Rainin Distinguished Professorship in Inflamatory Bowel Disease, UCSF
Member, Immunology Graduate Program, UCSF
| CONTACT | |
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averil.ma@ucsf.edu Box 0451, UCSF; San Francisco, CA 94143-0451 |
| EDUCATION | |
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Harvard University, Cambridge, MA, B.A., 1980, Biochemistry
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| PROFESSIONAL EXPERIENCE | |
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1984-87 |
Medical resident, internal medicine, Massachusetts General Hospital, Boston, MA |
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1987-89 |
Clinical Fellow, gastroenterology, Columbia Presbyterian Hospital, New York, NY |
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1989-91 |
Research Fellow/Instructor, CPMC, New York, NY |
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1991-96 |
Instructor/Assistant Professor, Children's Hospital, Immune Disease Institute, Boston, MA |
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1996-03 |
Assistant Professor, Medicine, Ben May Institute, University of Chicago, Chicago, IL |
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2003-04 |
Associate Professor (with tenure) Medicine, Ben May Institute, U of Chicago |
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2004-06 |
Associate Professor of Medicine, Director, UCSF Colitis and Crohn's Disease Center, Program in Biomedical Sciences (BMS), UCSF, San Francisco, CA |
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2006-present |
Rainin Distinguished Professor of Medicine, Program in Biological Sciences (PIBS), UCSF |
| HONORS & AWARDS | |
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1984 |
Alpha Omega Alpha |
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1989 |
James McDonnell Scholar in Molecular Oncology |
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1997 |
Cancer Research Institute Scholar |
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2001 |
American Society of Clinical Investigation |
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2001 |
AGA/GRG Young Investigator Award |
| SELECTED PUBLICATIONS | |
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(selected from a total of 66) | |
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Ma A, Smith R, Tesfaye A, Achacoso P, Dildrop R, Rosenberg N, and Alt FW. 1991. Mechanism of endogenous myc gene down-regulation in Eu-N-myc tumors. Mol Cell Biol 11;440-444. | |
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Ma A, Fisher PE, Oltz E, Dildrop R, Rathbun G, Achacoso P, Stall A, and Alt FW. 1992. Surface IgM mediated down-regulation of RAG gene expression in Eu-N-myc B cell lines. EMBO 11;2727-2734. | |
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Ma A, Moroy T, Collum R, Weintraub H, Alt FW, and Blackwell TK. 1993. DNA binding of N and L-myc proteins. Oncogene 8;1093-1098. | |
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Ma A, Pena J, Chang B, Margosian E, Davidson L, Alt FW, and Thompson CB. 1995. Bcl-x regulates the survival of double positive thymocytes. PNAS USA 92;4763-67. | |
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Shinkai Y, Ma A, Cheng H, and Alt FW. 1995. CD3 and CD3 cytoplasmic domains can independently generate signals for T cell development and function. Immunity 2;401-411. | |
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Ma A, Pena J, Chang B, Margosian E, Davidson L, Alt FW, and Thompson CB. 1995. Bcl-x regulates the survival of double positive thymocytes. PNAS USA 92;4763-67. | |
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Willerford D, Chen J, Ferry JA, Davidson L, Ma A, and Alt FW. 1995. IL-2 receptor chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3;521-530. | |
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Ma A, Datta M, Margosian E, Chen J and Horak I. 1995. T cells, but not B cells are required for bowel inflammation in IL-2 deficient mice. J Exp Med 182;1567-1572. | |
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Lodolce JP, Boone DL, Dassopoulos T, Chai S, Swain RE, Trettin S, and Ma A. 1998. Interleukin-15R maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9;669-676. | |
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Ma, A, Boone, DL, and Lodolce, JP. 2000. Pleiotropic functions of IL-15: Not so IL-2 like after all. J Exp Med 191;753-755. | |
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Lee EG, Boone DL, Chai S, Libby S, Chien M, Lodolce JP, and Ma A. 2000. Failure to regulate TNF induced NF-B and cell death responses in A20 deficient mice. Science 289;2350-54. | |
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Lodolce JP, Burkett P, Boone DL, Chien M, Chai S, and Ma A. 2001. T cell independent IL-15R signals are required for bystander T cell responses. J Exp Med 194;1187-94. | |
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Boone DL, Dassopoulos T, Lodolce JP, Chai S, Chien M, and Ma A. 2002. Interleukin-2 deficient mice develop colitis in the absence of CD28 costimulation. IBD 8;35-42. | |
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Boone DL and Ma A. 2002. Connecting the dots from Toll-like receptors to innate immune cells and inflammatory bowel disease. J Clin Inv 111;1284-1286. | |
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O'Shea JJ, Ma A, and Lipsky P. 2002. Cytokines and autoimmunity. Nat Rev Immunol 2;37-45. | |
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Schluns KS, Williams K, Ma A, Zheng XX, and LeFrancois L. 2002. Requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells. J Immunol (Cutting Edge) 168;4827-31. | |
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Becker TC, Wheery J, Boone DL, Kaja-Krishna M, Antia R, Ma A, and Ahmed R. 2002. Role of IL-15 receptor alpha signals in immune responses to LCMV. J Exp Med 195;1541-48. | |
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Koka R, Burkett P, Boone DL, Lodolce JP, Chien M, Chan F, and Ma A. 2003. IL-15R deficient NK cells survive in normal but not IL-15R deficient mice. J Exp Med 197;977-984. | |
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Burkett P, Koka R, Chien M, Chai S, Chan F, Ma A, and Boone DL. 2003. IL-15R expression on CD8+ T cells is dispensable for T cell memory. PNAS USA 100;4724-4729. | |
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Burkett PR, Koka R, Chien M, Boone DL, Ma A. 2004. Generation, maintenance, and function of memory T cells. Adv Immunol. 83:191-231. | |
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Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, Wu P, Wiesmann C, Baker R, Boone DL, Ma A, Koonin EV, Dixit VM. 2004. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 430, 694-699. | |
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Koka R, Burkett P, Chien M, Chai S, and Ma A. 2004. Murine dendritic cells require IL-15R to prime NK cells. J Immunol (Cutting Edge)173;3594-3598. | |
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Boone DL, Turer EE, Lee EG, Ahmad RC, Wheeler MT, Tsui C, Hurley P, Chien M, Chai S, Hitotsumatsu O, McNally E, Pickart C, and Ma A. 2004. The ubiquitin modifiying enzyme A20 is essential for terminating TLR signaling. Nat Immunol 5;1052-60. | |
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Burkett PR, Koka R, Chien M, Chai S, and Ma A. 2004. Coordinate expression and trans presentation of IL-15R and IL-15 supports NK cell and memory CD8+ T cell homeostasis. J Exp Med 200;825-834. | |
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Ma A, Koka R, and Burkett PR. 2006. Diverse functions of IL-2, IL-7 and IL-15 in lymphoid homeostasis. Ann Rev Immunol 24:657-79. | |
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Ma A and Turer EE. 2006. E2 enzymes expand the Ubi-verse of immune receptor signaling. Nat Immunol 7;903-904. | |
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Hutti JE, Turk BE, Asara JM, Ma A, Cantley LC, and Abbott DW. 2007. IKKb phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NFkB pathway. Mol Cell Bio 27;7451-7461. | |
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Ma A. 2007. T-bet sends host-microbe mutualism awry. Cell 131;33-35. | |
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Turer EE, Tavares R, Hitotsumatsu O, Advincula R, Lee BL, Shifrin N, Malynn BA, and Ma A. 2008. Homeostatic MyD88 dependent signals cause lethal inflammation in the absence of A20 J Exp Med 205;451-464. | |
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Hitotsumatsu O, Ahmad RC, Tavares R, Wang M, Philpott D, Turer EE, Lee BL, Shifrin N, Advincula R, Malynn BA, Werts C, and Ma A. 2008. The ubiquitin editing enzyme A20 restricts NOD2 triggered signals. Immunity 28;381-390. | |
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Mortier E, Woo T, Advincula R, Gozalo S, and Ma A. 2008. IL-15R chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans-presentation. J Exp Med 205;1213-1225. | |
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Werner SL, Kearns JD, Zadorozhnaya V, Lynch C, O'Dea E, Boldin MP, Ma A, Baltimore D, and Hoffman A. Encoding NFkB temporal control in response to TNF: distinct roles for the negative regulators IkBa and A20. 2008. Genes Dev 22;2093-2101. | |
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Musone SL, Taylor KE, Lu TT, Nititham J, Ferreira RC, Ortmann W, Shifrin N, Petri MA, Kamboh MI, Manzi S, Seldin MF, Gregersen PK, Behrens TW, Ma A, Kwok PY and Criswell LA. 2008. Multiple polymorphisms in the TNFAIP3 [A20] region are independently associated with systemic lupus erythematosus. Nat Genetics 40;1062-1064. | |
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Ma A. 2008. Unresolved ER stress inflames the intestine. Cell 134;724-726. | |
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Oshima S, Turer EE, Callahan JA, Advincula R, Chai S, Barrera J, Shifrin N, Lee B, Woo T, Yen B, Malynn BA, and Ma A. 2008. ABIN-1 is a ubiquitin sensor that restricts TNF induced cell death and sustains embryonic development. Nature (in press). |
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10/28/08 |
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