Rainin Distinguished Professorship in Inflamatory Bowel Disease, UCSF
| CONTACT | |
|
ama1@itsa.ucsf.edu Box 0451, UCSF; San Francisco, CA 94143-0451 |
additional websites: |
| EDUCATION | |
|
Harvard University, Cambridge, MA, B.A., 1980, Biochemistry
|
|
| PROFESSIONAL EXPERIENCE | |
|
1984-87 |
Medical resident, internal medicine, Massachusetts General Hospital, Boston, MA |
|
1987-89 |
Clinical Fellow, gastroenterology, Columbia Presbyterian Hospital, New York, NY |
|
1989-91 |
Research Fellow/Instructor, Laboratory of Dr. Frederick W. Alt, CPMC, New York, NY |
|
1991-95 |
Instructor, Laboratory of Dr. Frederick W. Alt, Children's Hospital, Center for Blood Research, Beth Israel Hospital, Boston, MA |
|
1995-1996 |
Assistant Professor, Beth Israel Hospital, Harvard Medical School, Boston, MA |
|
1996-2003 |
Assistant Professor, Medicine, Committee on Immunology, University of Chicago, Chicago, IL |
|
2001-2003 |
Assistant Professor, Ben May Institute for Cancer Research, Committee on Cancer Biology, U of Chicago |
|
2003-2004 |
Associate Professor (with tenure) Medicine, Ben May Institute, Committees on Immunology, Cancer Biology, U of Chicago |
|
2004-present |
Rainin Distinguished Associate Professor of Medicine in Residence, Program in Immunology and Biomedical Sciences, UCSF, San Francisco, CA |
|
2006-present |
Rainin Distinguished Professor of Medicine, UCSF, San Francisco, CA |
| HONORS & AWARDS | |
|
1984 |
Alpha Omega Alpha |
|
1989 |
James McDonnell Scholar in Molecular Oncology |
|
1997 |
Cancer Research Institute Scholar |
|
2001 |
American Society of Clinical Investigation |
|
2001 |
AGA/GRG Young Investigator Award |
| SELECTED PUBLICATIONS | |
|
(selected from a total of 55) | |
|
Dildrop R, Ma A, Zimmerman K, Hsu E, Tesfaye A, DePinho R, and Alt, F.W. 1989. IgH enhancer- mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c-myc expression. EMBO Jl 8;1121-1128. | |
|
Ma A, Smith R, Tesfaye A, Achacoso P, Dildrop R, Rosenberg N, and Alt FW. 1991. Mechanism of endogenous myc gene down-regulation in Eu-N-myc tumors. Mol Cell Biol 11;440-444. | |
|
Ma A, Fisher PE, Oltz E, Dildrop R, Rathbun G, Achacoso P, Stall A, and Alt FW. 1992. Surface IgM mediated down-regulation of RAG gene expression in Eu-N-myc B cell lines. EMBO Jl 11;2727-2734. | |
|
Ma A, Moroy T, Collum R, Weintraub H, Alt FW, and Blackwell TK. 1993. DNA binding of N and L-myc proteins. Oncogene 8;1093-1098. | |
|
Blackwell TK, Huang J, Ma A, Alt FW, Eisenman RN, and Weintraub H. 1993. Binding of myc proteins to canonical and non-canonical sequences. Mol Cell Biol 13;5216-24. | |
|
Chen JC, Ma A, Young F, and Alt FW. 1994. IL-2 receptor alpha chain expression on pre-B cells. Int Immunol 6:1265-1268. | |
|
Shinkai Y, Ma A, Cheng H, and Alt FW. 1995. CD3 and CD3 cytoplasmic domains can independently generate signals for T cell development and function. Immunity 2;401-411. | |
|
Ma A, Pena J, Chang B, Margosian E, Davidson L, Alt FW, and Thompson CB. 1995. Bcl-x regulates the survival of double positive thymocytes. PNAS USA 92;4763-67. | |
|
Willerford D, Chen J, Ferry JA, Davidson L, Ma A, and Alt FW. 1995. IL-2 receptor chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3;521-530. | |
|
Ma A, Datta M, Margosian E, Chen J and Horak I. 1995. T cells, but not B cells are required for bowel inflammation in IL-2 deficient mice. J Exp Med 182;1567-1572. | |
|
Ma, A. 1997. Fas and the immunologically underprivileged intestine. Gastro 113;345-8. | |
|
Minn A, Swain RE, Ma A, and Thompson CB. 1998. Recent progress on the regulation of apoptosis by Bcl-2 family members. Ann Rev Imm 70;245-279. | |
|
Lodolce JP, Burkett P, Boone DL, Chien M, Chai S, and Ma A. 2001. T cell independent IL-15R signals are required for bystander T cell responses. J Exp Med 194;1187-94. | |
|
Boone DL, Dassopoulos T, Lodolce JP, Chai S, Chien M, and Ma A. 2002. Interleukin-2 deficient mice develop colitis in the absence of CD28 costimulation. Inflam Bowel Dis 8;35-42. | |
|
Boone DL, Lee EG, Libby S, Gibson PJ, Chien M, Chan F, Madonia M, Burkett PR, and Ma A. 2002. Recent Advances in Understanding NF-kB regulation. Inflam Bowel Dis 8;201-212. | |
|
Boone DL and Ma A. 2002. Connecting the dots from Toll-like receptors to innate immune cells and inflammatory bowel disease. J Clin Inv 111;1284-1286. | |
|
O'Shea JJ, Ma A, and Lipsky P. 2002. Cytokines and autoimmunity. Nat Rev Immunol 2;37-45. | |
|
Schluns KS, Williams K, Ma A, Zheng XX, and LeFrancois L. 2002. Requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells. J Immunol (Cutting Edge) 168;4827-31. | |
|
Becker TC*, Wheery J*, Boone DL*, Kaja-Krishna M, Antia R, Ma A, and Ahmed R. 2002. Role of IL-15 receptor alpha signals in immune responses to LCMV. J Exp Med 195;1541-48. | |
|
Koka R, Burkett P, Boone DL, Lodolce JP, Chien M, Chan F, and Ma A. 2003. IL-15R deficient NK cells survive in normal but not IL-15R deficient mice. J Exp Med 197;977-984. | |
|
Burkett P, Koka R, Chien M, Chai S, Chan F, Boone DL, and Ma A. 2003. IL-15R expression on CD8+ T cells is dispensable for T cell memory. PNAS USA 100;4724-4729. | |
|
Boone DL, Dassopoulos T, Chai S, Chien M, Lodolce JP and Ma A. 2003. Fas is not essential for lamina propria T lymphocyte homeostasis. Am J Phys 285;G382. | |
|
Burkett PR, Koka R, Chien M, Boone DL, Ma A. 2004. Generation, maintenance, and function of memory T cells. Adv Immunol. 83:191-231. | |
|
Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, Wu P, Wiesmann C, Baker R, Boone DL, Ma A, Koonin EV, Dixit VM. 2004. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 430, 694-699. | |
|
Koka R, Burkett P, Chien M, Chai S, and Ma A. 2004. Murine dendritic cells require IL-15R to prime NK cells. J Immunol (Cutting Edge)173;3594-3598. | |
|
Boone DL, Turer EE, Lee EG, Ahmad RC, Wheeler MT, Tsui C, Hurley P, Chien M, Chai S, Hitotsumatsu O, McNally E, Pickart C, and Ma A. 2004. The ubiquitin modifiying enzyme A20 is essential for terminating TLR signaling. Nat Immunol 5;1052-60. | |
|
Burkett PR, Koka R, Chien M, Chai S, and Ma A. 2004. Coordinate expression and trans presentation of IL-15R and IL-15 supports NK cell and memory CD8+ T cell homeostasis. J Exp Med 200;825-834. | |
|
Ma A, Koka R, and Burkett PR. 2006. Diverse functions of IL-2, IL-7 and IL-15 in lymphoid homeostasis. Ann Rev Immunol 24:657-79. | |
|
Ma A and Turer EE. 2006. E2 enzymes expand the Ubi-verse of immune receptor signaling. Nat Immunol 7;903-904. |
|
|
12/6/06 |
|
