Professor of Medicine, UCSF
| CONTACT | |
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jmaher@medsfgh.ucsf.edu SFGH, Bldg. 40, 4102, San Francisco, CA 94143 |
| EDUCATION | |
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Duke University, BA, 1972-1976, Chemistry
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| PROFESSIONAL EXPERIENCE | |
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Jan-June, 1980 |
Research Fellow in Hematology, Duke University Med. Ctr. (W. F. Rosse, preceptor) |
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July 1980-1983 |
Resident in Internal Medicine, Duke University Medical Center |
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July 1983-1984 |
Clinical Fellow in Gastroenterology, University of California, San Francisco |
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July 1984-1987 |
Research Fellow in Gastroenterology, University of California, San Francisco (D. Montgomery Bissell and F. Joseph Roll, preceptors) |
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July 1987-1995 |
Assistant Professor of Medicine, University of California, San Francisco |
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July 1995-2003 |
Associate Professor of Medicine, University of California, San Francisco |
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July 2003-present |
Professor of Medicine, University of California, San Francisco |
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July 1997-present |
Director, Rice Liver Center Laboratory, San Francisco General Hospital |
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Jun 1998-Jan 2001 |
Interim Chief of Gastroenterology, San Francisco General Hospital |
| HONORS & AWARDS | |
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1975 |
Phi Beta Kappa, Duke University |
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1982-83 |
Assistant Chief Resident in Medicine, Duke University Medical Center |
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1985-86 |
American Liver Foundation Postdoctoral Research Fellowship |
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1986-87 |
American Gastroenterological Association Research Fellowship |
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1989-90 |
Faculty Development Award, UCSF |
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1994-96 |
Alcoholic Beverage Medical Research Foundation Award |
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1996 |
Member of NIAAA Research Delegation on Alcoholic Liver Disease, Mexico |
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1996-01 |
Research Scientist Development Award, NIAAA |
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1996-01 |
Associate Editor, Hepatology |
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1997-02 |
Editorial Board, American Journal of Physiology |
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2001-05 |
Editorial Board, Hepatology |
| SELECTED PUBLICATIONS | |
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Bissell DM, Arenson DM, Maher JJ, Roll FJ. Support of cultured hepatocytes by a laminin rich gel: Evidence for a functionally significant subendothelial matrix in normal liver. J Clin Invest 1987; 79:801 812. | |
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Maher JJ, Friedman SL, Roll FJ, Bissell DM. Immunolocalization of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocytes in primary culture. Gastroenterology 1988; 82:450-459. | |
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Maher JJ, Bissell DM, Friedman SL, Roll FJ. Collagen measured in primary cultures of normal rat hepatocytes derives from lipocytes within the monolayer. J Clin Invest 1988; 82:450-459 | |
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Maher JJ, McGuire RF. Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo. J Clin Invest 1990; 86:1641-1648. | |
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Friedman SL, Rockey DC, McGuire RF, Maher JJ, Boyles JK, Yamasaki G. Isolated hepatic lipocytes and Kupffer cells from normal human liver: morphologic and functional characteristics in primary culture. Hepatology 1992; 15:234-243. | |
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Maher JJ. Cell-specific expression of hepatocyte growth factor in liver: upregulation in sinusoidal endothelial cells after carbon tetrachloride. J Clin Invest 1993;91:2244-2252. | |
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Maher JJ, Friedman SL. Parenchymal and nonparenchymal cell interactions in liver. Semin Liver Dis 1993; 13:13-20. | |
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Maher JJ, Bissell DM. Cell-matrix interactions in liver. Semin Cell Biol 1993; 4:189-201 | |
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Maher JJ, Tzagarakis C. Partial cloning of the laminin M subunit from adult rat lipocytes: expression of the M subunit by cells isolated from normal and injured liver. Hepatology 1994;19:764-770. | |
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Maher JJ, Zia S, Tzagarakis C. Acetaldehyde-induced stimulation of collagen synthesis and gene expression is dependent on conditions of cell culture: studies with rat lipocytes and fibroblasts. Alcohol: Clin Exp Res 1994;18:403-409. | |
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Maher JJ, Tzagarakis C, Gimenez A. Malondialdehyde enhances collagen synthesis by lipocytes only upon activation in primary culture. Alcohol Alcohol 1994;29:605-610. | |
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Maher JJ. Rat hepatocytes and Kupffer cells interact to produce interleukin-8 (CINC) in the setting of ethanol. Am J Physiol 1995;269:G518-G523. | |
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Maher JJ, Scott MK, Saito JM, Burton MC. Adenovirus-mediated expression of cytokine-induced neutrophil chemoattractant (CINC) in rat liver induces a neutrophilic hepatitis. Hepatology 1997;25:624-630. | |
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Maher JJ, Saito JM, Neuschwander-Tetri BA. Glutathione regulation in rat hepatic stellate cells: comparative studies in primary culture and in liver injury in vivo. Biochem Pharmacol 1997;53;637-641. | |
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Maher JJ, Neuschwander-Tetri, BA. Manipulation of glutathione stores in rat hepatic stellate cells does not alter collagen synthesis Hepatology 1997; 26:618-623. | |
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Maher JJ, Lozier JS, Scott MK. Rat hepatic stellate cells produce cytokine-induced neutrophil chemoattractant in culture and in vivo. Am J Physiol 1998; 275:G847-G853. | |
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Maher JJ. Leukocytes as modulators of stellate cell activity. Alcohol: Clin Exp Res 1999;23:917-21. | |
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Maher JJ. Cytokines and the liver . Semin Liver Dis 1999;19:109-116. | |
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Friedman SL, Maher JJ, Bissell DM. Mechanisms and therapy of hepatic fibrosis; report of the AASLD Single Topic Basic Research Conference. Hepatology 2000;32:1403-1408. | |
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Saito JM, Maher JJ. Bile duct ligation in rats induces biliary expression of cytokine-induced neutrophil chemoattractant. Gastroenterology 2000;118:1157-1168. | |
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Wang R, Ferrell LD, Faouzi S, Maher JJ, Bishop JM. Activation of the met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice. J Cell Biol 2001;153:1023-1034. | |
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Sonda S, Ting L-M, Novak S, Kim K, Maher JJ, Farese RV Jr, Ernst JD. Cholesterol esterification by host and parasite is essential for optimal proliferation of Toxoplasma gondii. J Biol Chem 2001;276:34434-40. | |
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Maher JJ. Interactions between hepatic stellate cells and the immune system. Semin Liver Dis 2001; 21:417-426. | |
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Faouzi S, Burckhardt B, Campe C, Schrum L, Rippe R, Maher JJ. Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-ÄéB-independent, caspase-3-dependent pathway. J Biol Chem 2001;276:49077-49082. | |
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Björkegren J, Beigneux A, Bergö M, Maher JJ, Young SG. Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury. J Biol Chem 2002;277:5476-5483. | |
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Saito JM, Bostick MK, Campe CB, Xu J, Maher JJ. Infiltrating neutrophils in bile duct-ligated livers do not promote hepatic fibrosis. Hepatol Res 2003;25:180-191. | |
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Xu J, Lee G, Wang H, Vierling JM, Maher JJ. Limited role of CXC chemokines in the pathogenesis of alpha-naphthylisothiocyanate (ANIT)-induced liver injury. Am J Physiol 2004;287:G734-G741. |
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3/15/05 |
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