Professor of Chemistry and Biochemistry, San Francisco State University
Investigator, Comprehensive Minority Institution/Cancer Center Partnership, San Francisco State University and UCSF Helen Diller Family Comprehensive Cancer Center
| CONTACT | |
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macher@sfsu.edu SFSU, ORSP/ADM 471/OBR, 1600 Holloway, San Francisco, CA 94132 |
| EDUCATION | |
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University of California, Riverside, B.S., 1971, Biochemistry
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| PROFESSIONAL EXPERIENCE | |
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1978-1982 |
Assistant Research Biochemist, Cancer Research Institute, University of California San Francisco |
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1982-1987 |
Associate Research Biochemist, Cancer Research Institute, University of California, San Francisco, Adjunct Associate Professor of Pharmaceutical Chemistry |
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1985-1989 |
Member of the Pathobiochemistry Study Section, National Institutes of Health |
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1987-1993 |
Associate Professor of Chemistry and Biochemistry, Department of Chemistry and Biochemistry, San Francisco State University |
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1991-2006 |
Member of the Editorial Board of the journal Glycobiology |
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1993- |
Professor of Chemistry and Biochemistry, Department of Chemistry and Biochemistry, San Francisco State University |
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1998-1999 |
Chair, Department of Chemistry and Biochemistry, San Francisco State University |
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1999-2001 |
Associate Dean, Research and Sponsored Programs, San Francisco State University |
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2001-2002 |
Assistant Vice President, Research and Sponsored Programs, San Francisco State University |
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2002-2004 |
Associate Vice President, Research and Sponsored Programs |
| HONORS & AWARDS | |
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1971 |
National Science Foundation Research Fellowship |
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1973-1974 |
National Defense Education Act Fellowship |
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1989, 1990 |
Meritorious Performance and Professional Promise Award, San Francisco State University |
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1995 |
First Visiting Professor, Program to Internationalize Research, Institute of Immunology and Inflammation of the Vrije Universiteit, Amsterdam, The Netherlands |
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1995 |
Invited Lecturer, First Annual Research Conference, Leukemia Research Foundation, Inc. |
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1995-96, 1996-97, 1998-99 |
California State University, Merit Award |
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2007-2009 |
Sigma Xi Distinguished Lecturer |
| SELECTED PUBLICATIONS | |
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(from 94) | |
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Li, J., Yen, T-Y., Allende, M.L., Joshi, R.K., Cai, J., Pierce, W.M., Jaskiewicz, E., Darling, D.S., Macher, B.A., and Young, W.W. (2000) Disulfide bonds of GM2 synthase homodimers: Antiparallel orientation of the catalytic domains. J. Biol. Chem. 275: 41476-41486 | |
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Angata, K., Yen, T-Y., El-Battari, A., Macher, B.A., and Fukuda, M. (2001) Unique Disulfide Bond Structures Found in ST8Sia IV Polysialyltransferase Are Required for Its Activity. J. Biol. Chem. 276: 15369-15377 | |
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de Vries, T., Yen, T-Y., Joshi, R.K., Storm, J., van den Eijnden, D.H., Knegtel, R.M.A., Bunschoten, H., Joziasse, D.H., and Macher, B.A. (2001) Neighboring cysteine residues in human fucosyltransferase VII are engaged in disulfide bridges, forming small loop structures. Glycobiology 11: 423-432 | |
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Shetterly, S., Tom, I., Yen, T-Y., Joshi, R., Lee, L., Wang, P.G., and Macher, B.A. (2001) α1,3Galactosyltransferase: New sequences and characterization of conserved cysteine residues. Glycobiology, 11, 645-653 | |
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de Vries, T., Knegtel, R.M.A., Holmes, E.H., and Macher, B.A. (2001) Fucosyltransferases: structure/function studies. Glycobiology, 11, 119-128 | |
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Yen, T-Y., Yan, H., and Macher, B.A. (2002) Identifying Closely Spaced Disulfide Bonds in Peptides and Proteins by Liquid Chromatography/Electrospray Ionization-Tandem Mass Spectrometry. J Mass Spectrometry, 37, 15-30. | |
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Thomas, S., Yen, T-Y, and Macher, B.A. (2002) Eukaryotic Glycosyltransferases: Cysteines and Disulfides. Glycobiology, 12, 4G-7G. | |
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Yen, T-Y., Yan, H., and Macher, B.A., Bryson, S., Chang, X., Tvaroska, I., Lew, A.M., and Datti, A. (2003) Highly Conserved Cysteines of Mouse Core 2 β1,6 N-Acetylglucosaminyltransferase-I form a Network of Disulphide Bonds and Include a Catalytically Essential Thiol. J. Biol. Chem. 278: 45864-45881 | |
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Vo, L.H., Yen, T-Y. Macher, B.A., and Hedrick, J.L. (2003) Identification of the ZPC Oligosaccharide Ligand Involved in Sperm Binding and the Glycan Structures of Xenopus laevis Vitelline Envelope Glycoproteins. Biol. Reprod. 69: 1822-18 | |
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Jost, F., de Vries, T. Knegtel, R.M.A., and Macher, B.A. (2005) Mutation of amino acids in the alpha 1,3-fucosyltransferase motif affects enzyme activity and Km for donor and acceptor substrates. Glycobiology 15: 165-175 | |
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Yen, T.-Y.; Macher, B.A. (2006) Determination of glycosylation sites and disulfide bond structures using LC/ESI-MS/MS analysis", Methods in Enzymology 415: 103-113 | |
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Molina, P., Knegtel, R.M.A., and Macher, B.A. (2007) Site-Directed Mutagenesis of Glutamate 317 of Bovine α-1,3Galactosyltransferase and Its Effect on Enzyme Activity: Implications for Reaction Mechanism. Biochimica et Biophysica Acta, 1770: 1266-1273. | |
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Shetterly, S., Jost, F., Watson, S.R., Knegtel, R.M.A., Bruce A. Macher, B.A., and Holmes, E.H. (2007) Site-specific fucosylation of sialylated polylactosamines by FucT-V and FucT-VI is defined by amino acids near the N-terminus of the catalytic domain. J. Biol. Chem. 282: 24882 - 24892. | |
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Macher, B.A., and Yen, T-Y. (2007) Proteins at membrane surfaces - a review of approaches. Molecular BioSyst., 3: 705 - 713 | |
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1/22/08 |
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