Jacquelyn J. Maher, MD

Duke University, BA, 1972-1976, Chemistry
Duke University Medical Center, MD, 1976-1979
Duke University Medical Center, 1/1980-6/1980, Research Fellowship, Hematology
Duke University Medical Center, 1980-1983, Internal Medicine Residency
University of California, San Francisco, 1983-1984, Clinical Fellowship, GI
University of California, San Francisco, 1984-1987, Research Fellowship, GI

• Jan-June, 1980
  Research Fellow in Hematology, Duke University Med. Ctr. (W. F. Rosse, preceptor)
• July 1980-1983
  Resident in Internal Medicine, Duke University Medical Center
• July 1983-1984
  Clinical Fellow in Gastroenterology, University of California, San Francisco
• July 1984-1987
  Research Fellow in Gastroenterology, University of California, San Francisco (D. Montgomery Bissell and F. Joseph Roll, preceptors)
• July 1987-1995
  Assistant Professor of Medicine, University of California, San Francisco
• July 1995-2003
  Associate Professor of Medicine, University of California, San Francisco
• July 2003-present
  Professor of Medicine, University of California, San Francisco
• July 1997-present
  Director, Rice Liver Center Laboratory, San Francisco General Hospital
• Jun 1998-Jan 2001
  Interim Chief of Gastroenterology, San Francisco General Hospital

• 1975
  Phi Beta Kappa, Duke University
• 1982-83
  Assistant Chief Resident in Medicine, Duke University Medical Center
• 1985-86
  American Liver Foundation Postdoctoral Research Fellowship
• 1986-87
  American Gastroenterological Association Research Fellowship
• 1989-90
  Faculty Development Award, UCSF
• 1994-96
  Alcoholic Beverage Medical Research Foundation Award
• 1996
  Member of NIAAA Research Delegation on Alcoholic Liver Disease, Mexico
• 1996-01
  Research Scientist Development Award, NIAAA
• 1996-01
  Associate Editor, Hepatology
• 1997-02
  Editorial Board, American Journal of Physiology
• 2001-05
  Editorial Board, Hepatology

• Bissell DM, Arenson DM, Maher JJ, Roll FJ. Support of cultured hepatocytes by a laminin rich gel: Evidence for a functionally significant subendothelial matrix in normal liver. J Clin Invest 1987; 79:801 812.
• Maher JJ, Friedman SL, Roll FJ, Bissell DM. Immunolocalization of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocytes in primary culture. Gastroenterology 1988; 82:450-459.
• Maher JJ, Bissell DM, Friedman SL, Roll FJ. Collagen measured in primary cultures of normal rat hepatocytes derives from lipocytes within the monolayer. J Clin Invest 1988; 82:450-459
• Maher JJ, McGuire RF. Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo. J Clin Invest 1990; 86:1641-1648.
• Friedman SL, Rockey DC, McGuire RF, Maher JJ, Boyles JK, Yamasaki G. Isolated hepatic lipocytes and Kupffer cells from normal human liver: morphologic and functional characteristics in primary culture. Hepatology 1992; 15:234-243.
• Maher JJ. Cell-specific expression of hepatocyte growth factor in liver: upregulation in sinusoidal endothelial cells after carbon tetrachloride. J Clin Invest 1993;91:2244-2252.
• Maher JJ, Friedman SL. Parenchymal and nonparenchymal cell interactions in liver. Semin Liver Dis 1993; 13:13-20.
• Maher JJ, Bissell DM. Cell-matrix interactions in liver. Semin Cell Biol 1993; 4:189-201
• Maher JJ, Tzagarakis C. Partial cloning of the laminin M subunit from adult rat lipocytes: expression of the M subunit by cells isolated from normal and injured liver. Hepatology 1994;19:764-770.
• Maher JJ, Zia S, Tzagarakis C. Acetaldehyde-induced stimulation of collagen synthesis and gene expression is dependent on conditions of cell culture: studies with rat lipocytes and fibroblasts. Alcohol: Clin Exp Res 1994;18:403-409.
• Maher JJ, Tzagarakis C, Gimenez A. Malondialdehyde enhances collagen synthesis by lipocytes only upon activation in primary culture. Alcohol Alcohol 1994;29:605-610.
• Maher JJ. Rat hepatocytes and Kupffer cells interact to produce interleukin-8 (CINC) in the setting of ethanol. Am J Physiol 1995;269:G518-G523.
• Maher JJ, Scott MK, Saito JM, Burton MC. Adenovirus-mediated expression of cytokine-induced neutrophil chemoattractant (CINC) in rat liver induces a neutrophilic hepatitis. Hepatology 1997;25:624-630.
• Maher JJ, Saito JM, Neuschwander-Tetri BA. Glutathione regulation in rat hepatic stellate cells: comparative studies in primary culture and in liver injury in vivo. Biochem Pharmacol 1997;53;637-641.
• Maher JJ, Neuschwander-Tetri, BA. Manipulation of glutathione stores in rat hepatic stellate cells does not alter collagen synthesis Hepatology 1997; 26:618-623.
• Maher JJ, Lozier JS, Scott MK. Rat hepatic stellate cells produce cytokine-induced neutrophil chemoattractant in culture and in vivo. Am J Physiol 1998; 275:G847-G853.
• Maher JJ. Leukocytes as modulators of stellate cell activity. Alcohol: Clin Exp Res 1999;23:917-21.
• Maher JJ. Cytokines and the liver . Semin Liver Dis 1999;19:109-116.
• Friedman SL, Maher JJ, Bissell DM. Mechanisms and therapy of hepatic fibrosis; report of the AASLD Single Topic Basic Research Conference. Hepatology 2000;32:1403-1408.
• Saito JM, Maher JJ. Bile duct ligation in rats induces biliary expression of cytokine-induced neutrophil chemoattractant. Gastroenterology 2000;118:1157-1168.
• Wang R, Ferrell LD, Faouzi S, Maher JJ, Bishop JM. Activation of the met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice. J Cell Biol 2001;153:1023-1034.
• Sonda S, Ting L-M, Novak S, Kim K, Maher JJ, Farese RV Jr, Ernst JD. Cholesterol esterification by host and parasite is essential for optimal proliferation of Toxoplasma gondii. J Biol Chem 2001;276:34434-40.
• Maher JJ. Interactions between hepatic stellate cells and the immune system. Semin Liver Dis 2001; 21:417-426.
• Faouzi S, Burckhardt B, Campe C, Schrum L, Rippe R, Maher JJ. Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-B-independent, caspase-3-dependent pathway. J Biol Chem 2001;276:49077-49082.
• Björkegren J, Beigneux A, Bergö M, Maher JJ, Young SG. Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury. J Biol Chem 2002;277:5476-5483.
• Saito JM, Bostick MK, Campe CB, Xu J, Maher JJ. Infiltrating neutrophils in bile duct-ligated livers do not promote hepatic fibrosis. Hepatol Res 2003;25:180-191.
• Xu J, Lee G, Wang H, Vierling JM, Maher JJ. Limited role of CXC chemokines in the pathogenesis of alpha-naphthylisothiocyanate (ANIT)-induced liver injury. Am J Physiol 2004;287:G734-G741.