Joseph (Mike) McCune, MD, PhD

Harvard College, A.B., 1975, Biochemistry
The Rockefeller University, Ph.D., 1981, Cell Biology/Immunology
Cornell Medical College, M.D., 1982, Medicine

• 1982-84
  Resident in Internal Medicine, University of California, San Francisco
• 1984-86
  Infectious Disease Fellow, UCSF
• 1985-88
  Postdoctoral Fellow, Department of Pathology, Stanford University School of Medicine
• 1986-present
  Physician, UCSF AIDS Clinic, San Francisco General Hospital (SFGH)
• 1988-91
  Scientific Director, SyStemix, Inc.
• 1991-94
  Vice-President, New Enterprise Research Division, SyStemix, Inc.
• 1993-94
  Director: SyStemix-Sandoz Antiviral Project & SyStemix-Sandoz HIV Gene Therapy Joint Venture (Progenesys, Inc)
• 1995-1999
  Associate Investigator, Gladstone Institute of Virology and Immunology (GIVI)
• 1999-2006
  Senior Investigator, GIVI
• 1995-1999
  Associate Professor of Medicine, UCSF
• 1995-2006
  Associate Director, General Clinical Research Center, SFGH
• 2003-2004
  Visiting Professor (on sabbatical), Institut Pasteur, Paris, France
• 2006-2008
  Director and PI of the UCSF Clinical and Translational Science Institute
• 2005-2008
  Senior Associate Dean of Clinical and Translational Research
• 2006-present
  Chief of the Division of Experimental Medicine
• 1999-present
  Professor of Medicine, UCSF

• 1972-75
  National Merit Scholarship
• 1972-75
  Harvard National Scholarship
• 1975-76
  Michael C. Rockefeller Memorial Fellowship
• 1986-89
  Pfizer Postdoctoral Fellowship in Infectious Diseases
• 1987
  Diplomate, Internal Medicine
• 1996-2000
  Elizabeth Glaser Scientist Award
• 1999
  Member, American Society for Clinical Investigation
• 2000
  Member, American Association of Physicians
• 2000-2005
  Burroughs Wellcome Fund Clinical Scientist Award in Translational Research
• 2001
  NIH MERIT Award
• 2004
  NIH Director's Pioneer Award
• 2006
  NIH Clinical and Translational Science Institute Award
• 2007
  Pediatric Fellows and Fellows Leadership and Advocacy Group Mentorship Award, nominee
• 2007
  UCSF Postdoctoral Scholar’s Association Outstanding Mentor Award

• (selected from 191)
• Napolitano LA, Grant RM, Deeks SG, Schmidt D, De Rosa SC, Herzenberg LA, Herndier BG, Andersson J, McCune JM. Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis. Nature Med. 7:73-79, 2001.
• Hellerstein MK, Hoh RA, Hanley MB, Cesar D, Lee D, Neese RA, McCune JM. Subpopulations of long lived and short-lived T-cells in advanced HIV-1 infection. J. Clin. Invest. 112: 956-966, 2003.
• Hartigan-O’Connor D, Abel K, McCune JM. Suppression of SIV-specific CD4+ T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression, J. Exp. Med., 204:2679-92, 2007.
• Mold JE, Michaelsson J, Burt TD, Muench MO, Beckerman KP, Busch MP, Lee T-H, Nixon DF, and McCune JM. Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science, 322:1562-65, 2008. PMCID: PMC2648820.
• Napolitano LA, Schmidt D, Gotway MB, Ameli N, Filbert EL, Ng MM, Clor JL, Epling L, Sinclair E, Baum PD, Li K, Killian ML, Bacchetti P, McCune JM. Growth hormone enhances thymic function in HIV-infected adults. J. Clin. Invest. 118:1085-98, 2008. PMCID: PMC2248326.
• Favre D, Lederer S,* Kanwar B,* Min Ma Z,* Proll S, Kasakow Z, Mold J, Swainson L, Barbour JD, Baskin CR, Palermo R, Pandrea I, Miller C, Katze M, McCune JM. Critical loss of the balance between TH17 and T regulatory cell populations in pathogenic SIV infection. PLoS Pathogens, 5(2):e1000295, 2009 (*co-equal authors). PMCID: PMC2635016.
• Loke P,* Favre D,* Hunt PW, Leung JM, Kanwar B, Martin JN, Deeks SG, McCune JM. Correlating cellular and molecular signatures of mucosal immunity that distinguish HIV controllers from non-controllers. Blood, Feb 16, 2010. PMCID: PMC2858476.
• Swainson L, Mold J, Bajpai U, and McCune JM. 2010. Expression of the autoimmune susceptibility gene FcRL3 on human regulatory T cells is associated with dysfunction and high levels of programmed cell death-1. J Immunol 184: 3639-47. PMCID: PMC2894810.
• Stoddart CA, Keir ME, McCune JM. IFN-a-mediated induction of CCR5 leads to expanded HIV-1 tropism in vivo. PLoS Pathogens, 6:e1000766, 2010. PMCID: PMC2824759.
• Favre D,* Mold J,* Hunt P, Kanwar B, Loke P, Seu L, Barbour J, Lowe MM, Jayawardene A, Aweeka F, Huang Y, Douek D, Brenchley JM, Martin JN, Hecht FM, Deeks SG, McCune JM. Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of Th17 and regulatory T cells in HIV disease. Science Translational Medicine, 2:32ra36, 2010. (*co-equal authors). PMCID: PMC3034445.
• Favre D, Stoddart CA, Emu B, Hoh R, Martin JN, Deeks, SG, McCune JM. HIV infection generates dysfunctional CD8low naive T cells. Blood, 117:2189-99, 2011. PMCID: PMC3062328 [Available on 2012/2/17].
• Burt T, Seu L, Mold JE, Kappas A, McCune JM. Naïve human T cells are activated and proliferate in response to the heme oxygenase-1 inhibitor tin mesoporphyrin. J. Immunol. 185:5279-88, 2010. PMID: 290921523
• Mold JE, Venkatasubrahmanyam S, Burt TD, Michaelsson J, Rivera J, Galkina SA, Weinberg K, Stoddart CA, McCune JM. Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans. Science, 330:1695, 2010. PMID: 21164017
• Baum PD, Young JJ, Zhang Q, Kasakow Z, McCune JM. Design, construction, and validation of a modular library of sequence diversity standards for PCR. Anal Biochem, Nov 25, 2010. PMCID: PMC3073996 [Available on 2012/4/1].
• Babik JM, Cohan D, Monto A, Hartigan-O’Connor DJ, McCune JM. The human fetal immune response to hepatitis C virus exposure in utero. J. Infect. Dis. 203:196-206, 2011. PMCID: PMC3071071 [Available on 2012/1/15].