tmauro@itsa.ucsf.edu
(415) 750-2091 (voice)
(415) 751-3927 (fax)

Veterans Affairs Medical Center, VAMC 190, San Francisco, CA 94121

Bryn Mawr College, Pennsylvania, A.B., 1974-76
Bryn Mawr College, Pennsylvania, 1977-79, English, Biology
Medical College of Pennsylvania, Pennsylvania PA, M.D., 1979-83
Hahneman Medical College of Pennsylvania, PA, Internship, 1983-84, Internal Medicine
NIH Medical Training Grant, Physiology Department, Univ. of Pennsylvania, PA, Research Fellowship, 1984-85
Univ. of California, Davis, CA, Residency, 1985-87, Dermatology
Univ. of California, Davis, CA, Chief Resident, 1987-88, Dermatology

Mauro T, Pappone PA, RR Isseroff: Extracellular calcium affects the membrane currents of cultured human keratinocytes. J Cell Physiol 143:13-20, 1990.

Mauro T, Isseroff, R. Pappone, P.A. Ion channels are linked to keratinocyte differentiation. J. Memb. Biol. 132: 201-209, 1993.

Lee SH, Elias PM, Feingold KR, Mauro T: A role for ions in barrier recovery after acute perturbation. J Invest Dermatol 102:976-979, 1994.

Mauro T, Dixon DB, Isseroff RR, Pappone PA: Amiloride blocks a non-specific cation channel and inhibits Ca2+-induced keratinocyte differentiation. J Invest Dermatol 105:203-208, 1995.

Bikle DD, Ratnam A, Mauro T, Pillai S: Changes in calcium responsiveness and handling during keratinocyte differentiation. Potential role of the calcium receptor. J. Clin Invest 97:1085-1093, 1996.

Grando SA, Horton RM, Mauro T, Kust DA, Lee TX, Dahl MV: Activation of keratinocyte nicotinic cholinergic receptor stimulates Ca++ influx and enhances cell differentiation. J Invest Dermatol: 107:412-418, 1996.

Mauro T, Dixon DB, Komuves L, Hanley K, Pappone PA: Keratinocyte K+ channels mediate Ca++- induced differentiation. J Invest Dermatol: 108:864-870, 1997.

Mao-Qiang M, Mauro T, Bench G, Warren R, Elias PM, Feingold KR: Calcium and potassium inhibit barrier recovery after disruption, independent of the type of insult in hairless mice. Exp Dermatol: 36-40, 1997

Oda Y, Timpe L, McKenzie RC, Sauder DN, Largman C, Mauro T: Alternatively spliced forms of the cGMP gated channel in human keratinocytes. FEBS letters: 414:140-145, 1997.

Elias PM, Cullander C, Mauro T, Rassner U, Kömüves LG, Brown BE, Menon GK. The secretory granular cell: The outermost granular cell as a specialized secretory cell. J Invest Dermatol. Symposium Proceedings 3:87-100, 1998.

Elias PM, Nau P, Hanley K, Crumrine D, Bench G, Sideras-Haddad E, Mauro T, Williams M, Feingold K: Formation of the epidermal calcium gradient coincides with key milestones of barrier ontogenesis in the rodent. J Invest Dermatol: 110:399-405, 1998.

Mauro T, Greyson S, Gao WN, Man M-Q, Kriehuber E, Behne M, Feingold KR, Elias PM: Barrier recovery is impeded at neutral pH, independent of ionic effects: implications for extracellular lipid processing. Arch Derm Res: 290:211-215, 1998.

Mauro T, Bench G, Sidderas-Haddad E, Feingold K, Elias PM, Cullander C: Acute barrier perturbation abolishes the Ca2+ and K+ gradients in murine epidermis: quantitative measurement using PIXE. J Invest Dermatol: 111(6):1198-201, 1998.

Oda Y, Imanzahrai A, Kwong A, Kömüves L, Elias PM, Largman C, Mauro, T. Epithelial sodium channels are upregulated during epidermal differentiation. J Invest Dermatol 113(5):796-801, 1999.

Hu Z, Bonifas JM, Beech J, Bench G, Shigihara T, Ikeda S, Mauro T, Epstein EH. Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey Disease. Nature Genetics 24(1):61-65, 2000.

Oda Y, Chia-Ling T, Chang W, Crumrine D, Komuves L, Mauro T, Elias P, Bikle DD. The Ca2+- sensing receptor and its alternatively spliced form in murine epidermal differentiation. J Biol Chem 275(2):1183-1190, 2000.

Komuves LG, Shen WF, Kwong A, Stelnicki E, Rozenfeld S, Oda Y, Blink A, Krishnan K, Lau B, Mauro T, Largman C. Changes in HOXB6 homeodomain protein structure and localization during human epidermal development and differentiation. Dev Dyn 218(4): 636-47, 2000.

Behne MJ, Elias PM, Mauro T. The Antiporter NHE1 influences the function of the SC pH gradient. Journal Skin Barrier Research. 3: 3-10, 2001.

Mauro T, Guitard M, Behne M, Oda Y, Crumrine D, Komuves L, Rassner U, Elias PM, Hummler E. The ENaC channel is required for normal epidermal differentiation. J Invest Dermatol 118:589-94, 2002.

Sugarman J, Mauro T, Frieden I. Treatment of ulcerated hemangiomas with Becaplermin. Archives of Dermatology 138: 314-6, 2002.

Komuves L, Oda Y, Tu C-L, Chang WH, Ho-Pao CL, Mauro T, Bikle DD. 2002. The epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation. J Cell Physiol 192:45-54, 2002.

Hanson KM, Barry NP, Behne MJ, Mauro T, Gratton E, Clegg R. Fluorescence lifetime imaging of the skin stratum corneum pH gradient. Biophysical Journal 83: 1682-90, 2002.

Behne MJ, Meyer J, Hanson KM, Barry NP, Crumrine D, Lee J-D, Murata S, Clegg RW, Holleran WM, Elias PM, Mauro T. The Sodium/Hydrogen Antiporter, NHE1, Regulates Stratum Corneum Extracellular Acidification and Permeability Barrier Function. J Biol Chem 277(49): 47399-406, 2002.

Behne MJ, Aronchik I, Bench G, Epstein E, Pozzan T and Mauro T. Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores. J Invest Dermatol 121(4): 688-694, 2003.

Aronchik I, Leopoldt L, Crumrine D, Epstein E, Behne MJ, Mauro T. Defective cell-to-cell adhesion in HHD is linked to abnormal actin polymerization and decreased intracellular ATP concentration. J Invest Dermatol 121(4): 681-687, 2003.

McKenzie RC, Boyce F, Szepietowski JC, Mauro T. Defective cyclic Guanosine monophosphate (cGMP) -gated calcium channels and the pathogenesis of psoriasis. Acta Derm Venereol. 2003;83(6):414-8.

Mauro T. "The Discovery Channel": CRAC'king the Code of Calcium Influx. J Invest Dermatol. 121(1): IX-X, 2003.

Behne, M.J., Barry, N., Hanson, K., Gratton, E., Mauro, T. Calcium-fluorescence lifetime imaging in ex vivo skin II. J Invest Dermatol. 122:A81, 2004

Fluhr JW, Mao-Qiang M, Brown BE, Hachem JP, Moskowitz DG, Demerjian M, Haftek M, Serre G, Crumrine D, Mauro TM, Elias PM ,Feingold KR. Functional consequences of a neutral pH in neonatal rat stratum corneum. J Invest Dermatol, 123:140-151, 2004.

Racz, E., Behne, M.J., Aronchik, I., Mauro, T. Upregulation of the involucrin gene as a response to increased Ca2+ concentration is impaired in Hailey-Hailey keratinocytes. J Invest Dermatol. 122:A89, 2004.

Aronchik, I., Racz, E., Li, L., Behne, M., Mauro, T. Apoptotic signaling pathways in Darier's disease keratinocytes. J Invest Dermatol. 122:A91, 2004.

McCormick JA, Feng Y, Dawson K, Behne MJ, Yu B, Wang J, Wyatt AW, Henke G, Grahammer F, Mauro TM, Lang F ,Pearce D. Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development. Mol Biol Cell, 15:4278-4288, 2004.

Fluhr J, Behne M, Brown BE, Moskowitz DG, Selden C, Mao-Qiang M, Mauro T, Elias PM ,Feingold K. Stratum corneum acidification in neonatal skin: Secretory phospholipase A2 and the sodium/hydrogen antiporter-1 acidify neonatal rat stratum corneum. J Invest Dermatol, 122:320-329, 2004.

Aronchik A, Behne MJ, Bikle DD, Mauro T. ATP2C1, PMCA, CaR, Trp1 and Trp4 Upregulation Compensate for ATP2A2 Mutations in SERCA2+/- Mouse Keratinocytes. J Cell Science (submitted).

Fluhr JW, Mao-Qiang M, Brown BE, Hachem J-P, Moskowitz DG, Haftek M, Crumrine D, Mauro TM, Elias PM, Feingold KR. Functional consequences of a neutral stratum corneum pH in neonates. J Invest Dermatol (submitted).

11/15/04