5765.

Continolo, S., Baruzzi, A., Majeed, M., Caveggion, E., Fumagalli, L., Lowell, C.A., Berton, G. (2005) The proto-oncogene Fgr regulates cell migration and this requires it's membrane localization. Exp. Cell. Res., 302: 253-269.

Kitaura, J., Kinoshita, T., Matsumoto, M., Chung, S., Kawakami, Y., Leitges, M., Wu, D., Lowell, C.A., Kawakami, T. (2005) IgE- and IgE/antigen-mediated mast cell migration in an autocrine/paracrine fashion. Blood 105: 3222-3229.

Zhang, H., Meng, F., Chu, C-L., Takai, T., Lowell, C.A. (2005) The Src-family kinases Hck and Fgr negatively regulate chemokine signaling in neutrophils and dendritic cells through the inhibitory receptor PIR-B. Immunity, 22,225-246.

Kitaura, J., Eto, K., Kinoshita, T., Kawakami, Y., Leitges, M., Lowell, C.A., Kawakami. T. (2005) Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases. J Immunol. 174:4495-4504

Hamerman, J.A., Tchao, N.K., Lowell, C.A., Lanier, L.L. (2005) Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat. Immunol. 6:579-586.

Underhill, D.M., Rossnagle, E., Lowell. C.A., Simmons, R.M. (2005) Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood 106:2543-2450

Chu, C.L. and Lowell, C.A. (2005) The Lyn kinase differentially regulates dendritic cell generation and maturation. J. Immunol. 175:2880-2889.

Berton, G., Mocsai, A., Lowell, C.A. (2005) Src kinases and Syk: key regulators of phagocytic cell activation. Trends Immunol., 26, 208-214.

Yu, M., Lowell, C.A., Neel, B.G., Gu, H. (2006) Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcRI. J. Immunol. 176:2421-2429.

Lowell, C.A. (2006) Rewiring phagocytic signal transduction. Immunity 24: 243-245.

Lowell, C.A. (2006) Beautiful blistering Blood 107: 849-850.

Karur, V.G., Lowell, C.A., Besmer, P., Agosti, V., Wojchowski, D.M. (2006) Lyn kinase promotes erythroblast expansion and late-stage development. Blood. 2006 May 16; [Epub ahead of print]

Looney M.R., Su, X., Van Ziffle, J.A., Lowell, C.A., Matthay, M.A. (2006) Neutrophils and their Fcgamma receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest. 116:1615-1623.

Mermel, C.H., McLemore, M.L., Liu, F., Pereira, S., Woloszynek, J., Lowell, C. A., Link, D.C. (2006) Src-family kinases are important negative regulators of G-CSF dependent granulopoiesis. Blood 108:2562-2568.

Hirahashi, J., Mekala, D., Van Ziffle, J., Xiao, L., Saffaripour, S., Wagner, D.D., Shapiro, S.D., Lowell, C., Mayadas, T.N. (2006) Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Immunity 25: 271-283

*Zhang, H., Ulrich, S.Y., Green, C.E., Chen, H., Saranto, M.R., Hu, Y., Wara, D., Simon, S.I., Lowell, C.A. (2006) Impaired integrin-dependent function in Wiskott-Aldrich Syndrome Protein-deficient murine and human neutrophils. Immunity. 25: 285-295. * Selected for cover issue and mini-review.

12/7/06