Professor, Anesthesia and Pharmaceutical Chemistry, UCSF
| CONTACT | |
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marksj@anesthesia.ucsf.edu SFGH 3C-38, San Francisco, CA 94143 |
| EDUCATION | |
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University of California, Berkeley, Biochemistry
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| PROFESSIONAL EXPERIENCE | |
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1979-1982 |
Residency in Internal Medicine, University of California, San Francisco |
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1982-1983 |
Fellowship in Critical Care Medicine, University of California, San Francisco |
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1983-1984 |
Assistant Professor of Medicine, University of California, San Francisco |
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1984-1986 |
Residency in Anesthesia, University of California, San Francisco |
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1986-1989 |
Assistant Professor of Anesthesia and Medicine, University of California, San Francisco |
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1992-1994 |
Assistant Professor of Anesthesia and Pharmaceutical Chemistry; |
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1994-1998 |
Associate Professor of Anesthesia and Pharmaceutical Chemistry |
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1997-present |
Director, Medical-Surgical Intensive Care Unit, San Francisco General Hospital |
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1998-present |
Professor of Anesthesia and Pharmaceutical Chemistry |
| HONORS & AWARDS | |
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(1975) |
Phi Beta Kappa |
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(1979) |
Alpha Omega Alpha |
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(1994) |
Beckman Young Investigator Award |
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(1995, 1996) |
CaPCURE Research Award |
| SELECTED PUBLICATIONS | |
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(30 of 136 total) | |
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Marks JD, Hoogenboom HR, Bonnert TP, McCafferty J, Griffiths AD, Winter G. Bypassing immunization: Human antibodies from V-gene libraries displayed on phage. J. Mol. Biol. 222: 581-597, 1991. | |
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Marks JD, Griffiths AD, Malmqvist, M., Clackson T, Bye JM and Winter G. Bypassing immunization: High affinity human antibodies by chain shuffling. Bio/Technology. 10: 779-783, 1992. | |
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Marks JD, Hoogenboom HR, Griffiths AD and Winter G. Molecular evolution of proteins on filamentous phage: mimicking the strategy of the immune system. J. Biol. Chem. 267: 16007-16010, 1992. | |
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Schier R, Bye J, McCall A, Adams GP, Weiner LM, Marks JD. Isolation of high affinity human anti-c-erbB-2 single chain Fv using affinity driven selection. J. Mol. Biol. 255: 28-43, 1996. | |
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Schier R, McCall A, Adams GP, Marshall K, Yim M, Merritt H, Crawford RS, Weiner LM, Marks JD. Isolation of high affinity anti-c-erbB2 single-chain Fv by molecular evolution of the complementarity determining regions in the centre of the antibody combining site. J. Mol. Biol. 263: 551-567, 1996. | |
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Marks C and Marks JD. Phage libraries: a new route to clinically useful antibodies. N. Engl. J. Med. 335: 730-734, 1996. | |
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Adams GP, Schier R, Marshall K, Wolf EJ, McCall A, Marks JD and Weiner LM. Influence of affinity on the in vitro and in vivo binding properties of human single chain Fv molecules directed against c-erbB-2. Cancer Res. 58: 485-490, 1998. | |
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Adams, GP, Schier R, Marshall K, Wolf EJ, McCall A, Weiner LM and Marks JD. Prolonged in vivo tumor retention of a human diabody targeting the extracellular domain of human HER2/neu. Brit. J. Cancer. 77: 1405-1412, 1998. | |
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Sheets MD, Amersdorfer P, Finnern R, Sargent P, Lindqvist E, Schier R, Hemingsen G, Wong C, Gerhart JC, Marks JD. Efficient construction of a large non-immune phage antibody library: The production of panels of high affinity human single chain antibodies to protein antigens. Proc. Natl. Acad. Sci. USA. 95: 6157-6162, 1998. | |
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McCall AM, Amoroso AR, Sautes C, Marks JD and Weiner LM. Characterization of anti-mouse Fc gamma RII single-chain Fv fragments derived from human phage display libraries. Immunotechnology. 4: 71-87, 1998. | |
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Becerril B, Poul M-A and Marks JD. Towards selection of internalizing antibodies from phage libraries. Biochem. Biophys. Res. Comm. 255, 386-393, 1999. | |
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Poul M-A and Marks JD. Targeted gene delivery to mammalian cells by filamentous bacteriophage. J. Mol. Biol. 288: 203-211, 1999. | |
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Poul, M-A, Becerril B, Nielsen UB, Morisson P, and Marks JD. Selection of tumor specific internalizing human antibodies from phage libraries. J. Mol. Biol. 301: 1149-1161, 2000. | |
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Liu B, Marks JD. Applying phage antibodies to proteomics: selecting single chain Fv antibodies to antigens blotted on nitrocellulose. Anal Biochem. 286:119-128, 2000. | |
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Nielsen UB, Adams GP, Weiner LM, Marks JD. Targeting of bivalent anti-ErbB2 diabody antibody fragments to tumor cells is independent of the intrinsic antibody affinity. Cancer Res. 60:6434-40, 2000 | |
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Neve RM, Nielsen UB, Kirpotin DB, Poul MA, Marks JD, Benz CC. Biological effects of anti-ErbB2 single chain antibodies selected for internalizing function. Biochem Biophys Res Comm. 280(1):274-279, 2001. | |
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Heitner T, Moor A, Hasan T, Garrison J, Marks C, and Marks JD. Selection of cell binding and internalizing epidermal growth factor receptor antibodies from a phage display library. J. Imm.. Meth. 248: 17-30, 2001. | |
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Park JW, Hong K, Kirpotin DB, Colbern G, Shalaby R, Baselga J, Shao Y, Nielsen UB, Marks JD, Moore D, Papahadjopoulos D, and Benz CC. Anti-HER2 immunoliposomes: enhanced anticancer efficacy due to targeted delivery. Clin. Cancer Res. 8:1172-1181, 2002. | |
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Nielsen UB, Kirpotin DB, Pickering EM, Hong K, Park JW, Shalaby MR, Shao Y, Benz CC, and Marks JD. Therapeutic efficacy of anti-ErbB2 immunoliposomes targeted by a phage antibody selected for cellular endocytosis. Biochim. Biophys. Acta 159:109-118, 2002. | |
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O'Connell D, Becerril B, Roy-Burman A, Daws M, and Marks JD. Phage vs phagemid libraries for generation of human monoclonal antibodies. J. Mol. Biol. 321:49-56, 2002. | |
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Mamot C, Drummond DC, Greiser U, Hong K, Kirpotin DB, Marks JD, Park JW. EGFR-targeted immunoliposomes mediate specific and efficient drug delivery to EGFR- and EGFRvIII-overexpressing tumor cells. Cancer Res. 63:3154-3161, 2003. | |
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Liu B, Conrad F, Cooperberg MR, Kirpotin D, Marks JD. Mapping tumor epitope space by direct selection of antibody gene diversity library on prostate cancer cell surfaces. Cancer Res. 64:704-710, 2004. | |
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Weaver-Feldhaus JM, Lou J, Coleman JR, Siegel RW, Marks JD, and Feldhaus M. Yeast mating for combinatorial Fab library generation and surface display. FEBS Letters. 23:24-34, 2004. | |
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Adams GP, Shaller CC, Dadachova K, Simmons HH, Horak EM, Tesfaye A, Marks JD, Brechbiel MW, Weiner LM. A Single Treatment of 90Y-CHX-AÓ C6.5 Diabody Inhibits the Growth of Established Human Tumor Xenografts in Mice. Cancer Res. 64:6200-6206, 2004. | |
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Robinson MK, Doss M, Shaller C, Narayanan D, Adler LP, Gonzalez Trotter DE, Marks JD, and Adams GP. Quantitative immunoPET imaging of HER2-positive xenografts with an Iodine-124 labeled anti-HER2 diabody. Cancer Res. 65:1471-1478, 2005. | |
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Nellis DF, Ekstrom DL, Kirpotin DB, Zhu J, Andersson R, Broadt TL, Ouellette TF, Perkins SC, Roach JM, Drummond DC, Hong K, Marks JD, Park JW, and Giardina SL. Pre-clinical manufacture of an anti-HER2 scFv-PEG-DSPE, liposome -inserting conjugate: Part 1: Gram-scale production and purification. Biotechnol. Progress. 21:205-220, 2005. | |
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Nellis DF, Giardina SL, Janini G, Shenoy SR, Marks JD, Tsai R, Drummond DC, Hong K, Park JW Ouellette TF, Perkins SC, and Kirpotin DB. Pre-clinical manufacture of an anti-HER2 scFv-PEG-DSPE, liposome -inserting conjugate: Part II: Conjugate micelle identity, purity, stability, and potency analysis. Biotechnol. Progress. 21: 221-232, 2005. | |
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Horak E, Heitner T, Robinson MK, Simmons HH, Garrison J, Russeva M, Furmanova P, Lou J, Zhou E, Weiner LM, Adams GP, Marks JD. Isolation of scFvs to in vitro produced extracellular domains of EGFR family members. Cancer Biother. Radiopharm. 20:603-613, 2005. | |
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Kirpotin DB, Drummond DC, Shao Y, Shalaby MR, Hong K, Nielsen UB, Marks JD, Benz CC, and Park JW. Antibody targeting of long circulating nanoparticles does not increase tumor localization but does increase internalization in animal models. Cancer Res. 66: 6732-6740, 2006. | |
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Nielsen UB, Kirpotin DB, Pickering EM, Drummond DC, and Marks JD. A novel assay for monitoring internalization of nanocarroer coupled antibodies. BMC Immunol. Oct 2; 7: 24 (Epub ahead of print). |
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1/30/07 |
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