Associate Professor, Dept of Biochemistry & Biophysics, UCSF
| CONTACT | |
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hitenmadhani@gmail.com Box 2200, UCSF; San Francisco, CA 94143-2200 |
additional websites: |
| EDUCATION | |
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Stanford University, Stanford, California, B.S., M.S., 1986, Biological Sciences
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| PROFESSIONAL EXPERIENCE | |
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1984-1986 |
Undergraduate, Dept of Biological Sciences, Stanford University, Dr. Philip C. Hanawalt, Genomic Organization of Centromeric α-satellite DNA in Primate Cells, Differential DNA Repair in Transcriptionally Active and Inactive Proto-oncogenes. |
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1986-1987 |
Medical, Dept of Microbiology, UCSF, Dr. Harold E. Varmus, Ribosomal Frameshifting in Retroviral Gene Expression. |
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1989-1993 |
Graduate, Dept of Biochemistry and Biophysics, UCSF, Dr. Christine Guthrie, Spliceosomal RNA Rearrangements: Implications for the Mechanism of RNA Splicing. |
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1995-1999 |
Postdoctoral, Whitehead Institute, Dr. Gerald R. Fink, Mechanisms that Determine the Specificity of MAP Kinase Signal Transduction. |
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1999-2005 |
Assistant Professor, Dept of Biochemistry & Biophysics, UCSF |
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2005- |
Associate Professor, Dept of Biochemistry & Biophysics, UCSF |
| HONORS & AWARDS | |
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1982 |
President's Award for Outstanding Academic Achievement in the Freshman Year |
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1983 |
CRC Book Award for Outstanding Freshman in Chemistry |
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1985 |
Phi Beta Kappa |
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1986 |
Firestone Medal for Excellence in Research |
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1986 |
Undergraduate Honors Thesis, Department of Biological Sciences. “α-DNA in African Green Monkey Cells is Organized into Extremely Long Tandem Arrays” |
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1986 |
Sigma Xi |
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1986 |
Fox Award for Outstanding Undergraduate in Department of Biological Sciences |
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1995-1998 |
Helen Hay Whiteney Foundation Postdoctoral Research Fellowship |
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1998-2002 |
Burroughs-Wellcome Fund Cancer Award |
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2000-2005 |
David and Lucille Packard Foundation Fellowship for Scientists and Engineers |
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2005 |
Leukemia and Lymphoma Society Scholar |
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University of California, San Francisco: |
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1987 |
Dean's Prize for Student Research |
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1988 |
Dean's Prize for Student Research |
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1991-1992 |
Chancellor's Fellowship |
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1996 |
Finalist, Pharmacia-Science Prize |
| SELECTED PUBLICATIONS | |
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Madhani, H.D., Leadon, S.A., Smith, C.A., and Hanawalt, P.C. (1986). α-DNA in african green monkey cells is organized into extremely long tandem arrays. J. Biol. Chem 261: 2314-2318. |
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Madhani, H.D., Bohr, V.A. and Hanawalt, P.C. (1986). Differential DNA repair in transcriptionally active and inactive proto-oncogenes: c-abl and c-mos. Cell 45:417-423. |
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Madhani, H.D., Jacks, T. and Varmus, H.E. (1988). Signals for the expression of the HIV pol gene by ribosomal frameshifting in The Control of Human Retrovirus Gene Expression, B. Cullen and F. Wong-Staal, eds. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1988), pp. 119-125. |
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Jacks, T., Madhani, H.D., Masiarz, F.R., and Varmus, H.E. (1988). Signals for ribosomal frameshifting in the Rous Sarcoma virus gag-pol region. Cell 55:447-458. |
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Madhani, H.D., Bordonn, R. & Guthrie, C. (1990). Multiple roles for U6 snRNA in the splicing pathway. Genes Dev. 4:2274-2287. |
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Madhani, H.D. & Guthrie, C. (1992). A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome. Cell 71: 803-817. |
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Madhani, H.D. & Guthrie, C. (1994a). Randomization-selection analysis of snRNAs in vivo: Evidence for a tertiary interaction in the spliceosome. Genes Dev. 8: 1071-1086. |
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Madhani, H.D. & Guthrie, C. (1994b). Genetic interactions between the yeast helicase homolog Prp16 and spliceosomal snRNAs identify candidate ligands for the Prp16 RNA-dependent ATPase. Genetics 137:677-687. |
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Madhani, H.D. and Guthrie, C. (1994c) Dynamic RNA-RNA interactions in the spliceosome. Annu. Rev. Genet. 28: 1-26. |
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Madhani, H.D. & Fink, G.R. (1997). Combinatorial control required for the specificity of yeast MAPK signaling. Science 275: 1314-1317. |
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Madhani, H.D., Styles, C.A. & Fink, G.R. (1997). MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation. Cell 91: 673-684. |
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Madhani, H.D. & Fink, G.R. (1998). The riddle of MAP kinase signaling specificity. Trends Genet. 14: 151-155. |
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Madhani, H.D., & Fink, G.R. (1998). The control of fungal differentiation and virulence. Trends Cell Biol. 8: 348-352. |
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Rupp, S., Summers, E., Lo, H., Madhani, H.D. & Fink, G.R. (1999) MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene. EMBO J. 18: 1257-1269. |
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Madhani, H.D., Galitski, T., Lander, E.S.& Fink, G.R. (1999) Effectors of a developmental MAP kinase cascade revealed by expression signatures of signaling mutants. Proc. Natl. Acad. Sci. USA 96: 12530-12535. |
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Madhani, H.D. (2000). Interplay of intrinsic and extrinsic signals in yeast differentiation. Proc. Nat. Acad. Sci. USA 97: 13461-13463. |
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Madhani, H.D. (2001) Accounting for receptor tyrosine kinase signaling specificity. Cell 106:9-11. |
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Brugnera, E., Haney, L., Grimsley, C., Lu, M., Walk S.F., Tosello-Trampont, A.C., Macara I.G., Madhani, H.D., Fink G.R., Ravichandran K.S.(2002) Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. Nat. Cell Biol. 4:574-82. |
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Hwang, W., Venkatasubrahmanyam, S., Ianculescu, A.G., Tong, A., Boone, C., Madhani, H.D. (2003) A conserved RING finger protein required for histone H2B monoubiquitination and cell size control. Mol. Cell 11: 261-266. Published online Dec. 28, 2002. |
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Meneghini, M.D., Wu., M, and Madhani, H.D. (2003) Conserved histone variant H2A.Z prevents the ectopic spread of silent heterochromatin. Cell 112, 725-736. |
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Kobor, M.S., Venkatasubrahmanyam, S., Meneghini, M.D., Gin, J.W., Jennings, J.L., Link, A.J., Madhani, H.D. , Rine, J. (2004) Swr1p, a conserved member of the ATP-dependent chromatin remodeling enzyme family, forms a multisubunit complex with histone variant H2A.Z and mediates its deposition into euchromatin. PLoS Biology 2:587-599. |
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Schwartz, M.A. and Madhani, H.D. (2004) Principles of MAP kinase signaling specificity in Saccharomyces cerevisiae. Annual Review of Genetics. 38: 725-48. |
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Bao, M.Z., Schwartz, M.A., Cantin, G.T., Yates, J.R. 3rd, Madhani, H.D. (2004). Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast. Cell 119(7): 911-1000. |
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Kung, C., Kenski, D.M., Dickerson, S.H., Howson, R.W., Kuyper, L.F., Madhani, H.D., and Shokat, K. (2005). Chemical Profiling to identify intracellular targets of a multiplex kinase inhibitor. Proc. Natl. Acad. Sci. USA 102: 3587-3592. |
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Raisner, R.M., Hartley, P.D., Meneghini, M.D., Bao, M.Z., Liu, C.L., Schreiber, S.L., Rando, O.J., Madhani, H.D. (2005) Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin. Cell 123(2): 233-248. |
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Kung C, Kenski DM, Krukenberg K, Madhani HD, Shokat KM. (2006) Selective kinase inhibition by exploiting differential pathway sensitivity. Chem Biol. Apr:13(4):399-407. |
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Raisner RM, Madhani HD. (2006) Patterning chromatin: form and function for H2A.Z variant nucleosomes. Curr Opin Genet Dev. Apr;16(2):119-24. Epub 2006 Feb 28. |
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Schwartz MA, Madhani HD. (2006) Control of MAPK signaling specificity by a conserved residue in the MEK-binding domain of the yeast scaffold protein Ste5. Curr Genet. Feb 4:1-13. |
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12/8/06 |
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