Professor of Medicine; Chief, Division of Experimental Medicine; Senior Associate Dean of Clinical and Translational Research, UCSF
Member, Biomedical Sciences Program (BMS), Herbert Boyer Program in Biological Sciences (PIBS), and Immunology Graduate Program, UCSF
| CONTACT | |
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mike.mccune@ucsf.edu Box 1234, UCSF; San Francisco, CA 94143-1234 |
| EDUCATION | |
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Harvard College, A.B., 1975, Biochemistry
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| PROFESSIONAL EXPERIENCE | |
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1982-84 |
Resident in Internal Medicine, University of California, San Francisco |
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1984-86 |
Infectious Disease Fellow, University of California, San Francisco |
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1985-88 |
Postdoctoral Fellow, Department of Pathology, Stanford University School of Medicine |
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1987-present |
Physician, University of California, AIDS Clinic, San Francisco General Hospital |
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1988-91 |
Scientific Director, SyStemix, Inc. |
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1991-94 |
Vice-President, New Enterprise Research Division, SyStemix, Inc. |
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1993-94 |
Director: SyStemix-Sandoz Antiviral Project & SyStemix-Sandoz HIV Gene Therapy Joint Venture (Progenesys, Inc) |
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1995-1999 |
Associate Investigator, Gladstone Institute of Virology and Immunology |
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1999-present |
Senior Investigator, Gladstone Institute of Virology and Immunology |
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1995-present |
Associate Professor of Medicine, University of California, San Francisco |
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1995-present |
Associate Director, General Clinical Research Center, San Francisco General Hospital |
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2003-2004 |
Visiting Professor (on sabbatical), Institut Pasteur, Paris, France |
| HONORS & AWARDS | |
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1972-75 |
Harvard National Scholarship |
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1975-76 |
Michael C. Rockefeller Memorial Fellowship |
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1986-89 |
Pfizer Postdoctoral Fellowship in Infectious Diseases |
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1987 |
Diplomate, Internal Medicine |
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1996-2000 |
Elizabeth Glaser Scientist Award |
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1999 |
Member, American Society for Clinical Investigation |
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2000 |
Member, American Association of Physicians |
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2000-2005 |
Burroughs Wellcome Fund Clinical Scientist Award in Translational Research |
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2001 |
NIH MERIT Award |
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2004 |
NIH Director's Pioneer Award |
| SELECTED PUBLICATIONS | |
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(selected from 130) | |
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McCune JM, Humphreys RE, Yocum RR, Strominger JL. Enhanced representation of HL-A antigens on human lymphocytes after mitogenesis induced by phytohemagglutinin or Epstein-Barr virus. Proc. Natl. Acad. Sci. USA 72:3206-3209, 1975. | |
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Humphreys RE, McCune JM, Chess L, Herrman HC, Malenka DJ, Mann DL, Parham P, Schlossman SF, Strominger JL. Isolation and immunologic characterization of a human, B-lymphocyte-specific, cell surface antigen. J. Exp. Med. 144: 98-112, 1976. | |
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McCune JM, Lingappa VR, Fu SM, Blobel G, Kunkel HG. Biogenesis of membrane-bound and secreted immunoglobulins. I. Two distinct translational products of human mu chain, with identical N-termini and different C-termini. J. Exp. Med. 152: 463-468, 1980. | |
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McCune JM, Rabin LB, Feinberg MB, Lieberman M, Kosek JC, Reyes GR, and Weissman IL. Endoproteolytic cleavage of gp160 is required for the activation of human immunodeficiency virus. Cell. 53: 53-67, 1988. | |
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McCune JM, Namikawa R, Kaneshima H, Shultz LD, Lieberman M, and Weissman IL. The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science. 241: 1632-1639, 1988. | |
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Namikawa R, Kaneshima H, Lieberman M, Weissman IL, and McCune JM. Infection of the SCID-hu mouse by HIV-1. Science. 242: 1684-1686, 1988. | |
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McCune JM, Namikawa R, Shih C-C, Rabin L, and Kaneshima H. Suppression of HIV infection in AZT-treated SCID-hu mice. Science. 247: 564-566, 1990. | |
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Namikawa R, Weilbaecher KN, Kaneshima H, Yee EJ, McCune JM. Long-term human hematopoiesis in the SCID-hu mouse. J. Exp. Med. 172: 1055-1063, 1990. | |
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Bonyhadi ML, Rabin L, Salimi S, Brown DA, Kosek J, McCune JM, Kaneshima H. HIV induces thymus depletion in vivo. Nature. 363: 728-732, 1993. | |
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Su L, Kaneshima H, Bonyhadi M, Salimi S, Kraft D, Rabin L, McCune JM. HIV-1 induced thymocyte depletion is associated with indirect cytopathicity and infection of progenitor cells in vivo. Immunity. 2: 25-36, 1995. | |
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Jenkins M, Hanley MB, Moreno MB, Wieder E, McCune JM. Human immunodeficiency virus-1 infection interrupts thymopoiesis and multilineage hematopoiesis in vivo, Blood. 91: 2672-2678, 1998. | |
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McCune JM, Loftus R, Schmidt DK, Carroll P, Webster D, Swor-Yim LB, Francis IR, Gross BH, Grant RM. High prevalence of thymic tissue in adults with Human Immunodeficiency Virus-1 infection. J. Clin. Invest. 101 (11): 2301-2308, 1998. | |
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Komanduri KV, Viswanathan MN, Wieder ED, Schmidt DK, Bredt BM, Jacobson MA, McCune JM. Restoration of Cytomegalovirus-specific CD4+ T-lymphocyte responses after ganciclovir and highly active antiretroviral therapy in individuals infected with HIV-1. Nature Med. 4: 953-956, 1998. | |
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Berkowitz RD, Beckerman KP, Schall TJ, McCune JM. CXCR4 and CCR5 expression delineates targets for HIV-1 disruption of T cell differentiation. J. Immunol. 161: 3702-3710, 1998. | |
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Hellerstein M, Hanley MB, Cesar D, Siler S, Papageorgopoulos C, Wieder E, Schmidt D, Hoh R, Neese R, Macallan D, Deeks S, McCune JM. Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans. Nature Med. 5:83-89, 1999. | |
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McCune JM, Hanley MB, Cesar D, Halvorsen R, Hoh R, Schmidt D, Wieder E, Deeks S, Siler S, Neese R, Hellerstein M. Factors influencing T-cell turnover in HIV-1-seropositive patients. J. Clin. Invest. 105:R1-R8, 2000. | |
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Napolitano LA, Grant RM, Deeks SG, Schmidt D, De Rosa SC, Herzenberg LA, Herndier BG, Andersson J, McCune JM. Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis. Nature Med. 7:73-79, 2001. | |
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Napolitano LA, Lo JC, Gotway MB, Mulligan K, Barbour JD, Schmidt D, Grant RM, Halvorsen RA, Schambelan M, 20. McCune JM. Increased thymic mass and circulating naive CD4+ T cells in HIV-1-infected adults treated with growth hormone. AIDS. 16: 1103-1111, 2002. | |
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Keir ME, Stoddart CA, Linquist-Stepps V, Moreno ME, McCune JM. IFN-ƒ¿ secretion by type 2 predendritic cells up-regulates MHC class I in the HIV-1-infected thymus. J. Immunol. 168: 325-331, 2002. | |
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Napolitano LA, Stoddart CA, Hanley MB, Wieder E, McCune JM. Effects of Interleukin-7 on early human thymocyte progenitor cells in vitro and in SCID-hu thy/liv mice. J. Immunol. 171:645-654, 2003. | |
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Hellerstein MK, Hoh RA, Hanley MB, Cesar D, Lee D, Neese RA, McCune JM. Subpopulations of long-lived and short-lived T-cells in advanced HIV-1 infection. J. Clin. Invest. 112: 956-966, 2003 | |
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Deeks SG, Martin JN, Sinclair E, Harris J, Neilands T, Maecker HT, Hagos E, Wrin T, Petropoulos CJ, Bredt B, McCune JM. Strong cell-mediated immune responses are associated with the maintenance of low-level viremia in antiretroviral-treated individuals with drug-resistant human immunodeficiency virus type 1. J. Infect. Dis. 189:312-21, 2004. | |
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Emu B, Sinclair E, Favre D, Moretto WJ, Hsue P, Hoh R, Martin JN, Nixon DF, McCune JM, Deeks S. Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment. J Virol, 79:14169-78, 2005. | |
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Hanley MB, Napolitano LA, McCune JM. Growth hormone-induced stimulation of multilineage human hematopoiesis. Stem Cells, 23:1170-79, 2005. |
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7/2/07 |
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