Hiten Madhani, MD, PhD

Stanford University, Stanford, California, B.S., M.S., 1986, Biological Sciences
University of California, San Francisco, Ph.D., 1993, Genetics
University of California, San Francisco, M.D., 1995, Medicine
Whitehead Institute, Cambridge, Massachusetts, Postdoctoral, 1995-1999, Signal Transduction

• 1986-1987
  Medical Training: Dept of Microbiology, UCSF. Dr. Harold E. Varmus, Ribosomal Frameshifting in Retroviral Gene Expression.
• 1989-1993
  Graduate: Dept of Biochemistry and Biophysics, UCSF. Dr. Christine Guthrie, Spliceosomal RNA Rearrangements: Implications for the Mechanism of RNA Splicing.
• 1995-1999
  Postdoctoral: Whitehead Institute. Dr. Gerald R. Fink, Mechanisms that Determine the Specificity of MAP Kinase Signal Transduction.
• 1999-2005
  Assistant Professor, Dept of Biochemistry and Biophysics, UCSF 2005-2008 Associate Professor, Dept of Biochemistry and Biophysics, UCSF
• 2008-present
  Professor, Dept of Biochemistry and Biophysics, UCSF

• 1987
  Dean's Prize for Student Research, University of California, San Francisco
• 1988
  Dean's Prize for Student Research, University of California, San Francisco
• 1991-1992
  Chancellor's Fellowship, University of California, San Francisco
• 1996
  Finalist, Pharmacia-Science Prize
• 1995-1998
  Helen Hay Whitney Foundation Postdoctoral Research Fellowship
• 1998-1999
  Burroughs-Wellcome Fund Career Development Award
• 2000-2005
  David and Lucile Packard Foundation Fellowship for Scientists and Engineers
• 1999-2002
  Burroughs-Wellcome Fund Career Development Award
• 2005-2010
  Leukemia and Lymphoma Society Scholar

• Madhani, H.D. & Fink, G.R. (1997). Combinatorial control required for the specificity of yeast MAPK signaling. Science 275: 1314-1317.
• Madhani, H.D., Styles, C.A. & Fink, G.R. (1997). MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation. Cell 91: 673-684.
• Meneghini, M.D., Wu, M. & Madhani, H.D. (2003). Conserved histone variant H2A.Z prevents the ectopic spread of silent heterochromatin. Cell 112: 725-736.
• Bao, M.Z., Schwartz, M.A., Cantin, G.T., Yates, J.R. 3rd & Madhani, H.D. (2004). Pheromonedependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast. Cell 119: 911-1000.
• Raisner, R.M., Hartley, P.D., Meneghini, M.D., Bao, M.Z., Liu, C.L., Schreiber, S.L., Rando, O.J. & Madhani, H.D. (2005). Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin. Cell 123: 233-248. PMCID: PMC2039754.
• Chun, C.D., Liu. O.W. & Madhani, H.D. (2007). A link between virulence and homeostatic responses to hypoxia during infection by the human fungal pathogen Crytococcus neoformans. PLoS Pathog. 3: e22. PMCID: PMC1803011.
• Venkatasubrahmanyam, S., Hwang, W.W. Meneghini, M.D., Tong, A.H. & Madhani, H.D. (2007). Genome-wide, as opposed to local, antisilencing is mediated redundantly by the euchromatic factors Set1 and H2A.Z. Proc Natl Acad Sci USA 104: 16609-16614. PMCID: PMC2034229.
• Chow, E.D., Liu, O.W., O'Brien, S & Madhani, H.D. (2007). Exploration of whole-genome responses of the human AIDS-associated yeast pathogen Cryptococcus neoformans var grubii: nitric oxide stress and body temperature. Current Genet. 57: 137-148.
• Liu, O.W., Kelly, M.J., Chow, E.D. & Madhani, H.D. (2007). Parallel beta-helix proteins required for accurate capsule polysaccharide synthesis and virulence in the yeast Cryptococcus neoformans. Eukaryot Cell. 6: 630-40. PMCID: PMC1865648.
• Raisner, R.M. & Madhani, H.D. (2008). Genomewide screen for negative regulators of sirtuin activity in S. cerevisiae reveals 40 loci and links to metabolism. Genetics 179: 1933-1944. PMCID: PMC2516070.
• Rougemaille, M., Shankar, S., Braun, S., Rowley, M. & Madhani, H.D. (2008). Ers1, a rapidly diverging protein essential for RNA interference-dependent heterochromatic silencing in Schizosaccharomyces pombe. J. Biol. Chem. 283: 25770-25773. PMCID: PMC2533792.
• Breslow, D.K., Cameron, D.M., Collins, S.R., Schuldiner, M., Stewart-Ornstein, J., Newman, H.W., Braun, S., Madhani, H.D., Krogan, N.J. & Weissman, J.S. (2008). A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nature Methods 5: 711-718. PMCID: PMC2756093.
• Liu, O.W., Chun, C.D., Chow, E.D., Chen, C., Madhani, H.D.* & Noble, S.M. (2008). Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans. Cell 135: 174-188. *Corresponding author. PMCID: PMC2628477.
• Hartley, P.D. & Madhani, H.D. (2009). Mechanisms that specify nucleosome location and identity. Cell 137: 445-458.
• Hwang, W.W. and Madhani, H.D. (2009). Nonredundant requirement for multiple histone modifications for early anaphase release of the mitotic exit regulator Cdc14 from nucleolar chromatin. PLoS Genetics 5(8): e1000588. PMCID: PMC2716543.
• McCullagh, E., Seshan, A., El-Samad, H. & Madhani, H.D. (2010) Coordinate conrol of gene expression noise and interchromosomal interactions in a MAP kinase pathway. Nat. Cell Biol. 12(10): 1-11.